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1 Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes
article 1995    
Author: Twisk, J. · Wit, E.C.M. de · Princen, H.M.G.
Keywords: Biology · bile acid · chenodeoxycholic acid · cholesterol 7alpha monooxygenase · cholic acid · deoxycholic acid · lithocholic acid · messenger rna · oxygenase · sterol · taurocholic acid · animal cell · article · bile acid synthesis · cholesterol metabolism · controlled study · enzyme inhibition · gene repression · liver cell culture · nonhuman · priority journal · rat · transcription regulation · Adenosine Triphosphate · Animal · Bile Acids and Salts · Cells, Cultured · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Down-Regulation · Gene Expression Regulation, Enzymologic · Liver · Male · Mitochondria · Oxidoreductases · Rats · Rats, Wistar · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Taurocholic Acid · Transcription, Genetic
[Abstract]

2 Expression of the xylulose 5-phosphate phosphoketolase gene, xpkA, from Lactobacillus pentosus MD363 is induced by sugars that are fermented via the phosphoketolase pathway and is repressed by glucose mediated by CcpA and the mannose phosphoenolpyruvate phosphotransferase system
article 2002    
Author: Posthuma, C.C. · Bader, R. · Engelmann, R. · Postma, P.W. · Hengstenberg, W. · Pouwels, P.H.
Keywords: Environment · Amino acids · Aldehyde-Lyases · Amino Acid Sequence · Bacterial Proteins · Bacteria (microorganisms) · Bifidobacterium · Bifidobacterium animalis · Cloning · Enzymes · Escherichia coli · Glucose · Catabolites · Genes · Gene Deletion · Gene Expression Regulation, Bacterial · Gene expression · Gene induction · Gene repression · Gene sequence · Lactobacillus · Lactobacillus pentosus · Mannose · Molecular Sequence Data · Posibacteria · Prokaryota · Pentosephosphates · Phosphoenolpyruvate Sugar Phosphotransferase System · Repressor Proteins · Sequence Alignment · Sequence Analysis, DNA · Bacterial enzyme · Carbon catabolite protein a · Mannose phosphoenolpyruvate phosphotransferase · Unclassified drug · Xylulose 5 phosphate phosphoketolase · Bacterium · Bacterial gene · Bacterium mutant · Enzyme activity · Enzyme purification · Fermentation · Molecular cloning · Nonhuman · Nucleotide sequence · Xpka gene · DNA-Binding Proteins
[PDF] [Abstract]

3 Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes
article 1993    
Author: Twisk, J. · Lehmann, E.M. · Princen, H.M.G.
Keywords: Health · bile acid · chenodeoxycholic acid · cholesterol 7alpha monooxygenase · deoxycholic acid · glycocholic acid · messenger rna · animal cell · bile acid synthesis · controlled study · culture medium · dose time effect relation · down regulation · enzyme activity · enzyme regulation · feedback system · gene expression regulation · gene repression · genetic transcription · hydrophobicity · kinetics · liver cell · liver cell culture · monolayer culture · negative feedback · nonhuman · transcription regulation · Animal · Base Sequence · Bile Acids and Salts · Cells, Cultured · Chenodeoxycholic Acid · Cholesterol 7-alpha-Hydroxylase · Cholic Acid · Cholic Acids · Feedback · Gene Expression Regulation · Glycocholic Acid · Kinetics · Liver · Male · Molecular Sequence Data · Rats · RNA, Messenger · Support, Non-U.S. Gov't · Taurocholic Acid · Transcription, Genetic
[Abstract]

4 Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA
article 2007    
Author: Eefting, D. · Grimbergen, J.M. · Vries, M.R. de · Weel, V. van · Kaijzel, E.L. · Que, I. · Moon, R.T. · Löwik, C.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · double stranded RNA · histidine · luciferase · oligonucleotide · plasmid vector · small interfering RNA · toll like receptor 4 · uridine · animal cell · animal experiment · article · bioluminescence · controlled study · electroporation · gastrocnemius muscle · gene expression · gene function · gene repression · gene silencing · human · human cell · immune response · in vivo gene transfer · in vivo study · male · mouse · nonhuman · nonviral gene delivery system · protein expression · restenosis · RNA interference · transgene · treatment planning · tumor · viral gene delivery system · Animals · Cattle · Cell Line, Transformed · Cell Transformation, Viral · Electroporation · Feasibility Studies · Gene Silencing · Genes, Reporter · Humans · Hypoxanthine Phosphoribosyltransferase · Lipopolysaccharides · Luciferases · Luminescent Measurements · Male · Mice · Mice, Inbred Strains · Muscle, Skeletal · NIH 3T3 Cells · Plasmids · RNA Interference · RNA, Messenger · RNA, Small Interfering · Time Factors · Toll-Like Receptor 4 · Murinae
[Abstract]

5 Parallelogram approach using rat-human In vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Wortelboer, H. · Herwijnen, M. van · Gottschalk, R. · Jong, C.H.C. de · Boorsma, A. · Paules, R.S. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Toxicology · Biotechnology · Acetaminophen · Gene expression profiling · Hepatocyte-based in vitro models · Interspecies extrapolation · Liver injury · T-profiler · oxidoreductase · paracetamol · adult · aged · animal cell · animal experiment · animal model · animal tissue · article · biological activity · cell function · chemical analysis · controlled study · energy consumption · enzyme activity · female · gene expression profiling · gene repression · human · human cell · human tissue · human versus animal comparison · in vitro study · in vivo study · liver cell · liver metabolism · liver mitochondrion · liver toxicity · male · nonhuman · rat · species comparison · toxicogenetics · Acetaminophen · Adult · Aged · Analgesics, Non-Narcotic · Animals · Cell Survival · Cells, Cultured · Female · Hepatitis, Toxic · Hepatocytes · Humans · In Situ Hybridization · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Rats, Wistar · RNA · Species Specificity · Toxicogenetics · Rattus · Rodentia
[Abstract]

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