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1 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

2 In vitro models for the prediction of in vivo performance of oral dosage forms
article 2014    
Author: Kostewicz, E.S. · Abrahamsson, B. · Brewster, M. · Brouwers, J. · Butler, J. · Carlert, S. · Dickinson, P.A. · Dressman, J. · Holm, R. · Klein, S. · Mann, J. · McAllister, M. · Minekus, M. · Muenster, U. · Müllertz, A. · Verwei, M. · Vertzoni, M. · Weitschies, W. · Augustijns, P.
Keywords: Biology · Biorelevant · In vitro evaluation · In vivo biopharmaceutical performance · Innovative Medicines Initiative (IMI) · Oral Biopharmaceutical Tools (OrBiTo) · Oral drug formulations · Albendazole · Amprenavir · Bile acid · Celecoxib · Cinnarizine · Cyclodextrin · Danazol · Diclofenac · Dipyridamole · Excipient · Gelucire · Ketoconazole · Loviride · Montelukast · Octanol · Propranolol · Saquinavir · Controlled drug release · Drug absorption · Drug bioavailability · Drug development · Drug dosage form · Drug formulation · Drug penetration · Drug solubility · Gastrointestinal motility · Human · Hydrodynamics · In vitro study · In vivo study · Lipolysis · Nonhuman · Precipitation · Prediction · Priority journal · Quality control · Review · Simulation · Tablet disintegration · Food and Nutrition · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · ELSS - Earth, Life and Social Sciences
[Abstract]

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