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1 Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Winther, M.P.J. de · Hof, B. van 't · Zee, A. van der · Boom, H. van der · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Hypertriglyceridemia · LDL receptor · LDL receptor-related protein · VLDL triglyceride lipolysis · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Gene Expression · Hypertriglyceridemia · Lipolysis · Mice · Mice, Knockout · Point Mutation · Receptors, LDL · Triglycerides
[Abstract]

2 Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism
article 2007    
Author: Henneman, P. · Schaap, F.G. · Havekes, L.M. · Rensen, P.C.N. · Frants, R.R. · Tol, A. van · Hattori, H. · Smelt, A.H.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · apoAV · Hypertriglyceridemia · Lipoprotein lipase · Plasma apoAV concentration · SNP-analysis · apolipoprotein A5 · adult · allele · article · circulation · controlled study · endoplasmic reticulum · female · gene frequency · gene mutation · genetic polymorphism · genetic variability · haplotype · human · hypertriglyceridemia · lipolysis · major clinical study · male · priority journal · protein secretion · single nucleotide polymorphism · Adult · Alleles · Apolipoproteins A · Base Sequence · Case-Control Studies · DNA Primers · Female · Gene Frequency · Haplotypes · Humans · Hypertriglyceridemia · Male · Middle Aged · Polymorphism, Single Nucleotide
[Abstract]

3 Effects of fish oil on oxidation resistance of VLDL in hypertriglyceridemic patients
article 1996    
Author: Hau, M.-F. · Smelt, A.H.M. · Bindels, A.J.G.H. · Sijbrands, E.J.G. · Laarse, A. van der · Onkenhout, W. · Duyvenvoorde, W. van · Princen, H.M.G.
Keywords: Biology · fish oil · hypertriglyceridemia · LDL oxidation · omega-3 fatty acids · VLDL oxidation · alpha tocopherol · cholesterol · fish oil · high density lipoprotein cholesterol · low density lipoprotein cholesterol · omega 3 fatty acid · polyunsaturated fatty acid · triacylglycerol · very low density lipoprotein cholesterol · adult · article · clinical article · diet supplementation · fat intake · fatty acid blood level · human · hyperlipidemia · hypertriglyceridemia · lipid blood level · lipid oxidation · lipoprotein blood level · male · oral drug administration · priority journal · Adult · Diet · Fish Oils · Humans · Hypertriglyceridemia · Lipid Peroxidation · Lipoproteins, VLDL · Male · Middle Aged
[Abstract]

4 Sympathetic nervous system control of triglyceride metabolism: Novel concepts derived from recent studies
article 2014    
Author: Geerling, J.J. · Boon, M.R. · Kooijman, S. · Parlevliet, E.T. · Havekes, L.M. · Romijn, J.A. · Meurs, I.M. · Rensen, P.C.N.
Keywords: Biology · Brown adipose tissue · Fatty acids · Hypertriglyceridemia · Hypothalamus · Liver · White adipose tissue · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

5 Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1
article 1998    
Author: Jong, M.C. · Gijbels, M.J.J. · Dahlmans, V.E.H. · Gorp, P.J.J. van · Koopman, S.-J. · Ponec, M. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Apolipoprotein C · Hypertriglyceridemia · Sebaceous glands · Sebum production · Triglycerides · Animals · Apolipoprotein C-I · Apolipoproteins C · Epidermis · Female · Humans · Hyperlipidemias · Lipids · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Skin Abnormalities
[Abstract]

6 Apolipoprotein E2 (Lys146→Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides
article 2000    
Author: Beer, F. de · Dijk, K.W. van · Jong, M.C. · Vark, L.C. van · Zee, A. van der · Hofker, M.H. · Fallaux, F.J. · Hoeben, R.C. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Adenoviridae · Alleles · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Gene Expression · Gene Transfer Techniques · Humans · Hydrolysis · Hyperlipoproteinemia Type III · Hypertriglyceridemia · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · Point Mutation · RNA, Messenger · Triglycerides
[Abstract]

7 The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides
article 2007    
Author: Moen, C.J.A. · Tholens, A.P. · Voshol, P.J. · Haan, W. de · Havekes, L.M. · Gargalovic, P. · Lusis, A.J. · Dyk, K.W. van · Frants, R.R. · Hofker, M.H. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Congenic mice · Lipoprotein clearance · Lipoprotein lipase · Lipoproteins · Triglyceride hydrolysis · Animals · Chylomicrons · Female · Genetic Techniques · Hypertriglyceridemia · Lipase · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Mice · Mice, Congenic · Postprandial Period · Triglycerides
[PDF] [Abstract]

8 In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Hof, H.B. van 't · Zee, A. van der · Santamarina-Fojo, S. · Berkel, T.J.C. van · Havekes, L.M. · Hofker, M.H.
Keywords: Health · Adenovirus-mediated gene transfer · Hepatic VLDL triglyceride production · Hypertriglyceridemia · LDL receptor-related protein · VLDL-triglyceride lipolysis · Adenovirus · Adenoviridae · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Immunohistochemistry · Lipolysis · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Receptors, LDL · Transfection · Triglycerides
[PDF] [Abstract]

9 Generation of a recombinant apolipoprotein E variant with improved biological functions: Hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia
article 2005    
Author: Kypreos, K.E. · Dijk, K.W. van · Havekes, L.M. · Zannis, V.I.
Keywords: Biology · Biomedical Research · Amino acids · Biochemistry · Cholesterol · Genes · Molecular biology · Mutagenesis · Alanines · Apolipoprotein E (apoE) · High density lipoprotein (HDL) · Ultracentrifugation analysis · Proteins · High density lipoprotein · Leucine · Lipoprotein lipase · Phenylalanine · Recombinant apolipoprotein E · Recombinant protein · Triacylglycerol · Tryptophan · Unclassified drug · Valine · Very low density lipoprotein · Adenovirus · Amino acid substitution · Animal experiment · Carboxy terminal sequence · Controlled study · Density gradient centrifugation · Electron microscopy · Gene transfer · Human cell · Hydrophobicity · Hyperlipidemia · Hypertriglyceridemia · Mouse · Mutation · Nonhuman · Protein expression · Protein function · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Hypertriglyceridemia · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Mutagenesis, Site-Directed · Mutation, Missense · Peptide Fragments · Recombinant Proteins · Transgenes · Triglycerides
[PDF] [Abstract]

10 Apolipoprotein AV: Low concentration, high impact
article 2005    
Author: Rensen, P.C.N. · Dijk, K.W. van · Havekes, L.M.
Keywords: Biomedical Research · Apolipoprotein A5 · High density lipoprotein · Lipoprotein lipase · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · APOA5 protein, human · Editorial · Enzyme linked immunosorbent assay · Homeostasis · Ischemic heart disease · Lipid metabolism · Nonhuman · Protein assembly · Triacylglycerol blood level · Animal · Blood · Metabolism · Note · Physiology · Animals · Apolipoproteins · Apolipoproteins A · Homeostasis · Humans · Hypertriglyceridemia · Triglycerides
[Abstract]

11 Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
article 2002    
Author: Grefhorst, A. · Elzinga, B.M. · Voshol, P.J. · Plösch, T. · Kok, T. · Bloks, V.W. · Sluijs, F.H. van der · Havekes, L.M. · Romijn, J.A. · Verkade, H.J. · Kuipers, F.
Keywords: Animals · Anticholesteremic Agents · Apolipoproteins E · Carrier Proteins · Cell Line · DNA-Binding Proteins · Hypertriglyceridemia · Lipids · Lipoproteins, VLDL · Liver · Male · Membrane Proteins · Mice · Mice, Inbred C57BL · Phospholipid Transfer Proteins · Rats · Receptors, Cytoplasmic and Nuclear · Receptors, LDL · Receptors, Retinoic Acid · Receptors, Thyroid Hormone · Sulfonamides · Triglycerides · Animalia · Mus musculus
[PDF] [Abstract]

12 ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency
article 2008    
Author: Gerritsen, G. · Hoogt, C.C. van der · Schaap, F.G. · Voshol, P.J. · Kypreos, K.E. · Maeda, N. · Groen, A.K. · Havekes, L.M. · Rensen, P.C.N. · Dijk, K.W. van
Keywords: Health · Physiological Sciences · Adenovirus-mediated gene transfer · APOE2-knockin mice · Apolipoprotein A-V · Apolipoprotein C-III · Apolipoprotein E2 · Lipoprotein lipase-mediated very low density lipoprotein-triglyceride hydrolysis · apolipoprotein A · apolipoprotein A5 · apolipoprotein B · apolipoprotein C · apolipoprotein C3 · apolipoprotein D · apolipoprotein E · apolipoprotein M · beta2 glycoprotein 1 · clusterin · heparin · Apoa5 protein, mouse · apolipoprotein · Adenovirus · animal experiment · animal model · cholesterol blood level · conference paper · controlled study · disease association · female · gene overexpression · hypertriglyceridemia · in vivo study · lipoprotein deficiency · mouse · nonhuman · stimulation · triacylglycerol blood level · animal · blood · gene transfer · genetics · mouse mutant · physiology · Adenoviridae · Animals · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins · Gene Transfer Techniques · Hypertriglyceridemia · Lipids · Lipoprotein Lipase · Male · Mice · Mice, Knockout
[PDF] [Abstract]

13 Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue
article 2006    
Author: Boer, M.A.M. den · Berbée, J.F.P. · Reiss, P. · Valk, M. van der · Voshol, P.J. · Kuipers, F. · Havekes, L.M. · Rensen, P.C.N. · Romijn, J.A.
Keywords: Dyslipidemia · FA metabolism · Protease inhibitor · TG metabolism · Transgenic mice · Albumin · Lipoprotein lipase · Proteinase inhibitor · Ritonavir · Triacylglycerol · Triolein · Very low density lipoprotein · Anticoagulant agent · Apolipoprotein E · Apolipoprotein E3 (Leidein) · Diagnostic agent · Fatty acid · Heparin · Tritium · Very low density lipoprotein cholesterol · Adipose tissue · Animal tissue · Clearance · Controlled study · Drug mechanism · Emulsion · Enzyme activity · Fat intake · Fatty acid metabolism · Fatty acid transport · Half life time · Hypertriglyceridemia · Lipid diet · Lipodystrophy · Lipolysis · Mouse · Nonhuman · Postprandial state · Transgenic mouse · Triacylglycerol blood level · Biosynthesis · Blood · Chemically induced disorder · Drug effect · Enzyme activation · Genetics · Human immunodeficiency virus infection · Metabolism · Adipose Tissue · Animals · Anticoagulants · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Emulsions · Enzyme Activation · Fatty Acids · Female · Heparin · HIV Infections · HIV Protease Inhibitors · Hypertriglyceridemia · Lipolysis · Lipoprotein Lipase · Mice · Mice, Transgenic · Postprandial Period · Ritonavir · Triglycerides · Triolein · Tritium
[Abstract]

14 Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet
article 2011    
Author: Diepen, J.A. van · Vroegrijk, I.O.C.M. · Berbée, J.F.P. · Shoelson, S.E. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N. · Voshol, P.J.
Keywords: Biology · Inflammation · Lipid metabolism · Very low-density lipoprotein · acetylsalicylic acid · apolipoprotein C1 · immunoglobulin enhancer binding protein · transcription factor RelA · triacylglycerol · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · controlled study · drug mechanism · drug targeting · enzyme inhibition · gene expression · hypertriglyceridemia · in vivo study · lipid diet · lipogenesis · lipoprotein blood level · male · metabolic syndrome X · mouse · nonhuman · priority journal · protein expression · risk factor · triacylglycerol blood level · aspirin · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

15 The expression of type III hyperlipoproteinemia: Involvement of lipolysis genes
article 2009    
Author: Henneman, P. · Sman-de Beer, F. van der · Moghaddam, P.H. · Huijts, P. · Stalenhoef, A.F.H. · Kastelein, J.J.P. · Duijn, C.M. van · Havekes, L.M. · Frants, R.R. · Dijk, K.W. van · Smelt, A.H.M.
Keywords: Biology · Biomedical Research · adenine · apolipoprotein A5 · apolipoprotein C3 · apolipoprotein E2 · cytosine · guanine · lipoprotein lipase · liver triacylglycerol lipase · thymine · adult · aged · article · controlled study · disease severity · female · gene expression · gene frequency · gene function · gene linkage disequilibrium · genetic association · genetic polymorphism · genetic variability · human · human cell · hyperlipidemia · hyperlipoproteinemia type 3 · hypertriglyceridemia · lipolysis · lipoprotein blood level · major clinical study · male · mutational analysis · Netherlands · priority journal
[Abstract]

16 Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor : Contribution to the hypertriglyceridemic action of retinoids
article 1998    
Author: Vu-Dac, N. · Gervois, P. · Torra, I.P. · Fruchart, J.C. · Kosykh, V. · Kooistra, T. · Princen, H.M.G. · Dallongeville, J. · Staels, B.
Keywords: Health · Gene regulation · Hyperlipidemia · Nuclear receptors · Retinoids · Triglycerides · Adult · Apolipoprotein C-III · Apolipoproteins C · Benzoates · Carcinoma, Hepatocellular · Cells, Cultured · Dimerization · Double-Blind Method · Gene Expression Regulation · Hela Cells · Humans · Hypertriglyceridemia · Isotretinoin · Liver · Liver Neoplasms · Male · Mutagenesis, Site-Directed · Promoter Regions (Genetics) · Receptors, Cytoplasmic and Nuclear · Receptors, Retinoic Acid · Recombinant Fusion Proteins · Regulatory Sequences, Nucleic Acid · Retinoid X Receptors · Retinoids · Tetrahydronaphthalenes · Transcription Factors · Transcription, Genetic · Transfection · Tumor Cells, Cultured
[PDF] [Abstract]

17 Effect of apolipoprotein E and insulin resistance on VLDL particles in combined hyperlipidemic patients
article 1996    
Author: Sijbrands, E.J.G. · Westendorp, R.G.J. · Hoffer, M.J.V. · Frants, R.R. · Meinders, A.E. · Souverijn, J.H.M. · Leuven, J.A.G. · Laarse, A. van der · Havekes, L.M. · Smelt, A.H.M.
Keywords: Biology · ApoE · Combined hyperlipidemia · Hyperinsulinemia · Particle size · VLDL · apolipoprotein e · insulin · very low density lipoprotein · adult · aged · article · clinical trial · controlled clinical trial · controlled study · diet · female · genetic analysis · heterozygosity · human · human tissue · hyperlipidemia · hypertriglyceridemia · insulin resistance · lipid analysis · major clinical study · male · priority journal · Adult · Aged · Apolipoproteins E · Cholesterol, VLDL · Fasting · Female · Humans · Hyperlipidemia, Familial Combined · Insulin · Insulin Resistance · Lipoproteins, VLDL · Male · Middle Aged · Particle Size · Triglycerides
[Abstract]

18 Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
article 2005    
Author: Berbée, J.F.P. · Hoogt, C.C. van der · Sundararaman, D. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein C-I · Fatty acids · Lipid metabolism · Lipoprotein lipase · Triglycerides · Very low density lipoprotein · Lipoprotein receptor · Tritium · Very low density lipoprotein · Animal experiment · Animal model · Cholesterol blood level · Controlled study · Enzyme activity · Half life time · Hyperlipidemia · Hyperlipoproteinemia type 3 · Lipolysis · Mouse · Nonhuman · Pathophysiology · Protein expression · Transgenic mouse · Animals · Apolipoproteins · Apolipoproteins C · Apolipoproteins E · Humans · Hypertriglyceridemia · Lactoferrin · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phenotype · Time Factors
[PDF] [Abstract]

19 Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals
article 2004    
Author: Hofman, M.K. · Groenendijk, M. · Verkuijlen, P.J.J.H. · Jonkers, I.J.A.M. · Mohrschladt, M.F. · Smelt, A.H.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · CYP7A1 · Hyperlipidaemia · Modifier gene · Polymorphism · Triglycerides · apolipoprotein E3 · cholesterol · cholesterol 7alpha monooxygenase · isoprotein · lipid · low density lipoprotein · triacylglycerol · very low density lipoprotein · controlled study · DNA polymorphism · familial hypercholesterolemia · gene control · homozygosity · hyperlipidemia · hyperlipoproteinemia type 3 · lipid blood level · major clinical study · promoter region · triacylglycerol blood level · Adult · Aged · Cholesterol 7-alpha-Hydroxylase · Female · Gene Frequency · Genotype · Humans · Hypertriglyceridemia · Male · Middle Aged · Polymorphism, Genetic · Promoter Regions (Genetics) · Triglycerides
[Abstract]

20 ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglycerides (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis
article 2004    
Author: Schaap, F.G. · Rensen, P.C.N. · Voshol, P.J. · Vrins, C. · Vliet, H.N. van der · Chamuleau, R.A.F.M. · Havekes, L.M. · Groen, A.K. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · Data reduction · Enzymes · Gene transfer · Metabolism · Reaction kinetics · Lipolytic conversion · Lipoproteins · Biochemistry · Apolipoprotein A · Apolipoprotein a5 · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Animal experiment · APO5 gene · Gene · Gene transfer · Hydrolysis · Hyperlipidemia · Hypertriglyceridemia · Lipid blood level · Lipid metabolism · Lipoprotein blood level · Mouse · Nonhuman · Triacylglycerol blood level · Adenoviridae · Adipose Tissue · Animals · Apolipoproteins · Dose-Response Relationship, Drug · Gene Transfer Techniques · Hydrolysis · Kinetics · Lipids · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Inbred C57BL · Muscle, Skeletal · Postprandial Period · Rats · Recombinant Proteins · Time Factors · Triglycerides · Animalia · Murinae
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 21 found. Next | Sort by date