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1 On the in vivo and in vitro interaction of tissue-type plasminogen activator with liver cells
article 1993    
Author: Otter, M.
Keywords: Biology · Tissue plasminogen activator · Animal cell · Animal experiment · Animal tissue · Drug blood level · Drug clearance · Drug receptor binding · Fibrinolysis · Liver cell · Nonhuman · Note · Rat
[Abstract]

2 Pharmacokinetics and bioavailability of dapsone in the beagle dog
article 1989    
Author: Hekman, P. · Rens, P. van · Rietvel, E.C. · Coert, A.
Keywords: Nutrition · Dapsone · Animal experiment · Dog · Drug bioavailability · Drug blood level · Drug determination · Intravenous drug administration · Nonhuman · Oral drug administration · Preliminary communication
[Abstract]

3 Analytical possibilities for the detection of stanozolol and its metabolites
article 2002    
Author: Poelmans, S. · Wasch, K. de · Brabander, H.F. de · Wiele, M. van de · Courtheyn, D. · Ginkel, L.A. van · Sterk, S.S. · Delahaut, Ph. · Dubois, M. · Schilt, R. · Nielen, M. · Vercammen, J. · Impens, S. · Stephany, R. · Hamoir, T. · Pottie, G. · Poucke, C. van · Peteghem, C. van
Keywords: Health · Analytical research · Anabolic steroids · GC-MS · LC-MS · Metabolites · Stanozolol · anabolic agent · chemical compound · stanozolol · chemistry · conference paper · drug blood level · drug metabolism · extraction · gas chromatography · hydrolysis · immunoaffinity chromatography · kidney clearance · liquid chromatography · liquid liquid extraction · literature · mass spectrometry · metabolite · nonhuman · priority journal · solid phase extraction · urinary excretion · urine · Animalia
[Abstract]

4 Pharmacokinetics of oestriol after repeated oral administration to dogs
article 2003    
Author: Hoeijmakers, M. · Janszen, B. · Coert, A. · Horspool, L.
Keywords: Drugs Chemistry · Physiological Sciences · estriol · incurin · animal experiment · area under the curve · article · blood sampling · calculation · controlled study · dog · dose response · drug accumulation · drug blood level · enterohepatic circulation · female · individualization · nonhuman · radioimmunoassay · statistical analysis · tablet formulation · urine incontinence · Administration, Oral · Animals · Dogs · Estriol · Female · Urinary Incontinence · Animalia · Canidae · Canis familiaris
[Abstract]

5 Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes
article 2004    
Author: Treijtel, N. · Barendregt, A. · Freidig, A.P. · Blaauboer, B.J. · Eijkeren, J.C.H. van
Keywords: Biology · Physiological Sciences · 4 tolylsulfonylurea · carboxytolbutamide · hydroxytolbutamide · sulfonylurea derivative · tolbutamide · unclassified drug · addition reaction · animal cell · article · cell culture · controlled study · drug blood level · drug clearance · in vitro study · in vivo study · liquid chromatography · liver cell · mass spectrometry · mathematical model · nonhuman · priority journal · radiochemistry · rat · Animals · Cells, Cultured · Hepatocytes · Male · Metabolic Clearance Rate · Models, Biological · Rats · Rats, Wistar · Tolbutamide · Animalia
[Abstract]

6 Evening dietary tryptophan improves post-sleep behavioral and brain measures of memory function in healthy subjects
article 2006    
Author: Markus, C.R. · Jonkman, L.M. · Lammers, J.H.C.M. · Deutz, N.E.P.
Keywords: Biology · Toxicology and Applied Pharmacology · Alpha-Lactalbumin · ERB · Performance · Sleep · Sleep Complaints · Tryptophan · alpha lactalbumin · placebo · tryptophan · adult · behavior change · blood level · brain function · clinical trial · controlled clinical trial · controlled study · diet supplementation · disease severity · double blind procedure · drug blood level · editorial · electroencephalography · female · human · human experiment · male · memory · memory disorder · normal human · protein intake · sleep disorder · task performance · treatment outcome · treatment response
[Abstract]

7 13-week oral toxicity study with stanol esters in rats
article 1999    
Author: Turnbull, D. · Whittaker, M.H. · Frankos, V.H. · Jonker, D.
Keywords: Nutrition · Alpha tocopherol · Cholesterol · Fatty acid ester · Phospholipid · Phytosterol · Vitamin d · Vitamin k group · Animal tissue · Cholesterol blood level · Controlled study · drug blood level · drug safety · drug tolerability · female · liver level · male · nonhuman · oral drug administration · phospholipid blood level · priority journal · rat · vitamin blood level · Animals · Blood Coagulation · Diet · Erythrocytes · Esters · Female · Liver · Male · Phytosterols · Rats · Rats, Wistar · Vitamins · Animalia · Rattus norvegicus
[Abstract]

8 Quantification of perifosine, an alkylphosphocholine anti-tumour agent, in plasma by pneumatically assisted electrospray tandem mass spectrometry coupled with high-performance liquid chromatography
article 1999    
Author: Knebel, N.G. · Grieb, S. · Winkler, M. · Locher, M. · Vlis, E. van der · Verheij, E.R.
Keywords: Nutrition · Alkylphosphocholine · Perifosine · Antineoplastic agent · Miltefosine · Perifosine · Unclassified drug · Accuracy · Automation · Calibration · Controlled study · Drug blood level · Drug determination · High performance liquid chromatography · Human · Human experiment · Human tissue · Mass spectrometry · Oral drug administration · Priority journal · Solid phase extraction · Technique · Calibration · Chromatography, High Pressure Liquid · Humans · Mass Spectrometry · Phosphorylcholine · Quality Control · Spectrometry, Fluorescence · Spectrophotometry, Ultraviolet
[Abstract]

9 Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients
article 1998    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Gall, H.E. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Creatinine · Adult · Aged · Area under the curve · Clinical article · Creatinine blood level · Dna adduct · Dna drug complex · Drug blood level · Drug effect · Drug half life · Female · Human · Intravenous drug administration · Kidney function · Male · Malignant neoplastic disease · Priority journal · Amifostine · Antineoplastic Agents · Cisplatin · DNA Adducts · Drug Interactions · Female · Half-Life · Hemofiltration · Humans · Leukocytes · Male · Middle Aged · Neoplasms · Platinum · Radiation-Protective Agents
[Abstract]

10 Pharmacokinetics of carboplatin with and without amifostine in patients with solid tumors
article 1997    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Eeltink, C.M. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Pharmacology · Amifostine · Carboplatin · Adult · Blood sampling · Clinical article · Clinical trial · Controlled clinical trial · Creatinine blood level · Creatinine clearance · Drug blood level · Drug efficacy · Drug half life · Enzyme linked immunosorbent assay · Female · Human · Intravenous drug administration · Male · Phase 1 clinical trial · Solid tumor · Amifostine · Animals · Antineoplastic Agents · Carboplatin · Dose-Response Relationship, Drug · Half-Life · Kidney · Kidney Function Tests · Metabolic Clearance Rate · Mice · Mice, Nude · Neoplasms
[Abstract]

11 Determination of the B2 vitamer flavin-adenine dinucleotide in whole blood by high-performance liquid chromatography with fluorometric detection
article 1982    
Author: Speek, A.J. · Schaik, F. van · Schrijver, J. · Schreurs, W.H.P.
Keywords: Nutrition · Flavine adenine nucleotide · Flavine nucleotide · Riboflavin · Nicotinamide adenine dinucleotide · Blood · Blood and hemopoietic system · Drug blood level · Drug determination · Fluorometry · High performance liquid chromatography · Human · Human cell · In vitro study · Methodology · Normal human · Normal value · Preliminary communication · Theoretical study · Article · Chemistry · Spectrofluorometry · Chromatography, High Pressure Liquid · Human · Microchemistry · NAD · Spectrometry, Fluorescence
[Abstract]

12 The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: A longitudinal study
article 1994    
Author: Groen, K. · Breimer, D.D. · Jansen, E.J. · Bezooijen, C.F.A. van
Keywords: Health · 3 hydroxymethylphenazone · 4 hydroxyphenazone · Norphenazone · Phenazone · Adolescent · Aged · Body weight · Controlled study · Drug blood level · Drug clearance · Drug metabolism · Drug urine level · Enantiomer · Enzyme activity · Enzyme specificity · High performance liquid chromatography · Nonhuman · Survival rate · Aging · Animal · Antipyrine · Cytochrome P-450 Enzyme System · Enzyme Induction · Hexobarbital · Longitudinal Studies · Male · Metabolic Clearance Rate · Phenobarbital · Rats · Rats, Inbred BN · Stereoisomerism
[Abstract]

13 The dependence of the blood level of the oxime HS 6 on the severity of organophosphate poisoning
article 1976    
Author: Wolthuis, O.L. · Clason-van der Wiel, H.J. · Visser, R.P.L.S.
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Atropine · Cholinesterase inhibitor · Dimethyl ether · Soman · Drug analysis · Drug blood level · Drug intoxication · Intoxication · Intravenous drug administration · Pharmacokinetics · Plasma · Pralidoxime derivative · Rat · Respiratory failure · Theoretical study · Animal · Antidotes · Atropine · Dose-Response Relationship, Drug · Lethal Dose 50 · Male · Organophosphorus Compounds · Oximes · Rats · Soman
[Abstract]

14 Toxicokinetics of hexavalent chromium in the rat after intratracheal administration of chromates of different solubilities
article 1983    
Author: Bragt, P.C. · Dura, E.A. van
Keywords: Biology · Chromic acid · Chromium · Lead chromate · Radioisotope · Sodium chromate cr 51 · Animal experiment · Drug blood level · Endotracheal intubation · Inhalational drug administration · Nonhuman · Occupational exposure · Respiratory system · Toxicokinetics · Zinc chromate · Animal · Chromium · Intubation, Intratracheal · Kinetics · Male · Rats · Rats, Inbred Strains · Solubility · Support, Non-U.S. Gov't · Tissue Distribution
[Abstract]

15 Generic solid phase extraction-liquid chromatography-tandem mass spectrometry method for fast determination of drugs in biological fluids
article 2003    
Author: Schellen, A. · Ooms, B. · Lagemaat, D. van de · Vreeken, R. · Dongen, W.D. van
Keywords: Drugs Pharmacology · Analytical research · Drug analysis · Generic method · Body fluids · Drug products · Mass spectrometers · Solid phase extraction · High performance liquid chromatography · caffeine · carbamazepine · paclitaxel · paracetamol · procainamide · propranolol · ranitidine · sulfadiazine · sulfamerazine · theobromine · theophylline · accuracy · article · controlled study · drug blood level · drug determination · high performance liquid chromatography · human · linear system · physical chemistry · priority journal · quantitative analysis · solid phase extraction · tandem mass spectrometry · technique · time · Chromatography, High Pressure Liquid · Humans · Mass Spectrometry · Pharmaceutical Preparations · Reproducibility of Results · Sensitivity and Specificity · Spectrophotometry, Ultraviolet
[Abstract]

16 Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept
article 2014    
Author: Mooij, M.G. · Duijn, E. van · Knibbe, C.A.J. · Windhorst, A.D. · Hendrikse, N.H. · Vaes, W.H.J. · Spaans, E. · Fabriek, B.O. · Sandman, H. · Grossouw, D. · Hanff, L.M. · Janssen, P.J.J.M. · Koch, B.C.P. · Tibboel, D. · Wildt, S.N. de
Keywords: Nutrition · Carbon 14 · Drug metabolite · Paracetamol · Accelerator mass spectrometry · Blood sampling · Child · Clinical article · Drug blood level · Drug metabolism · Female · Human · Indwelling catheter · Infant · Limit of quantitation · Liquid chromatography · Male · Mass spectrometry · Maximum plasma concentration · Newborn · Open study · Pharmacokinetics · Pilot study · Preschool child · Priority journal · Single drug dose · Time to maximum plasma concentration · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

17 Dermal exposure assessment to benzene and toluene using charcoal cloth pads
article 2005    
Author: Wendel de Joode, B. van · Tielemans, E. · Vermeulen, R. · Wegh, H. · Kromhout, H.
Keywords: Health · Food and Chemical Risk Analysis · Benzene · Charcoal cloth pads · Dermal exposure · Toluene · acetylcysteine derivative · benzene · charcoal · organic solvent · toluene · airborne particle · ambient air · article · clothing · concentration (parameters) · drug blood level · human · industrial worker · inhalation · job analysis · occupational exposure · occupational hazard · occupational toxicology · personal monitoring · petrochemical industry · skin absorption · Administration, Cutaneous · Benzene · Charcoal · Chemical Industry · Environmental Exposure · Environmental Monitoring · Humans · Job Description · Occupational Exposure · Permeability · Petroleum · Toluene · Volatilization
[Abstract]

18 Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
article 2015    
Author: Garner, C.R. · Park, K.B. · French, N.S. · Earnshaw, C. · Schipani, A. · Selby, A.M. · Byrne, L. · Siner, S. · Crawley, F.P. · Vaes, W.H.J. · Duijn, E. van · ligt, R. de · Varendi, H. · Lass, J. · Grynkiewicz, G. · Maruszak, W. · Turner, M.A.
Keywords: Biology · Exploratory clinical study · Microdosing · Paediatric pharmacokinetics · Paracetamol · Unclassified drug · Accelerator mass spectrometry · Area under the curve · Child · Drug blood level · Drug clearance · Drug half life · Female · Human · Infant · Major clinical study · Male · Mass spectrometry · Maximum plasma concentration · Pharmacokinetics · Plasma concentration-time curve · Time to maximum plasma concentration · Ultra performance liquid chromatography · Volume of distribution · Healthy for Life · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

19 Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models
article 2011    
Author: Kleemann, R. · Verschuren, L. · Morrison, M. · Zadelaar, A.S.M. · Erk, M.J. van · Wielinga, P.Y. · Kooistra, T.
Keywords: Nutrition · Anti-inflammatory · Atherosclerosis · Cholesterol · CRP · Inflammation · Polyphenol · Proliferation · Quercetin · C reactive protein · endothelial leukocyte adhesion molecule 1 · fibrinogen · immunoglobulin enhancer binding protein · quercetin · vascular cell adhesion molecule 1 · animal experiment · animal model · antiinflammatory activity · article · atherosclerosis · cardiovascular risk · controlled study · drug activity · drug blood level · drug effect · endothelium cell · human · human cell · inflammation · liver cell · male · mouse · nonhuman · priority journal · protein expression · risk factor · transgenic mouse · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 38 found. Next | Sort by date