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Showing 1 to 11 of 11 found. | Sort by date

1 The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man
article 2010    
Author: Louisse, J. · Jong, E. de · Sandt, J.J.M. van de · Blaauboer, B.J. · Woutersen, R.A. · Piersma, A.H. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Nutrition · Biomedical Research · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Glycol ethers · Physiologically based kinetic modeling
[Abstract]

2 Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity
article 2011    
Author: Louisse, J. · Gönen, S. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Pharmacology · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · In vitro · Retinoids · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay
article 2012    
Author: Strikwold, M. · Woutersen, R.A. · Spenkelink, B. · Punt, A. · Rietjens, I.M.C.M.
Keywords: Alternative toxicity testing · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · Potency ranking · Substituted phenols · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants
article 2013    
Author: Piersma, A.H. · Bosgra, S. · Duursen, M.B.M. van · Hermsen, S.A.B. · Jonker, L.R.A. · Kroese, E.D. · Linden, S.C. van der · Man, H. · Roelofs, M.J.E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Westerhout, J. · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative assay · Aromatase · CALUX · Embryonic stem cell test · ReProGlo · Test battery · Toxicokinetics · Zebrafish embryotoxicity assay · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human
article 2013    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Biology · Alternative for animal testing · Embryonic stem cell test (EST) · In vitro-in vivo (IVIV) extrapolation · Phenol · Physiologically based kinetic (PBK) modelling · Risk assessment · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

6 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context
article 2015    
Author: Kroese, E.D. · Bosgra, S. · Buist, H.E. · Lewin, G. · Linden, S.C. van der · Man, H.Y. · Piersma, A.H. · Rorije, E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative model · CALUX · Developmental toxicity · Embryonic stem cell test · Grouping · Read across · ReProGlo · Zebrafish embryotoxicity assay · 2 ethylhexanoic acid · 2 methylhexanoic acid · Dibutyltin dichloride · monobutyltin trichloride · Monoethylhexyl phthalate · Monomethyl phthalate · Toxic substance · Tributyltin chloride · Unclassified drug · Valproic acid · Analytic method · Animal cell · Assay · CALUX battery · Chemical analysis · Chemical procedures · Chemical structure · Controlled study · Developmental toxicity · Dosimetry · Embryonic stem cell test · Embryotoxicity · Fertilization · In vitro study · Morphology · Mouse · Nonhuman · ReProGlo assay · Toxicokinetics · Zebrafish embryotoxicity test · Animalia · Danio rerio · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
article 2009    
Author: Jong, E. de · Louisse, J. · Verwei, M. · Blaauboer, B.J. · Sandt, J.J.M. van de · Woutersen, R.A. · Rietjens, I.M.C.M. · Piersma, A.H.
Keywords: Chemistry · Toxicology and Applied Pharmacology · Alternatives to animal testing · Developmental toxicology · Embryonic stem cells · Glycol ethers · butoxyacetic acid · ethoxyacetic acid · glycol ether alkoxy acid metabolite · methoxyacetic acid · phenoxyacetic acid · toxin · unclassified drug · animal cell · article · cell differentiation · chemical analysis · chemical structure · concentration response · controlled study · cytotoxicity test · developmental disorder · developmental toxicity · embryonic stem cell · embryonic stem cell test · embryotoxicity · heart muscle cell · in vivo study · mouse · nonhuman · sensitivity analysis · toxicokinetics · Animal Testing Alternatives · Animals · Biotransformation · Cell Differentiation · Cell Survival · Dose-Response Relationship, Drug · Embryonic Development · Embryonic Stem Cells · Glycols · Kinetics · Mice · Models, Statistical · Myocytes, Cardiac · Predictive Value of Tests · Reference Standards · Structure-Activity Relationship · Teratogens · Animalia
[Abstract]

8 Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
article 2006    
Author: Verwei, M. · Burgsteden, J.A. van · Krul, C.A.M. · Sandt, J.J.M. van de · Freidig, A.P.
Keywords: Biology · Biomedical Research · Alternative test method · Developmental toxicity · Embryonic stem cells · PBPK model · 2 ethoxyethanol · 2 methoxyethanol · acetic acid derivative · ethoxyacetic acid · fluorouracil · methotrexate · methoxyacetic acid · retinoic acid · unclassified drug · animal cell · article · computer model · controlled study · embryo · embryo development · embryonic stem cell · embryotoxicity · exposure · metabolism · mouse · nonhuman · prediction · priority journal · risk assessment · rodent · Animal Testing Alternatives · Animals · Cell Line · Cell Survival · Dose-Response Relationship, Drug · Embryo · Mice · Models, Biological · Predictive Value of Tests · Rats · Risk Assessment · Stem Cells · Teratogens · Toxicity Tests · Rodentia
[Abstract]

9 Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites
article 2010    
Author: Louisse, J. · Bai, Y. · Verwei, M. · Sandt, J.J.M. van de · Blaauboer, B.J. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · BALB/c-3T3 cells · Embryonic stem cells · Embryotoxicity · Glycol ethers · Intracellular pH · Mechanism · acetazolamide · acetic acid derivative · alkoxyacetic acid glycol ether derivative · amiloride · butoxyacetic acid · ethoxyacetic acid · fluorouracil · methoxyacetic acid · phenoxyacetic acid · retinoic acid · unclassified drug · valproic acid · acidification · animal cell · animal cell culture · article · cell differentiation · cell pH · cell strain 3T3 · controlled study · embryonic stem cell · embryotoxicity · metabolite · mouse · nonhuman · pH measurement · Acetazolamide · Acetic Acids · Animals · BALB 3T3 Cells · Cell Differentiation · Embryo, Mammalian · Embryonic Stem Cells · Ethylene Glycols · Glycolates · Hydrogen-Ion Concentration · Intracellular Fluid · Mice · Teratogens · Valproic Acid
[Abstract]

10 Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery
article 2014    
Author: Zimmer, B. · Pallocca, G. · Dreser, N. · Foerster, S. · Waldmann, T. · Westerhout, J. · Julien, S. · Krause, K.H. · Van Thriel, C. · Hengstler, J.G. · Sachinidis, A. · Bosgra, S. · Leist, M.
Keywords: Pharmacology · Developmental toxicity testing · hESC-based test system · Neural crest migration assay · Test battery-based compound screening · abiraterone · arsenic trioxide · beta interferon · chlorpromazine · cyproconazole · environmental chemical · gefitinib · geldanamycin · polybrominated diphenyl ether · triadimefon · unclassified drug · animal cell · cell migration · concentration (parameters) · concentration response · controlled study · cytotoxicity · data mining · developmental toxicity · embryonic stem cell · HEK293 cell line · human · human cell · in vivo study · migration inhibition · mouse · neural crest cell · neurotoxicity · nonhuman · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

11 Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate
article 2009    
Author: Dartel, D.A.M. van · Pennings, J.L.A. · Hendriksen, P.J.M. · Schooten, F.J. van · Piersma, A.H.
Keywords: Alternative test method · Differentiation · Embryonic stem cells · Monobutyl phthalate · Transcriptomics · monobutyl phthalic acid · oligonucleotide · phthalic acid · RNA · Unclassified drug · Animal cell · Cell differentiation · Cell proliferation · Controlled study · Embryonic stem cell · Gene control · Heart muscle cell · Mesoderm · Microarray analysis · Modulation · Mouse · Nonhuman · Pluripotent stem cell · Animals · Cell Differentiation · Cell Proliferation · Cells, Cultured · Dose-Response Relationship, Drug · Embryonic Stem Cells · Gene Expression Profiling · Gene Expression Regulation, Developmental · Gene Regulatory Networks · Mice · Muscle Contraction · Myocytes, Cardiac · Oligonucleotide Array Sequence Analysis · Phthalic Acids · Risk Assessment · Time Factors · Toxicity Tests
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date