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Showing 1 to 7 of 7 found. | Sort by date

1 Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea
article 1996    
Author: Philip, P.A. · Souliotis, V.L. · Harris, A.L. · Salisbury, A. · Tates, A.D. · Mitchell, K. · Delft, J.H.M. van · Ganesan, T.S. · Kyrtopoulos, S.A.
Keywords: Biology · dacarbazine · hydroxyurea · hypoxanthine phosphoribosyltransferase · adult · aged · article · clinical article · dna adduct · dna repair · female · gene mutation · human · intravenous drug administration · leukocyte · male · melanoma · priority journal · Antineoplastic Combined Chemotherapy Protocols · Dacarbazine · DNA Adducts · DNA Repair · Female · Guanine · Humans · Hydroxyurea · Hypoxanthine Phosphoribosyltransferase · Leukocytes · Male · Melanoma · Middle Aged · Mutation · O(6)-Methylguanine-DNA Methyltransferase
[Abstract]

2 Gene-mutation assays in lambda-lacZ transgenic mice : comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium
article 1998    
Author: Delft, J.H.M. van · Bergmans, A. · Dam, F.J. van · Tates, A.D. · Howard, L. · Winton, D.J. · Baan, R.A.
Keywords: Biology · λlacZ · Dlb-1 · hprt · Mutagenesis · Transgenic mouse · ethylnitrosourea · hypoxanthine phosphoribosyltransferase · mesylic acid ethyl ester · methylnitrosourea · mutagenic agent · animal cell · animal experiment · animal tissue · article · controlled study · gene · gene mutation · intestine epithelium · mouse · mutagenesis · mutagenicity · nonhuman · priority journal · small intestine mucosa · spleen cell · transgenic mouse · Alkylating Agents · Animals · Ethyl Methanesulfonate · Ethylnitrosourea · Genetic Markers · Hypoxanthine Phosphoribosyltransferase · Intestinal Mucosa · Intestine, Small · Lac Operon · Methylnitrosourea · Mice · Mice, Inbred C57BL · Mice, Transgenic · Mutagenicity Tests · Mutagens · Mutation · Spleen · Animalia · Mus musculus
[Abstract]

3 IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans
article 2000    
Author: Albertini, R.J. · Anderson, D. · Douglas, G.R. · Hagmar, L. · Hemminki, K. · Merlo, F. · Natarajan, A.T. · Norppa, H. · Shuker, D.E.G. · Tice, R. · Waters, M.D. · Aitio, A.
Keywords: Biomarkers · Biomonitoring · Genotoxic carcinogens · Guideline · Human populations · WHO · carcinogen · hypoxanthine phosphoribosyltransferase · blood analysis · carcinogenicity · chromosome aberration · comet assay · cytogenetics · DNA adduct · DNA damage · ethics · fluorescence in situ hybridization · gene mutation · genotoxicity · human · micronucleus test · patient monitoring · practice guideline · priority journal · protein binding · review · risk assessment · sampling · sister chromatid exchange · statistical analysis · technique · Carcinogens · Chromosome Aberrations · DNA Damage · Environmental Health · Environmental Monitoring · Humans · Hypoxanthine Phosphoribosyltransferase · In Situ Hybridization, Fluorescence · International Cooperation · Lymphocytes · Micronucleus Tests · Mutagens · Sister Chromatid Exchange · Toxicity Tests · United Nations · World Health Organization
[Abstract]

4 Genetic and reproductive toxicity of butadiene and isoprene
article 2001    
Author: Anderson, D.
Keywords: Nutrition · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · sister chromatid exchange · spermatozoon motility · tissue distribution · Animals · Butadienes · Female · Hemiterpenes · Humans · Male · Mice · Mutagenicity Tests · Mutagens · Occupational Exposure · Ovary · Pentanes · Pregnancy · Rats · Reproduction · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium
[Abstract]

5 UV-induced effects
article 2005    
Author: Liebsch, M. · Spielmann, H. · Pape, W. · Krul, C. · Deguercy, A. · Eskes, C.A.M.
Keywords: Health · Physiological Sciences · cosmetic · hypoxanthine phosphoribosyltransferase · acute toxicity · allergenicity · animal testing replacement · cell line · chromosome aberration · comet assay · DNA damage · gene mutation · genotoxicity · human · in vivo study · micronucleus · model · nonhuman · photosensitization · phototoxicity · point mutation · priority journal · radiation exposure · radiation hazard · review · standardization · ultraviolet A radiation · ultraviolet radiation · validation process · Animal Testing Alternatives · Animals · Cell Line · Consumer Product Safety · Cosmetics · Dermatitis, Photoallergic · Dermatitis, Phototoxic · DNA · DNA Damage · Drug Stability · Erythrocytes · European Union · Hemolysis · Humans · Mutagenicity Tests · Mutagens · Photosensitizing Agents · Skin · Skin Irritancy Tests · Ultraviolet Rays · Animalia
[Abstract]

6 Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons
article 2000    
Author: Kappers, W.A. · Och, F.M.M. van · Groene, E.M. de · Horbach, G.J.
Keywords: Nutrition · Acetyltransferase · Amestest · AminoPAHs · Cytochrome P450 · HPRT · Mutagenicity · NIH/3T3 cells · NitroPAHs · Shuttle vector · V79 cells · Cytochrome P450 · Polycyclic aromatic hydrocarbon · Animal cell · Cell strain 3T3 · Controlled study · Enzyme activity · Gene locus · In vitro study · Mouse · Mutagenicity · Nonhuman · Priority journal · Reaction analysis · Reporter gene · Shuttle vector · 3T3 Cells · Animals · Cell Line · Cell Survival · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Enzyme Inhibitors · Ethyl Methanesulfonate · Fluorenes · Humans · Hypoxanthine Phosphoribosyltransferase · Ketoconazole · Lac Operon · Mice · Microsomes, Liver · Mutagenicity Tests · Mutagens · Mutation · Polycyclic Hydrocarbons, Aromatic · Pyrenes · Rats · Recombinant Fusion Proteins · Salmonella typhimurium · Theophylline · Animalia · Cricetinae · Cricetulus griseus · Eukaryota · Salmonella typhimurium · Typhimurium
[Abstract]

7 Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA
article 2007    
Author: Eefting, D. · Grimbergen, J.M. · Vries, M.R. de · Weel, V. van · Kaijzel, E.L. · Que, I. · Moon, R.T. · Löwik, C.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · double stranded RNA · histidine · luciferase · oligonucleotide · plasmid vector · small interfering RNA · toll like receptor 4 · uridine · animal cell · animal experiment · article · bioluminescence · controlled study · electroporation · gastrocnemius muscle · gene expression · gene function · gene repression · gene silencing · human · human cell · immune response · in vivo gene transfer · in vivo study · male · mouse · nonhuman · nonviral gene delivery system · protein expression · restenosis · RNA interference · transgene · treatment planning · tumor · viral gene delivery system · Animals · Cattle · Cell Line, Transformed · Cell Transformation, Viral · Electroporation · Feasibility Studies · Gene Silencing · Genes, Reporter · Humans · Hypoxanthine Phosphoribosyltransferase · Lipopolysaccharides · Luciferases · Luminescent Measurements · Male · Mice · Mice, Inbred Strains · Muscle, Skeletal · NIH 3T3 Cells · Plasmids · RNA Interference · RNA, Messenger · RNA, Small Interfering · Time Factors · Toll-Like Receptor 4 · Murinae
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 7 of 7 found. | Sort by date