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1 Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis
article 2019    
Author: Salic, K. · Gart, E. · Verschuren, L. · Duyvenvoorde, W. van · Wong, K.E. · Keijer, J. · Bobeldijk-Pastorova, I. · Wielinga, P.Y. · Kleemann, R.
Keywords: Acylcarnitines · Lipid peroxidation · Metabolomics · Mitochondria · Non-alcoholic fatty liver disease · Obesity · Transcriptomics · β-oxidation
[PDF] [Abstract]

2 Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD
article 2019    
Author: Gart, E. · Souto Lima, E. · Schuren, F · Ruiter, C.G.F. de · Attema, J. · Verschuren, L. · Keijer, J. · Salic, K. · Morrison, M.C. · Kleemann, R.
Keywords: Biology · Non-alcoholic fatty liver disease · Obesity · Liver · Short-chain fatty acids; · Gut permeability · Adipose tissue inflammation
[PDF] [Abstract]

3 Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies
article 2015    
Author: Morrison, M.C. · Kleemann, R.
Keywords: Health · MIF · Adipose tissue · Insulin resistance · Non-alcoholic fatty liver disease · Obesity · Type 2 diabetes · Macrophage migration inhibition factor · Comorbidity · Correlation analysis · Fatty liver · Glucose homeostasis · Human · Lipid storage · Liver fibrosis · Non insulin dependent diabetes mellitus · Nonalcoholic fatty liver · Nonhuman · Review · Weight reduction · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

4 Mice expressing only the mutant APOE3Leiden gene show impaired VLDL secretion
article 2001    
Author: Mensenkamp, A.R. · Teusink, B. · Baller, J.F.W. · Wolters, H. · Havinga, R. · Dijk, K.W. van · Havekes, L.M. · Kuipers, F.
Keywords: Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Fatty Liver · Lipid Metabolism · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · RNA, Messenger · Triglycerides
[Abstract]

5 Role of metabolic overload and metabolic inflammation in the development of Nonalcoholic Steatohepatitis (NASH)
dissertation 2015    
Author: Liang, W.
Keywords: Health · Metabolic syndromes · Fatty liver · Insulin resistance · Dyslipidemia · Fibrosis · NAFLD/NASH · Histology · Pathogensis · Factors · Chronic inflammation · Transcription factors · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

6 A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
article 2018    
Author: Schutte, S. · Esser, D. · Hoevenaars, F.P.M. · Hooiveld, G.J.E.J. · Priebe, M.G. · Vonk, R.J. · Wopereis, S. · Afman, L.A.
Keywords: Health · Fatty liver · NAFLD · Steatosis · Overweight · Obesity · Whole grain wheat · Refined wheat · Dietary intervention · Mixed-meal challenge test · Adipose tissue health · Microbiota · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Metabolomics (liver and blood profiling) in a mouse model in response to fasting: A study of hepatic steatosis
article 2007    
Author: Ginneken, V. van · Verhey, E. · Poelmann, R. · Ramakers, R. · Dijk, K.W. van · Ham, L. · Voshol, P. · Havekes, L. · Eck, M. van · Greef, J. van der
Keywords: Analytical research · Biomedical research · Hepatic steatosis · Lipids · Liver · Metabolomics · Starvation · Triacylglycerols · cholesterol · cholesterol ester · low density lipoprotein cholesterol · phosphatidylcholine · phospholipid derivative · triacylglycerol · animal experiment · animal model · animal tissue · article · blood examination · controlled study · diet restriction · fatty liver · high performance thin layer chromatography · lipid blood level · lipid storage · liver homogenate · male · mass spectrometry · metabolomics · mouse · nonhuman · priority journal · reversed phase liquid chromatography · starvation · Animals · Blood · Cholesterol Esters · Chromatography, High Pressure Liquid · Disease Models, Animal · Fatty Liver · Food Deprivation · Lipoproteins, LDL · Liver · Male · Mice · Mice, Inbred C57BL · Phosphatidylcholines · Phospholipids · Triglycerides · Mammalia
[Abstract]

8 Toxicogenomics directory of chemically exposed human hepatocytes
article 2014    
Author: Grinberg, M. · Stöber, R.M. · Edlund, K. · Rempel, E. · Godoy, P. · Reif, R. · Widera, A. · Madjar, K. · Schmidt-Heck, W. · Marchan, R. · Sachinidis, A. · Spitkovsky, D. · Hescheler, J. · Carmo, H. · Arbo, M.D. · Water, B. van de · Wink, S. · Vinken, M. · Rogiers, V. · Escher, S. · Hardy, B. · Mitic, D. · Myatt, G. · Waldmann, T. · Mardinoglu, A. · Damm, G. · Seehofer, D. · Nüssler, A. · Weiss, T.S. · Oberemm, A. · Lampen, A. · Schaap, M.M. · Luijten, M. · van Steeg, H. · Thasler, W.E. · Kleinjans, J.C.S. · Stierum, R.H. · Leist, M. · Rahnenführer, J. · Hengstler, J.G.
Keywords: Biology · Bioinformatics · Biomarker identification · Cirrhosis · Hepatocellular cancer · Hepatotoxicity · In vivo validation · SEURAT-1 · Steatosis · Toxicotranscriptomics · Unsupervised clustering · allyl alcohol · biological marker · chemical compound · cytochrome P450 1A1 · cytochrome P450 3A4 · galactosamine · isoniazid · ketoconazole · liver protein · paracetamol · propranolol · thyroid hormone · transcription factor · triazolam · valproic acid · binding site · cell stress · data base · down regulation · fatty liver · gene expression · gene ontology · human · liver cell · liver cell carcinoma · liver cirrhosis · liver disease · microarray analysis · mutation · nonalcoholic fatty liver · quantitative analysis · real time polymerase chain reaction · RNA extraction · toxicogenomics · transcriptomics · upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes
article 2015    
Author: Liang, W. · Verschuren, L. · Mulder, P. · Hoorn, J.W.A. van der · Verheij, J. · Dam, A.D. van · Boon, M.R. · Princen, H.M.G. · Havekes, L.M. · Kleemann, R. · Hoek, A.M. van den
Keywords: Biology · Alanine aminotransferase · Aspartate aminotransferase · Glucose · High density lipoprotein cholesterol · Insulin · Interleukin 6 · Low density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Salsalate · Triacylglycerol · Alanine aminotransferase blood level · Animal cell · Animal experiment · Animal model · Animal tissue · Aspartate aminotransferase blood level · Body weight · Controlled study · Down regulation · Drug efficacy · Drug response · Dyslipidemia · Energy metabolism · Fatty acid oxidation · Fatty liver · Gene expression · Glucose blood level · Glycemic control · Hepatitis · Insulin blood level · Insulin resistance · Lipid metabolism · Lipogenesis · Male · Mouse · Nonalcoholic fatty liver · Nonhuman · Treatment duration · Treatment outcome · Triacylglycerol blood level · Upregulation · Weight gain · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

10 Uniform procedure of 1H NMR analysis of rat urine and toxicometabonomics Part II : Comparison of NMR profiles classification of hepatotoxicity
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.-P.H.T.M. · Smit, M.J. · Zandberg, P. · Horbach, G.J. · Mellema, J.-R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Cholestasis · Hepatotoxicity · Metabonomics · Necrosis · NMR · Steatosis · Urinalysis · 1 naphthyl isothiocyanate · biological marker · bromobenzene · carbon tetrachloride · chlorpromazine · ethinylestradiol · ibuprofen · iproniazid · isoniazid · methyltestosterone · mianserin · paracetamol · phenobarbital · placebo · tetracycline · thioacetamide · animal experiment · animal tissue · article · controlled study · diagnostic accuracy · diagnostic value · drug blood level · drug urine level · early diagnosis · fatty liver · histopathology · intermethod comparison · intrahepatic cholestasis · liver necrosis · liver toxicity · male · nonhuman · pattern recognition · prediction · principal component analysis · proton nuclear magnetic resonance · rat · urinalysis · Animals · Biological Markers · Cholestasis · Fatty Liver · Hepatitis, Toxic · Liver · Magnetic Resonance Spectroscopy · Male · Necrosis · Pattern Recognition, Automated · Principal Component Analysis · Rats · Rats, Wistar · Urine · Animalia · Rattus
[Abstract]

11 Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
article 2014    
Author: Liang, W. · Menke, A.L. · Driessen, A. · Koek, G.H. · Lindeman, J.H. · Stoop, R. · Havekes, L.M. · Kleemann., R. · Hoek, A.M. van den
Keywords: Biology · Adult · Animal experiment · Animal model · Clinical article · Controlled study · Female · Hepatitis · Histopathology · Human · Human tissue · Human versus animal comparison · Liver biopsy · Liver fibrosis · Liver hypertrophy · Macrovesicular steatosis · Male · Microvesicular steatosis · Nonalcoholic fatty liver · Nonhuman · Process development · Reproducibility · Scoring system · Steatosis · Validation process · Rodentia · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

12 Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model
article 2017    
Author: Koppen, A. van · Verschuren, L. · Hoek, A.M. van den · Verheij, J. · Morrison, M.C. · Li, K. · Nagabukuro, H. · Costessi, A. · Caspers, M.P.M. · Broek, T.J. van den · Sagartz, J. · Kluft, C. · Beysen, C. · Emson, C. · Gool, A.J. van · Goldschmeding, R. · Stoop, R. · Bobeldijk-Pastorova, I. · Turner, S.M. · Hanauer, G. · Hanemaaijer, R.
Keywords: Biology · ALT, alanine aminotransferase · AST, aspartate aminotransferase · DEG, differentially expressed genes; Diagnosis · ECM, extracellular matrix · HFD, high-fat diet · IPA, Ingenuity Pathway Analysis · LDLr-/-, low-density lipoprotein receptor knock out · Liver Disease; Metabolic Syndrome · NAFLD, nonalcoholic fatty liver disease · NASH, nonalcoholic steatohepatitis · Systems Biology · THBS1, thrombospontin-1 · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

13 Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study
article 2018    
Author: Morrison, M.C. · Kleemann, R. · Koppen, A. van · Hanemaaijer, R. · Verschuren, L.
Keywords: Biology · Liver · NASH, · Inflammation · Molecular · Gene expression · Translational · Mouse · Human · Translational · Cytokine · Growth factor · Transcription factor · Animal experiment · Animal model · Controlled study · Extracellular matrix · Gene expression profiling · Human tissue · Inflammation · Lipid diet · Lipid metabolism · Liver biopsy · Mouse · Nonalcoholic fatty liver · Nonhuman · Transcriptomics · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

14 Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice
article 2006    
Author: Duivenvoorden, I. · Voshol, P.J. · Rensen, P.C.N. · Duyvenvoorde, W. van · Romijn, J.A. · Emeis, J.J. · Havekes, L.M. · Nieuwenhuizen, W.F.
Keywords: Health Biology · Food technology · APOE*3Leiden mice · Cholesterol · Free fatty acids · Sphingolipids · Steatosis · Triacylglycerol · alanine aminotransferase · amyloid · apolipoprotein E3 · cholesterol · cholesterol ester · fatty acid · messenger RNA · phytosphingosine · RNA · sphingolipid · triacylglycerol · apolipoprotein E · apolipoprotein E3 (Leidein) · very low density lipoprotein · animal experiment · animal model · animal tissue · article · cholesterol blood level · cholesterol metabolism · controlled study · diet supplementation · dose response · drug effect · drug structure · fatty liver · female · gene expression · hepatitis · lipogenesis · lipolysis · mouse · nonhuman · nutritional assessment · plasma clearance · prophylaxis · animal · blood · chemistry · cholesterol intake · enzymology · feces · genetics · intestine absorption · lipid metabolism · liver · metabolism · physiology · randomization · transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Cholesterol, Dietary · Dose-Response Relationship, Drug · Fatty Acids, Nonesterified · Fatty Liver · Feces · Female · Gene Expression · Intestinal Absorption · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Random Allocation · RNA · Sphingolipids · Triglycerides
[Abstract]

15 Low-grade inflammation, diet composition and health: Current research evidence and its translation
article 2015    
Author: Minihane, A.M. · Vinoy, S. · Russell, W.R. · Baka, A. · Roche, H.M. · Tuohy, K.M. · Teeling, J.L. · Blaak, E.E. · Fenech, M. · Vauzour, D. · McArdle, H.J. · Kremer, B.H.A. · Sterkman, L. · Vafeiadou, K. · Benedetti, M.M. · Williams, C.M. · Calder, P.C.
Keywords: Biology · Biomarkers · Chronic diseases · Health claims · Low-grade inflammation · Bacterium lipopolysaccharide · Biological marker · C reactive protein · Chemokine · Flavonoid · Interleukin 6 · Tumor necrosis factor alpha · Alzheimer disease · Atherosclerosis · Carbohydrate intake · Cardiovascular disease · Chronic disease · Chronic inflammation · Cytokine production · Degenerative disease · Diet · Endotoxemia · Fat intake · Human · Inflammation · Intestine flora · Maternal obesity · Mucosal immunity · Nervous system inflammation · Non insulin dependent diabetes mellitus · Nonalcoholic fatty liver · Nonhuman · Review · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

16 Inhibition of the central melanocortin system decreases brown adipose tissue activity
article 2014    
Author: Kooijman, S. · Boon, M.R. · Parlevliet, E.T. · Geerling, J.J. · Pol, V. van de · Romijn, J.A. · Havekes, L.M. · Meurs, I. · Rensen, P.C.N.
Keywords: Biology · Energy expenditure · Liver · Triglycerides · Very low density lipoprotein · White adipose tissue · Apolipoprotein E · Fat droplet · Melanocortin · Melanocortin 3 receptor · Melanocortin 4 receptor · N acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide] · Triacylglycerol · Uncoupling protein 1 · Animal experiment · Animal tissue · Body fat · Brown adipose tissue · Central melanocortin system · Controlled study · Dyslipidemia · Endocrine system · Fat mass · Fatty liver · Female · Food intake · Hormone inhibition · Lipid analysis · Lipid oxidation · Lipid storage · Mouse · Nonhuman · Obesity · Signal transduction · Weight gain · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

17 Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil
article 2015    
Author: Mulder, P. · Stavro, P.M. · Manuel Suárez, M. · Arola-Arnal, A. · Duyvenvoorde, W. van · Kooistra, T. · Wielinga, P.Y. · Kleemann, R.
Keywords: Biology · Amyloid A protein · Mouse · Nonhuman · Tisk factor amyloid A protein · Cell adhesion molecule · Low density lipoprotein cholesterol · Polyunsaturated fatty acid · Refined pumpkin seed oil · Saturated fatty acid · Theobroma oil · Triacylglycerol · Unclassified drug · Unsaturated fatty acid · Vegetable oil · Virgin pumpkin seed oil · Animal cell · Animal experiment · Animal model · Animal tissue · Antiinflammatory activity · Atherosclerosis · Controlled study · Disease association · Disease severity · Dyslipidemia · Fat intake · Female · Inflammation · Lipid composition · Lipid metabolism · Nonalcoholic fatty liver · Phytochemistry · Risk assessment · Risk factor · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

18 Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance
article 2004    
Author: Muurling, M. · Hoek, A.M. van den · Mensink, R.P. · Pijl, H. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Free fatty acid metabolism · Hepatic fat accumulation · Lipid metabolism · Peroxisome proliferator-activated receptor-γ · Rosiglitazone · Diacylglycerol · Glucose · Ketone body · Peroxisome proliferator activated receptor gamma · Rosiglitazone · Triacylglycerol · Adipose tissue · Animal experiment · Animal model · Animal tissue · APOC1 gene · Cholesterol blood level · Controlled study · Fatty acid metabolism · Gene · Gene overexpression · Gluconeogenesis · Glucose blood level · Glucose transport · Hyperglycemia · Hyperinsulinemia · Hyperlipidemia · Insulin blood level · Insulin resistance · Lipid metabolism · Lipid storage · Mouse · Nonhuman · Obesity · Transgenic mouse · Triacylglycerol blood level · Weight reduction · Animals · Apolipoprotein C-I · Apolipoproteins C · Blood Glucose · Body Weight · Fatty Acids · Fatty Liver · Gene Expression · Humans · Hyperglycemia · Hyperinsulinism · Hyperlipidemias · Insulin · Insulin Resistance · Mice · Mice, Transgenic
[PDF] [Abstract]

19 Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons from Animal Models
article 2004    
Author: Boer, M. den · Voshol, P.J. · Kuipers, F. · Havekes, L.M. · Romijn, J.A.
Keywords: Biology · Biomedical Research · Fatty acid metabolism · Glucose metabolism · Insulin resistance · Lipoprotein metabolism · Mouse models · Alcohol · Triacylglycerol · Animal experiment · Animal model · Disease association · Dyslipidemia · Endocrine system · Genetic transcription · Glucose metabolism · Lnsulin resistance · Lipid liver level · Metabolic syndrome X · Mouse · Non insulin dependent diabetes mellitus · Nonhuman · Partition coefficient · Pathophysiology · Rodent · Short survey · Adipose Tissue · Animals · Diabetes Mellitus, Type 2 · Dogs · Fatty Acids · Fatty Liver · Glucose · Homeostasis · Humans · Hyperlipidemias · Insulin Resistance · Liver · Metabolic Syndrome X · Mice · Models, Animal · Models, Biological · Obesity · Rats · Rats, Zucker · Transcription, Genetic · Triglycerides
[Abstract]

20 Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice
article 2006    
Author: Boer, M.A.M. den · Voshol, P.J. · Schröder-van Der Elst, J.P. · Korsheninnikova, E. · Ouwens, D.M. · Kuipers, F. · Havekes, L.M. · Romijn, J.A.
Keywords: Biology · Biomedical Research · Amyloid A protein · fibrinogen · interleukin 10 · protein kinase B · Animal experiment · Calorimetry · Cholesterol blood level · Controlled study · Experimental model · Fatty liver · Feeding · Glucose blood level · Hlucose metabolism · High performance liquid chromatography · Hyperinsulinemia · Insulin sensitivity · Lipid diet · Lipid metabolism · Mouse · Nonhuman · Phosphorylation · Steatosis · Triacylglycerol blood level · Adipose Tissue · Animals · Blood Glucose · Chromatography, Thin Layer · Diet · Dietary Fats · Energy Metabolism · Fibrinogen · Genotype · Glucose · Glucose Clamp Technique · Insulin Resistance · Interleukin-10 · Lipid Metabolism · Lipids · Liver Diseases · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Phenotype · Serum Amyloid A Protein
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 21 found. Next | Sort by date