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Showing 1 to 13 of 13 found. | Sort by date

1 Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis
article 1998    
Author: Hofker, M.H. · Vlijmen, B.J.M. van · Havekes, L.M.
Keywords: Health · APOE · Apolipoprotein · Cholesterol · Gene targeting · Lipoprotein · Triglyceride · Animals · Apolipoproteins E · Arteriosclerosis · Disease Models, Animal · Humans · Hyperlipidemias · Mice · Mice, Transgenic
[Abstract]

2 Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding
article 1995    
Author: Ree, J.H. van · Gijbels, M.J.J. · Broek, W.J.A.A. van den · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · Cholesterol deposition · Familial dysbetalipoproteinemia · Gene targeting · Hypercholesterolemia · Lipoprotein metabolism · Mouse model · apolipoprotein e · cholesterol · animal experiment · animal model · article · cholesterol diet · familial hypercholesterolemia · gene targeting · histology · hyperlipoproteinemia type 3 · lipoprotein metabolism · mouse · nonhuman · priority journal · xanthomatosis · Animal · Apolipoproteins E · Cholesterol, Dietary · Human · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Support, Non-U.S. Gov't · Xanthomatosis
[Abstract]

3 Efficient gene targeting in Penicillium chrysogenum using novel Agrobacterium-mediated transformation approaches
article 2013    
Author: Boer, P. de · Bronkhof, J. · Duki, K. · Kerkman, R. · Touw, H. · Berg , M. van den · Offringa, R.
Keywords: Nutrition · Gene targeting · Agrobacterium-mediated transformation · Penicillium chrysogenum · Non-homologous end joining · Bi-partite method · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Increased response to cholesterol feeding in apolipoprotein C1-deficient mice
article 1995    
Author: Ree, J.H. van · Hofker, M.H. · Broek, J.A.A. van den · Deursen, J.M.A. van · Boom, H. van der · Frants, R.R. · Wieringa, B. · Havekes, L.M.
Keywords: Biology · apolipoprotein c1 · apolipoprotein e · very low density lipoprotein · animal cell · animal experiment · animal model · article · cholesterol blood level · cholesterol intake · controlled study · embryo · female · gene targeting · hep 2 cell · homozygosity · hypercholesterolemia · lipoprotein deficiency · lipoprotein metabolism · mouse · mutant · nonhuman · priority journal · stem cell · triacylglycerol blood level · Animal · Apolipoproteins C · Cholesterol · Cholesterol, Dietary · Gene Targeting · Heterozygote · Homozygote · Lipoproteins, HDL Cholesterol · Lipoproteins, LDL Cholesterol · Lipoproteins, VLDL Cholesterol · Mice · Mice, Inbred C57BL · Mice, Inbred CBA · Mice, Transgenic · Mutation · Receptors, LDL · Support, Non-U.S. Gov't · Triglycerides
[Abstract]

5 Towards replacing closed with open target selection strategies
article 2005    
Author: Werf, M.J. van der
Keywords: Biology · Biotechnology · Data reduction · Genes · Knowledge engineering · Metabolism · Technology · Bioproducts · Metabolomics · Proteomics · Strain improvement · Microorganisms · analytic method · cell interaction · data analysis · genomics · metabolic engineering · metabolomics · microbial kinetics · nonhuman · priority journal · proteomics · review · strain identification · transcriptomics · Bacteria · Gene Expression · Gene Targeting · Genetic Engineering · Genomics · Models, Biological
[Abstract]

6 Development of a system for integrative and stable transformation of the zygomycete Rhizopus oryzae by Agrobacterium-mediated DNA transfer
article 2004    
Author: Michielse, C.B. · Salim, K. · Ragas, P. · Ram, A.F.J. · Kudla, B. · Jarry, B. · Punt, P.J. · Hondel, C.A.M.J.J. van den
Keywords: Biology · Biotechnology · Agrobacterium tumefaciens · Rhizopus oryzae · Transformation · Zygomycete · article · controlled study · defense mechanism · DNA transfer · gene locus · gene targeting · genetic stability · genomics · molecular dynamics · nonhuman · priority journal · Rhizobium radiobacter · Rhizopus oryzae · tandem repeat · Zygomycetes · Chromosomal Instability · DNA, Fungal · Genetic Markers · Mitosis · Orotidine-5'-Phosphate Decarboxylase · Rhizobium · Rhizopus · Transformation, Genetic · Agrobacterium · Agrobacterium tumefaciens · Aspergillus · Emericella nidulans · Rhizopus · Rhizopus niveus · Rhizopus oryzae
[Abstract]

7 Agrobacterium-mediated transformation as a tool for functional genomics in fungi
article 2005    
Author: Michielse, C.B. · Hooykaas, P.J.J. · Hondel, C.A.M.J.J. van den · Ram, A.F.J.
Keywords: Biology · Analytical research · Agrobacterium tumefaciens · Fungal transformation · Insertional mutagenesis · Targeted mutagenesis · bacterial DNA · DNA integration · DNA synthesis · DNA transfer · functional genomics · fungal genetics · fungal strain · gene expression regulation · gene targeting · genetic transformation · molecular genetics · nonhuman · priority journal · review · Rhizobium · Rhizobium radiobacter · Bacterial Proteins · Base Sequence · DNA, Fungal · Genome, Fungal · Genomics · Mutagenesis, Insertional · Mutagenesis, Site-Directed · Plasmids · Rhizobium · Saccharomyces cerevisiae · Agrobacterium · Agrobacterium tumefaciens · Fungi
[Abstract]

8 Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice
article 1994    
Author: Ree, J.H. van · Broek, W.J.A.A. van den · Dahlmans, V.E.H. · Groot, P.H.E. · Vidgeon-Hart, M. · Frants, R.R. · Wieringa, B. · Havekes, L.M. · Hofker, M.H.
Keywords: Nutrition · Atherosclerotic plaques · Cholesterol-rich diets · Gene targeting · Hyperlipoproteinemia · Mouse model · Apolipoprotein e · Cholesterol · Nitric oxide · Animal experiment · Animal model · Animal tissue · Aorta · Cholesterol diet · Controlled study · Female · Heterozygosity · Histology · Hyperlipoproteinemia type 3 · Male · Mouse · Aging · Apolipoproteins E · Arteriosclerosis · Blotting, Northern · Blotting, Western · Cholesterol · Diet, Atherogenic · Disease Susceptibility · Heterozygote · Hypercholesterolemia · Lipids · Mice · Mice, Inbred C57BL · Mice, Mutant Strains
[Abstract]

9 Transcriptome analysis of a phenol-producing Pseudomonas putida S12 construct: Genetic and physiological basis for improved production
article 2008    
Author: Wierckx, N.J.P. · Ballerstedt, H. · Bont, J.A.M.de · Winde, J.H.de · Ruijssenaars, H.J. · Wery, J.
Keywords: Biology · Biomedical Research · lyase · phenol · tryptophan · tyrosine · amino acid synthesis · article · bacterial gene · bacterial metabolism · bacterial mutation · bacterium mutant · bioaccumulation · biosynthesis · gene disruption · gene expression profiling · gene expression regulation · gene identification · gene targeting · nonhuman · nucleotide sequence · priority journal · Pseudomonas putida · sequence analysis · transcriptomics · Gene Deletion · Gene Expression Profiling · Metabolic Networks and Pathways · Mutagenesis, Insertional · Phenol · Phenylpyruvic Acids · Pseudomonas putida · Tryptophan · Tyrosine · Tyrosine Phenol-Lyase · Up-Regulation · Pseudomonas putida
[Abstract]

10 A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
article 2010    
Author: Eefting, D. · Seghers, L. · Grimbergen, J.M. · Vries, M.R. de · Boer, H.C. de · Lardenoye, J.W.H.P. · Jukema, J.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Health · Biomedical Research · Gene therapy · Matrix metalloproteinases · Plasmin(ogen) · Vascular surgery · Vein graft disease · apolipoprotein E3 · aprotinin · hybrid protein · matrix metalloproteinase · matrix metalloproteinase inhibitor · plasmin · plasmin inhibitor · plasminogen activator · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 1 amino terminal fragment of urokinase type plasminogen activator bovine pancreas trypsin inhibitor · unclassified drug · urokinase receptor · animal cell · animal experiment · animal model · animal tissue · article · carotid artery · cell surface · controlled study · electroporation · expression vector · female · gene overexpression · gene targeting · genetic transfection · human · human tissue · hypercholesterolemia · in vivo culture · intima · male · mouse · nonhuman · nonviral gene delivery system · priority journal · vein graft disease
[Abstract]

11 Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis
article 2008    
Author: Dihal, A.A. · Woude, H. van der · Hendriksen, P.J.M. · Charif, H. · Dekker, L.J. · IJsselstijn, L. · Boer, V.C.J. de · Alink, G.M. · Burgers, P.C. · Rietjens, I.M.C.M. · Woutersen, R.A. · Stierum, R.H.
Keywords: Biology · Toxicology and Applied Pharmacology · Biomarker · Colorectal cancer · Quercetin · Transcriptomics · fatty acid · glutathione peroxidase 2 · heat shock protein · mitogen activated protein kinase · peroxisome proliferator activated receptor alpha · quercetin · transcriptome · animal experiment · animal model · article · cancer prevention · cell cycle · colon mucosa · colorectal cancer · controlled study · down regulation · energy metabolism · Fischer 344 rat · gene expression · gene targeting · genetic analysis · glycolysis · lipid degradation · male · nonhuman · nucleotide sequence · priority journal · proteomics · rat · statistical significance · tumor biopsy · Animals · Colon · Colorectal Neoplasms · Diet · Down-Regulation · Fatty Acids · Gene Expression Profiling · Glycolysis · Intestinal Mucosa · Male · Mitochondria · Proteome · Quercetin · Rats · Rats, Inbred F344 · Rattus
[Abstract]

12 Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation
article 2007    
Author: Bezooijen, R.L. van · Svensson, J.P. · Eefting, D. · Visser, A. · Horst, G. van der · Karperien, M. · Quax, P.H.A. · Vrieling, H. · Papapoulos, S.E. · Dijke, P. ten · Löwik, W.G.M.C.
Keywords: Biology · Biomedical Research · BMP · Bone formation · Microarray · Sclerostin · Signal transduction · SOST · Wnt · Bone morphogenetic protein · Dickkopf 1 protein · Glycoprotein · Growth factor · Protein inhibitor · Sclerostin · Wnt protein · Animal cell · Animal experiment · Animal tissue · Bone disease · Bone mass · Cell differentiation · Controlled study · DNA microarray · Electroporation · Embryo · Expression vector · Gastrocnemius muscle · Gene · Gene expression profiling · Gene targeting · Genetic transcription · Human · Human cell · In vivo study · Male · Mouse · Nonhuman · Ossification · Osteoblast · Osteocyte · Osteosclerosis · Protein family · Reporter gene · Signal transduction · SOST gene · Van buchem disease · Animals · Bone Development · Bone Morphogenetic Proteins · Cells, Cultured · Electroporation · Gene Expression Regulation · Genes, Reporter · Genetic Markers · Humans · Mesoderm · Mice · Muscle, Skeletal · Oligonucleotide Array Sequence Analysis · Recombinant Proteins · Signal Transduction · Transfection · Wnt Proteins
[Abstract]

13 Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma
article 2009    
Author: Kuhlmann, K.F.D. · Geer, M.A. van · Bakker, C.T. · Dekker, J.E.M. · Havenga, M.J.E. · Oude Elferink, R.P.J. · Gouma, D.J. · Bosma, P.J. · Wesseling, J.G.
Keywords: Biology · Biomedical Research · Adenovirus · Fiber-chimeric · Pancreatic cancer · Serotype · adenovirus vector · bacterial enzyme · coxsackie virus and adenovirus receptor · cytosine deaminase · flucytosine · green fluorescent protein · red fluorescent protein · virus DNA · virus fiber protein · Adenovirus fiber gene · Adenovirus fiber knob 5 · Adenovirus type 16 · Adenovirus type 50 · antineoplastic activity · article · bacterial gene · cancer cell culture · cell viability · controlled study · cytosine deaminase gene · drug cytotoxicity · drug efficacy · drug mechanism · drug specificity · fiber chimeric human adenovirus 5 · gene directed enzyme prodrug therapy · gene expression · gene targeting · human · Human adenovirus · Human adenovirus 5 · human cell · human tissue · liver cell culture · molecular cloning · nonhuman · pancreas adenocarcinoma · priority journal · protein domain · protein expression · suicide gene · viral gene delivery system · virus fiber · virus gene · Adenoviridae · Cell Line · Cell Line, Tumor · Flow Cytometry · Gene Therapy · Genetic Vectors · Green Fluorescent Proteins · Humans · Pancreatic Neoplasms · Polymerase Chain Reaction · Recombinant Fusion Proteins · Recombination, Genetic · Transduction, Genetic · Viral Envelope Proteins · Adenoviridae
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date