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1 Alu-repeat polymorphism in the tissue-type plasminogen activator (t-PA) gene, t-PA levels and risk of familial myocardial infarction (MI)
article 1996    
Author: Iacoviello, L. · Castelnuovo, A. di · Knijff, P. de · Orazio, A. d · Amore, C. · Kluft, C. · Donati, M.B.
Keywords: Biology · Tissue plasminogen activator · Conference paper · Fibrinolysis · Genetic polymorphism · Heart infarction · Human · Risk factor
[Abstract]

2 Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size
article 2009    
Author: Schalkwijk, D.B. van · Graaf, A.A. de · Ommen, B. van · Bochove, K. van · Rensen, P.C.N. · Havekes, L.M. · Pas, N.C.A. van de · Hoefsloot, H.C.J. · Greef, J. van der · Freidig, A.P.
Keywords: Health · Physiological Sciences · Data analysis · Genetic polymorphism · Hepatic lipase · Kinetics · Lipoprotein lipase · Mathematical modeling · Stable isotope flux data
[PDF] [Abstract]

3 The radial immunodiffusion assay for plasma Histidine-rich Glycoprotein (HRG) based on a polyclonal antibody, shows a different specificity towards the two variants of a common amino acid polymorphism
article 1996    
Author: Hennis, B.C. · Hoffmann, J.J.M.L. · Kluft, C.
Keywords: Biology · amino acid · glycoprotein · histidine rich glycoprotein · polyclonal antibody · unclassified drug · conference paper · controlled study · genetic polymorphism · human · immunoassay · immunodiffusion · priority journal · risk factor · thrombosis
[Abstract]

4 Apolipoprotein A-IV polymorhism and its effect on plasma lipid and apolipoprotein concentrations
article 1988    
Author: Knijff, P. de · Rosseneu, M. · Beisiegel, U. · Keersgieter, W. de · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Triacylglycerol · Apolipoprotein blood level · Heredity · Lipid blood level · Population genetics · Protein polymorphism · Blood · Genetic polymorphism · Genetics · Phenotype · Adult · Alleles · Animal · Apolipoproteins · Apolipoproteins A · Apolipoproteins B · Cholesterol · Gene Frequency · Human · Lipids · Male · Phenotype · Polymorphism (Genetics) · Rabbits · Triglycerides
[PDF] [Abstract]

5 Toenails: An easily accessible and long-term stable source of DNA for genetic analyses in large-scale epidemiological studies [8]
article 2007    
Author: Breda, S.G. van · Hogervorst, J.G. · Schouten, L.J. · Knaapen, A.M. · Delft, J.H. van · Goldbohm, R.A. · Schooten, F.J. van · Brandt, P.A. van den
Keywords: Biology · Food and Chemical Risk Analysis · DNA · age · DNA determination · DNA isolation · genetic analysis · genetic epidemiology · genetic polymorphism · genotype · human · letter · multiplex polymerase chain reaction · nail · Netherlands · quality control · sampling · toe · toe nail · DNA · Electrophoresis, Capillary · Epidemiologic Studies · Genotype · Humans · Nails · Neutrons · Polymerase Chain Reaction · Polymorphism, Genetic · Specimen Handling · Time Factors · Toes

6 The association between IGF-1 polymorphisms, IGF-1 serum levels, and cognitive functions in healthy adults: The amsterdam growth and health longitudinal study
article 2014    
Author: Licht, C.M.M. · Turenhout, L.C. van · Deijen, J.B. · Koppes, L.L.J. · Mechelen, W. van · Twisk, J.W.R. · Drent, M.L.
Keywords: Workplace · Somatomedin C · Adult · Body mass · Caucasian · Clinical assessment · Cognition · Gene frequency · Gene location · Genetic association · Genetic polymorphism · Heterozygote · Homozygote · Human experiment · IGF 1 gene · Intelligence quotient · Mental task · Mental test · Middle aged · Paired associate learning · Promoter region · Protein blood level · Spatial memory · Working memory · Work and Employment · Healthy Living · Resilient Organisations · WHC - Work, Health and Care · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

7 Glutathione conjugation as a bioactivation reaction
article 2000    
Author: Bladeren, P.J. van
Keywords: Nutrition · Bioactivation · Glutathione conjugates · Glutathione S-transferases · Cysteine · Glutathione · Glutathione transferase · Lyase · Catalysis · Chemical binding · Chemical reaction · Chromosomal localization · Conjugation · Covalent bond · Detoxification · Enzyme activation · Enzyme activity · Enzyme induction · Enzyme inhibition · Enzyme mechanism · Gene location · Genetic polymorphism · Human · Nonhuman · Protein expression · Reaction analysis · Reduction · Animals · Biotransformation · Carbon-Sulfur Lyases · Enzyme Induction · Glutathione · Glutathione Transferase · Humans · Metabolic Detoxication, Drug · Oxidation-Reduction · Xenobiotics
[Abstract]

8 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · (Anti)carcinogenic · Biotransformation · Dietary compound · Modulation · Cytochrome p450 · Glutathione transferase · Biotransformation · Cancer risk · Carcinogenesis · Drug detoxification · Enzyme activity · Genetic polymorphism · Human · Nutrition · Priority journal · Review · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Diet · Gene Expression Regulation, Neoplastic · Glutathione Transferase · Humans · Kinetics · Neoplasms · Variation (Genetics) · Xenobiotics
[Abstract]

9 Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: Differences between older men and women
article 1997    
Author: Mennen, L.I. · Maat, M.P.M. de · Schouten, E.G. · Kluft, C. · Jong, P.T.V.M. de · Hofman, A. · Grobbee, D.E.
Keywords: Biology · Blood clotting factor 7 · Triacylglycerol · Adult · Aged · Allele · Cardiovascular risk · Controlled study · Genetic association · Genetic polymorphism · Genotype · Human cell · Major clinical study · Regression analysis · Sex difference · Triacylglycerol blood level · Aging · Alleles · Factor VII · Female · Genotype · Humans · Male · Middle Aged · Polymorphism, Genetic · Sex Characteristics · Triglycerides
[Abstract]

10 An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels
article 1995    
Author: Hennis, B.C. · Boomsma, D.I. · Boheemen, P.A. van · Engesser, L. · Kievit, P. · Dooijewaard, G. · Kluft, C.
Keywords: Biology · glycoprotein · histidine · adult · age · article · blood level · controlled study · environmental factor · genetic polymorphism · human · inheritance · major clinical study · maximum likelihood method · normal human · pedigree · priority journal · Alleles · Amino Acids · Analysis of Variance · Blood Proteins · Case-Control Studies · Chromosome Mapping · Glycoproteins · Humans · Likelihood Functions · Molecular Weight · Pedigree · Phenotype · Polymorphism, Genetic · Proteins
[Abstract]

11 Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia
article 1997    
Author: Maat, M.P.M. de · Knipscheer, H.C. · Kastelein, J.J.P. · Kluft, C.
Keywords: Biology · C reactive protein · Ciprofibrate · Acute phase response · Cardiovascular disease · Clinical trial · Controlled clinical trial · Controlled study · Drug effect · Drug mechanism · Fibrinogen blood level · Genetic polymorphism · Hypercholesterolemia · Major clinical study · Oral drug administration · Randomized controlled trial · Risk factor · Adult · Antilipemic Agents · Clofibric Acid · Female · Fibrinogen · Gemfibrozil · Humans · Hyperlipidemias · Male · Middle Aged
[Abstract]

12 Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study
article 1997    
Author: Meulenbelt, I. · Bijkerk, C. · Wildt, S.C.M. de · Miedema, H.S. · Valkenburg, H.A. · Breedveld, F.C. · Pols, H.A.P. · TeKoppele, J.M. · Sloos, V.F.G. · Hofman, A. · Slagboom, P.E. · Duijn, C.M. van
Keywords: Health · Biomedical Research · adult · allele · article · cartilage matrix · controlled study · coxitis · female · gene locus · genetic polymorphism · genetic predisposition · genetic variability · genotype · human · major clinical study · male · osteoarthritis · priority journal · Aged · Extracellular Matrix Proteins · Female · Genes · Glycoproteins · Hip Joint · Humans · Male · Middle Aged · Osteoarthritis · Proteins · Proteoglycans · Sex Characteristics
[PDF] [Abstract]

13 Factor VII polymorphisms in populations with different risks of cardiovascular disease
article 1997    
Author: Maat, M.P.M. de · Green, F. · Knijff, P. de · Jespersen, J. · Kluft, C.
Keywords: Biology · Factor VII polymorphisms · FVII:C · Ischemic heart disease · blood clotting factor 7 · adult · amino acid sequence · article · caribbean islands · coronary risk · disease association · europe · female · genetic polymorphism · greenland · human · incidence · ischemic heart disease · major clinical study · male · priority journal · protein determination · race difference · risk assessment · Adult · Aged · Factor VII · Female · Humans · Male · Middle Aged · Myocardial Ischemia · Polymorphism, Genetic · Promoter Regions (Genetics) · Risk
[Abstract]

14 Interindividual variation in the response by fibrinogen, C-reactive protein and interleukin-6 to yellow fever vaccination
article 2004    
Author: Verschuur, M. · Beek, M.T. van der · Tak, H.S. · Visser, L.G. · Maat, M.P.M. de
Keywords: Biology · Biomedical Research · Acute phase proteins · Interindividual variation · Polymorphisms · C reactive protein · Pasteur merieux · Yellow fever vaccine · Adult · Allele · Clinical article · Controlled study · Drug effect · Female · Fibrinogen blood level · Genetic polymorphism · Genetic variability · Male · Yellow fever flavivirus · C-Reactive Protein · Cardiovascular Diseases · Fibrinogen · Homozygote · Humans · Inflammation · Interleukin-6 · Vaccination · Variation (Genetics) · Yellow Fever Vaccine
[Abstract]

15 Matrix metalloproteinases in premature coronary atherosclerosis: influence of inhibitors, inflammation, and genetic polymorphisms
article 2007    
Author: Nanni, S. · Melandri, G. · Hanemaaijer, R. · Cervi, V. · Tomasi, L. · Altimari, A. · Lent, N. van · Tricoci, P. · Bacchi, L. · Branzi, A.
Keywords: Health · Biomedical Research · biological marker · gelatinase A · gelatinase B · glucose · haptoglobin · matrix metalloproteinase · stromelysin · tissue inhibitor of metalloproteinase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · adult · article · controlled study · coronary artery atherosclerosis · correlation analysis · enzyme activity · enzyme blood level · exon · genetic polymorphism · glucose blood level · human · human tissue · inflammation · major clinical study · male · metabolic disorder · pathogenesis · priority journal · protein expression · protein localization
[Abstract]

16 The expression of type III hyperlipoproteinemia: Involvement of lipolysis genes
article 2009    
Author: Henneman, P. · Sman-de Beer, F. van der · Moghaddam, P.H. · Huijts, P. · Stalenhoef, A.F.H. · Kastelein, J.J.P. · Duijn, C.M. van · Havekes, L.M. · Frants, R.R. · Dijk, K.W. van · Smelt, A.H.M.
Keywords: Biology · Biomedical Research · adenine · apolipoprotein A5 · apolipoprotein C3 · apolipoprotein E2 · cytosine · guanine · lipoprotein lipase · liver triacylglycerol lipase · thymine · adult · aged · article · controlled study · disease severity · female · gene expression · gene frequency · gene function · gene linkage disequilibrium · genetic association · genetic polymorphism · genetic variability · human · human cell · hyperlipidemia · hyperlipoproteinemia type 3 · hypertriglyceridemia · lipolysis · lipoprotein blood level · major clinical study · male · mutational analysis · Netherlands · priority journal
[Abstract]

17 Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism
article 2007    
Author: Henneman, P. · Schaap, F.G. · Havekes, L.M. · Rensen, P.C.N. · Frants, R.R. · Tol, A. van · Hattori, H. · Smelt, A.H.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · apoAV · Hypertriglyceridemia · Lipoprotein lipase · Plasma apoAV concentration · SNP-analysis · apolipoprotein A5 · adult · allele · article · circulation · controlled study · endoplasmic reticulum · female · gene frequency · gene mutation · genetic polymorphism · genetic variability · haplotype · human · hypertriglyceridemia · lipolysis · major clinical study · male · priority journal · protein secretion · single nucleotide polymorphism · Adult · Alleles · Apolipoproteins A · Base Sequence · Case-Control Studies · DNA Primers · Female · Gene Frequency · Haplotypes · Humans · Hypertriglyceridemia · Male · Middle Aged · Polymorphism, Single Nucleotide
[Abstract]

18 Alcohol consumption and type 2 diabetes: Influence of genetic variation in alcohol dehydrogenase
article 2007    
Author: Beulens, J.W.J. · Rimm, E.B. · Hendriks, H.F.J. · Hu, F.B. · Manson, J.E. · Hunter, D.J. · Mukamal, K.J.
Keywords: Health · Biomedical Research · alcohol dehydrogenase · alcohol dehydrogenase 1C · adult · alcohol consumption · alcohol oxidation · article · controlled study · disease association · female · gene frequency · genetic polymorphism · genotype · heterozygote · homozygote · human · major clinical study · male · morbidity · non insulin dependent diabetes mellitus · priority journal · risk factor · Adult · Alcohol Dehydrogenase · Alcohol Drinking · Case-Control Studies · Diabetes Mellitus, Type 2 · Female · Gene Frequency · Genotype · Humans · Male · Middle Aged · Polymorphism, Genetic · Questionnaires · Reference Values · Smoking · Variation (Genetics)
[Abstract]

19 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

20 Combined Association and Linkage Analysis Applied to the APOE Locus
article 2004    
Author: Beekman, M. · Posthuma, D. · Heijmans, B.T. · Lakenberg, N. · Suchiman, H.E.D. · Snieder, H. · Knijff, P. de · Frants, R.R. · Ommen, G.J.B. van · Kluft, C. · Vogler, G.P. · Slagboom, P.E. · Boomsma, D.I.
Keywords: ApoE level · Fine-mapping · Quantitative trait locus · Twin pairs · chromosome 19 · cohort analysis · gene locus · gene mapping · genetic association · genetic linkage · genetic polymorphism · genotype · linkage analysis · lipoprotein blood level · quantitative trait locus · short tandem repeat · twins · Adolescent · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoprotein E4 · Apolipoproteins E · Chromosomes, Human, Pair 19 · Cohort Studies · Female · Genotype · Humans · Linkage (Genetics) · Lod Score · Male · Netherlands · Polymorphism, Genetic · Quantitative Trait, Heritable · Genetta
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 34 found. Next | Sort by date