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1 The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI
article 2008    
Author: Hu, L. · Hoogt, C.C. van der · Espirito Santo, S.M.S. · Out, R. · Kypreos, K.E. · Vlijmen, B.J.M. van · Berkel, T.J.C. van · Romijn, J.A. · Havekes, L.M. · Dijk, K.W. van · Rensen, P.C.N.
Keywords: Biology · Apolipoprotein · Denovirus-mediated gene transfer · Lipoprotein lipase · Low density lipoprotein receptor · Low density lipoprotein receptor-related protein · Transgenic mice · Triglyceride-rich emulsion particles · Very low density lipoprotein receptor · apolipoprotein E · cell surface protein · cholesterol · lipoprotein lipase · low density lipoprotein receptor · low density lipoprotein receptor related protein · proteoglycan · proteoheparan sulfate · scavenger receptor BI · triacylglycerol · very low density lipoprotein · very low density lipoprotein receptor · CD36 antigen · ligand · very low density lipoprotein cholesterol · Adenovirus · animal cell · animal experiment · animal tissue · article · cell isolation · cell surface · controlled study · enzyme activity · in vitro study · in vivo study · internalization · lipid analysis · liver cell · male · mouse · nonhuman · priority journal · protein expression · regulatory mechanism · animal · blood · emulsion · genetics · liver · metabolism · mouse mutant · Animals · Antigens, CD36 · Cholesterol, VLDL · Emulsions · LDL-Receptor Related Proteins · Ligands · Lipoprotein Lipase · Liver · Male · Mice · Mice, Knockout · Proteoglycans · Receptors, LDL · Healthy for Life · Healthy Living
[Abstract]

2 Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice
article 2004    
Author: Bovenschen, N. · Dijk, K.W. van · Havekes, L.M. · Mertens, K. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Clearance · Factor VIII · Knockout mice · Low-density lipoprotein receptor-related protein · Very low-density lipoprotein receptor · blood clotting factor 8 · cholesterol · triacylglycerol · very low density lipoprotein receptor · animal experiment · article · catabolism · cholesterol blood level · controlled study · knockout mouse · male · mouse · nonhuman · plasma clearance · priority journal · triacylglycerol blood level · Animals · Factor VIII · Integrases · LDL-Receptor Related Proteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

3 Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
article 2005    
Author: Espirito Santo, S.M.S. · Rensen, P.C.N. · Goudriaan, J.R. · Bensadoun, A. · Bovenschen, N. · Voshol, P.J. · Havekes, L.M. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Apolipoprotein E · Hepatic lipase · Hyperlipidemia · Lipoprotein lipase · Low density lipoprotein receptor · Postprandial response · Transgenic mice · Very low density lipoprotein receptor · Very low density lipoproteins · Lipid · Low density lipoprotein receptor · Low density lipoprotein receptor related protein · Triacylglycerol lipase · Very low density lipoprotein receptor · Leucine responsive regulatory protein · Lipoprotein · Transcription factor · Animal experiment · Animal model · Animal tissue · Controlled study · Female · gene deletion · Hyperlipidemia · Lipid blood level · Lipid diet · Male · Mouse · Nonhuman · Protein defect · Species comparison · Triacylglycerol blood level · Triacylglycerol lipase blood level · Wild type · Chemistry · Genetics · Metabolism · Pathology · Physiology · Polymerase chain reaction · Time · Transgenic mouse · Alleles · Animals · Cholesterol · DNA-Binding Proteins · Genotype · Hyperlipidemias · Leucine-Responsive Regulatory Protein · Lipid Metabolism · Lipoproteins · Mice · Mice, Transgenic · Polymerase Chain Reaction · Receptors, LDL · Time Factors · Transcription Factors · Triglycerides
[PDF] [Abstract]

4 PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE
article 2014    
Author: Ason, B. · Hoorn, J.W.A. van der · Chan, J. · Lee, E. · Pieterman, E.J. · Nguyen, K.K. · Di, M. · Shetterly, S. · Tang, J. · Yeh, W.C. · Schwarz, M. · Jukema, J.W. · Scott, R. · Wasserman, S.M. · Princen, H.M.G. · Jackson, S.
Keywords: Biology · Anti-proprotein convertase subtilisin/kexin type 9 antibody · Apolipoprotein E · Low density lipoprotein receptor · Proprotein convertase subtilisin/kexin type 9 · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

5 Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
article 2004    
Author: Mulder, M. · Jansen, P.J. · Janssen, B.J.A. · Berg, W.D.J. van de · Boom, H. van der · Havekes, L.M. · Kloet, R.E. de · Ramaekers, F.C.S. · Blokland, A.
Keywords: Environment · Alzheimer's disease · Apolipoprotein E · Lipid metabolism · Low-density lipoprotein receptor family · Memory · Low density lipoprotein receptor · Synaptophysin · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Controlled study · Hippocampus · Homozygosity · Knockout mouse · Maze test · Memory disorder · Mouse · Nerve ending · Nonhuman · Spatial memory · Task performance · Wild type · Working memory · Animals · Cell Count · Hippocampus · Male · Maze Learning · Memory Disorders · Mice · Mice, Inbred C57BL · Mice, Knockout · Presynaptic Terminals · Receptors, LDL · Synapses
[Abstract]

6 Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
article 2004    
Author: Espirito Santo, S.M.S. · Pires, N.M.M. · Boesten, L.S.M. · Gerritsen, G. · Bovenschen, N. · Dijk, K.W. van · Jukema, J.W. · Princen, H.M.G. · Bensadoun, A. · Li, W.P. · Herz, J. · Havekes, L.M. · Vlijmen, B.J.M. van
Keywords: Blood clotting factor 8 · Cholesterol · Ligand · Lipoprotein lipase · Liver protein · Low density lipoprotein receptor · Low density lipoprotein receptor related protein · Tissue plasminogen activator · Triacylglycerol · Von Willebrand factor · Animal experiment · Animal model · Animal tissue · Atherogenesis · Cholesterol blood level · Controlled study · Hyperlipoproteinemia type 3 · Liver function · Liver metabolism · Mouse · Nonhuman · Protein deficiency · Triacylglycerol blood level · Animals · Aorta · Apolipoproteins E · Arteriosclerosis · Blood Coagulation Factors · Cholesterol · LDL-Receptor Related Protein 1 · Lipids · Liver · Male · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

7 LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus
article 2007    
Author: Mulder, M. · Koopmans, G. · Wassink, G. · Mansouri, G.A. · Simard, M.-L. · Havekes, L.M. · Prickaerts, J. · Blokland, A.
Keywords: Health · Biomedical Research · Apolipoprotein E · Cholesterol · Low density lipoprotein receptor · Memory · Neurogenesis · Synaptic density · apolipoprotein E · broxuridine · cholesterol · iodine 125 · low density lipoprotein · low density lipoprotein receptor · synaptophysin · Alzheimer disease · animal cell · animal experiment · animal tissue · article · astrocytoma cell · cell proliferation · cholesterol metabolism · concentration response · controlled study · dentate gyrus · hippocampus · knockout mouse · male · memory · mouse · nerve cell plasticity · nerve fiber growth · nervous system development · neuroblastoma cell · nonhuman · pathogenesis · priority journal · spatial memory · synaptogenesis · wild type · Animals · Biological Markers · Bromodeoxyuridine · Cell Count · Cell Line, Tumor · Cell Proliferation · Cholesterol · Dentate Gyrus · Down-Regulation · Hippocampus · Humans · Male · Mice · Mice, Knockout · Neural Pathways · Neuronal Plasticity · Presynaptic Terminals · Receptors, LDL · Synaptophysin
[Abstract]

8 Scavenger Receptor BI Plays a Role in Facilitating Chylomicron Metabolism
article 2004    
Author: Out, R. · Kruijt, J.K. · Rensen, P.C.N. · Hildebrand, R.B. · Vos, P. de · Eck, M. van · Berkel, T.J.C. van
Keywords: Biology · Biomedical Research · Emulsions · Metabolism · Proteins · Cell association · High density lipoproteins (HDL) · Biochemistry · Chylomicron · High density lipoprotein cholesterol · Low density lipoprotein receptor · Low density lipoprotein receptor related protein · Oxidized low density lipoprotein · Scavenger receptor · Scavenger receptor BI · Triacylglycerol · Unclassified drug · Animal cell · Animal experiment · Cholesterol transport · Controlled study · Emulsion · Internalization · Lipid metabolism · Liver cell · Molecular recognition · Mouse · Nonhuman · Postprandial state · Animals · Antigens, CD36 · Binding Sites · Biological Transport · Chylomicron Remnants · Chylomicrons · Emulsions · Hepatocytes · Mice · Mice, Mutant Strains · Receptors, Immunologic · Receptors, Scavenger · Scavenger Receptors, Class B · Tissue Distribution · Triglycerides · Animalia
[PDF] [Abstract]

9 Low-density lipoproteins are degraded in HepG2 cells with low efficiency
article 1993    
Author: Lombardi, P. · Mulder, M. · Wit, E. de · Berkel, T.J.C. van · Frants, R.R. · Havekes, L.M.
Keywords: Low density lipoprotein · Low density lipoprotein receptor · Cell density · Cell fractionation · Comparative study · Density gradient centrifugation · Endosome · Hepatoma cell · Human cell · Internalization · Isotope labeling · Lipoprotein metabolism · Protein degradation · Receptor down regulation · Biological Transport · Cell Aggregation · Cell Line · Cells, Cultured · Down-Regulation · Fibroblasts · Human · Iodine Radioisotopes · Kinetics · Lipoproteins, LDL · Liver · Lysosomes · Receptors, LDL · Support, Non-U.S. Gov't
[Abstract]

10 An acceptor splice site mutation in intron 16 of the low density lipoprotein receptor gene leads to an elongated, internalization defective receptor
article 1993    
Author: Lombardi, P. · Hoffer, M.J.V. · Top, B. · Wit, E. de · Gevers Leuven, J.A. · Frants, R.R. · Havekes, L.M.
Keywords: Denaturating gradient gel electrophoresis · Polymerase chain reaction · Complementary dna · Low density lipoprotein receptor · Case report · Dna sequence · Familial hypercholesterolemia · Gel electrophoresis · Mutation · Pedigree analysis · Polymerase chain reaction · Adult · Amino Acid Sequence · Base Sequence · Cells, Cultured · Electrophoresis · Female · Homozygote · Human · Hypercholesterolemia, Familial · Introns · Molecular Sequence Data · Pedigree · Point Mutation · Reading Frames · Receptors, LDL · RNA Splicing · Sequence Analysis, DNA · Support, Non-U.S. Gov't
[Abstract]

11 Degradation of tissue-type plasminogen activator by human monocyte- derived macrophages is mediated by the mannose receptor and by the low- density lipoprotein receptor-related protein
article 1995    
Author: Noorman, F. · Braat, E.A.M. · Rijken, D.C.
Keywords: Biology · aminocaproic acid · lipopolysaccharide · low density lipoprotein receptor · mannose receptor · receptor protein · tissue plasminogen activator · article · controlled study · hemostasis · human · human cell · macrophage · molecular interaction · normal human · priority journal · protein degradation · receptor affinity · Cell Differentiation · Cells, Cultured · Dexamethasone · Human · LDL-Receptor Related Protein 1 · Lipopolysaccharides · Macrophages · Monocytes · Receptors, Cell Surface · Receptors, Immunologic · Support, Non-U.S. Gov't · Tissue Plasminogen Activator
[Abstract]

12 Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model
article 2017    
Author: Koppen, A. van · Verschuren, L. · Hoek, A.M. van den · Verheij, J. · Morrison, M.C. · Li, K. · Nagabukuro, H. · Costessi, A. · Caspers, M.P.M. · Broek, T.J. van den · Sagartz, J. · Kluft, C. · Beysen, C. · Emson, C. · Gool, A.J. van · Goldschmeding, R. · Stoop, R. · Bobeldijk-Pastorova, I. · Turner, S.M. · Hanauer, G. · Hanemaaijer, R.
Keywords: Biology · ALT, alanine aminotransferase · AST, aspartate aminotransferase · DEG, differentially expressed genes; Diagnosis · ECM, extracellular matrix · HFD, high-fat diet · IPA, Ingenuity Pathway Analysis · LDLr-/-, low-density lipoprotein receptor knock out · Liver Disease; Metabolic Syndrome · NAFLD, nonalcoholic fatty liver disease · NASH, nonalcoholic steatohepatitis · Systems Biology · THBS1, thrombospontin-1 · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

13 Apolipoprotein AV: Low concentration, high impact
article 2005    
Author: Rensen, P.C.N. · Dijk, K.W. van · Havekes, L.M.
Keywords: Biomedical Research · Apolipoprotein A5 · High density lipoprotein · Lipoprotein lipase · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · APOA5 protein, human · Editorial · Enzyme linked immunosorbent assay · Homeostasis · Ischemic heart disease · Lipid metabolism · Nonhuman · Protein assembly · Triacylglycerol blood level · Animal · Blood · Metabolism · Note · Physiology · Animals · Apolipoproteins · Apolipoproteins A · Homeostasis · Humans · Hypertriglyceridemia · Triglycerides
[Abstract]

14 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

15 Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein [2]
article 2007    
Author: Hu, L. · Bovenschen, N. · Havekes, L.M. · Vlijmen, B.J.M. van · Tamsma, J.T.
Keywords: Biology · Biomedical Research · adenovirus vector · beta galactosidase · complementary DNA · liver protein · low density lipoprotein receptor related protein · plasminogen activator inhibitor 1 · protein inhibitor · receptor associated protein · serum amyloid A · animal experiment · animal model · controlled study · half life time · in vivo study · letter · mouse · nonhuman · plasma clearance · priority journal · protein blood level · protein expression · protein function · protein protein interaction · regulatory mechanism · Animals · LDL-Receptor Related Protein 1 · Mice · Mice, Knockout · Pharmacokinetics · Plasminogen Activator Inhibitor 1

16 Predicting individual responses to pravastatin using a physiologically based kinetic model for plasma cholesterol concentrations
article 2014    
Author: Pas, N.C.A. van de · Rullmann, J.A.C. · Woutersen, R.A. · Ommen, B. van · Rietjens, I.M.C.M. · Graaf, A.A. de
Keywords: Biology · Cholesterol · LDL · PBK modeling · Personalized medicine · Statin response · Virtual subjects · cholesterol · High density lipoprotein cholesterol · Low density lipoprotein cholesterol · Low density lipoprotein receptor · Pravastatin · Very low density lipoprotein cholesterol · Cholesterol blood level · Cholesterol synthesis · Drug effect · Drug mechanism · Human · Kinetics · Major clinical study · Monte Carlo method · Physiologically based kinetic · Protein expression · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

17 Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
article 1994    
Author: Knijff, P. de · Maagdenberg, A.M.J.M. van den · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Apolipoprotein (apo) E · Atherosclerosis · Familial Dysbetalipoproteinemia (FD) · Mutations · Polymorphisms · Type III Hyperlipoproteinemia · Cholesterol · Chylomicron · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · Alzheimer disease · Atherosclerosis · Cholesterol blood level · Coronary artery disease · Creutzfeldt jakob disease · Gene mutation · Genetic heterogeneity · Genetic linkage · Genetic polymorphism · Ligand binding · Lipoprotein metabolism · Alleles · Amino Acid Sequence · Base Sequence · DNA · Female · Gene Frequency · Human · Hyperlipidemia · Hyperlipoproteinemia Type III · Lipids · Lipoproteins · Male · Molecular Sequence Data · Mutation · Variation (Genetics)
[Abstract]

18 Different effects of lipopolysaccharide on plasminogen activator inhibitor-1 production in aortic media in vivo and in culture
article 1996    
Author: Leeuwen, R.T.J. van · Quax, P.H.A. · Tippins, J.R. · Antoniw, J.W. · Andreotti, F. · Maseri, A. · Kluft, C. · Sperti, G.
Keywords: Biology · Endotoxin · Plasminogen activator inhibitor-1 · Rabbit · Rat · Smooth muscle · Tissue-type plasminogen activator · alpha 2 macroglobulin · endotoxin · fibrin · lipopolysaccharide · low density lipoprotein receptor · messenger rna · plasminogen activator inhibitor 1 · rna · tissue plasminogen activator · animal cell · animal experiment · animal model · aorta media · article · blood vessel wall · cell culture · cell migration · controlled study · culture medium · gene expression · immunoblotting · intima · metastasis · nonhuman · northern blotting · priority journal · protein degradation · rabbit · rat · spectrophotometry · thrombus · vascular endothelium · vascular smooth muscle
[Abstract]

19 Inhibition of mannose receptor-mediated-clearance of tissue-type plasminogen activator (t-PA) by dextran : A new explanation for its antithrombotic effect
article 1997    
Author: Noorman, F. · Barrett-Bergshoeff, M.M. · Bekkers, M. · Emeis, J.J. · Rijken, D.C.
Keywords: Biology · Anticoagulant agent · Dextran · Dextran 40 · Dextran 70 · Low density lipoprotein receptor · Mannose receptor · Tissue plasminogen activator · Animal experiment · Bolus injection · Controlled study · Deep vein thrombosis · Drug infusion · Drug mechanism · Human · Human cell · Macrophage · Male · Monocyte · Nonhuman · Plasma clearance · Priority journal · Protein blood level · Rat · Thrombogenesis · Acetylgalactosamine · Animals · Cells, Cultured · Depression, Chemical · Dextrans · Fibrinolytic Agents · Glucose · Humans · Lectins, C-Type · Macrophages · Male · Mannose · Mannose-Binding Lectins · Metabolic Clearance Rate · Protein Binding · Rats · Rats, Wistar · Receptors, Cell Surface · Receptors, LDL · Recombinant Proteins · Tissue Plasminogen Activator
[Abstract]

20 Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
article 2015    
Author: Berbeé, J.F.P. · Boon, M.R. · Khedoe, P.P.S.J. · Bartelt, A. · Schlein, C. · Worthmann, A. · Kooijman, S. · Hoeke, G. · Mol, I.M. · John, C. · Jung, C. · Vazirpanah, N. · Brouwers, L.P.J. · Gordts, P.L.S.M. · Esko, J.D. · Hiemstra, P.S. · Havekes, L.M. · Scheja, L. · Heeren, J. · Rensen, P.C.N.
Keywords: Biology · 5 [2 [[2 (3 chlorophenyl) 2 hydroxyethyl]amino]propyl] 1,3 benzodioxole 2,2 dicarboxylic acid · Apolipoprotein E · Cholesterol · Fatty acid · Low density lipoprotein receptor · Triacylglycerol · Bioenergetics · Fat · Fatty acid · Obesity · Plasma · Rodent · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Beta adrenergic stimulation · Brown adipose tissue · Cholesterol blood level · Cholesterol metabolism · Controlled study · Energy expenditure · Fatty acid transport · Female · Hypercholesterolemia · Lipolysis · Liver clearance · Mouse · Triacylglycerol blood level · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 25 found. Next | Sort by date