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1 Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types
article 1995    
Author: Vliet, A.K. van · Thiel, G.C.F. van · Huisman, R.H. · Moshage, H. · Yap, S.H. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitor · Human cell · Lovastatin · Pravastatin · Simvastatin · Sterol synthesis · Transport · hydroxymethylglutaryl coenzyme a reductase inhibitor · mevinolin · pravastatin · simvastatin · controlled study · human · human cell · liver cell · priority journal · sterol synthesis · Blotting, Northern · Cells, Cultured · Endothelium, Vascular · Female · Granulosa Cells · Human · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Liver · Lovastatin · Pigment Epithelium of Eye · RNA, Messenger · Simvastatin · Sterols · Umbilical Veins
[Abstract]

2 Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle
article 1996    
Author: Vliet, A.K. van · Nègre-Arrariou, P. · Thiel, G.C.F. van · Bolhuis, P.A. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitors · Human myoblasts · Sterol synthesis · Adenosine triphosphate · Hydroxymethylglutaryl coenzyme a reductase inhibitor · Mevinolin · Mitochondrial enzyme · Cell culture · Cell proliferation · Cell viability · Concentration response · Controlled study · Dna synthesis · Human cell · Human tissue · Muscle biopsy · Myoblast · Myopathy · Skeletal muscle · Acetic Acid · Adenosine Triphosphate · Anticholesteremic Agents · Cell Division · Cell Survival · Cells, Cultured · DNA · Enzyme Inhibitors · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lovastatin · Mitochondria · Muscle, Skeletal · Oxidoreductases · Pravastatin · Simvastatin · Sterols
[Abstract]

3 Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice
article 2003    
Author: Delsing, D.J.M. · Jukema, J.W. · Wiel, M.A. van de · Emeis, J.J. · Laarse, A. van der · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Atherosclerosis · Calcification · Calcium antagonists · Inflammation · Statins · Amlodipine · Atorvastatin · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Very low density lipoprotein cholesterol · Animal model · Animal tissue · Aorta root · Cholesterol blood level · Cholesterol diet · Controlled study · Drug effect · Inflammation · Mouse · Nonhuman · Amlodipine · Animals · Aorta, Thoracic · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Blood Pressure · Calcium Channel Blockers · Cholesterol · Cholesterol, Dietary · Drug Therapy, Combination · Female · Heptanoic Acids · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Mice · Mice, Transgenic · Pyrroles
[Abstract]

4 Cholestrol content of the rat lens is lowered by administration of simvastatin, but not pravastatin
article 1993    
Author: Vries, A.C.J. de · Vermeer, M.A. · Bredman, J.J. · Bar, P.R. · Cohen, L.H.
Keywords: Pharmacology · 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors · hypocholesterolaemic drugs · antilipemic agent · drug derivative · hydroxymethylglutaryl coenzyme A reductase inhibitor · hypocholesterolemic agent · mevinolin · animal experiment · cholesterol metabolism · oral drug administration · biosynthesis · dose response · drug effect · enzymology · liver microsome · metabolism · organ culture · rat strain · time · Aging · Animal · Anticholesteremic Agents · Antilipemic Agents · Cholesterol · Dose-Response Relationship, Drug · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lens, Crystalline · Lovastatin · Microsomes, Liver · Organ Culture · Pravastatin · Rats · Rats, Wistar · Simvastatin · Time Factors
[Abstract]

5 Cholesteryl ester transfer protein inhibition: Effect on reverse cholesterol transport?
article 2006    
Author: Rensen, P.C.N. · Havekes, L.M.
Keywords: Biology · Biomedical Research · 2 methylpropanethioic acid s [2 [1 (2 ethylbutyl)cyclohexylcarboxamido]phenyl] ester · Atorvastatin · Cholesterol ester transfer protein inhibitor · Fibric acid derivative · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Nicotinic acid · Torcetrapib · Atherosclerosis · Cholesterol transport · Clinical trial · Drug efficacy · Drug mechanism · Dyslipidemia · Editorial · Ischemic heart disease · Nonhuman · Plasma clearance · Protein expression · Reverse cholesterol transport · Animals · Biological Transport · Cardiovascular Diseases · Carrier Proteins · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Glycoproteins · Humans · Lipid Metabolism · Lipoproteins, HDL · Rabbits · Risk Factors
[Abstract]

6 Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins
article 2008    
Author: Bergheanu, S.C. · Reijmers, T. · Zwinderman, A.H. · Bobeldijk, I. · Ramaker, R. · Liem, A.-H. · Greef, J. van der · Hankemeier, T. · Jukema, J.W.
Keywords: Biology · Atorvastatin · Cardiovascular risk · Phosphatidylcholines · Rosuvastatin · Sphingomyelins · Atorvastatin · Cholesterol · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Low density lipoprotein cholesterol · Phosphatidylcholine · Rosuvastatin · Sphingomyelin · Triacylglycerol · Adult · Aged · Article · Cardiovascular risk · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Coronary artery disease · Drug dose increase · Drug efficacy · Drug megadose · Female · Human · Lipid blood level · Lipid metabolism · Lipidomics · Liquid chromatography · Low drug dose · Major clinical study · Male · Mass spectrometry · Multicenter study · Phase 3 clinical trial · Randomized controlled trial · Therapy effect · Treatment outcome · Chromatography, Liquid · Dose-Response Relationship, Drug · Fluorobenzenes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Mass Spectrometry · Prospective Studies · Pyrimidines · Pyrroles · Sulfonamides
[Abstract]

7 Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-κB activity and lowering of cholesterol
article 2010    
Author: Vries-van der Weij, J. de · Toet, K. · Zadelaar, A.S.M. · Wielinga, P.Y. · Kleemann, R. · Rensen, P.C.N. · Kooistra, T.
Keywords: Health · Biomedical Research · Anti-inflammatory treatment · Established lesions · Inflammation · Mouse model of atherosclerosis · NF-κB · On-top of statin treatment · Reduce further progression of atherosclerosis · Serum amyloid A (SAA) · Statin · hydroxymethylglutaryl coenzyme A reductase inhibitor · immunoglobulin enhancer binding protein · salicylic acid · serum amyloid A · STAT3 protein · animal experiment · animal model · antiinflammatory activity · aorta · article · atherosclerosis · atherosclerotic plaque · cholesterol blood level · cholesterol diet · controlled study · disease course · drug effect · female · histology · hypercholesterolemia · inflammation · liver · low fat diet · macrophage · mouse · nonhuman · priority journal · risk factor · treatment outcome
[Abstract]

8 Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin
article 2003    
Author: Kleemann, R. · Princen, H.M.G. · Emeis, J.J. · Jukema, J.W. · Fontijn, R.D. · Horrevoets, A.J.G. · Kooistra, T. · Havekes, L.M.
Keywords: Biology · Biomedical Research · Cell adhesion molecules · Inhibitors · Amyloid A protein · Cell adhesion molecule · Fibrinogen · Monocyte chemotactic protein 1 · Rosuvastatin · Statine derivative · Tumor necrosis factor alpha · Antiinflammatory agent · Apolipoprotein E · Apolipoprotein E3 (Leidein) · Cytokine · Fluorobenzene · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Lipid · Lipoprotein · Pyrimidine derivative · Sulfonamide · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta root · Cell adhesion · Cholesterol blood level · Cholesterol diet · Controlled study · Inflammation · Monocyte · Mouse · Nonhuman · Nucleotide sequence · Transgenic mouse · Blood · Drug effect · Genetics · Immunology · Metabolism · Pathology · Animals · Anti-Inflammatory Agents · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Cell Adhesion · Cholesterol · Cytokines · Female · Fluorobenzenes · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Lipoproteins · Macrophages · Mice · Mice, Transgenic · Monocytes · Pyrimidines · Sulfonamides
[Abstract]

9 Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-Leiden mice
article 2005    
Author: Delsing, D.J.M. · Post, S.M. · Groenendijk, M. · Solaas, K. · Boom, H. van der · Duyvenvoorde, W. van · Wit, E.C.M. de · Bloks, V.W. · Kuipers, F. · Havekes, L.M. · Princen, H.M.G.
Keywords: Biomedical Research · Gene expression · Lipid metabolism · Lipoproteins · Statin · diacylglycerol acyltransferase · hydroxymethylglutaryl coenzyme A reductase inhibitor · mevinolin · phospholipid · rosuvastatin · very low density lipoprotein · animal tissue · biliary excretion · cholesterol blood level · cholesterol diet · cholesterol synthesis · controlled study · enzyme activity · gene expression · hepatobiliary system · lipid blood level · lipid composition · lipid diet · lipid liver level · lipolysis · mouse · nonhuman · priority journal · rat · statistical significance · triacylglycerol blood level · Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Bile · Bile Acids and Salts · Cholesterol · Cholesterol, VLDL · Chromatography, High Pressure Liquid · Feces · Female · Fluorobenzenes · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Liver · Mice · Mice, Transgenic · Pyrimidines · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Sterols · Sulfonamides · Triglycerides
[Abstract]

10 Mouse models for atherosclerosis and pharmaceutical modifiers
article 2007    
Author: Zadelaar, A.S.M. · Kleemann, R. · Verschuren, L. · Vries-van der Weij, J. de · Hoorn, J. van der · Princen, H.M. · Kooistra, T.
Keywords: Biology · Biomedical Research · ACE inhibitors · AT1 receptor antagonists · Atherosclerosis · LXR · Mouse models · Pharmaceutical drugs · PPAR · Statins · atorvastatin · avasimibe · candesartan · captopril · cholesterol acyltransferase inhibitor · dipeptidyl carboxypeptidase inhibitor · hydralazine · hydroxymethylglutaryl coenzyme A reductase inhibitor · irbesartan · losartan · ly 465608 · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · olmesartan · perindopril · peroxisome proliferator activated receptor alpha agonist · pirinixic acid · pitavastatin · pravastatin · quinapril · ramipril · rosuvastatin · simvastatin · telmisartan · temocapril · unindexed drug · valsartan · zofenopril · antihypertensive agent · antilipemic agent · apolipoprotein E · atherosclerosis · pathophysiology · sensitivity and specificity · Animals · Antihypertensive Agents · Antilipemic Agents · Apolipoproteins E · Atherosclerosis · Disease Models, Animal · Dose-Response Relationship, Drug · Drug Administration Schedule · Dyslipidemias · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypertension · Male · Mice · Mice, Knockout · Mice, Transgenic · Sensitivity and Specificity
[Abstract]

11 Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
article 2009    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Verheijen, J.H. · Bockel, J.H. van · Geelkerken, R.H. · Lindeman, J.H.N.
Keywords: Biology · Biomedical Research · antihypertensive agent · antithrombocytic agent · cystatin C · cysteine proteinase · doxycycline · gelatinase B · hydroxymethylglutaryl coenzyme A reductase inhibitor · messenger RNA · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · abdominal aorta aneurysm · adult · aged · aorta wall · article · clinical article · clinical trial · controlled clinical trial · controlled study · dose response · drug effect · drug megadose · drug tolerability · enzyme activity · enzyme assay · female · gene expression · human · human tissue · immunohistochemistry · low drug dose · male · neutrophil · polymerase chain reaction · priority journal · protein degradation · quantitative analysis · randomized controlled trial · treatment duration · Western blotting · Aged · Aged, 80 and over · Aorta, Abdominal · Aortic Aneurysm, Abdominal · Cardiovascular Agents · Cystatin C · Cysteine Endopeptidases · Dose-Response Relationship, Drug · Doxycycline · Female · Gene Expression Regulation, Enzymologic · Humans · Male · Matrix Metalloproteinases · Middle Aged · Neutrophil Infiltration · Neutrophils · Prospective Studies · Protease Inhibitors · RNA, Messenger · Time Factors · Tissue Inhibitor of Metalloproteinase-1 · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

12 Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro
article 2004    
Author: Kleemann, R. · Verschuren, L. · Rooij, B.J. de · Lindeman, J. · Maat, M.M.de · Szalai, A.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biomedical Research · Antilipemic agent · C reactive protein · CCAAT enhancer binding protein · Cholesterol · Fenofibrate · Hydroxymethylglutaryl coenzyme A reductase inhibitor · I kappa B alpha · Immunoglobulin enhancer binding protein · Interleukin 1beta · Peroxisome proliferator activated receptor agonist · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor alpha agonist · Pirinixic acid · Protein p50 · Unclassified drug · Animal experiment · Animal model · Animal tissue · Antiinflammatory activity · Atherogenesis · Atherosclerosis · Cardiovascular risk · Cell culture · Cholesterol blood level · Controlled study · Hepatoma cell · Human cell · Inflammation · Liver cell · Mouse · Nonhuman · Transgenic mouse · Animals · C-Reactive Protein · Carcinoma, Hepatocellular · CCAAT-Enhancer-Binding Proteins · Cell Line, Tumor · Cholesterol · Down-Regulation · Gene Expression · Hepatocytes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · I-kappa B Proteins · Interleukin-1 · Male · Mice · Mice, Transgenic · NF-kappa B · NF-kappa B p50 Subunit · Pyrroles · Receptors, Cytoplasmic and Nuclear · Simvastatin · Transcription Factors · Up-Regulation
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date