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Showing 1 to 19 of 19 found. | Sort by date

1 Putting pharmacogenetics into practice
article 2006    
Author: Hopkins, M.M. · Ibarreta, D. · Gaisser, S. · Enzing, C.M. · Ryan, J. · Martin, P.A. · Lewis, G. · Detmar, S. · Akker-van Marle, M.E. van den · Hedgecoe, A.M. · Nightingale, P. · Dreiling, M. · Hartig, K.J. · Vullings, W. · Forde, T.
Keywords: Health · c=Clinical practice · Drug efficacy · Drug response · Drug safety · Health care system · Pharmacogenomics · Policy · Review · Vocational education · Biotechnology · Drug Approval · Drug Design · Drug Industry · Pharmacogenetics · Research · United States

2 Usefulness of temazepam and zaleplon to induce afternoon sleep
article 2006    
Author: Simons, M. · Koerhuis, C.L. · Valk, P.J.L. · Oord, M.H.A.H. van den
Keywords: Defence · hypnotic agent · placebo · temazepam · zaleplon · adult · alertness · clinical trial · cognition · controlled clinical trial · controlled study · crossover procedure · double blind procedure · drug efficacy · drug safety · fatigue · human · human experiment · male · military service · muscle strength · night · human performance · quality control · shift worker · sleep induction · somnolence · Acetamides · Attention · Benzodiazepines · drugs · sleep · chronobiology · military
[Abstract]

3 Subchronic oral toxicity studies with y-cyclodextrin in rats
article 1998    
Author: Lina, B.A.R. · Bär, A.
Keywords: Biology · gamma cyclodextrin · lactose · animal experiment · animal tissue · article · body weight · controlled study · diarrhea · dose response · drug safety · drug toxicity · female · fluid intake · male · nonhuman · oral drug administration · organ weight · priority journal · rat · Administration, Oral · Animal Feed · Animals · Body Weight · Cecum · Cyclodextrins · Diarrhea · Drinking · Eating · Feces · Female · gamma-Cyclodextrins · Hematologic Tests · Kidney · Lactose · Liver · Male · Organ Size · Rats · Rats, Wistar · Animalia · Rattus norvegicus · Rodentia
[Abstract]

4 Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development
article 2006    
Author: Greef, J. van der · Adourian, A. · Muntendam, P. · McBurney, R.N.
Keywords: Biology · Analytical research · biological marker · drug metabolite · new drug · bioinformatics · body fluid · data base · decision making · drug determination · drug efficacy · drug marketing · drug research · drug safety · human · medical technology · metabolomics · multiple sclerosis · non insulin dependent diabetes mellitus · nonhuman · osteoarthritis · phenotype · postmarketing surveillance · proteomics · review · serology · structure activity relation
[Abstract]

5 13-week oral toxicity study with stanol esters in rats
article 1999    
Author: Turnbull, D. · Whittaker, M.H. · Frankos, V.H. · Jonker, D.
Keywords: Nutrition · Alpha tocopherol · Cholesterol · Fatty acid ester · Phospholipid · Phytosterol · Vitamin d · Vitamin k group · Animal tissue · Cholesterol blood level · Controlled study · drug blood level · drug safety · drug tolerability · female · liver level · male · nonhuman · oral drug administration · phospholipid blood level · priority journal · rat · vitamin blood level · Animals · Blood Coagulation · Diet · Erythrocytes · Esters · Female · Liver · Male · Phytosterols · Rats · Rats, Wistar · Vitamins · Animalia · Rattus norvegicus
[Abstract]

6 Safety evaluation of synthetic β-carotene
article 1999    
Author: Woutersen, R.A. · Wolterbeek, A.P.M. · Appel, M.J. · Berg, H. van den · Goldbohm, R.A. · Feron, V.J.
Keywords: Toxicology · Absorption · Cancer prevention · Distribution · Lung cancer · Toxicity · beta carotene · cancer risk · carcinogenicity · chronic toxicity · drug absorption · drug distribution · drug safety · drug transport · genotoxicity · human · nonhuman · reproductive toxicity · review · toxicity testing · Absorption · Animals · Antioxidants · beta Carotene · Cell Transformation, Neoplastic · Chemoprevention · Drug Interactions · Humans · Intervention Studies · Lung Neoplasms · Mice · Rats · Rats, Sprague-Dawley · Skin Neoplasms · Smoking · Animalia
[Abstract]

7 Considering patient safety in autonomous e-mental health systems - Detecting risk situations and referring patients back to human care
article 2019    
Author: Tielman, M.L. · Neerincx, M.A. · Pagliari, C. · Rizzo, A. · Brinkman, W.P.
Keywords: Assistive technologies · Chatbots · Conversational agents · eHealth · Persuasive computing · Risk · Robotics · Virtual agents · Adult · Assistive technology · Conversation · Crowdsourcing · Drug safety · Female · Human · Interview · Major clinical study · Male · Mental health · Motivation · Patient referral · Patient safety · Persuasive communication · Risk assessment · Sleep · Standing · Telehealth · Healthy for Life · Healthy Living
[PDF] [Abstract]

8 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

9 Lactotripeptides and antihypertensive effects: A critical review
article 2009    
Author: Boelsma, E. · Kloek, J.
Keywords: Health Nutrition · Biomedical Research · Antihypertensive effects · Blood pressure · Lactotripeptides · Milk peptides · antihypertensive agent · Beta adrenergic receptor blocking agent · Calcium antagonist · Dipeptidyl carboxypeptidase inhibitor · Lactotripeptide derivative · Placebo · Unclassified drug · Absence of side effects · Antihypertensive activity · Antihypertensive therapy · Blood chemistry · Blood pressure regulation · Caucasian · Clinical trial · Diastolic blood pressure · Dose response · Dose time effect relation · Drug bioavailability · Drug efficacy · Drug megadose · Drug potency · Drug safety · Food intake · Human · Hypertension · Japanese · Low drug dose · Nonhuman · Race difference · Review · Side effect · Systolic blood pressure · Treatment duration
[PDF] [Abstract]

10 Nonclinical testing of vaccines: Report from a workshop
article 2009    
Author: Laan, J.W. van der · Forster, R. · Ledwith, B. · Gruber, M. · Gould, S. · Segal, L. · Penninks, A.
Keywords: Health · Adjuvants · Developmental and reproductive toxicology · DNA vaccines · Nonclinical evaluation · Safety testing · Therapeutic vaccines · Vaccines · diphtheria pertussis tetanus vaccine · DNA vaccine · immunological adjuvant · immunomodulating agent · live vaccine · Meningococcus vaccine · pertussis vaccine · vaccine · Wart virus vaccine · conference paper · disease model · drug dose regimen · drug efficacy · drug research · drug safety · drug screening · drug tolerability · electroporation · human · immune response · immunogenicity · male fertility · nonhuman · pharmacodynamics · practice guideline · priority journal · reproductive toxicity · tattooing · toxicity testing · toxicology · vaccination · workshop
[Abstract]

11 Randomized controlled trial assessing a traditional Chinese medicine remedy in the treatment of primary dysmenorrhea
article 2006    
Author: Kennedy, S. · Jin, X. · Yu, H. · Zhong, S. · Magill, P. · Vliet, T. van · Kistemaker, C. · Voors, C. · Pasman, W.
Keywords: Health · Analytical research · Biomedical research · Angelica sinensis extract · Corydalis yanhusuo extract · ibuprofen · Paeonia lactiflora extract · placebo · plant extract · unclassified drug · adult · Angelica sinensis · article · Chinese medicine · clinical article · clinical trial · controlled clinical trial · controlled study · Corydalis · disease duration · double blind procedure · drug efficacy · drug safety · dysmenorrhea · female · headache · human · Paeonia · patient compliance · priority journal · randomization · randomized controlled trial · tablet · visual analog scale · Adolescent · Adult · Drugs, Chinese Herbal · Dysmenorrhea · Female · Humans · Medicine, Chinese Traditional · Middle Aged · Pilot Projects · Placebo Effect · Treatment Outcome
[Abstract]

12 Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
article 2015    
Author: Mesens, N. · Crawfordb, A.D. · Menke, A. · Hung, P.D. · Goethem, F. van · Nuyts, R. · Hansen, E. · Wolterbeek, A. · Gompel, J. van · Witte, P. de · Esguerra, C.V.
Keywords: Nutrition · Zebrafish larvae · Screening assay · Lfabp10a · Hepatotoxicity · DILI · Alpidem · Amiodarone · Bosentan · Buspirone · Diclofenac · Fatty acid binding protein · Fatty acid binding protein 10a · Glycogen · Ketorolac · Nefazodone · Paracetamol · Reactive oxygen metabolite · Rosiglitazone · Tacrine · Tamoxifen · Tetracycline · Troglitazone · Unclassified drug · Zolpidem · Adult · Animal tissue · Cell vacuole · Cholestasis · Circulation · Concentration response · Controlled study · Drug safety · Female · Glycogen analysis · Heart rate · Histology · Histopathology · In situ hybridization · Larval stage · Liver cell · Liver level · Liver size · Liver toxicity · Male · Mitochondrial membrane · Mitochondrial toxicity · Molecular cloning · Nonhuman · Protein expression · Steatosis · Toxicity testing · Zebra fish · Danio rerio · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

13 Preoperative predictors of postsurgical adhesion formation and the Prevention of Adhesions with Plasminogen Activator (PAPA-study): results of a clinical pilot study
article 2009    
Author: Hellebrekers, B.W.J. · Trimbos-Kemper, T.C.M. · Boesten, L. · Jansen, F.W. · Kolkman, W. · Trimbos, J.B. · Press, R.R. · Poelgeest, M.I.E. van · Emeis, S.J. · Kooistra, T.
Keywords: Health · Biomedical Research · CRP · early second-look laparoscopy · fibrinolytic system · Myomectomy · predictors of adhesion formation · prevention of adhesions · reteplase · C reactive protein · fibrin degradation product · plasminogen activator inhibitor 1 · reteplase · Ringer lactate solution · tissue plasminogen activator · adult · article · clinical article · clinical trial · controlled study · drug efficacy · drug safety · female · human · myomectomy · peritoneal fluid · plasma · priority journal · second look surgery · uterus synechia · Adult · Ascitic Fluid · Female · Gynecologic Surgical Procedures · Humans · Incidence · Infertility, Female · Leiomyoma · Myometrium · Pilot Projects · Plasminogen Activators · Postoperative Complications · Preoperative Care · Prognosis · Risk Factors · Tissue Adhesions · Uterine Neoplasms · Young Adult
[Abstract]

14 Recent methodology in the phytochemical analysis of ginseng
article 2008    
Author: Angelova, N. · Kong, H.-W. · Heijden, R. van de · Yang, S.-Y. · Choi, Y.H. · Kim, H.K. · Wang, M. · Hankemeier, T. · Greef, J. van der · Xu, G. · Verpoorte, R.
Keywords: Health · Biomedical Research · Ginsenosides · Mass spectrometry · Metabolomics · Panax ginseng · Ginseng extract · Phenol · Saponin · Analytic method · Antineoplastic activity · Biosensor · Drug absorption · Drug determination · Drug distribution · Drug efficacy · Drug excretion · Drug half life · Drug metabolism · Drug safety · Drug structure · Electrospray mass spectrometry · Enzyme linked immunosorbent assay · Fourier transform mass spectrometry · Ginseng · High performance liquid chromatography · Human · Immunoregulation · Ion cyclotron resonance mass spectrometry · Liquid chromatography · Liver protection · Mass spectrometry · Metabolomics · Near infrared reflectance spectroscopy · Nonhuman · Nuclear magnetic resonance spectroscopy · Plant root · Quality control · Review · Sensitivity analysis · Structure analysis · Systems biology · Drugs, Chinese Herbal · Ginsenosides · Mass Spectrometry · Panax · Spectroscopy, Fourier Transform Infrared · Spectroscopy, Near-Infrared · Panax ginseng
[Abstract]

15 Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-heptafluoropropane) following whole-body exposure
article 2000    
Author: Emmen, H.H. · Hoogendijk, E.M.G. · Klöpping-Ketelaars, W.A.A. · Muijser, H. · Duistermaat, E. · Ravensberg, J.C. · Alexander, D.J. · Borkhataria, D. · Rusch, G.M. · Schmit, B.
Keywords: Nutrition · Apaflurane · Cfc 12 · Chlorofluorocarbon · Dichlorodifluoromethane · Hfc 227 · Norflurane · Unclassified drug · Adult · Aerosol · Blood pressure · Central nervous system disease · Clinical trial · Concentration response · Controlled clinical trial · Controlled study · Double blind procedure · Drug blood level · Drug delivery system · Drug elimination · Drug excretion · Drug safety · Electrocardiogram · Exposure · Female · Human · Human experiment · Lung function · Male · Metered dose inhaler · Normal human · Priority journal · Pulse rate · Respiratory tract disease · Sex difference · Steady state · Vapor · Administration, Inhalation · Adult · Aerosol Propellants · Atmosphere Exposure Chambers · Blood Pressure · Chlorofluorocarbons, Methane · Dose-Response Relationship, Drug · Double-Blind Method · Electrocardiography · Female · Half-Life · Humans · Hydrocarbons, Fluorinated · Inhalation Exposure · Male · Respiratory Function Tests · Safety · Sex Characteristics
[Abstract]

16 Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors
article 2006    
Author: Verhaagh, S. · Jong, E. de · Goudsmit, J. · Lecollinet, S. · Gillissen, G. · Vries, M. de · Leuven, K. van · Que, I. · Ouwehand, K. · Mintardjo, R. · Weverling, G.J. · Radošević, K. · Richardson, J. · Eloit, M. · Lowik, C. · Quax, P. · Havenga, M.
Keywords: Biology · Biomedical Research · Adenovirus vector · Beta galactosidase · CD8 antigen · Gag protein · Luciferase · Membrane cofactor protein · Simian immunodeficiency virus vaccine · Animal cell · Animal experiment · Antigen expression · Antigen function · Camera · CD8+ T lymphocyte · Cellular immunity · Controlled study · Dendritic cell · Drug potency · Drug safety · Female · Gene expression · Human adenovirus · Imaging system · Kidney cell · Lung alveolus epithelium · Male · Mouse · Mouse strain · Muscle cell · Nonhuman · Receptor affinity · Transgenic mouse · Viral gene delivery system · Virus replication · Wild type · Adenoviruses, Human · Animals · Antigens, CD46 · Genetic Vectors · Humans · Mice · Mice, Transgenic · Virus Replication · Adenoviridae · Animalia · Human adenovirus · Mus musculus · Simian immunodeficiency virus
[Abstract]

17 Drug-eluting stents studies in mice: Do we need atherosclerosis to study restenosis?
article 2006    
Author: Pires, N.M.M. · Jukema, J.W. · Daemen, M.J.A.P. · Quax, P.H.A.
Keywords: Health · Biomedical Research · (Histo)Pathology · Animal models · Atherosclerosis · Drug-eluting stents · Restenosis · 7 hexanoyltaxol · Dactinomycin · Dexamethasone · Everolimus · Paclitaxel · Paclitaxel derivative · Qp 2 · Rapamycin · Tacrolimus · Thalidomide · Unclassified drug · Artery intima proliferation · Atherosclerosis · Blood pressure variability · Clinical trial · Coronary stent · Cost effectiveness analysis · Disease exacerbation · Disease model · Drug efficacy · Drug eluting stent · Drug release · Drug safety · Evaluation · Healing impairment · Hypersensitivity reaction · In-stent restenosis · Mouse strain · Nonhuman · Pain · Rash · Respiratory tract disease · Restenosis · Side effect · Thrombosis · Animals · Atherosclerosis · Coronary Restenosis · Disease Models, Animal · Drug Delivery Systems · Drug Evaluation, Preclinical · Humans · Mice · Paclitaxel · Sirolimus · Stents
[Abstract]

18 Rescuing drug discovery: In vivo systems pathology and systems pharmacology
article 2005    
Author: Greef, J. van der · McBurney, R.N.
Keywords: Pharmacology Health · Analytical research · 5' methoxyhydnocarpin · berberine · biological marker · ginseng extract · herbaceous agent · Hypericum extract · paroxetine · unclassified drug · article · bioinformatics · cardiovascular disease · clinical trial · cost benefit analysis · cost control · cost effectiveness analysis · data base · depression · drug approval · drug design · drug efficacy · drug indication · drug industry · drug information · drug marketing · drug research · drug response · drug safety · drug screening · drug targeting · growth inhibition · health care · health care cost · health program · human · in vivo study · non insulin dependent diabetes mellitus · nonhuman · patient compliance · prediction · prescription · priority journal · productivity · quantitative analysis · standard · system analysis · validation process · animal · diagnosis · economics · mass communication · review · Animals · Cost-Benefit Analysis · Diagnosis · Diffusion of Innovation · Drug Approval · Drug Design · Drug Evaluation · Drug Evaluation, Preclinical · Drug Industry · Humans
[Abstract]

19 Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology
article 2005    
Author: Wang, M. · Lamers, R.J.A.N. · Korthout, H.A.A.J. · Nesselrooij, J.H.J. van · Witkamp, R.F. · Heijden, R. van der · Voshol, P.J. · Havekes, L.M. · Verpoorte, R. · Greef, J. van der
Keywords: Health Pharmacology · Analytical research · Metabolomics · Systems biology · Traditional Chinese Medicine (TCM) · 5' methoxyhdnocarpin · Alanine aminotransferase · Alkaloid · Apolipoprotein E · Berberine · Biflavonoid · Bilobalide · Cannabidiol · Cannabis · Chaconine · Cholesterol · Flavonoid · Ginkgo biloba extract · Ginkgolide · Glucoside · Herbaceous agent · Insulin · Low density lipoprotein · Plant extract · Prodrug · Salicylic acid · Saligenin · Saponin · Solanine · Tetrahydrocannabinol · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Alanine aminotransferase blood level · Animal experiment · Animal model · Atherosclerosis · Bark · Blood flow · Chinese medicine · Clinical pharmacology · Controlled study · Data analysis · DNA microarray · Drug effect · Drug efficacy · Drug potentiation · Drug research · Drug safety · Drug targeting · Female · Ginkgo biloba · Headache · Herbal medicine · High performance liquid chromatography · Human · Human experiment · Insulin resistance · Insulin sensitivity · Ion cyclotron resonance mass spectrometry · Lipid metabolism · Liver function · Male · Mass spectrometry · Medicinal plant · Metabolic syndrome X · Metabolite · Molecular pharmacology · Nonhuman · Nuclear magnetic resonance spectroscopy · Pain · Phytotherapy · Plant leaf · Proton nuclear magnetic resonance · Rat · Thin layer chromatography · Traditional medicine · Willow · Drugs, Chinese Herbal · Humans · Pharmacology · Phytotherapy
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date