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1 The mutagenicity of isoniazid in salmonella and its effects on DNA repair and synthesis in human fibroblasts
article 1980    
Author: Wade, D.R. · Lohman, P.H.M.
Keywords: Biology · Hydrazine · Isoniazid · Manganese · Abstract report · Adverse drug reaction · Cell culture · Chemical mutagenesis · DNA repair · DNA synthesis · Fibroblast · Human · Human cell · In vitro study · Liver microsome · Mouse · Mutagenicity · Normal human · Pharmacokinetics · Rat · Salmonella · Salmonella typhimurium · Soft tissue
[Abstract]

2 Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP)
article 2015    
Author: Reinen, J. · Nematollahi, L. · Fidder, A. · Vermeulen, N.P.E. · Noort, D. · Commandeur, J.N.M.
Keywords: Toxicology · Cytochrome P450 1A2 · Cytochrome P450 2C18 · Cytochrome P450 2D6 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Organophosphorus compound · Unclassified drug · Animal cell · Biotransformation · Cholinesterase inhibition · Controlled study · Enzyme inactivation · Humans · human cell · Hydrolysis · IC50 · In vitro study · Liver microsome · Liver microsome metabolism · Neurotoxicity · Nonhuman · Rats · Acetylcholinesterase, 9000-81-1 · Cholinesterase, 9001-08-5 · cytochrome P450, 9035-51-2 · Cytochrome P450 3A4, 329736-03-0 · Cytochrome P450 3A5, 336874-97-6 · Tri ortho cresyl phosphate, 78-30-8 · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

3 Inhibition of zaleplon metabolism by cimetidine in the human liver : in vitro studies with subcellular fractions and precision-cut liver slices
article 2002    
Author: Renwick, A.B. · Ball, S.E. · Tredger, J.M. · Price, R.J. · Walters, D.G. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition · Aldehyde oxidase · Cimetidine · Cytochrome P450 3A · Reduced nicotinamide adenine dinucleotide phosphate · Zaleplon · Cell fractionation · Drug inhibition · Drug metabolism · Human · Human cell · Human tissue · In vitro study · Liver metabolism · Liver microsome · Liver slice · Acetamides · Cimetidine · Cytosol · Dose-Response Relationship, Drug · Drug Interactions · Enzyme Inhibitors · Humans · Hypnotics and Sedatives · Inhibitory Concentration 50 · Kinetics · Liver · Models, Chemical · Pyrimidines · Subcellular Fractions · Staphylococcus phage 3A
[Abstract]

4 Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, L. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Androstenedione · Boldenone · Drug metabolite · Animal tissue · Cattle · Conference paper · Drug feces level · Drug metabolism · Drug urine level · Gas chromatography · Liver cell · Liver microsome · Mass spectrometry · Nonhuman · Animals · Cells, Cultured · Feces · Gas Chromatography-Mass Spectrometry · Liver · Male · Microsomes, Liver · Testosterone
[PDF] [Abstract]

5 In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, T. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Biological marker · Boldenone · Clostebol · Estrane derivative · Ethylestrenol · Norethandrolone · Steroid · Animal tissue · Cattle · Conference paper · Controlled study · Drug abuse · Drug determination · Drug metabolism · Drug monitoring · Female · Liver · Liver cell culture · Liver metabolism · Liver microsome · Male · Model · Nonhuman · Steroid metabolism · Anabolic Agents · Animals · Biological Markers · Cattle · Cells, Cultured · Drug Residues · Estradiol · Ethylestrenol · Liver · Microsomes, Liver · Models, Biological · Norethandrolone · Predictive Value of Tests · Testosterone
[PDF] [Abstract]

6 Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol
article 1996    
Author: Bessems, J.G.M. · Koppele, J.M. te · Dijk, P.A. van · Stee, L.L.P. van · Commandeur, J.N.M. · Vermeulen, N.P.E.
Keywords: Toxicology · beta naphthoflavone · cytochrome p450 · glutathione · paracetamol · paracetamol derivative · phenobarbital · animal tissue · article · controlled study · drug oxidation · liver microsome · male · nonhuman · rat · Acetaminophen · Animals · Benzoquinones · beta-Naphthoflavone · Cytochrome P-450 Enzyme System · Gas Chromatography-Mass Spectrometry · Glutathione · Imines · Kinetics · Male · Microsomes, Liver · Oxidation-Reduction · Rats · Rats, Wistar · Spectrophotometry, Ultraviolet · Animalia · Armoracia rusticana
[Abstract]

7 Report of a workshop on bacterial in vitro mutagenicity test systems
article 1978    
Author: Mattern, I.E. · Greim, H.
Keywords: Biology · 2 Aminoanthracene · 2 Nitrofluorene · Aflatoxin · Aroclor 1254 · Benzo[a]pyrene · Clophen a50 · Cyclophosphamide · Diethylnitrosamine · Dimethylnitrosamine · Mesylic acid ethyl ester · Methylnitronitrosoguanidine · Mitomycin c · N (2 fluorenyl)acetamide · Nitrosomorpholine · Polychlorinated biphenyl · Unclassified drug · Vinylidene chloride · 4 Nitroquinoline · Abstract report · Animal experiment · Bacterium · Benzoflavone · Drug activation · Drug metabolism · Drug screening · Hamster · In vitro study · Liver microsome · Methodology · Mouse · Mutagen testing · Mutagenesis · Rat
[Abstract]

8 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

9 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

10 Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment
article 1996    
Author: Hissink, A.M. · Oudshoorn, M.J. · Ommen, B. van · Haenen, G.R.M.M. · Bladeren, P.J. van
Keywords: 1,2 dichlorobenzene · ascorbic acid · cytochrome p450 · epoxide hydrolase · glutathione · glutathione transferase · isoniazid · phenobarbital · animal cell · animal experiment · article · biotransformation · conjugation · controlled study · covalent bond · human · human cell · hydrolysis · liver microsome metabolism · liver toxicity · male · nonhuman · rat · Animals · Biotransformation · Chlorobenzenes · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Humans · Insecticides · Isoenzymes · Male · Microsomes, Liver · Protein Binding · Rats · Rats, Inbred F344 · Rats, Sprague-Dawley · Rats, Wistar · Risk Assessment · Species Specificity · Spectrophotometry, Ultraviolet · Animalia · Rattus norvegicus
[Abstract]

11 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

12 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

13 Cholestrol content of the rat lens is lowered by administration of simvastatin, but not pravastatin
article 1993    
Author: Vries, A.C.J. de · Vermeer, M.A. · Bredman, J.J. · Bar, P.R. · Cohen, L.H.
Keywords: Pharmacology · 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors · hypocholesterolaemic drugs · antilipemic agent · drug derivative · hydroxymethylglutaryl coenzyme A reductase inhibitor · hypocholesterolemic agent · mevinolin · animal experiment · cholesterol metabolism · oral drug administration · biosynthesis · dose response · drug effect · enzymology · liver microsome · metabolism · organ culture · rat strain · time · Aging · Animal · Anticholesteremic Agents · Antilipemic Agents · Cholesterol · Dose-Response Relationship, Drug · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lens, Crystalline · Lovastatin · Microsomes, Liver · Organ Culture · Pravastatin · Rats · Rats, Wistar · Simvastatin · Time Factors
[Abstract]

14 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

15 Acetoxy drug : Protein transacetylase of buffalo liver - Characterization and mass spectrometry of the acetylated protein product
article 2004    
Author: Kohli, E. · Gaspari, M. · Raj, H.G. · Parmar, V.S. · Sharma, S.K. · Greef, J. van der · Kumari, R. · Gupta, G. · Seema · Khurana, P. · Tyagi, Y.K. · Watterson, A.C. · Olsen, C.E.
Keywords: Chemistry Biology · Analytical research · Acetoxy drug · MALDI-TOF · Protein acetylation · Protein mass spectrometry · Transacetylase · 7,8 diacetoxy 4 methylcoumarin · 7,8 dihydroxy 4 methylcoumarin · acyltransferase · coumarin derivative · liver enzyme · monoacetoxymonohydroxy 4 methylcoumarin · peptide derivative · trypsin · unclassified drug · acetylation · animal cell · article · buffalo · catalysis · enzyme analysis · enzyme purification · liver microsome · mass spectrometry · matrix assisted laser desorption ionization time of flight mass spectrometry · model · molecular weight · nonhuman · peptide mapping · polyacrylamide gel electrophoresis · priority journal · Acetylation · Acetyltransferases · Amino Acid Sequence · Animals · Buffaloes · Coumarins · Glutathione Transferase · Liver · Microsomes, Liver · Molecular Sequence Data · Peptides · Protein Structure, Tertiary · Proteins · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Bubalus
[Abstract]

16 Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450
article 1998    
Author: Bessems, J.G.M. · Groot, M.J. de · Baede, E.J. · Koppele, J.M. te · Vermeulen, N.P.E.
Keywords: Nutrition · Analgesic agent · Cytochrome p450 · Horseradish peroxidase · Hydrogen peroxide · Paracetamol · Reduced nicotinamide adenine dinucleotide phosphate · Analgesia · Animal experiment · Animal tissue · Biotransformation · Catalysis · Drug metabolism · Electron spin resonance · Enzyme activity · Liver microsome · Male · Nonhuman · Oxidation · Rat · Acetaminophen · Animals · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP2B1 · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Electron Spin Resonance Spectroscopy · Free Radicals · Horseradish Peroxidase · Hydrogen · Male · Microsomes, Liver · NADP · Oxidation-Reduction · Rats · Rats, Wistar · Thermodynamics · Animalia · Armoracia rusticana · Rickettsia sp. PAR
[Abstract]

17 Persistent alterations in regional brain glial fibrillary acidic protein and synaptophysin levels following pre- and postnatal polychlorinated biphenyl exposure
article 1996    
Author: Morse, D.C. · Plug, A. · Wesseling, W. · Berg, K.J. van den · Brouwer, A.
Keywords: Toxicology · aroclor 1254 · calcineurin · ethoxyresorufin deethylase · glial fibrillary acidic protein · polychlorinated biphenyl · synaptophysin · animal experiment · animal tissue · article · brain · brain region · brain stem · brain weight · cerebellum · controlled study · corpus striatum · dose response · female · fetus · fetus weight · immunochemistry · liver microsome · male · neurotoxicity · newborn · nonhuman · olfactory tract · prefrontal cortex · pregnancy · rat · sex difference · Animals · Animals, Newborn · Antithyroid Agents · Aroclor 1254 · Aroclors · Biological Markers · Body Weight · Brain · Brain Stem · Ca(2+)-Calmodulin Dependent Protein Kinase · Cerebellum · Cytochrome P-450 CYP1A1 · Female · Glial Fibrillary Acidic Protein · Male · Organ Size · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Reproduction · Synaptophysin · Animalia
[Abstract]

18 Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes
article 2004    
Author: Price, R.J. · Scott, M.P. · Walters, D.G. · Stierum, R.H. · Groten, J.P. · Meredith, C. · Lake, B.G.
Keywords: Nutrition · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · BHT · Butylated hydroxytoluene · CDNB · CH · Cumene hydroperoxide · CYP · Cytochrome P450 · DCNB · Enzyme induction · GSH S-transferase · Rat liver · Thiabendazole · Xenobiotic metabolism · apoprotein · butylcresol · cytochrome P450 1A · cytochrome P450 1A1 · cytochrome P450 1A2 · cytochrome P450 2B · cytochrome P450 2B1 · cytochrome P450 2B2 · glutathione transferase · messenger RNA · tiabendazole · animal cell · animal experiment · article · controlled study · dose response · drug megadose · enzyme activation · enzyme activity · enzyme induction · enzyme metabolism · enzyme substrate · liver microsome metabolism · liver mitochondrion · liver weight · male · nonhuman · nucleotide sequence · protein blood level · rat · xenobiotic metabolism · Acyltransferases · Administration, Oral · Animals · Antinematodal Agents · Antioxidants · Butylated Hydroxytoluene · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Glutathione Transferase · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Thiabendazole
[Abstract]

19 17α-Ethyl-5β-estrane-3α,17β-diol, a biological marker for the abuse of norethandrolone and ethylestrenol in slaughter cattle
article 1999    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, L. · Miert, A.S.J.P.A.M. van · Hendriks, L. · Zande, D.J.M. van der · Adriaensens, P. · Jacobs, M.-P. · Raus, J.
Keywords: Nutrition · 17α-Ethyl-5β-estrane-3α,17β-diol · Ethylestrenol · Norethandrolone · Steroids · Biological marker · Ethylestrenol · Norethandrolone · 17Alpha ethyl 5 xi estrane 3 xi,17 beta diol · Drug derivative · Drug residue · Estradiol · Animal experiment · Animal tissue · Article · Biotransformation · Cattle · Drug abuse · Drug metabolism · Drug monitoring · Feces · Female · Intramuscular drug administration · Liver · Liver cell culture · Male · Nonhuman · Priority journal · Reduction · Urine · Animal · Animal husbandry · Chemistry · High performance liquid chromatography · Liver microsome · Mass fragmentography · Nuclear magnetic resonance spectroscopy · Sensitivity and specificity · Standard · Thin layer chromatography · Ultraviolet spectrophotometry · Biological Markers · Cattle · Chromatography, High Pressure Liquid · Chromatography, Thin Layer · Drug Residues · Estradiol · Ethylestrenol · Gas Chromatography-Mass Spectrometry · Magnetic Resonance Spectroscopy · Male · Microsomes, Liver · Norethandrolone · Reference Standards · Sensitivity and Specificity · Spectrophotometry, Ultraviolet
[Abstract]

20 The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro
article 2005    
Author: Parnham, M.J. · Bogaards, J.J.P. · Schrander, F. · Schut, M.W. · Orešković, K. · Mildner, B.
Keywords: Health Pharmacology · Physiological Sciences · Cytochrome P450 · Metabolism · PLD-118 · 2 amino 4 methylenecyclopentanecarboxylic acid · alpha naphthoflavone · amino acid · antifungal agent · bufuralol · chlorzoxazone · coumarin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2B6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · cytochrome P450 3A · diclofenac · diethyldithiocarbamic acid · ethoxyresorufin · ketoconazole · mephenytoin · monoclonal antibody · monoclonal antibody 2B6 · quinidine · reduced nicotinamide adenine dinucleotide phosphate · resorufin · sulfaphenazole · testosterone · umbelliferone · unclassified drug · unindexed drug · analytic method · animal tissue · article · candidiasis · concentration response · controlled study · derivatization · dog · drug structure · enzyme assay · enzyme inhibition · enzyme stability · enzyme substrate · fluorescence analysis · high performance liquid chromatography · human · human tissue · in vitro study · liver homogenate · liver microsome metabolism · nonhuman · rat · structure analysis · Administration, Oral · Animals · Antifungal Agents · Chemistry, Pharmaceutical · Cycloleucine · Cytochrome P-450 Enzyme System · Dogs · Drug Evaluation, Preclinical · Humans · Microsomes, Liver · Rats · Ribosomal Proteins
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 20 found. | Sort by date