Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Search results also available in MS Excel format.

Showing 1 to 20 of 32 found. Next | Sort by date

1 Reduction of use of animals in regulatory genotoxicity testing : Identification and implementation opportunities-Report from an ECVAM workshop
article 2009    
Author: Pfuhler, S. · Kirkland, D. · Kasper, P. · Hayashi, M. · Vanparys, P. · Carmichael, P. · Dertinger, S. · Eastmond, D. · Elhajouji, A. · Krul, C.A.M. · Rothfuss, A. · Schoening, G. · Smith, A. · Speit, G. · Thomas, C. · Benthem, J. van · Corvi, R.
Keywords: Biology · Physiological Sciences · Animal use · Genotoxicity in vivo · Reduction
[Abstract]

2 90-Day feeding and genotoxicity studies on a refined arachidonic acid-rich oil
article 2009    
Author: Casterton, P.L. · Curry, L.L. · Lina, B.A.R. · Wolterbeek, A.P.M. · Kruger, C.L.
Keywords: Nutrition · Toxicology and Applied Pharmacology · 90-Day feeding study · ARA-rich oil · Arachidonic acid · Genotoxicity
[Abstract]

3 The FEMA GRAS assessment of α,β-unsaturated aldehydes and related substances used as flavor ingredients
article 2008    
Author: Adams, T.B. · Gavin, C.L. · Taylor, S.V. · Waddell, W.J. · Cohen, S.M. · Feron, V.J. · Goodman, J. · Rietjens, I.M.C.M. · Marnett, L.J. · Portoghese, P.S. · Smith, R.L.
Keywords: Nutrition · α,β-Unsaturated aldehydes · FEMA GRAS · Flavor ingredients · Genotoxicity · 2 hexenal · aldehyde · flavoring agent · sorbic acid · carcinogenicity · chemical analysis · flavor · genotoxicity · hydrolysis · reproductive toxicity · review · safety · Aldehydes · Animals · Carcinogens · Flavoring Agents · Food Analysis · Humans · Mutagens · Reproduction · Animalia
[Abstract]

4 Formation and removal of genotoxic activity during UV/H<sub>2</sub>O<sub>2</sub>-GAC treatment of drinking water
article 2011    
Author: Heringa, M.B. · Harmsen, D.J.H. · Beerendonk, E.F. · Reus, A.A. · Krul, C.A.M. · Metz, D.H. · Ijpelaar, G.F.
Keywords: Nutrition · Biomedical Research · AOP · Drinking water · Genotoxicity · Oxidation · Photolysis · UV · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility
article 2018    
Author: Reisinger, K. · Blatz, V. · Brinkmann, J. · Downs, T.R. · Fischer, A. · Henkler, F. · Hoffmann, S. · Krul, C. · Liebsch, M. · Luch, A. · Pirow, R. · Reus, A.A. · Schulz, M. · Pfuhler, S.
Keywords: Biology · Comet assay · Dermal exposure · DNA damage · In vitro genotoxicity · Phenion®FT · Skin · 7,12 dimethylbenz[a]anthracene · Aphidicolin · Cadmium chloride · Cyclohexanone · Ethylnitrosourea · Fallic acid propyl ester · Mitomycin · Phthalic acid bis(2 ethylhexyl) ester · Cell isolation · Controlled study · Cytotoxicity test · Genotoxicity assay · Human · Human tissue · Predictive value · Priority journal · Reproducibility · Validation study · Biomedical Innovation · Healthy Living · Life Triskelion BV · RAPID - Risk Analysis for Products in Development TARA - Toxicology and Risk Assessment · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

6 Induction of somatic mutations but not methylated DNA adducts in λlacZ transgenic mice by dichlorvos
article 1999    
Author: Pletsa, V. · Steenwinkel, M.-J.S.T. · Delft, J.H.M. van · Baan, R.A. · Kyrtopoulos, S.A.
Keywords: Nutrition · Dimethylsulphate · Methylating agents · N7-Methylguanine · O6-Methylguanine · Organosphosphate insecticides · 6 o methylguanine · 7 methylguanine · Dichlorvos · Dimethyl sulfate · Animal cell · Bone marrow cell · Controlled study · DNA adduct · DNA methylation · Genotoxicity · Liver cell · Mouse · Mutation rate · Nonhuman · Priority journal · Somatic mutation · Transgenic mouse · Animals · Dichlorvos · DNA Methylation · Guanine · Insecticides · Lac Operon · Mice · Mice, Transgenic · Mutation · Mus musculus
[Abstract]

7 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

8 Carcinogenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Prentice, D. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Health · Biomedical Research · animal testing alternative · carcinogenesis · carcinogenicity · cell communication · cell culture · cell transformation · gap junction · genotoxicity · heterozygosity · nonhuman · priority journal · review · risk assessment · standardization · transgenic mouse · validation process · Animal Testing Alternatives · Animals · Carcinogenicity Tests · Carcinogens · Cell Transformation, Neoplastic · Cells, Cultured · Consumer Product Safety · Cosmetics · European Union · Gap Junctions · Mice · Mice, Transgenic · Quantitative Structure-Activity Relationship · Rats · Animalia · Mus musculus

9 A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
article 2005    
Author: Smith, R.L. · Cohen, S.M. · Doull, J. · Feron, V.J. · Goodman, J.I. · Marnett, L.J. · Portoghese, P.S. · Waddell, W.J. · Wagner, B.M. · Hall, R.L. · Higley, N.A. · Lucas-Gavin, C. · Adams, T.B.
Keywords: Nutrition Safety · Food and chemical risk analysis · Chemical mixtures · Essential oils · Natural flavor complexes · Safety evaluation · Flavoring agent · Unclassified drugs · Chemical composition · Chemical structure · Chemotaxonomy · Food processing · Food safety · Gastrointestinal absorption · Genotoxicity · Health hazards · Metabolism · Risk assessment · Consumer product safety · Drug evaluation · Flavoring agents · Food industry · Food technology
[Abstract]

10 The in vivo rat skin photomicronucleus assay: Phototoxicity and photogenotoxicity evaluation of six fluoroquinolones
article 2012    
Author: Reus, A.A. · Usta, M. · Kenny, J.D. · Clements, P.J. · Pruimboom-Brees, I. · Aylott, M. · Lynch, A.M. · Krul, C.A.M.
Keywords: Research · ciprofloxacin · gatifloxacin · gemifloxacin · levofloxacin · lomefloxacin · methoxsalen · quinoline derived antiinfective agent · sparfloxacin · animal tissue · article · carcinogenicity · controlled study · epidermis cell · female · genotoxicity · hairless mouse · histopathology · in vitro study · in vivo study · micronucleus · micronucleus test · nonhuman · phototoxicity · priority journal · rat · single drug dose · skin · Sprague Dawley rat · Biomedical Innovation · Healthy Living · Triskelion BV · TARA - Toxicology and Risk Assessment · TNO Bedrijven
[Abstract]

11 Toxicokinetics and metabolism
article 2005    
Author: Coecke, S. · Blaauboer, B.J. · Elaut, G. · Freeman, S. · Freidig, A. · Gensmantel, N. · Hoet, P. · Kapoulas, V.M. · Ladstetter, B. · Langley, G. · Leahy, D. · Mannens, G. · Meneguz, A. · Monshouwer, M. · Nemery, B. · Pelkonen, O. · Pfaller, W. · Prieto, P. · Proctor, N. · Rogiers, V. · Rostami-Hodjegan, A. · Sabbioni, E. · Steiling, W. · Sandt, J.J.M. van de
Keywords: Toxicology · Food and Chemical Risk Analysis · cosmetic · acute toxicity · artificial membrane · bioavailability · biotransformation · carcinogenicity · cell line · cell strain CACO 2 · computer model · concentration response · electric resistance · eye irritation · genotoxicity · human · metabolism · nonhuman · phototoxicity · plasma protein binding · practice guideline · priority journal · reproductive toxicity · review · skin absorption · skin sensitization · species difference · toxicokinetics · validation process · Animals · Biotransformation · Consumer Product Safety · Cosmetics · Drug Administration Routes · European Union · Humans

12 Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters
article 1999    
Author: Turnbull, D. · Frankos, V.H. · Delft, J.H.M. van · Vogel, N. de
Keywords: Nutrition · Fatty acid ester · Vegetable oil · Chemical structure · Chromosome aberration · Food safety · Gene mutation · Genotoxicity · Mammal cell · Priority journal · Salmonella typhimurium · Wood · Animals · Carcinogenicity Tests · CHO Cells · Chromosome Aberrations · Cricetinae · DNA Mutational Analysis · Evaluation Studies · Mice · Mutagens · Phytosterols · Plant Oils · Salmonella typhimurium · Tumor Cells, Cultured · Wood · Bacteria (microorganisms) · Mammalia · Salmonella typhimurium · Typhimurium
[Abstract]

13 Comparison of the X-gal- and P-gal-based systems for screening of mutant λlacZ phages originating from the transgenic mouse strain 40.6
article 1996    
Author: Mientjes, E.J. · Steenwinkel, M.J.S.T. · Delft, J.H.M. van · Lohman, P.H.M. · Baan, R.A.
Keywords: Nutrition · λgt10lacZ phage · Muta Mouse · P-gal · Positive selection · Transgenic mouse, strain 40.6 · X-gal · benzo[a]pyrene · ethylnitrosourea · animal experiment · article · bacteriophage · brain · controlled study · female · genotoxicity · liver · mouse · mutagen testing · mutant · mutation rate · nonhuman · priority journal · screening test · transgenic mouse · Animals · Bacteriophage lambda · Benzo(a)pyrene · Brain · Ethylnitrosourea · Galactosides · Indoles · Liver · Mice · Mice, Transgenic · Mutagens · Mutation
[Abstract]

14 Effect of eugenol on the mutagenicity of benzo[a]pyrene and the formation of benzo[a]pyrene-DNA adducts in the X-lacZ-transgenic mouse.
article 1996    
Author: Rompelberg, C.J.M. · Steenwinkel, M.J.S.T. · Asten, J.G. van · Delft, J.H.M. van · Baan, R.A. · Verhagen, H.
Keywords: Toxicology · Antimutagenicity · Benzo[a]pyrene · DNA adduct · Eugenol · Transgenic mouse · benzo[a]pyrene · eugenol · animal experiment · article · controlled study · dna adduct · genotoxicity · male · mouse · mutagenicity · mutation rate · nonhuman · oral drug administration · priority journal · transgenic mouse · Animals · Antimutagenic Agents · Benzo(a)pyrene · Biotransformation · Body Weight · Diet · DNA Adducts · Eugenol · Glutathione Transferase · Lac Operon · Liver · Male · Mice · Mice, Transgenic · Mutagens · Phosphorus Radioisotopes · Animalia · Gale · Mus musculus
[Abstract]

15 Effect of short-term dietary administration of eugenol in humans
article 1996    
Author: Rompelberg, C.J.M. · Vogels, J.T.W.E. · Vogel, N. de · Bruijntjes-Rozier, G.C.D.M. · Stenhuis, W.H. · Bogaards, J.J.P. · Verhagen, H.
Keywords: Nutrition · Antigenotoxicity · Eugenol · GST · antitoxin · eugenol · glutathione transferase · mitomycin c · vinblastine · article · biotransformation · blood sampling · chromosome aberration · controlled study · enzyme activity · erythrocyte · genotoxicity · human · human experiment · leukocyte · male · micronucleus · priority journal · xenobiotic metabolism · Acetaminophen · Adult · Antibiotics, Antineoplastic · Antineoplastic Agents, Phytogenic · Biotransformation · Cells, Cultured · Chromosome Aberrations · Cross-Over Studies · Erythrocytes · Eugenol · Glutathione Transferase · Humans · Intervention Studies · Leukocytes · Liver · Magnetic Resonance Spectroscopy · Male · Mitomycin · Vinblastine
[Abstract]

16 Safety evaluation of synthetic β-carotene
article 1999    
Author: Woutersen, R.A. · Wolterbeek, A.P.M. · Appel, M.J. · Berg, H. van den · Goldbohm, R.A. · Feron, V.J.
Keywords: Toxicology · Absorption · Cancer prevention · Distribution · Lung cancer · Toxicity · beta carotene · cancer risk · carcinogenicity · chronic toxicity · drug absorption · drug distribution · drug safety · drug transport · genotoxicity · human · nonhuman · reproductive toxicity · review · toxicity testing · Absorption · Animals · Antioxidants · beta Carotene · Cell Transformation, Neoplastic · Chemoprevention · Drug Interactions · Humans · Intervention Studies · Lung Neoplasms · Mice · Rats · Rats, Sprague-Dawley · Skin Neoplasms · Smoking · Animalia
[Abstract]

17 Genetic and reproductive toxicity of butadiene and isoprene
article 2001    
Author: Anderson, D.
Keywords: Nutrition · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · sister chromatid exchange · spermatozoon motility · tissue distribution · Animals · Butadienes · Female · Hemiterpenes · Humans · Male · Mice · Mutagenicity Tests · Mutagens · Occupational Exposure · Ovary · Pentanes · Pregnancy · Rats · Reproduction · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium
[Abstract]

18 Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone
article 2003    
Author: Roza, L. · Vogel, N. de · Delft, J.H.M. van
Keywords: Biology Health · Physiological Sciences · Antimutagen · Clastogenicity · Human lymphocytes · Hydroquinone · Mutagenicity · hydrogen peroxide · hydroquinone · hydroquinone derivative · mutagenic agent · oxidizing agent · article · concentration response · controlled study · cytotoxicity · genotoxicity · human · human cell · lymphocyte culture · male · metabolic activation · mutagenicity · normal human · structural chromosome aberration · animal · biotransformation · cell culture · chromatid · chromosome aberration · drug effect · in vitro study · liver · lymphocyte · metabolism · mutagen testing · rat · Wistar rat · Animalia · Animals · Biotransformation · Cells, Cultured · Chromatids · Chromosome Aberrations · Humans · Hydrogen Peroxide · Hydroquinones · Liver · Lymphocytes · Male · Mutagenicity Tests · Mutagens · Oxidants · Rats · Rats, Wistar
[Abstract]

19 Locust bean gum safety in neonates and young infants: An integrated review of the toxicological database and clinical evidence
article 2014    
Author: Meunier, L. · Garthoff, J.A. · Schaafsma, A. · Krul, L. · Schrijver, J. · Goudoever, J.B. van · Speijers, G. · Vandenplas, Y.
Keywords: Health · Carob bean gum · Gastro-oesophageal reflux · Infant formula · Infants · Locust bean gum · Regurgitation · Thickener · Food additive · Galactomannan · Locust beam gum · Polysaccharide · Unclassified drug · Acute toxicity · Artificial milk · Carcinogenicity · Chemical structure · Chronic toxicity · Dietary intake · Food composition · Food safety · Genotoxicity · Human · Hypersensitivity · In vitro study · In vivo study · Nonhuman · Nutritional assessment · Priority journal · Reproductive toxicity · Safety · Surface property · Teratogenicity · Thickness · Toxicity testing · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

20 Safety evaluation of an α-cyclodextrin glycosyltranferase preparation
article 2004    
Author: Bär, A. · Krul, C.A.M. · Jonker, D. · Vogel, N. de
Keywords: Biology · Toxicology and Applied Pharmacology · alpha cyclodextrin glycosyltransferase · amylase · unclassified drug · Ames test · animal experiment · animal model · animal tissue · article · aspiration · bacterial strain · batch fermentation · chromosome aberration · controlled study · Escherichia coli · evaluation · female · food safety · foraging · gastroesophageal reflux · genetic recombination · genotoxicity · Klebsiella oxytoca · lymphocyte culture · male · nonhuman · priority journal · rat · respiratory tract disease · toxicity testing · Animals · Chromosome Aberrations · Escherichia coli · Female · Food Additives · Glucosyltransferases · Humans · Klebsiella · Lymphocytes · Male · Mutagenicity Tests · Rats · Rats, Wistar · Toxicity Tests · Toxicity Tests, Chronic · Escherichia coli · Klebsiella oxytoca
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 32 found. Next | Sort by date