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1 A rapid micromethod for apolipoprotein E phenotyping directly in serum
article 1987    
Author: Havekes, L.M. · Knijff, P. de · Beisiegel, U. · Havinga, J. · Smit, M. · Klasen, E.
Keywords: Apolipoprotein e · Blood and hemopoietic system · Human cell · Immunoblotting · Isoelectric focusing · Methodology · Micrometer · Serum · Apolipoproteins E · Chloroform · Guanidine · Guanidines · Human · Hyperlipoproteinemia Type III · Isoelectric Focusing · Methanol · Phenotype
[PDF] [Abstract]

2 Identification of three new mutations of the low density lipoprotein receptor gene in dutch familial hypercholesterolemic patients
article 1998    
Author: Lombardi, P. · Sijbrands, E.J.G. · Kamerling, S. · Smelt, A.H. · Havekes, L.M.
Keywords: Health · Adult · Aged · Codon, Terminator · DNA · DNA Mutational Analysis · Exons · Humans · Hyperlipoproteinemia Type II · Introns · Mutagenesis, Insertional · Mutation · Netherlands · Point Mutation · Receptors, LDL

3 Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice
article 1994    
Author: Ree, J.H. van · Broek, W.J.A.A. van den · Dahlmans, V.E.H. · Groot, P.H.E. · Vidgeon-Hart, M. · Frants, R.R. · Wieringa, B. · Havekes, L.M. · Hofker, M.H.
Keywords: Nutrition · Atherosclerotic plaques · Cholesterol-rich diets · Gene targeting · Hyperlipoproteinemia · Mouse model · Apolipoprotein e · Cholesterol · Nitric oxide · Animal experiment · Animal model · Animal tissue · Aorta · Cholesterol diet · Controlled study · Female · Heterozygosity · Histology · Hyperlipoproteinemia type 3 · Male · Mouse · Aging · Apolipoproteins E · Arteriosclerosis · Blotting, Northern · Blotting, Western · Cholesterol · Diet, Atherogenic · Disease Susceptibility · Heterozygote · Hypercholesterolemia · Lipids · Mice · Mice, Inbred C57BL · Mice, Mutant Strains
[Abstract]

4 Response of fibrinolytic activity and factor VIII-related antigen to stimulation with desmopressin in hyperlipoproteinemia
article 1982    
Author: Brommer, E.J.P. · Leuven, J.A.G. · Barrett-Bergshoeff, M.M. · Schouten, J.A.
Keywords: Biology · adrenalin · beta adrenergic receptor blocking agent · blood clotting factor 8 · clofibrate · desmopressin · low density lipoprotein · minisin · unclassified drug · blood and hemopoietic system · cardiovascular disease · cardiovascular system · fibrinolysis · hyperlipoproteinemia · major clinical study · Adult · Aged · Antigens · Argipressin · Cardiovascular Diseases · Cholesterol · Chylomicrons · Comparative Study · Desmopressin · Factor VIII · Female · Fibrinolysis · Human · Hyperlipoproteinemia · Male · Middle Age · Plasminogen Activators · Risk · Serum Globulins · Support, Non-U.S. Gov't · Triglycerides
[Abstract]

5 Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase
article 1998    
Author: Man, F.H.A.F. de · Beer, F. de · Laarse, A. van der · Smelt, A.H.M. · Leuven, J.A.G. · Havekes, L.M.
Keywords: Health · Atherosclerosis · Familial dysbetalipoproteinemia · Metabolism · Triglyceride · VLDL · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Female · Heparan Sulfate Proteoglycans · Heterozygote · Homozygote · Humans · Hyperlipoproteinemia Type III · Lipolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Male · Middle Aged
[Abstract]

6 Similar response to simvastatin in patients heterozygous for familial hypercholesterolemia with mRNA negative and mRNA positive mutations
article 1998    
Author: Sijbrands, E.J.G. · Lombardi, M.P. · Westendorp, R.G.J. · Gevers Leuven, J.A. · Meinders, A.E. · Laarse, A. van der · Frants, R.R. · Havekes, L.M. · Smelt, A.H.M.
Keywords: Health · Familial hypercholesterolemia · LDL receptor gene · Simvastatin · Xanthomas · Anticholesteremic Agents · Cholesterol, HDL · Cholesterol, LDL · Female · Heterozygote · Humans · Hyperlipoproteinemia Type II · Male · Middle Aged · Mutation · Receptors, LDL · RNA, Messenger · Simvastatin
[Abstract]

7 Opsporing familiaire hypercholesterolemie bij kinderen geindiceerd? Bij uitzondering wel [Search for familial hypercholesterolaemia in children indicated? Only exceptionally]
article 1997    
Author: Gevers Leuven, J.A.
Keywords: Health · Child · Cholesterol blood level · Diagnostic test · Familial hypercholesterolemia · Human · Ischemic heart disease · Note · Screening · Adolescent · Child · Cholesterol · Cholesterol, LDL · Diet, Fat-Restricted · Humans · Hyperlipoproteinemia Type II · Stress, Psychological
[Abstract]

8 Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158→Cys) homozygotes is associated with hyperinsulinemia
article 2002    
Author: Beer, F. de · Stalenhoef, A.F.H. · Hoogerbrugge, N. · Kastelein, J.J.P. · Leuven, J.A.G. · Duijn, C.M. van · Havekes, L.M. · Smelt, A.H.M.
Keywords: Adult · Age of Onset · Aging · Apolipoprotein E2 · Apolipoproteins E · Comorbidity · Coronary Disease · Estrogens · Female · Gene Expression · Gene Frequency · Homozygote · Humans · Hyperinsulinism · Hyperlipoproteinemia Type III · Male · Menopause · Middle Aged · Netherlands · Peripheral Vascular Diseases · Prevalence · Regression Analysis · Sex Factors
[Abstract]

9 Apolipoprotein E2 (Lys146→Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides
article 2000    
Author: Beer, F. de · Dijk, K.W. van · Jong, M.C. · Vark, L.C. van · Zee, A. van der · Hofker, M.H. · Fallaux, F.J. · Hoeben, R.C. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Adenoviridae · Alleles · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Gene Expression · Gene Transfer Techniques · Humans · Hydrolysis · Hyperlipoproteinemia Type III · Hypertriglyceridemia · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · Point Mutation · RNA, Messenger · Triglycerides
[Abstract]

10 C-reactive protein in patients with familial hypercholesterolemia: No effect of simvastatin therapy
article 2001    
Author: Mohrschladt, M.F. · Maat, M.P.M de · Westendorp, R.G.J · Smelt, A.H.M
Keywords: Adolescent · Adult · Aged · Aged, 80 and over · C-Reactive Protein · Cardiovascular Diseases · Female · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hyperlipoproteinemia Type II · Lipids · Male · Middle Aged · Osmolar Concentration · Risk Factors · Simvastatin
[Abstract]

11 Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree
article 1991    
Author: Knijff, P. de · Maagdenberg, A.M.J.M. van den · Stalenhoef, A.F.H. · Leuven, J.A.G. · Demacker, P.N.M. · Kuyt, L.P. · Frants, R.R. · Havekes, L.M.
Keywords: Adolescent · Adult · Age Factors · Aged · Alleles · Apolipoproteins E · Body Weight · Cholesterol · Female · Heterozygote · Heterozygote Detection · Human · Hyperlipoproteinemia Type III · Lipoproteins · Lipoproteins, VLDL Cholesterol · Male · Middle Age · Pedigree · Sex Factors · Support, Non-U.S. Gov't
[PDF] [Abstract]

12 Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
article 1994    
Author: Knijff, P. de · Maagdenberg, A.M.J.M. van den · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Apolipoprotein (apo) E · Atherosclerosis · Familial Dysbetalipoproteinemia (FD) · Mutations · Polymorphisms · Type III Hyperlipoproteinemia · Cholesterol · Chylomicron · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · Alzheimer disease · Atherosclerosis · Cholesterol blood level · Coronary artery disease · Creutzfeldt jakob disease · Gene mutation · Genetic heterogeneity · Genetic linkage · Genetic polymorphism · Ligand binding · Lipoprotein metabolism · Alleles · Amino Acid Sequence · Base Sequence · DNA · Female · Gene Frequency · Human · Hyperlipidemia · Hyperlipoproteinemia Type III · Lipids · Lipoproteins · Male · Molecular Sequence Data · Mutation · Variation (Genetics)
[Abstract]

13 Variability in cholesterol content in serum and aortic tissue in apolipoprotein E-deficient mice is comparable in inbred (129/Sv) and outbred (mixed 129/Sv and C57BL/6) mice [1]
article 1995    
Author: Ree, J.H. van · Broek, W.J.A.A. van den · Dahlmans, V.E.H. · Wieringa, B. · Frants, R.R. · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · animal experiment · animal model · aorta · atherosclerosis · cholesterol blood level · controlled study · female · genetic heterogeneity · hyperlipoproteinemia type 3 · inbred strain · letter · male · mouse · nonhuman · priority journal · strain difference · Aging · Animal · Aorta · Apolipoproteins E · Cholesterol · Comparative Study · Female · Male · Mice · Mice, Inbred Strains · Mice, Mutant Strains
[Abstract]

14 Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding
article 1995    
Author: Ree, J.H. van · Gijbels, M.J.J. · Broek, W.J.A.A. van den · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · Cholesterol deposition · Familial dysbetalipoproteinemia · Gene targeting · Hypercholesterolemia · Lipoprotein metabolism · Mouse model · apolipoprotein e · cholesterol · animal experiment · animal model · article · cholesterol diet · familial hypercholesterolemia · gene targeting · histology · hyperlipoproteinemia type 3 · lipoprotein metabolism · mouse · nonhuman · priority journal · xanthomatosis · Animal · Apolipoproteins E · Cholesterol, Dietary · Human · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Support, Non-U.S. Gov't · Xanthomatosis
[Abstract]

15 Reduced very-low-density lipoprotein fractional catabolic rate in apolipoprotein C1-deficient mice
article 1997    
Author: Jong, M.C. · Ree, J.H. van · Dahlmans, V.E.H. · Frants, R.R. · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · very low density lipoprotein · animal experiment · catabolism · controlled study · human · hyperlipoproteinemia · lipolysis · metabolism · mouse · nonhuman · priority journal · protein degradation · protein metabolism · transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins B · Apolipoproteins C · Cholesterol, Dietary · Female · Lipolysis · Lipoproteins, VLDL · Mice · Mice, Mutant Strains · Triglycerides · Ultracentrifugation · Animalia · Mus musculus
[Abstract]

16 Effect of infusion of 'tris-galactosyl-cholesterol' on plasma cholesterol, clearance of lipoprotein cholesteryl esters, and biliary secretion in the rat
article 1987    
Author: Kempen, H.J. · Kuipers, F. · Berkel, T.J.C. van · Vonk, R.J.
Keywords: Biology · Low density lipoprotein · Animal cell · Animal experiment · Animal model · Bile secretion · Cholesterol blood level · Galactose receptor · Gallbladder · Heredity · Hyperlipoproteinemia type 2 · Nonhuman · Pharmacogenetics · Animal · Bile · Cholesterol · Cholesterol Esters · Infusions, Intravenous · Lipoproteins, HDL · Lipoproteins, LDL · Liver · Male · Rats · Rats, Inbred Strains
[PDF] [Abstract]

17 Immunological discrimination between the human apolipoprotein E2(Arg158→Cys) and E3 isoforms
article 1992    
Author: Gerritse, K. · Knijff, P. de · Ierssel, G.V. · Havekes, L.M. · Frants, R.R. · Schellekens, M.M. · Zegers, N.D. · Claassen, E. · Boersma, W.J.A.
Keywords: Synthetic peptides · Type III hyperlipoproteinemia · Apolipoprotein e2 · Apolipoprotein e3 · Lipoprotein receptor · Monoclonal antibody · Amino acid sequence · Antigenicity · Binding affinity · Immunological tolerance · Lipid metabolism · Lipoprotein blood level · Nonhuman · Sequence homology · Amino Acid Sequence · Animal · Antibodies, Monoclonal · Antibody Specificity · Apolipoproteins E · Arginine · Cysteine · Enzyme-Linked Immunosorbent Assay · Epitopes · Female · Human · Immunoblotting · Isoelectric Focusing · Mice · Mice, Inbred BALB C · Molecular Sequence Data · Phenotype · Sequence Alignment
[PDF] [Abstract]

18 Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism
article 1999    
Author: Sijbrands, E.J.G. · Hoffer, M.J.V. · Meinders, A.E. · Havekes, L.M. · Frants, R.R. · Smelt, A.H.M. · Knijff, P. de
Keywords: Apolipoprotein E · Hyperinsulinemia · Hyperlipoproteinemia type III · Xanthomas · Adult · Aged · Aged, 80 and over · Apolipoprotein A-I · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins A · Apolipoproteins C · Apolipoproteins E · Cholesterol, HDL · Cholesterol, LDL · Cholesterol, VLDL · Family Health · Female · Gene Expression · Haplotypes · Homozygote · Humans · Hyperinsulinism · Hyperlipidemias · Male · Middle Aged · Pedigree · Polymorphism, Single Nucleotide · Promoter Regions (Genetics) · Xanthomatosis
[Abstract]

19 Apolipoprotein E1-Hammersmith (Lys146 → Asn;Arg147 → Trp), due to a dinucleotide substitution, is associated with early manifestation of dominant type III hyperlipoproteinaemia
article 1996    
Author: Hoffer, M.J.V. · Niththyananthan, S. · Naoumova, R.P. · Kibirige, M.S. · Frants, R.R. · Havekes, L.M. · Thompson, G.R.
Keywords: Biology · Dyslipidaemia · Cclofibrate · Colestyramine · Mercaptamine · Atherosclerosis · Case report · Adult · Anticholesteremic Agents · Antilipemic Agents · Apolipoproteins E · Child · Child, Preschool · Cholesterol · Cholestyramine · Cysteamine · Dinucleotide Repeats · DNA · Electrophoresis · Exons · Female · Genotype · Humans · Hyperlipoproteinemia Type III · Immunoblotting · Male · Nuclear Family · Phenotype · Point Mutation · Procetofen · Radiation-Protective Agents · Triglycerides
[Abstract]

20 Cardiovascular disease and mortality in statin-treated patients with familial hypercholesterolemia
article 2004    
Author: Mohrschladt, M.F. · Westendorp, R.G.J. · Gevers Leuven, J.A. · Smelt, A.H.M.
Keywords: Health · Biomedical Research · Familial hypercholesterolemia · Mortality · Prospective follow-up · Statins · Aged · Anamnesis · Cardiovascular risk · Controlled study · Follow up · Ischemic heart disease · Major clinical study · Prospective study · Statistical significance · Adult · Cardiovascular Diseases · Female · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hyperlipoproteinemia Type I · Male · Middle Aged · Myocardial Ischemia · Prognosis
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 29 found. Next | Sort by date