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1 Preliminary evaluation of an in vitro test for assessment of excitotoxicity by measurement of early gene (c-fos mRNA) levels
article 2000    
Author: Griffiths, R. · Grieve, A. · Scollon, J. · Scott, M. · Williams, C. · Meredith, C.
Keywords: c-fos mRNA · Cerebellar granule cells · Early gene levels · Excitotoxicity · Predictive test · amino acid receptor blocking agent · biological marker · excitotoxin · glutamate receptor · glutamate receptor antagonist · messenger RNA · animal cell · controlled study · cytotoxicity · gene activation · gene expression · granule cell · mouse · nerve cell necrosis · nonhuman · oncogene c fos · toxicity testing · Animals · Cell Death · Cell Survival · Cells, Cultured · Cerebellar Cortex · Dose-Response Relationship, Drug · Evaluation Studies · Excitatory Amino Acid Antagonists · Gene Expression Regulation · Genes, fos · Glutamic Acid · Mice · Proto-Oncogene Proteins c-fos · RNA, Messenger · Animalia
[Abstract]

2 Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity
article 2006    
Author: Boerboom, A.M.J.F. · Vermeulen, M. · Woude, H. van der · Bremer, B.I. · Lee-Hilz, Y.Y. · Kampman, E. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Aarts, J.M.M.J.G.
Keywords: Biology · Benzyl isothiocyanate · Fisetin · Glutathione transferase · Kaempferol · Luteolin · Myricetin · Quercetin · Reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) · Taxifolin · Tert butylhydroquinone · Animal cell · Antioxidant activity · Cancer cell culture · Cancer screening · Chemoprophylaxis · Controlled study · Drug potency · Drug structure · Electrophile responsive element mediated gene · Enzyme induction · Gene · Gene activation · Gene expression · Gene induction · Genetic transcription · Human cell · Molecular interaction · Mouse · Nonhuman · Reporter gene · Screening test · Stereospecificity · Structure activity relation · Tandem repeat · Transcription initiation · Validation study · Animals · Base Sequence · Cell Line · DNA Primers · Enzyme Induction · Flavonoids · Gene Expression · Genes, Reporter · Humans · Luciferases · Mice · Plasmids · Structure-Activity Relationship · Transcription, Genetic · Benzyl isothiocyanate · Electrophile-responsive element (EpRE) · Hepa-1c1c7 cells · Stable luciferase reporter cell lines · Transient transfection
[Abstract]

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