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1 Evaluating in vitro-in vivo extrapolation of toxicokinetics
article 2018    
Author: Wambaugh, J.F. · Hughes, M.F. · Ring, C.L. · MacMillan, D.K. · Ford, J. · Fennell, T.R. · Black, S.R. · Snyder, R.W. · Sipes, N.S. · Wetmore, B.A. · Westerhout, J. · Setzer, R.W. · Pearce, R.G. · Simmons, J.E. · Thomas, R.S.
Keywords: Biology · Environmental chemicals · IVIVE · Toxicokinetics · Animal experiment · Animal tissue · Clearance · Drug bioavailability · Health hazard · In vitro study · In vivo study · Nonhuman · Plasma · Prediction · Rat · Steady state · Toxicokinetics · Uncertainty · Volume of distribution
[Abstract]

2 The in vivo rat skin photomicronucleus assay: Phototoxicity and photogenotoxicity evaluation of six fluoroquinolones
article 2012    
Author: Reus, A.A. · Usta, M. · Kenny, J.D. · Clements, P.J. · Pruimboom-Brees, I. · Aylott, M. · Lynch, A.M. · Krul, C.A.M.
Keywords: Research · ciprofloxacin · gatifloxacin · gemifloxacin · levofloxacin · lomefloxacin · methoxsalen · quinoline derived antiinfective agent · sparfloxacin · animal tissue · article · carcinogenicity · controlled study · epidermis cell · female · genotoxicity · hairless mouse · histopathology · in vitro study · in vivo study · micronucleus · micronucleus test · nonhuman · phototoxicity · priority journal · rat · single drug dose · skin · Sprague Dawley rat · Biomedical Innovation · Healthy Living · Triskelion BV · TARA - Toxicology and Risk Assessment · TNO Bedrijven
[Abstract]

3 Toxicology in the 21st century - Working our way towards a visionary reality
article 2011    
Author: Berg, N. · Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Roggen, E.L.
Keywords: Health · -Omics · 21st Century vision · 3Rs · Computational · In vitro · Replacement · Testing strategy · Toxicity testing · Validation · article · biological model · education · Europe · ex vivo study · financial management · in vitro study · in vivo study · interpersonal communication · leadership · medical research · practice guideline · risk assessment · standardization · systems biology · toxicity testing · toxicology · validation process · Animalia · Healthy living · Biomedical Innovations · Themalijn
[Abstract]

4 Comparative genomics of human Lactobacillus crispatus isolates reveals genes for glycosylation and glycogen degradation: Implications for in vivo dominance of the vaginal microbiota
article 2019    
Author: Veer, C. van der · Hertzberger, R.Y. · Bruisten, S.M. · Tytgat, H.L.P. · Swanenburg, J. · Angelino-Bart, A. de Kat · Schuren, F. · Molenaar, D. · Reid, G. · Vries, H. de · Kort, R.
Keywords: Galamustine · Glycoconjugate · Glycogen · Glycosyltransferase · RNA 16S · Transposase · Amino acid sequence · Bacterial growth · Bacterial strain · Bacterium isolation · Carbohydrate metabolism · Comparative study · Enzyme activity · Female · Fermentation · Gene sequence · Genome analysis · Genomics · Genotype · Glycogen metabolism · Glycosylation · Human · In vivo study · Lactobacillus crispatus · Metagenomics · Neisseria gonorrhoeae · Nonhuman · Nucleotide sequence · Phenotype · RNA sequence · Sexually transmitted disease · Vagina flora · Whole genome sequencing · Healthy for Life · Healthy Living
[PDF] [Abstract]

5 Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo
article 2008    
Author: Haan, W. de · Out, R. · Berbée, J.F.P. · Hoogt, C.C. van der · Dijk, K.W.v. · Berkel, T.J.C. van · Romijn, J.A. · Wouter Jukema, J. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Physiological Sciences · High density lipoprotein · Oxidized LDL · SR-BI · Transgenic mice · cholesterol ester · high density lipoprotein cholesterol · scavenger receptor BI · Adenovirus · animal cell · cholesterol metabolism · dose response · in vivo study · liver cell · mouse · nonhuman · particle size · protein expression · Adenoviridae · Animals · Apolipoprotein C-I · Cholesterol, HDL · Gene Transfer Techniques · Hepatocytes · Humans · Mice · Mice, Knockout · Scavenger Receptors, Class B · Adenoviridae · Murinae · Mus · Mus musculus
[Abstract]

6 Analyses of human colonic mucus obtained by an in vivo sampling technique
article 2009    
Author: Hamer, H.M. · Jonkers, D.M.A.E. · Loof, A. · Houtvin, S.A.L.W. van · Troost, F.J. · Venema, K. · Kodde, A. · Koek, G.H. · Schipper, R.G. · Heerde, W.L. van · Brummer, R.J.
Keywords: Biology Health · Biomedical Research · Colon · Mucus · Proteomics · Secretory IgA · fucose · galactosamine · galactose · glucosamine · glycoprotein · Immunoglobulin A · Monosaccharide · Mucin · Oligosaccharide · Sialic acid · Adult · Anion exchange chromatography · Colon mucosa · Colon mucus · Concentration (parameters) · Cytology · Female · Human · Human tissue · In vivo study · Intestine epithelium · Male · Mucus · Normal human · Priority journal · Protein analysis · Proteomics · Sampling · Sigmoidoscopy · Surface enhanced laser desorption ionization time of flight mass spectrometry · Volunteer
[Abstract]

7 Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life
article 2013    
Author: Harb, H. · Tol, E.A.F. van · Heine, H. · Braaksma, M. · Gross, G. · Overkamp, K. · Hennen, M. · Alrifai, M. · Conrad, M.L. · Renz, H. · Garn, H.
Keywords: Biology · Asthma · LGG · Neonatal Animal Model · Prevention · Soluble Factors · Interleukin 10 · Probiotic Agent · Tumor Necrosis Factor Alpha · Allergic Airway Inflammation · Animal Cell · Animal Experiment · Article · Controlled Study · Cytokine Production · female · Helper Cell · Immunomodulation · In Vitro Study · In Vivo Study · Lactobacillus Rhamnosus · macrophage · Mouse · Newborn · Nonhuman · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Retrospective detection of sulfur mustard exposure by mass spectrometric analysis of adducts to albumin and hemoglobin: An in vivo study
article 2008    
Author: Noort, D. · Fidder, A. · Degenhardt-Langelaan, C.E.A.M. · Hulst, A.G.
Keywords: Albumin · Alkylation · Animal experiment · Article · Blood analysis · Cell membrane · Chemical reaction · Controlled study · Environmental exposure · Erythrocyte · In vivo study · Nonhuman · Alkylation · Animals · Affinity chromatography · Liquid chromatography · Environmental exposure · Environmental monitoring · Injections, Intravenous · Male · Pronase · Rats · Wistar · Mass spectrometry · Electrospray ionization · Tandem mass spectrometry · Rattus · Hemoglobin 9008-02-0 · Mustard gas 505-60-2 · Biological markers · Hemoglobins · Pronase, EC 3.4.24.- · Serum albumin
[Abstract]

9 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

10 Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes
article 2004    
Author: Treijtel, N. · Barendregt, A. · Freidig, A.P. · Blaauboer, B.J. · Eijkeren, J.C.H. van
Keywords: Biology · Physiological Sciences · 4 tolylsulfonylurea · carboxytolbutamide · hydroxytolbutamide · sulfonylurea derivative · tolbutamide · unclassified drug · addition reaction · animal cell · article · cell culture · controlled study · drug blood level · drug clearance · in vitro study · in vivo study · liquid chromatography · liver cell · mass spectrometry · mathematical model · nonhuman · priority journal · radiochemistry · rat · Animals · Cells, Cultured · Hepatocytes · Male · Metabolic Clearance Rate · Models, Biological · Rats · Rats, Wistar · Tolbutamide · Animalia
[Abstract]

11 Accumulation of Advanced Glycation End Products as a Molecular Mechanism for Aging as a Risk Factor in Osteoarthritis
article 2004    
Author: Groot, J. de · Verzijl, N. · Wenting-Wijk, M.J.G. van · Jacobs, K.M.G. · El, B. van · Roermund, P.M. van · Bank, R.A. · Bijlsma, J.W.J. · TeKoppele, J.M. · Lafeber, F.P.J.G.
Keywords: Biology Health · Biomedical Research · Advanced glycation end product · Ribose · Animal experiment · Animal model · Animal tissue · Anterior cruciate ligament · Collagen defect · Controlled study · Disease predisposition · Disease severity · Extracellular matrix · Histopathology · Hypothesis · In vivo study · Nonhuman · Pathogenesis · Aging · Animals · Anterior Cruciate Ligament · Cartilage, Articular · Chondrocytes · Disease Models, Animal · Dogs · Female · Glycosylation End Products, Advanced · Osteoarthritis · Risk Factors
[Abstract]

12 Strategies to replace in vivo acute systemic toxicity testing: The report and recommendations of ECVAM workshop 50
article 2004    
Author: Gennari, A. · Berghe, C. van den · Casati, S. · Castell, J. · Clemedson, C. · Coecke, S. · Colombo, A. · Curren, R. · Dal Negro, G. · Goldberg, A. · Gosmore, C. · Hartung, T. · Langezaal, I. · Lessigiarska, I. · Maas, W. · Mangelsdorf, I. · Parchment, R. · Prieto, P. · Sintes, J.R. · Ryan, M. · Schmuck, G. · Stitzel, K. · Stokes, W. · Vericat, J.A. · Gribaldo, L.
Keywords: Toxicology Health · Physiological Sciences · acute toxicity · conference paper · cytotoxicity · environmental protection · European Union · in vivo study · LD 50 · priority journal · toxicity testing · Acute Toxicity Tests · Animal Testing Alternatives · Animals · Cell Death · Cosmetics · Europe · Guidelines · Lethal Dose 50 · Mouth Diseases · Registries · Reproducibility of Results · Toxicity Tests · United States

13 Steady progression of osteoarthritic features in the canine groove model
article 2002    
Author: Marijnissen, A.C.A. · Roermund, P.M. van · Verzijl, N. · Tekoppele, J.M. · Bijlsma, J.W.J. · Lafeber, F.P.J.G.
Keywords: Biology · Biomedical Research · Canine model · Cartilage · Osteoarthritis · Proteoglycans · proteoglycan · Animal experiment · Animal model · Bone injury · Cartilage degeneration · Controlled study · Disease course · Femur condyle · Histopathology · In vivo study · Joint degeneration · Joint injury · Joint stability · Knee osteoarthritis · Laboratory test · Loading test · Nonhuman · Proteoglycan synthesis · Surgical technique · Synovitis · Treatment outcome · Animals · Cartilage, Articular · Disease Models, Animal · Dogs · Female · Joints · Osteoarthritis · Proteoglycans · Synovial Membrane · Time Factors
[Abstract]

14 Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis
article 2003    
Author: Killestein, J. · Hoogervorst, E.L.J. · Reif, M. · Blauw, B. · Smits, M. · Uitdehaag, B.M.J. · Nagelkerken, L. · Polman, C.H.
Keywords: Cytokines · THC · Dronabinol · Lipopolysaccharide · Tumor necrosis factor alpha · Ataxia · Clinical article · Controlled study · Drug effect · Headache · Immune function test · Immunomodulation · In vivo study · Mental instability · Somnolence · Spasticity · Vertigo · Xerostomia · Adjuvants, Immunologic · Administration, Oral · Adult · Cannabinoids · Cannabis · Confidence Intervals · Cross-Over Studies · Female · Humans · Male · Middle Aged · Multiple Sclerosis · Phytotherapy · Plant Extracts · Tetrahydrocannabinol
[Abstract]

15 A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting
article 2003    
Author: Lamers, R.-J.A.N. · Wessels, E.C.H.H. · Sandt, J.J.M. van de · Venema, K. · Schaafsma, G. · Greef, J. van der · Nesselrooij, J.H.J. van
Keywords: Nutrition Packaging · Analytical research · 1H NMR spectroscopy · Metabolic fingerprinting · Biochemical marker · Cell culture · Cell metabolism · Cell strain CACO 2 · Chemical analysis · Controlled study · Experimental model · Glucose metabolism · Health status · Human cell · In vitro study · In vivo study · Laboratory test · Multivariate analysis · Nutrition · Pilot study · Proton nuclear magnetic resonance · Alanine · Analysis of Variance · Caco-2 Cells · Colon · Fermentation · Glucose · Glutamic Acid · Humans · Inulin · Ketoglutaric Acids · Lactic Acid · Magnetic Resonance Spectroscopy · Niacin · Niacinamide · Proline · Succinic Acid
[Abstract]

16 Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage
article 2012    
Author: Vos, P.A.J.M. · Degroot, J. · Barten-Van Rijbroek, A.D. · Zuurmond, A.-M. · Bijlsma, J.W.J. · Mastbergen, S.C. · Lafeber, F.P.J.G.
Keywords: Health · canine · non-enzymatic glycation · osteoarthritis · pentosidine · proteoglycan · advanced glycation end product · carbohydrate · pentosidine · proteoglycan · ribose · threose · unclassified drug · animal cell · animal experiment · animal model · animal tissue · article · bone turnover · cartilage · cartilage cell · cartilage injury · controlled study · experimental dog · female · histopathology · in vivo study · joint degeneration · knee surgery · nonhuman · osteoarthritis · priority journal · synovitis · tissue level · Healthy for Life · Healthy Living · Life · MHR - Metabolic Health Research PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

17 Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet
article 2011    
Author: Diepen, J.A. van · Vroegrijk, I.O.C.M. · Berbée, J.F.P. · Shoelson, S.E. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N. · Voshol, P.J.
Keywords: Biology · Inflammation · Lipid metabolism · Very low-density lipoprotein · acetylsalicylic acid · apolipoprotein C1 · immunoglobulin enhancer binding protein · transcription factor RelA · triacylglycerol · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · controlled study · drug mechanism · drug targeting · enzyme inhibition · gene expression · hypertriglyceridemia · in vivo study · lipid diet · lipogenesis · lipoprotein blood level · male · metabolic syndrome X · mouse · nonhuman · priority journal · protein expression · risk factor · triacylglycerol blood level · aspirin · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

18 Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity) from new or modified dietary proteins
article 2018    
Author: Remington, B. · Broekman, H.C.H. · Blom, W.M. · Capt, A. · Crevel, R.W.R. · Dimitrov, I. · Faeste, C.K. · Fernandez-Canton, R. · Giavi, S. · Houben, G.F. · Glenn, K.C. · Madsen, C.B. · Kruizinga, A.K. · Constable, A.
Keywords: Nutrition · Allergen · Hazard analysis · IgE · Novel proteins · Risk assessment · Sensitization · Immunoglobulin E · Allergenicity · Antigen binding · Basophil activation test · Bioinformatics · Clinical study · Computer model · Cross reaction · DNA modification · Enzymatic degradation · Exposure · Food allergy · Health hazard · Human · Immunogenicity · In vitro study · In vivo study · Methodology · Nonhuman · Outcome assessment · Prick test · Protein analysis · Protein intake · Review · Risk factor · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

19 Feasibility of SPECT-CT imaging to study the pharmacokinetics of antisense oligonucleotides in a mouse model of Duchenne muscular dystrophy
article 2017    
Author: Steeg, E. van de · Läppchen, T. · Aguilera, B. · Jansen, H.T. · Muilwijk, D. · Vermue, R. · Hoorn, J.W. van der · Donato, K. · Rossin, R. · Visser, P.C. de · Vlaming, M.L.H.
Keywords: Nutrition · SPECT imaging · Antisense oligonucleotides · RNA-based therapeutics · Duchenne muscular dystrophy · Antisense oligonucleotides · Antisense oligonucleotide i 123 · Antisense oligonucleotide in 111 · Indium 111 · Iodine 123 · Tracer · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Drug distribution · Drug half life · Drug tissue level · Drug uptake · In vivo study · Male · Mouse · Mouse model · Nonhuman · Single photon emission computed tomography-computed tomography · Skeletal muscle · Target tissue · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

20 The role of collagen cross-links in biomechanical behavior of human aortic heart valve leaflets - Relevance for tissue engineering
article 2007    
Author: Balguid, A. · Rubbens, M.P. · Mol, A. · Bank, R.A. · Bogers, A.J.J.C. · Kats, J.P. van · Mol, B.A.J.M. de · Baaijens, F.P.T. · Bouten, C.V.C.
Keywords: Biology · Biomedical Research · Anisotropy · Biomechanics · Cardiovascular system · Correlation methods · Pressure effects · Tissue engineering · Anisotropic matrix · Biomechanical function · Dynamic tissue straining · Human aortic heart valve leaflets · Load-bearing matrix · Collagen · collagen · adult · article · biomechanics · cell survival · collagen metabolism · controlled study · cross linking · elasticity · female · heart function · heart valve · human · human cell · human tissue · hyperbarism · in vivo study · male · priority journal · protein cross linking · tissue engineering · young modulus · Aortic Valve · Biomechanics · Collagen · Female · Humans · Male · Middle Aged · Tissue Engineering
[Abstract]

Search results also available in MS Excel format.

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