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1 Toxicology in the 21st century - Working our way towards a visionary reality
article 2011    
Author: Berg, N. · Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Roggen, E.L.
Keywords: Health · -Omics · 21st Century vision · 3Rs · Computational · In vitro · Replacement · Testing strategy · Toxicity testing · Validation · article · biological model · education · Europe · ex vivo study · financial management · in vitro study · in vivo study · interpersonal communication · leadership · medical research · practice guideline · risk assessment · standardization · systems biology · toxicity testing · toxicology · validation process · Animalia · Healthy living · Biomedical Innovations · Themalijn
[Abstract]

2 Differential modulation by Akkermansia muciniphila and faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids
article 2014    
Author: Lukovac, S. · Belzer, C. · Pellis, L. · Keijser, B.J. · Vos, W.M. de · Montijn, R.C. · Roeselers, G.
Keywords: Biology · G protein coupled receptor 43 · Histone deacetylase · Membrane protein · Peroxisome proliferator activated receptor gamma · Protein Fiaf · Short chain fatty acid · Unclassified drug · Adult · Animal experiment · Animal tissue · Bacterial strain · Cell cycle regulation · Cell metabolism · Controlled study · Down regulation · Epigenetics · Ex vivo study · Fiaf gene · Gene · Gene control · Gene expression · Gene silencing · Gpr43 gene · Hdac3 gene · Hdac5 gene · Histone acetylation · Host pathogen interaction · Ileum · In vivo study · Intestine flora · Lipid metabolism · Lipolysis · Male · Mouse · Nonhuman · Nucleotide sequence · Ppargamma gene · Satiety · Transcription regulation · Akkermansia muciniphila · Faecalibacterium prausnitzii · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

3 A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices
article 2014    
Author: Westerhout, J. · Steeg, E. van de · Grossouw, D. · Zeijdner, E.E. · Krul, C.A.M. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Caco-2 · Food-effect · Human intestine · Intestinal absorption · InTESTine™ · Porcine intestine · Acebutolol · Atenolol · Candesartan · Cetirizine · Cimetidine · Ciprofloxacin · Diazepam · Digoxin · Famotidine · Hydrocortisone · Ibuprofen · Indometacin · Mannitol · Melagatran · Metoprolol · Mucin · Oxprenolol · Phenazone · Pindolol · Propranolol · Ranitidine · Salazosulfapyridine · Salicylic acid · Testosterone · Verapamil · Active transport · Animal tissue · CACO 2 cell line · Controlled study · Domestic pig · Drug absorption · Drug bioavailability · Drug penetration · Drug transport · Electric resistance · Ex vivo study · Female · Human · Human tissue · Intestine absorption · Intestine mucosa · Male · Nonhuman · Passive transport · Prediction · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Intragastric immunization with recombinant Lactobacillus casei expressing flagellar antigen confers antibody-independent protective immunity against Salmonella enterica serovar Enteritidis
article 2007    
Author: Kajikawa, A. · Satoh, E. · Leer, R.J. · Yamamoto, S. · Igimi, S.
Keywords: Biology · Biotechnology · Flagellin · Lactobacillus · Salmonella · Vaccine · antibody · antigen · flagellin · gamma interferon · recombinant antigen · animal experiment · animal model · animal tissue · antibody specificity · antigen antibody complex · antigen expression · antigen specificity · article · bacterial infection · bacterial strain · cellular immunity · drug efficacy · ex vivo study · feces analysis · female · immune response · immunity · immunization · Lactobacillus casei · lymphocyte · mouse · nonhuman · priority journal · Salmonella enterica · Salmonella enteritidis · salmonellosis · serum · Administration, Oral · Animals · Female · Flagellin · Humans · Immunization · Interferon Type II · Lactobacillus casei · Lymphocyte Activation · Mice · Mice, Inbred C3H · Recombination, Genetic · Salmonella enteritidis · Salmonella Infections, Animal · Salmonella Vaccines
[Abstract]

5 Relevance of Ara h1, Ara h2 and Ara h3 in peanut-allergic patients, as determined by immunoglobulin E Western blotting, basophil-histamine release and intracutaneous testing: Ara h2 is the most important peanut allergen
article 2004    
Author: Koppelman, S.J. · Wensing, M. · Ertmann, M. · Knulst, A.C. · Knol, E.F.
Keywords: Nutrition · Food technology · Allergens · Ara h1 · Ara h2 · Ara h3 · Basophils · Histamine release · Immunoblot · Peanut · Purification · Skin test · allergen · binding protein · histamine · immunoglobulin E · placebo · plant extract · adolescent · adult · aged · anamnesis · antigen purification · article · basophil degranulation · clinical article · concentration (parameters) · controlled study · cross linking · diagnostic procedure · dilution · ex vivo study · female · histamine release · human · immunoblotting · in vitro study · in vivo culture · intracutaneous test · ion exchange chromatography · male · molecular weight · pathogenesis · peanut allergy · priority journal · provocation test · skin test · standardization · Western blotting · Adolescent · Adult · Allergens · Antibody Specificity · Arachis hypogaea · Basophils · Blotting, Western · Dose-Response Relationship, Immunologic · Female · Food Hypersensitivity · Glycoproteins · Histamine Release · Humans · Immunoglobulin E · Male · Plant Proteins · Skin Tests
[Abstract]

6 Interferon-β therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis
article 2007    
Author: Zafranskaya, M. · Oschmann, P. · Engel, R. · Weishaupt, A. · Noort, J.M. van · Jomaa, H. · Eberl, M.
Keywords: Health · Biomedical Research · Autoimmunity · CFSE (5- (and 6-) carboxyfluorescein diacetate succinimidyl ester) · Disease progression · Immunotherapy · Myelin antigens · T-cell responses · beta1a interferon · CD45RO antigen · cytokine · interferon beta serine · myelin oligodendrocyte glycoprotein · adult · article · CD4+ T lymphocyte · CD8+ T lymphocyte · cell proliferation · clinical article · controlled study · correlation analysis · drug response · ex vivo study · female · functional status · human · human cell · immunotherapy · in vitro study · male · memory cell · multiple sclerosis · phenotype · prevalence · priority journal · Adult · Antigens, CD45 · CD4-Positive T-Lymphocytes · CD8-Positive T-Lymphocytes · Cell Proliferation · Cells, Cultured · Cytokines · Disease Progression · Flow Cytometry · Humans · Immunologic Memory · Immunophenotyping · Immunosuppressive Agents · Interferon-beta · Lymphocyte Activation · Middle Aged · Multiple Sclerosis, Relapsing-Remitting · Myelin-Associated Glycoprotein · T-Lymphocyte Subsets
[Abstract]

7 Xenobiotic metabolism in human skin and 3D human skin reconstructs: A review
article 2007    
Author: Gibbs, S. · Sandt, J.J.M. van de · Merk, H.F. · Lockley, D.J. · Pendlington, R.U. · Pease, C.K.
Keywords: Biology · 3D skin reconstructs · Cytochrome P450 · IDO expression · In vitro skin absorption · Microarray · Peptidases · 1 chloro 2,4 dinitrobenzene · 2 nitro 1,4 phenylenediamine · 4 aminophenol · alcohol dehydrogenase · aldehyde dehydrogenase · alpha tocopherol · atrazine · azo reductase · carnitine · cinnamaldehyde · cinnamyl alcohol · clobetasol propionate · cytochrome P450 · esterase · hydrogen peroxide · messenger RNA · nicotinic acid ethyl ester · oxygenase · phenylenediamine · propoxur · propranolol · resorufin · retinoic acid · retinol palmitate · T 2 toxin · toxic substance · triclosan · triolein · unindexed drug · xenobiotic agent · biotransformation · chemical carcinogenesis · environmental exposure · enzyme assay · ex vivo study · human · immunohistochemistry · in vitro study · nonhuman · Northern blotting · occupational exposure · protein expression · protein function · review · skin absorption · skin allergy · skin cancer · skin carcinogenesis · skin inflammation · skin sensitization · skin toxicity · toxicokinetics · Western blotting · xenobiotic metabolism · Biotransformation · Humans · Models, Biological · Skin · Xenobiotics
[Abstract]

8 Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure
article 2009    
Author: Jong, W.H. de · Arts, J.H.E. · Klerk, A. de · Schijf, M.A. · Ezendam, J. · Kuper, C.F. · Loveren, H. van
Keywords: Biology · Toxicology and Applied Pharmacology · Cytokine profiles · Inhalation exposure · Lymph node responses · Sensitizers · Skin exposure · 1 chloro 2,4 dinitrobenzene · concanavalin A · formaldehyde · gamma interferon · hexamethylene diisocyanate · interleukin 10 · interleukin 4 · isophorone · oxazolone · phthalic anhydride · salicylic acid methyl ester · toluene diisocyanate · trimellitic anhydride · animal cell · animal experiment · animal model · article · cell proliferation · cell suspension · concentration (parameters) · contact sensitivity · controlled study · cytokine production · ex vivo study · hypersensitivity reaction · inhalation · lymphadenectomy · lymphatic drainage · male · mouse · nonhuman · priority journal · protein induction · respiratory tract allergy · Administration, Cutaneous · Allergens · Animals · Biological Markers · Cell Proliferation · Cells, Cultured · Cytokines · Dermatitis, Allergic Contact · Dose-Response Relationship, Drug · Inhalation Exposure · Interferon-gamma · Interleukin-10 · Interleukin-4 · Local Lymph Node Assay · Lymph Nodes · Male · Mice · Mice, Inbred BALB C · Models, Animal · Respiratory Hypersensitivity · Animalia · Mus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 8 of 8 found. | Sort by date