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Showing 1 to 17 of 17 found. | Sort by date

1 A physiologically-based kinetic model for the prediction of plasma cholesterol concentrations in the mouse
article 2011    
Author: Pas, N.C.A. van de · Woutersen, R.A. · Ommen, B. van · Rietjens, I.M.C.M. · Graaf, A.A. de
Keywords: Biology · C · CE · cholesterol · cholesteryl ester · FC · free cholesterol · HDL · high density lipoprotein · knockout · KnockOut Mouse Data Inventory of cholesterol Phenotype · ko · KOMDIP · LDL · low density lipoprotein · PBK · physiologically based kinetic · TC · total plasma cholesterol · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53
article 2002    
Author: Thüsen, J.H. von der · Vlijmen, B.J.M. van · Hoeben, R.C. · Kockx, M.M. · Havekes, L.M. · Berkel, T.J.C. van · Biessen, E.A.L.
Keywords: Health · Carotid arteries · Genes · Muscle · Adenovirus vector · Apolipoprotein E · Beta galactosidase · Phenylephrine · Protein p53 · Animal experiment · Animal model · Atherogenesis · Atherosclerotic plaque · Carotid artery · Cell death · Controlled study · Gene overexpression · Genetic transfection · Knockout mouse · Mouse · Nonhuman · Rupture · Smooth muscle fiber · Thrombosis · Transgene · Tumor suppressor gene · Adenoviridae · Animals · Apolipoproteins E · Apoptosis · Arteriosclerosis · beta-Galactosidase · Biological Markers · Carotid Artery Diseases · Cell Division · Genetic Vectors · Immunohistochemistry · Mice · Mice, Knockout · Muscle, Smooth, Vascular · Transfection · Tumor Suppressor Protein p53
[Abstract]

3 Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice
article 2004    
Author: Bovenschen, N. · Dijk, K.W. van · Havekes, L.M. · Mertens, K. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Clearance · Factor VIII · Knockout mice · Low-density lipoprotein receptor-related protein · Very low-density lipoprotein receptor · blood clotting factor 8 · cholesterol · triacylglycerol · very low density lipoprotein receptor · animal experiment · article · catabolism · cholesterol blood level · controlled study · knockout mouse · male · mouse · nonhuman · plasma clearance · priority journal · triacylglycerol blood level · Animals · Factor VIII · Integrases · LDL-Receptor Related Proteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

4 Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
article 2004    
Author: Mulder, M. · Jansen, P.J. · Janssen, B.J.A. · Berg, W.D.J. van de · Boom, H. van der · Havekes, L.M. · Kloet, R.E. de · Ramaekers, F.C.S. · Blokland, A.
Keywords: Environment · Alzheimer's disease · Apolipoprotein E · Lipid metabolism · Low-density lipoprotein receptor family · Memory · Low density lipoprotein receptor · Synaptophysin · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Controlled study · Hippocampus · Homozygosity · Knockout mouse · Maze test · Memory disorder · Mouse · Nerve ending · Nonhuman · Spatial memory · Task performance · Wild type · Working memory · Animals · Cell Count · Hippocampus · Male · Maze Learning · Memory Disorders · Mice · Mice, Inbred C57BL · Mice, Knockout · Presynaptic Terminals · Receptors, LDL · Synapses
[Abstract]

5 Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/apoCI-knocked out mice
article 2002    
Author: Gautier, T. · Masson, D. · Jong, M.C. · Duverneuil, L. · Guern, N.L. · Deckert, V. · Barros, J.-P.P.de · Dumont, L. · Bataille, A. · Zak, Z. · Jiang, X.-C. · Tall, A.R. · Havekes, L.M. · Lagrost, L.
Keywords: Biology · Cholesterol · Chromatographic analysis · Esters · Proteins · Apolipoproteins · Biochemistry · High density lipoprotein · Very low density lipoprotein · Animal experiment · Concentration response · Controlled study · Gel permeation chromatography · Knockout mouse · Lipoprotein blood level · Mouse · Nonhuman · Protein deficiency · Protein expression · Transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins C · Carrier Proteins · Cholesterol Ester Transfer Proteins · Glycoproteins · Humans · Kinetics · Lipoproteins · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Animalia · Mus musculus
[PDF] [Abstract]

6 Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
article 2003    
Author: Voshol, P.J. · Haemmerle, G. · Ouwens, D.M. · Zimmermann, R. · Zechner, R. · Teusink, B. · Maassen, J.A. · Havekes, L.M. · Romijn, J.A.
Keywords: Health · Glucose · Hormone sensitive lipase · Insulin receptor · Protein kinase B · Triacylglycerol · Triacylglycerol lipase · Unclassified drug · Animal tissue · Controlled study · Enzyme activity · Enzyme deficiency · Enzyme mechanism · Enzyme phosphorylation · Fatty acid blood level · Gluconeogenesis · Glucose transport · Hormone sensitivity · Hyperinsulinemia · Insulin sensitivity · Knockout mouse · Lipid liver level · Lipolysis · Mouse · Nonhuman · Western blotting · Adiponectin · Animals · Blood Glucose · Cholesterol · Cholesterol Esterase · Fasting · Fatty Acids, Nonesterified · Glucose · Insulin · Intercellular Signaling Peptides and Proteins · Liver · Male · Mice · Mice, Knockout · Muscle, Skeletal · Proteins · Receptor, Insulin · Triglycerides
[Abstract]

7 LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus
article 2007    
Author: Mulder, M. · Koopmans, G. · Wassink, G. · Mansouri, G.A. · Simard, M.-L. · Havekes, L.M. · Prickaerts, J. · Blokland, A.
Keywords: Health · Biomedical Research · Apolipoprotein E · Cholesterol · Low density lipoprotein receptor · Memory · Neurogenesis · Synaptic density · apolipoprotein E · broxuridine · cholesterol · iodine 125 · low density lipoprotein · low density lipoprotein receptor · synaptophysin · Alzheimer disease · animal cell · animal experiment · animal tissue · article · astrocytoma cell · cell proliferation · cholesterol metabolism · concentration response · controlled study · dentate gyrus · hippocampus · knockout mouse · male · memory · mouse · nerve cell plasticity · nerve fiber growth · nervous system development · neuroblastoma cell · nonhuman · pathogenesis · priority journal · spatial memory · synaptogenesis · wild type · Animals · Biological Markers · Bromodeoxyuridine · Cell Count · Cell Line, Tumor · Cell Proliferation · Cholesterol · Dentate Gyrus · Down-Regulation · Hippocampus · Humans · Male · Mice · Mice, Knockout · Neural Pathways · Neuronal Plasticity · Presynaptic Terminals · Receptors, LDL · Synaptophysin
[Abstract]

8 Evaluation of the Xpa-Deficient Transgenic Mouse Model for Short-Term Carcinogenicity Testing: 9-Month Studies with Haloperidol, Reserpine, Phenacetin, and D-Mannitol
article 2004    
Author: Lina, B.A.R. · Woutersen, R.A. · Bruijntjes, J.P. · Benthem, J. van · Berg, J.A.H. van den · Monbaliu, J. · Thoolen, B.J.J.M. · Beems, R.B. · Kreijl, C.F. van
Keywords: Biology · Toxicology and Applied Pharmacology · Carcinogenicity testing · Carcinogens · DNA repair deficient · Knockout mice · Xpa · Xpa/p53 · haloperidol · mannitol · phenacetin · reserpine · animal experiment · animal tissue · article · cancer incidence · carcinogen testing · controlled study · DNA repair · evaluation · female · hyperplasia · kidney tumor · knockout mouse · male · maximum tolerated dose · mouse · nonhuman · priority journal · rare disease · survival · target organ · transgenic mouse · Administration, Oral · Animals · Carcinogenicity Tests · Diet · Disease Models, Animal · DNA-Binding Proteins · Dose-Response Relationship, Drug · Haloperidol · Mannitol · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Neoplasms, Experimental · Phenacetin · Reproducibility of Results · Reserpine · Time Factors · Xeroderma Pigmentosum Group A Protein · Animalia · Mus musculus · Rodentia
[Abstract]

9 Standardisation of environmental enrichment for laboratory mice and rats: Utilisation, practicality and variation in experimental results
article 2010    
Author: Baumans, V. · Loo, P.L.P. van · Pham, T.M.
Keywords: Biology · Physiological Sciences · brain derived neurotrophic factor · animal behavior · animal care · animal experiment · animal housing · animal wellbeing · article · Bagg albino mouse · breeding · C57BL 6 mouse · controlled study · environmental enrichment · experimental animal welfare · experimental mouse · experimental rat · exploratory behavior · female · foraging behavior · knockout mouse · male · mouse · nesting · nonhuman · open field test · rat · social behavior · Sprague Dawley rat · standardization · strain difference · survival · wild type · workload · Animalia · Mus · Rattus · Rattus norvegicus · Healthy for Life · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

10 P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury
article 2007    
Author: Huls, M. · Kramers, C. · Levtchenko, E.N. · Wilmer, M.J.G. · Dijkman, H.B.P.M. · Kluijtmans, L.A.J. · Hoorn, J.W.A. van der · Russel, F.G.M. · Masereeuw, R.
Keywords: Biology · ABC transporter · Drug transporter · Ischemia-reperfusion · Kidney dysfunction · ABC transporter · adenosine triphosphate · amino acid · calcium · creatinine · glucose · glycoprotein P · lithium · protein · sodium · amino acid urine level · animal model · animal tissue · calcium excretion · controlled study · creatinine clearance · diuresis · electron microscopy · glomerulus filtration rate · glucosuria · kidney blood flow · kidney cortex · kidney injury · kidney ischemia · kidney proximal tubule · kidney tubule necrosis · knockout mouse · oxidative stress · plasma clearance · priority journal · protein expression · protein function · sodium excretion · upregulation · urinary excretion · Amino Acids · Animals · Calcium · Diuresis · Fluorescent Antibody Technique · Glomerular Filtration Rate · Glycosuria · Immunohistochemistry · Ischemia · Kidney Failure, Acute · Kidney Tubules, Proximal · Male · Mice · Mice, Inbred Strains · Mice, Knockout · Mitochondria · P-Glycoprotein · Proteinuria · Renal Circulation · Sodium
[Abstract]

11 Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in apoE/LDLR double knockout mice
article 2006    
Author: Hu, L. · Boesten, L.S.M. · May, P. · Herz, J. · Bovenschen, N. · Huisman, M.V. · Berbée, J.F.P. · Havekes, L.M. · Vlijmen, B.J.M. van · Tamsma, J.T.
Keywords: Biology · Biomedical Research · Atherosclerosis · Genetically altered mice · LRP · Macrophage · Spolipoprotein E · CD3 antigen · Aholesterol · Lipoprotein · Low density lipoprotein receptor · Triacylglycerol · Animal cell · Animal model · Animal tissue · Aorta root · Atherogenesis · Cell count · Cholesterol blood level · Control group · Controlled study · Gene deletion · In vivo study · Knockout mouse · Male · Monocyte · Mouse · Nonhuman · Observation · Protein deficiency · Protein localization · Protein transport · Smooth muscle fiber · T lymphocyte · Triacylglycerol blood level · Animals · Apolipoproteins E · Collagen · Female · Gene Expression Regulation · LDL-Receptor Related Protein 1 · Lipoproteins · Macrophages · Mice · Mice, Knockout · Receptors, LDL
[Abstract]

12 Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL
article 2006    
Author: Westerterp, M. · Haan, W. de · Berbée, J.F.P. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Lipases transgenic mouse models · Very low density lipoprotein · apolipoprotein B · cholesterol · fatty acid · heparin · lipid · olive oil · triacylglycerol · very low density lipoprotein · animal experiment · animal tissue · cholesterol blood level · concentration response · controlled study · enzyme inhibition · gene dosage · gonad · hyperlipidemia · intestine absorption · knockout mouse · lipid absorption · lipid blood level · lipid metabolism · lipolysis · mouse · nonhuman · postprandial state · protein expression · triacylglycerol blood level · white adipose tissue · Animals · Apolipoprotein C-I · Apolipoproteins C · Apolipoproteins E · Cholesterol · Hyperlipidemias · Intestines · Lipase · Lipoprotein Lipase · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Postprandial Period
[PDF] [Abstract]

13 Activation of the innate immune system in atherosclerotic disease
article 2007    
Author: Oude Nijhuis, M.M. · Keulen, J.K. van · Pasterkamp, G. · Quax, P.H. · Kleijn, D.P.V. de
Keywords: Biomedical Research · Atherogenesis · Infection · Inflammation · Innate immunity · Toll-like receptors · antibiotic agent · azithromycin · e 5331 · e 5531 · e 5564 · eritoran · ligand · lipid A derivative · lipopolysaccharide antagonist · low density lipoprotein · malonaldehyde · oxidized low density lipoprotein · placebo · receptor blocking agent · toll like receptor · vaccine · antigen recognition · atherogenesis · atherosclerosis · clinical trial · disease course · drug megadose · drug targeting · genetic polymorphism · human · innate immunity · knockout mouse · low drug dose · nonhuman · priority journal · review · signal transduction · vaccination · Animals · Atherosclerosis · Communicable Diseases · Humans · Immunity, Natural · Immunotherapy · Inflammation · Ligands · Lipopolysaccharides · Lipoproteins · Peptidoglycan · Signal Transduction · Toll-Like Receptors · Vaccines
[Abstract]

14 Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice
article 2007    
Author: Westerterp, M. · Berbée, J.F.P. · Pires, N.M.M. · Mierlo, G.J.D. van · Kleemann, R. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biomedical Research · Apolipoproteins · Atherosclerosis · Hypercholesterolemia · Inflammation · Leukocytes · Lipoproteins · apolipoprotein C1 · apolipoprotein E · bacterium lipopolysaccharide · endothelial leukocyte adhesion molecule 1 · fibrinogen · tumor necrosis factor alpha · animal cell · animal experiment · animal model · animal tissue · aorta atherosclerosis · aorta root · article · atherogenesis · atherosclerosis · bacterial infection · controlled study · female · fibrinogen blood level · inflammation · knockout mouse · macrophage · mouse · nonhuman · priority journal · protein blood level · protein expression · Animals · Apolipoproteins C · Atherosclerosis · Biological Markers · Cells, Cultured · Cholesterol, HDL · E-Selectin · Female · Fibrinogen · Hypercholesterolemia · Lipopolysaccharides · Macrophages, Peritoneal · Male · Mice · Mice, Inbred C57BL · Mice, Mutant Strains · Monocytes · T-Lymphocytes · Tumor Necrosis Factor-alpha · Vasculitis
[ABSTRACT] [Abstract]

15 Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-α Activator Fenofibrate
article 2004    
Author: Gervois, P. · Kleemann, R. · Pilon, A. · Percevault, F. · Koenig, W. · Staels, B. · Kooistra, T.
Keywords: Biology · Biomedical Research · Biological organs · Enzyme kinetics · Lipids · Metabolism · Patient treatment · Plasmas · Acute phase response (APR) · Gene expression · Genetic engineering · Albumin · Alpha 2 macroglobulin · CCAAT enhancer binding protein · CCAAT enhancer binding protein alpha · CCAAT enhancer binding protein beta · CCAAT enhancer binding protein delta · Fenofibrate · Fibrinogen · Interleukin 6 · peroxisome proliferator activated receptor agonist · peroxisome proliferator activated receptor alpha · serum amyloid A · STAT3 protein · Stress activated protein kinase · Transcription factor · Unclassified drug · Acute phase response · Animal experiment · Animal tissue · Clinical article · Controlled study · Down regulation · Enzyme activation · Fibrinogen blood level · Gene expression regulation · Hyperlipidemia · In vivo study · Knockout mouse · Liver · Long term care · Male · Mouse · Nonhuman · Protein expression · Protein function · Protein phosphorylation · Transcription regulation · Wild type · Acute-Phase Reaction · Animals · Antilipemic Agents · Apolipoproteins · Down-Regulation · Fibrinogen · Haptoglobins · Humans · Interleukin-6 · Mice · Procetofen · Receptors, Cytoplasmic and Nuclear · Serum Amyloid A Protein · Signal Transduction · Transcription Factors · Animalia · Eukaryota
[PDF] [Abstract]

16 Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Impairs Very-Low-Density Lipoprotein Production
article 2004    
Author: Post, S.M. · Groenendijk, M. · Solaas, K. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Bile acid biosynthesis · Cholesterol 7α-hydroxylase · SREBP-1 · Bile acid · Cholesterol · Cholesterol 7alpha monooxygenase · Cholesterol ester · Cytochrome P450 isoenzyme · Messenger RNA · Sterol · Sterol regulatory element binding protein 1 · Unclassified drug · Very low density lipoprotein · Vitamin · Acyltransferase · Alpha tocopherol · Apolipoprotein E3 (Leidein) · Dgat1 protein, mouse · Diacylglycerol acyltransferase · Retinol · Animal experiment · Animal model · Animal tissue · Antioxidant activity · Bile acid synthesis · Catalysis · Cholesterol blood level · Cholesterol metabolism · Controlled study · Enzyme deficiency · Feces level · Gene · Gene expression · Hyperlipidemia · Knockout mouse · Lipid diet · Lipid metabolism · Lipogenesis · Lipoprotein synthesis · Nonhuman · Srebf1 gene · Triacylglycerol blood level · Atherogenic diet · Biosynthesis · Blood · Cross breeding · Feces · Genetics · Metabolism · Mouse mutant · Physiology · Acyltransferases · Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Bile Acids and Salts · Cholesterol 7-alpha-Hydroxylase · Cholesterol Esters · Crosses, Genetic · Diacylglycerol O-Acyltransferase · Diet, Atherogenic · Feces · Female · Hyperlipoproteinemia Type III · Ketone Bodies · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · RNA, Messenger · Sterols · Triglycerides · Vitamin A · Vitamin E
[Abstract]

17 Tumor necrosis factor-α plays an important role in restenosis development
article 2005    
Author: Monraats, P.S. · Pires, N.M.M. · Schepers, A. · Agema, W.R.P. · Boesten, L.S.M. · Vries, M.R. de · Zwinderman, A.H. · Maat, M.P.M. de · Doevendans, P.A.F.M. · Winter, R.J. de · Tio, R.A. · Waltenberger, J. · Hart, L.M. 't · Frants, R.R. · Quax, P.H.A. · Vlijmen, B.J.M. van · Havekes, L.M. · Laarse, A. van der · Wall, E.E. van der · Jukema, J.W.
Keywords: Biology Health · Biomedical Research · Haplotype · TNFα · Transgenic mice · Apolipoprotein E3 · Messenger RNA · Thalidomide · Tumor necrosis factor alpha · Adult · Aged · Angiography · Animal experiment · Animal model · Clinical practice · Disease marker · Drug delivery system · Genetic polymorphism · Heredity · Knockout mouse · Nonhuman · Percutaneous coronary intervention · Restenosis · Risk assessment · Screening · Aged · Alleles · Angina Pectoris · Angiography · Angioplasty, Transluminal, Percutaneous Coronary · Animals · Constriction, Pathologic · Coronary Angiography · Coronary Disease · Coronary Restenosis · Disease Models, Animal · Female · Femoral Artery · Gene Expression Regulation, Neoplastic · Genetic Predisposition to Disease · Genotype · Haplotypes · Humans · Inflammation · Ischemia · Linkage Disequilibrium · Male · Mice · Mice, Knockout · Mice, Transgenic · Middle Aged · Multivariate Analysis · Odds Ratio · Polymorphism, Genetic · Regression Analysis · Reverse Transcriptase Polymerase Chain Reaction · Risk Factors · RNA, Messenger · Thalidomide · Treatment Outcome · Tumor Necrosis Factor-alpha · Up-Regulation · Animalia · Mus musculus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date