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1 The ultimate radiochemical nightmare : upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule
article 2015    
Author: Uhm, J.I.M. van · Visser, G.W.M. · Schans, M.J. van der · Geldof, A.A. · Meuleman, E.J.H. · Nieuwenhuijzen, J.A.
Keywords: Botulinum neurotoxin A · Iodine-125 · Monoclonal antibody · PET research · Radio-iodination · Botulinum toxin A · Cetuximab · Cetuximab i 125 · Radiopharmaceutical agent · Unclassified drug · Biological activity · Controlled study · Drug purity · Gel permeation chromatography · High performance liquid chromatography · Human cell · Immunoreactivity · Iodination · Isotope labeling · Luminescence · Radioactivity · Radiochemistry · Reaction time · Thin layer chromatography · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[PDF] [Abstract]

2 Automated synthesis of [18F]gefitinib on a modular system
article 2012    
Author: Läppchen, T. · Vlaming, M.L.H. · Custers, E. · Lub, J. · Sio, C.F. · DeGroot, J. · Steinbach, O.C.
Keywords: Biology · Automated synthesis · Imaging of drug transporters · Modular system · PET tracer · Automated procedures · Automated synthesis · Gefitinib · In-vivo · Modular system · PET tracer · Radiochemical purity · Radiochemical yield · Radiosynthesis · Total synthesis · Transporter proteins · Automation · Biosynthesis · gefitinib f 18 · radiopharmaceutical agent · unclassified drug · analytic method · article · automation · drug purification · drug structure · drug synthesis · high performance liquid chromatography · priority journal · quality control · radiochemistry · radioisotope decay · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
article 2017    
Author: Raaphorst, R.M. · Savolainen, H. · Cantore, M. · Steeg, E. van de · Waarde, A. van · Colabufo, N.A. · Elsinga, P.H. · Lammertsma, A.A. · Windhorst, A.D. · Luurtsema, G.
Keywords: Biology · Apical and basolateral membrane · Bidirectional transport · Blood-brain barrier · Calcein-AM · Tritium labeling · Calcein · Mc 224 f 18 · Mc 225 f 18 · Multidrug resistance protein · N fluoroethylverapamil f 18 · O fluoroethyl norverapamil f 18 · Radiopharmaceutical agent · Unclassified drug · Verapamil c 11 · Animal experiment · Animal tissue · Chemical analysis · Controlled study · Drug accumulation · Drug blood level · Drug brain level · Drug half life · Enzyme inhibition · Fluoroethylation · In vitro study · In vivo study · Isotope labeling · Male · Mouse · Nonhuman · Positron emission tomography · Predictive value · Protein function · Radioactivity · Rat · Synthesis · Transport assay · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

4 PET imaging of disease progression and treatment effects in the experimental autoimmune encephalomyelitis rat model
article 2014    
Author: Paula Faria, D. de · Vlaming, M.L.H. · Copray, S.C.V.M. · Tielen, F. · Anthonijsz, H.J.A. · Sijbesma, J.W.A. · Buchpiguel, C.A. · Dierckx, R.A.J.O. · Hoorn, J.W.A. van der · Vries, E.F.J. de
Keywords: Biology · Demyelination · Multiple sclerosis · Neuroinflammation · PET imaging · Dexamethasone acetate · MeDAS c 11 · Myelin oligodendrocyte glycoprotein · N sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide c 11 · Radiopharmaceutical agent · Unclassified drug · Animal cell · Animal experiment · Animal model · Animal tissue · Brain region · Cell invasion · Controlled study · Demyelination · Disease course · Drug effect · Experimental autoimmune encephalomyelitis · Female · In vivo study · Microglia · Monocyte · Neuroimaging · Nonhuman · PET scanner · Positron emission tomography · Priority journal · Rat · Scoring system · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 4 of 4 found. | Sort by date