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1 Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea
article 1996    
Author: Philip, P.A. · Souliotis, V.L. · Harris, A.L. · Salisbury, A. · Tates, A.D. · Mitchell, K. · Delft, J.H.M. van · Ganesan, T.S. · Kyrtopoulos, S.A.
Keywords: Biology · dacarbazine · hydroxyurea · hypoxanthine phosphoribosyltransferase · adult · aged · article · clinical article · dna adduct · dna repair · female · gene mutation · human · intravenous drug administration · leukocyte · male · melanoma · priority journal · Antineoplastic Combined Chemotherapy Protocols · Dacarbazine · DNA Adducts · DNA Repair · Female · Guanine · Humans · Hydroxyurea · Hypoxanthine Phosphoribosyltransferase · Leukocytes · Male · Melanoma · Middle Aged · Mutation · O(6)-Methylguanine-DNA Methyltransferase
[Abstract]

2 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

3 Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters
article 1999    
Author: Turnbull, D. · Frankos, V.H. · Delft, J.H.M. van · Vogel, N. de
Keywords: Nutrition · Fatty acid ester · Vegetable oil · Chemical structure · Chromosome aberration · Food safety · Gene mutation · Genotoxicity · Mammal cell · Priority journal · Salmonella typhimurium · Wood · Animals · Carcinogenicity Tests · CHO Cells · Chromosome Aberrations · Cricetinae · DNA Mutational Analysis · Evaluation Studies · Mice · Mutagens · Phytosterols · Plant Oils · Salmonella typhimurium · Tumor Cells, Cultured · Wood · Bacteria (microorganisms) · Mammalia · Salmonella typhimurium · Typhimurium
[Abstract]

4 A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice
article 1993    
Author: HogenEsch, H. · Gijbels, M.J.J. · Offerman, E. · Hooft, J. van · Bekkum, D.W. van · Zurcher, C.
Keywords: Biology · broxuridine · intercellular adhesion molecule 1 · triamcinolone · epidermis hyperplasia · gene mutation · hematopoietic cell · histopathology · immunohistochemistry · macrophage function · neutrophil · remission · squamous epithelium · Adrenal Cortex Hormones · Animal · Chronic Disease · Cyclosporine · Dermatitis · Disease Models, Animal · Immunohistochemistry · Mast Cells · Mice · Mice, Inbred C57BL · Mutation · Rodent Diseases · Skin
[PDF] [Abstract]

5 Cost-effectiveness of 4 neonatal screening strategies for cystic fibrosis
article 2006    
Author: Akker-van Marle, M.E. van den · Dankert, H.M. · Verkerk, P.H. · Dankert-Roelse, J.E.
Keywords: Health · Jeugd en Gezondheid · Cost-effectiveness · Economic evaluation · Neonatal · Screening-newborn · DNA · Cost effectiveness analysis · Economic aspect · Gel electrophoresis · Gene mutation · Netherlands · Blood · Economics · Evaluation · Genetics · Immunoassay · Methodology · Newborn · Nucleotide sequence · Two dimensional gel electrophoresis · Cost-Benefit Analysis · Cystic Fibrosis · DNA Mutational Analysis · Electrophoresis, Gel, Two-Dimensional · Humans · Immunoassay · Infant, Newborn · Neonatal Screening · Trypsin
[Abstract]

6 Personalised nutrition: Status and perspectives
article 2007    
Author: Joost, H.G. · Gibney, M.J. · Cashman, K.D. · Görman, U. · Hesketh, J.E. · Mueller, M. · Ommen, B. van · Williams, C.M. · Mathers, J.C.
Keywords: Biomedical Research · Disease risk · Nutrigenetics · Nutrigenomics · Nutritional recommendations · Acyltransferase · Glutathione transferase · Xenobiotic agent · Carcinogenesis · Cholesterol metabolism · Diabetes mellitus · Dietary intake · Environmental factor · Familial hyperlipemia · Food composition · Gene interaction · Gene mutation · Genetic counseling · Genetic heterogeneity · Genetic screening · Genetic variability · Genotype phenotype correlation · Hypercholesterolemia · Hypertension · Mental deficiency · Nonhuman · Nutrient supply · Nutrigenomics · Nutritional assessment · Nutritional status · Nutritional value · Risk benefit analysis · Risk factor · Risk reduction · Single nucleotide polymorphism · Chronic Disease · Food · Genotype · Humans · Models, Genetic · Nutrition Disorders · Nutrition Physiology · Nutritional Requirements · Research
[PDF] [Abstract]

7 Gene-mutation assays in lambda-lacZ transgenic mice : comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium
article 1998    
Author: Delft, J.H.M. van · Bergmans, A. · Dam, F.J. van · Tates, A.D. · Howard, L. · Winton, D.J. · Baan, R.A.
Keywords: Biology · λlacZ · Dlb-1 · hprt · Mutagenesis · Transgenic mouse · ethylnitrosourea · hypoxanthine phosphoribosyltransferase · mesylic acid ethyl ester · methylnitrosourea · mutagenic agent · animal cell · animal experiment · animal tissue · article · controlled study · gene · gene mutation · intestine epithelium · mouse · mutagenesis · mutagenicity · nonhuman · priority journal · small intestine mucosa · spleen cell · transgenic mouse · Alkylating Agents · Animals · Ethyl Methanesulfonate · Ethylnitrosourea · Genetic Markers · Hypoxanthine Phosphoribosyltransferase · Intestinal Mucosa · Intestine, Small · Lac Operon · Methylnitrosourea · Mice · Mice, Inbred C57BL · Mice, Transgenic · Mutagenicity Tests · Mutagens · Mutation · Spleen · Animalia · Mus musculus
[Abstract]

8 Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study
article 2005    
Author: Brink, M. · Weijenberg, M.P. · Goeij, A.F.P.M. de · Roemen, G.M.J.M. · Lentjes, M.H.F.M. · Bruïne, A.P. de · Goldbohm, R.A. · Brandt, P.A. van den
Keywords: Health Nutrition · Food and Chemical Risk Analysis · Colon · Meat · Rectum · Wild-type K-ras · nitrosamine · polycyclic aromatic hydrocarbon · cancer incidence · cancer patient · colon cancer · dietary intake · female · gene mutation · genetic heterogeneity · genetic risk · major clinical study · rectum cancer · wild type · Aged · Case-Control Studies · Cohort Studies · Colonic Neoplasms · Diet · DNA Mutational Analysis · Female · Genes, ras · Humans · Male · Meat · Meat Products · Middle Aged · Netherlands · Rectal Neoplasms · Risk Factors · Seafood
[PDF] [Abstract]

9 Dietary folate and APC mutations in sporadic colorectal cancer
article 2006    
Author: Vogel, S. de · Engeland, M. van · Lüchtenborg, M. · Bruïne, A.P. de · Roemen, G.M.J.M. · Lentjes, M.H.F.M. · Goldbohm, R.A. · Brandt, P.A. van den · Goeij, A.F.P.M. de · Weijenberg, M.P.
Keywords: Nutrition · Food and Chemical Risk Analysis · folic acid · protein MLH1 · adult · aged · article · cancer risk · colon polyposis · colorectal cancer · controlled study · dietary intake · female · gene mutation · human · human tissue · incidence · major clinical study · male · Netherlands · oncogene K ras · protein expression · rectum cancer · vitamin intake · Aged · Carrier Proteins · Cohort Studies · Colonic Neoplasms · Colorectal Neoplasms · Diet · DNA, Neoplasm · Female · Folic Acid · Genes, APC · Humans · Male · Middle Aged · Mutation · Nuclear Proteins · Patient Selection · Proportional Hazards Models · Questionnaires · Rectal Neoplasms
[Abstract]

10 Dietary folate intake and K-ras mutations in sporadic colon and rectal cancer in the Netherlands Cohort Study
article 2005    
Author: Brink, M. · Weijenberg, M.P. · Goeij, A.F.P.M. de · Roemen, G.M.J.M. · Lentjes, M.H.F.M. · Bruïne, A.P. de · Engeland, M. van · Goldbohm, R.A. · Brandt, P.A. van den
Keywords: Health · Food and Chemical Risk Analysis · Men · Transversion · Wild-type · Women · folic acid · K ras protein · adenocarcinoma · adult · aged · article · cancer incidence · cancer risk · cohort analysis · colon cancer · confidence interval · data analysis · dietary intake · female · follow up · gene mutation · human · human tissue · major clinical study · male · Netherlands · oncogene K ras · priority journal · rectum cancer · rectum tumor · Aged · Cohort Studies · Colonic Neoplasms · Diet · DNA Mutational Analysis · Female · Folic Acid · Genes, ras · Humans · Male · Middle Aged · Mutation · Neoplasms · Netherlands · Rectal Neoplasms · Risk · Sex Factors
[Abstract]

11 Structure-function relationships of glucansucrase and fructansucrase enzymes from lactic acid bacteria
article 2006    
Author: Hijum, S.A.F.T. van · Kralj, S. · Ozimek, L.K. · Dijkhuizen, L. · Geel-Schutten, G.H. van
Keywords: Nutrition · Food technology · bacterial enzyme · calcium ion · fructan · fructan sucrase · glucan · glucan sucrase · oligosaccharide · polymer · signal peptide · sucrase · unclassified drug · amino acid substitution · binding site · catalysis · enzyme activity · enzyme mechanism · enzyme structure · gene mutation · lactic acid bacterium · nomenclature · nonhuman · nucleotide sequence · review · synthesis · Amino Acid Sequence · Bacterial Proteins · Fructans · Glycosyltransferases · Gram-Positive Bacteria · Lactic Acid · Molecular Sequence Data · Protein Conformation · Structure-Activity Relationship · Sucrase · Bacteria (microorganisms) · Negibacteria · Posibacteria
[Abstract]

12 Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism
article 2007    
Author: Henneman, P. · Schaap, F.G. · Havekes, L.M. · Rensen, P.C.N. · Frants, R.R. · Tol, A. van · Hattori, H. · Smelt, A.H.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · apoAV · Hypertriglyceridemia · Lipoprotein lipase · Plasma apoAV concentration · SNP-analysis · apolipoprotein A5 · adult · allele · article · circulation · controlled study · endoplasmic reticulum · female · gene frequency · gene mutation · genetic polymorphism · genetic variability · haplotype · human · hypertriglyceridemia · lipolysis · major clinical study · male · priority journal · protein secretion · single nucleotide polymorphism · Adult · Alleles · Apolipoproteins A · Base Sequence · Case-Control Studies · DNA Primers · Female · Gene Frequency · Haplotypes · Humans · Hypertriglyceridemia · Male · Middle Aged · Polymorphism, Single Nucleotide
[Abstract]

13 Animal products and K-ras codon 12 and 13 mutations in colon carcinomas
article 2000    
Author: Kampman, E. · Voskuil, D.W. · Kraats, A.A. van · Balder, H.F. · Muijen, G.N.P. van · Goldbohm, R.A. · Veer, P. van 't
Keywords: Nutrition · Calcium · Protein · Adult · Aged · Allele · Animal · Cancer risk · Case control study · Codon · Colon cancer · Controlled study · Diet · Female · Gene mutation · Human · Major clinical study · Male · Meat · Oncogene K ras · Polymerase chain reaction · Poultry · Priority journal · Statistical analysis · Animals · Calcium, Dietary · Carcinoma · Case-Control Studies · Codon · Colonic Neoplasms · Dairy Products · Dietary Fats · Dietary Proteins · DNA Adducts · DNA Mutational Analysis · DNA, Neoplasm · Female · Fishes · Food Habits · Genes, ras · Humans · Male · Meat · Middle Aged · Mutation · Netherlands · Odds Ratio · Polymerase Chain Reaction · Poultry · Questionnaires
[Abstract]

14 Mutation-based growth charts for SEDC and other COL2A1 related dysplasias
article 2012    
Author: Terhal, P.A. · Dommelen, P. van · Le Merrer, M. · Zankl, A. · Simon, M.E. · Smithson, S.F. · Marcelis, C. · Kerr, B. · Kinning, E. · Mansour, S. · Hennekam, R.C. · Hout, A.H. van der · Cormier-Daire, V. · Lund, A.M. · Goodwin, L. · Mégarbané, A. · Lees, M. · Betz, R.C. · Tobias, E.S. · Coucke, P. · Mortier, G.R.
Keywords: Health · COL2A1 · Growth · Spondylo-epiphyseal dysplasia congenita · arginine · asparagine · cysteine · glycine · valine · adult · adulthood · amino acid substitution · amino terminal sequence · anthropometric parameters · article · carboxy terminal sequence · child · codon · Col2a1 gene · female · gene · gene mutation · growth curve · human · major clinical study · male · nucleotide sequence · preschool child · priority journal · spondyloepiphyseal dysplasia · Healthy for Life · Healthy Living · Human · LS - Life Style · BSS - Behavioural and Societal Sciences
[Abstract]

15 Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma
article 2008    
Author: Dijk, B.A.C. van · Schouten, L.J. · Oosterwijk, E. · Hulsbergen van de · Kaa, C.A. · Kiemeney, L.A.L.M. · Goldbohm, R.A. · Schalken, J.A. · Brandt, P.A. van den
Keywords: Health · Renal cell carcinoma · Supplements · Von Hippel-Lindau gene mutations · alpha carotene · alpha tocopherol · ascorbic acid · beta cryptoxanthin · folic acid · von Hippel Lindau protein · adult · body mass · cancer risk · follow up · gene mutation · kidney carcinoma · major clinical study · vitamin intake · vitamin supplementation · Aged · Carcinoma, Renal Cell · Carotenoids · Case-Control Studies · Cohort Studies · Dietary Supplements · Female · Humans · Kidney Neoplasms · Male · Middle Aged · Netherlands · Nutrition Surveys · Proportional Hazards Models · Risk · Vitamins · von Hippel-Lindau Disease
[Abstract]

16 Alcohol consumption and mutations or promoter hypermethylation of the von Hippel-Lindau gene in renal cell carcinoma
article 2008    
Author: Schouten, L.J. · Dijk, B.A.C.van · Oosterwijk, E. · Engeland, M. van · Hulsbergen-Kaa, C.A. van de · Kiemeney, L.A.L.M. · Goldbohm, R.A. · Kester, A. · Vogel, S. de · Schalken, J.A. · Brandt, P.A. van den
Keywords: Health · Adult · Alcohol consumption · Cancer risk · Clear cell carcinoma · Controlled study · Disease association · DNA determination · Epigenetics · Gene mutation · Kidney carcinoma · Major clinical study · Risk assessment · Tumor gene · Von Hippel Lindau gene · Aged · Alcohol Drinking · Carcinoma, Renal Cell · Case-Control Studies · CpG Islands · DNA Methylation · Female · Humans · Kidney Neoplasms · Male · Middle Aged · Mutation · Proportional Hazards Models · Prospective Studies · Questionnaires · Risk Factors · Von Hippel-Lindau Tumor Suppressor Protein
[Abstract]

17 Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer
article 2008    
Author: Vogel, S. de · Bongaerts, B.W.C. · Wouters, K.A.D. · Kester, A.D.M. · Schouten, L.J. · Goeij, A.F.P.M. de · Bruïne, A.P. de · Goldbohm, R.A. · Brandt, P.A. van den · Engeland, M. van · Weijenberg, M.P.
Keywords: Health · Alcohol consumption · Cancer incidence · Cancer risk · Cohort analysis · Colon carcinogenesis · Colorectal carcinoma · Dietary intake · Epigenetics · Gene mutation · Microsatellite instability · Netherlands · Phenotype · Promoter region · Protein expression · Protein methylation · Sex difference · Vitamin intake · Adaptor Proteins, Signal Transducing · Aged · Cohort Studies · Colorectal Neoplasms · Diet · DNA Methylation · DNA, Neoplasm · Female · Folic Acid · Humans · Male · Methionine · Microsatellite Repeats · Middle Aged · Mutation · Netherlands · Nuclear Proteins · Phenotype · Promoter Regions (Genetics) · Proto-Oncogene Proteins B-raf · Questionnaires · Riboflavin · Vitamin B 12 · Vitamin B 6
[Abstract]

18 A novel mutation in the lysyl hydroxylase 1 gene causes decreased lysyl hydroxylase activity in an ehlers-danlos VIA patient
article 2005    
Author: Walker, L.C. · Overstreet, M.A. · Siddiqui, A. · Paepe, A. de · Ceylaner, G. · Malfait, F. · Symoens, S. · Atsawasuwan, P. · Yamauchi, M. · Ceylaner, S. · Bank, R.A. · Yeowell, H.N.
Keywords: Collagen cross-linking · Collagen disorders · Collagen hydroxylation · Human skin fibroblasts · Mutation analysis · complementary DNA · genomic DNA · Anamnesis · Baculovirus expression system · Case report · Cross linking · DNA determination · Ehlers Danlos syndrome · Enzyme active site · Enzyme activity · Gene expression · Gene mutation · Heterozygosity · Homozygosity · Joint laxity · Kyphoscoliosis · Mutational analysis · Phenotype · Preschool child · Protein folding · Skin fibroblast · Child, Preschool · Ehlers-Danlos Syndrome · Female · Humans · Mutation · Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase · Structure-Activity Relationship
[Abstract]

19 Alpha 2(I) collagen deficient oim mice have altered biomechanical integrity, collagen content, and collagen crosslinking of their thoracic aorta
article 2005    
Author: Pfeiffer, B.J. · Franklin, C.L. · Hsieh, F.H. · Bank, R.A. · Phillips, C.L.
Keywords: Biomechanics · Crosslinks · Oim · Type I collagen · functional group · hydroxyproline · pyridinoline · animal cell · animal model · animal tissue · artery disease · ascending aorta · biomechanics · blood vessel parameters · controlled study · descending aorta · evaluation · gene mutation · heterozygote · histology · molecule · morphological trait · mouse · mouse strain · nonhuman · osteogenesis imperfecta · priority journal · protein content · protein cross linking · protein deficiency · protein function · staining · thoracic aorta · wild type · Animals · Aorta, Thoracic · Biomechanics · Collagen · Collagen Type I · Mice · Mice, Mutant Strains · Osteogenesis Imperfecta
[Abstract]

20 Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
article 1994    
Author: Knijff, P. de · Maagdenberg, A.M.J.M. van den · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Apolipoprotein (apo) E · Atherosclerosis · Familial Dysbetalipoproteinemia (FD) · Mutations · Polymorphisms · Type III Hyperlipoproteinemia · Cholesterol · Chylomicron · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · Alzheimer disease · Atherosclerosis · Cholesterol blood level · Coronary artery disease · Creutzfeldt jakob disease · Gene mutation · Genetic heterogeneity · Genetic linkage · Genetic polymorphism · Ligand binding · Lipoprotein metabolism · Alleles · Amino Acid Sequence · Base Sequence · DNA · Female · Gene Frequency · Human · Hyperlipidemia · Hyperlipoproteinemia Type III · Lipids · Lipoproteins · Male · Molecular Sequence Data · Mutation · Variation (Genetics)
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 43 found. Next | Sort by date