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Showing 1 to 16 of 16 found. | Sort by date

1 Unraveling toxicological mechanisms and predicting toxicity classes with gene dysregulation networks
article 2013    
Author: Pronk, T.E. · Someren, P. van · Stierum, R.H. · Ezendam, J. · Pennings, J.L.A.
Keywords: Toxicology · Biomarkers · Classification · Network · Regulation · Skin sensitization · Toxicogenomics · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data
article 2014    
Author: Veen, J.W. van der · Soeteman-Hernández, L.G. · Ezendam, J. · Stierum, R. · Kuper, F.C. · Loveren, H. van
Keywords: Biology · Adverse outcome pathway · Allergic contact dermatitis · Human in vitro systems · Mechanisms of toxicity · Molecular map · Skin sensitization · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Peanut allergy: Sensitization by peanut oil-containing local therapeutics seems unlikely [4]
article 2004    
Author: Peeters, K.A.B.M. · Knulst, A.C. · Rynja, F.J. · Bruijnzeel-Koomen, C.A.F.M. · Koppelman, S.J.
Keywords: Nutrition · Food technology · arachis oil · allergenicity · animal experiment · animal model · comparative study · extraction · immunoblotting · letter · mouse · nonhuman · peanut allergy · priority journal · protein analysis · skin allergy · skin sensitization · Animals · Arachis hypogaea · Dermatologic Agents · Drug Contamination · Humans · Immunization · Peanut Hypersensitivity · Plant Oils

4 Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency
article 2013    
Author: Teunis, M. · Corsini, E. · Smits, M. · Madsen, C.B. · Eltze, T. · Ezendam, J. · Galbiati, V. · Gremmer, E. · Krul, C.A.M. · Landin, A. · Landsiedel, R. · Pieters, R. · Rasmussen, T.F. · Reinders, J. · Roggen, E. · Spiekstra, S. · Gibbs, S.
Keywords: Biology · Alternatives To Animal Use · Epidermal Equivalent · Keratinocytes · Prevalidation · Ring Study · Skin Sensitization · Tiered Test · Biomedical Innovation · Healthy Living · Healthy Living Life · HL - Healthy for Life RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social SciencesThemalijn
[Abstract]

5 Mass spectrometric identification of isocyanate-induced modifications of keratins in human skin
article 2015    
Author: Hulst, A.G. · Verstappen, D.R.W. · Riet-van Oeveren, D. van der · Vermeulen, N.P.E. · Noort, D.
Keywords: Adducts · Biomarkers · Exposure assessment · Isocyanates · Keratin · Skin · 2 methacryloyloxethyl isocyanate · 2 nitrophenylisocyanate · 2,6 toluene diisocyanate · 4 bromophenylisocyanate · Allylisocyanate · Biological marker · Elastin · Isocyanic acid derivative · Keratin · Lysine · Methylene diphenyl diisocyanate · Phenethylisocyanate · Pronase · Unclassified drug · Antigenicity · Asthma · Callus · Exposure · Human · Human tissue · Mass spectrometry · Protein analysis · Protein isolation · Protein modification · Skin sensitization · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

6 Toxicokinetics and metabolism
article 2005    
Author: Coecke, S. · Blaauboer, B.J. · Elaut, G. · Freeman, S. · Freidig, A. · Gensmantel, N. · Hoet, P. · Kapoulas, V.M. · Ladstetter, B. · Langley, G. · Leahy, D. · Mannens, G. · Meneguz, A. · Monshouwer, M. · Nemery, B. · Pelkonen, O. · Pfaller, W. · Prieto, P. · Proctor, N. · Rogiers, V. · Rostami-Hodjegan, A. · Sabbioni, E. · Steiling, W. · Sandt, J.J.M. van de
Keywords: Toxicology · Food and Chemical Risk Analysis · cosmetic · acute toxicity · artificial membrane · bioavailability · biotransformation · carcinogenicity · cell line · cell strain CACO 2 · computer model · concentration response · electric resistance · eye irritation · genotoxicity · human · metabolism · nonhuman · phototoxicity · plasma protein binding · practice guideline · priority journal · reproductive toxicity · review · skin absorption · skin sensitization · species difference · toxicokinetics · validation process · Animals · Biotransformation · Consumer Product Safety · Cosmetics · Drug Administration Routes · European Union · Humans

7 Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships
article 2005    
Author: Netzeva, T.I. · Worth, A.P. · Aldenberg, T. · Benigni, R. · Cronin, M.T.D. · Gramatica, P. · Jaworska, J.S. · Kahn, S. · Klopman, G. · Marchant, C.A. · Myatt, G. · Nikolova-Jeliazkova, N. · Patlewicz, G.Y. · Perkins, R. · Roberts, D.W. · Schultz, T.W. · Stanton, D.T. · Sandt, J.J.M. van de · Tong, W. · Veith, G. · Yang, C.
Keywords: Biology · Food and Chemical Risk Analysis · chemical environment · chemical industry · conference paper · decision theory · geometry · mathematical analysis · priority journal · probability · quantitative structure activity relation · skin sensitization · statistical analysis · water contamination · Animal Testing Alternatives · Animals · Education · European Union · Health Planning Guidelines · Quantitative Structure-Activity Relationship · Reproducibility of Results · Toxicity Tests

8 International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity
article 2014    
Author: Teunis, M.A.T. · Spiekstra, S.W. · Smits, M. · Adriaens, E. · Eltze, T. · Galbiati, V. · Krul, C.A.M. · Landsiedel, R. · Pieters, R. · Reinders, J. · Roggen, E. · Corsini, E. · Gibbs, S.
Keywords: Health · Epidermal equivalent · In vitro · NOEL · Sensitizer potency · 1 chloro 2,4 dinitrobenzene · 2 mercaptobenzothiazole · allergen · benzocaine · cinnamaldehyde · citral · cobalt chloride · formaldehyde · interleukin 1alpha · isoeugenol · oxazolone · phenylenediamine · accuracy · assay · controlled study · cytotoxicity · epidermal equivalent sensitizer potency assay · reproducibility · skin sensitization · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

9 Skin sensitisation and epidermal disposition: The relevance of epidermal disposition for sensitisation hazard identification and risk assessment: The report and recommendations of ECVAM workshop 59a
article 2007    
Author: Basketter, D. · Pease, C. · Kasting, G. · Kimber, I. · Casati, S. · Cronin, M. · Diembeck, W. · Gerberick, F. · Hadgraft, J. · Hartung, T. · Marty, J.P. · Nikolaidis, E. · Patlewicz, G. · Roberts, D. · Roggen, E. · Rovida, C. · Sandt, J. van de
Keywords: Food and Chemical Risk Analysis · cosmetic · analytic method · clearance · conference paper · environmental exposure · epidermis cell · gap junction · hazard assessment · immunity · mathematical computing · priority journal · protein binding · risk assessment · sensitization · skin sensitization · steady state · theoretical model · Allergens · Animal Testing Alternatives · Animals · Cells, Cultured · Guidelines · Humans · Risk Assessment · Skin · Skin Absorption · Skin Tests · Toxicity Tests

10 Safety evaluation of β-glucanase derived from Trichoderma reesei: Summary of toxicological data
article 1995    
Author: Coenen, T.M.M. · Schoenmakers, A.C.M. · Verhagen, H.
Keywords: Toxicology · barlican · beta glucan hydrolase · unclassified drug · animal experiment · article · chicken · chronic toxicity · controlled study · eye irritation · female · guinea pig · male · mutagenicity · nonhuman · rabbit · rat · skin irritation · skin sensitization · Administration, Oral · Animal · Animal Feed · beta-Glucosidase · Biological Products · Chickens · CHO Cells · Dermatitis, Contact · Environmental Exposure · Female · Food Additives · Guinea Pigs · Hamsters · Lethal Dose 50 · Male · Mutagenicity Tests · No-Observed-Adverse-Effect Level · Rabbits · Rats · Rats, Wistar · Salmonella typhimurium · Toxicity Tests · Trichoderma · Animalia · Cavia porcellus · Gallus gallus · Hypocrea jecorina · Oryctolagus cuniculus · Sus scrofa · Trichoderma
[Abstract]

11 Respiratory Allergy to Trimellitic Anhydride in Rats: Concentration-Response Relationships during Elicitation
article 2004    
Author: Arts, J.H.E. · Koning, M.W. de · Bloksma, N. · Kuper, C.F.
Keywords: Biology · Toxicology and Applied Pharmacology · drug vehicle · immunoglobulin E · methacholine · trimellitic anhydride · airway dynamics · animal experiment · animal model · animal tissue · article · breathing pattern · breathing rate · concentration response · controlled study · female · histopathology · immunoglobulin blood level · inhalation · larynx · larynx injury · lung · lung weight · nonhuman · priority journal · rat · respiratory tract allergy · skin sensitization · squamous cell metaplasia · tidal volume · trachea · Administration, Inhalation · Allergens · Animals · Body Weight · Bronchial Provocation Tests · Dose-Response Relationship, Drug · Female · Immunoglobulin E · Lung · Methacholine Chloride · No-Observed-Adverse-Effect Level · Organ Size · Phthalic Anhydrides · Rats · Rats, Inbred BN · Rats, Wistar · Respiratory Function Tests · Respiratory Hypersensitivity · Animalia · Rattus norvegicus
[Abstract]

12 The respiratory local lymph node assay as a tool to study respiratory sensitizers
article 2008    
Author: Arts, J.H.E. · Jong, W.H. de · Triel, J.J. van · Schijf, M.A. · Klerk, A. de · Loveren, H. van · Kuper, C.F.
Keywords: Health · Toxicology and Applied Pharmacology · Contact allergy · LLNA · Potency · Respiratory allergy · Sensitizers · 1 chloro 2,4 dinitrobenzene · allergen · formaldehyde · hexamethylene diisocyanate · isophorone · oxazolone · phthalic anhydride · salicylic acid methyl ester · trimellitic anhydride · airway · animal experiment · article · cell proliferation · concentration response · contact allergy · controlled study · histopathology · local lymph node assay · male · molecular weight · mouse · nonhuman · respiratory tract allergy · respiratory tract examination · skin sensitization · toxicity testing · Animals · Body Weight · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Local Lymph Node Assay · Male · Mass Spectrometry · Mice · Mice, Inbred BALB C · Organ Size · Particle Size · Respiratory System · Mus
[Abstract]

13 Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy?
article 2007    
Author: Peeters, K.A.B.M. · Koppelman, S.J. · Hoffen, E. van · Tas, C.W.H. van der · Hartog Jager, C.F. den · Penninks, A.H. · Hefle, S.L. · Bruijnzeel-Koomen, C.A.F.M. · Knol, E.F. · Knulst, A.C.
Keywords: Health · Food technology · Ara h 1 · Ara h 2 · Ara h 3 · Ara h 6 · DBPCFC · Eliciting dose · IgE-immunoblot · Peanut allergy · Purified allergen · SPT · allergen · adolescent · adult · aged · allergic reaction · article · clinical article · controlled study · disease severity · female · human · immunoblotting · male · peanut allergy · prick test · priority journal · skin sensitization · symptom · Adolescent · Adult · Aged · Allergens · Dose-Response Relationship, Immunologic · Double-Blind Method · Female · Glycoproteins · Humans · Immunoglobulin E · Male · Middle Aged · No-Observed-Adverse-Effect Level · Peanut Agglutinin · Peanut Hypersensitivity · Plant Proteins · Predictive Value of Tests · Skin · Skin Tests · Statistics, Nonparametric
[Abstract]

14 Xenobiotic metabolism in human skin and 3D human skin reconstructs: A review
article 2007    
Author: Gibbs, S. · Sandt, J.J.M. van de · Merk, H.F. · Lockley, D.J. · Pendlington, R.U. · Pease, C.K.
Keywords: Biology · 3D skin reconstructs · Cytochrome P450 · IDO expression · In vitro skin absorption · Microarray · Peptidases · 1 chloro 2,4 dinitrobenzene · 2 nitro 1,4 phenylenediamine · 4 aminophenol · alcohol dehydrogenase · aldehyde dehydrogenase · alpha tocopherol · atrazine · azo reductase · carnitine · cinnamaldehyde · cinnamyl alcohol · clobetasol propionate · cytochrome P450 · esterase · hydrogen peroxide · messenger RNA · nicotinic acid ethyl ester · oxygenase · phenylenediamine · propoxur · propranolol · resorufin · retinoic acid · retinol palmitate · T 2 toxin · toxic substance · triclosan · triolein · unindexed drug · xenobiotic agent · biotransformation · chemical carcinogenesis · environmental exposure · enzyme assay · ex vivo study · human · immunohistochemistry · in vitro study · nonhuman · Northern blotting · occupational exposure · protein expression · protein function · review · skin absorption · skin allergy · skin cancer · skin carcinogenesis · skin inflammation · skin sensitization · skin toxicity · toxicokinetics · Western blotting · xenobiotic metabolism · Biotransformation · Humans · Models, Biological · Skin · Xenobiotics
[Abstract]

15 Dose-response relationships and threshold levels in skin and respiratory allergy
article 2006    
Author: Arts, J.H.E. · Mommers, C. · Heer, C.de
Keywords: Health · Toxicology and Applied Pharmacology · Dose-Response · Elicitation · Respiratory Allergy · Sensitization · Skin Allergy · 1 chloro 2,4 dinitrobenzene · 1 fluoro 2,4 dinitrobenzene · acid anhydride · aldehyde · benzocaine · bronopol · chlorocresol · cytokine · dichromate potassium · diethylamine · ethylene · eugenol · formaldehyde · geraniol · glutaraldehyde · immunoglobulin E antibody · isocyanic acid derivative · isoeugenol · kathon cg · linalool · methacrylic acid derivative · myristic acid isopropyl ester · nickel · oxazolone · phthalic anhydride · rubber · subtilisin · toluene diisocyanate · tuberculin · unindexed drug · airway obstruction · analytic method · antigen specificity · CD4+ T lymphocyte · clinical study · concentration (parameters) · Dermatophagoides farinae · Dermatophagoides pteronyssinus · dose response · expiratory flow · exposure · forced expiratory volume · guinea pig · human · hypersensitivity reaction · Langerhans cell · nonhuman · occupational asthma · occupational hazard · respiratory tract allergy · review · safety · sensitivity analysis · skin allergy · skin defect · skin irritation · skin sensitization · skin test · urticaria · Allergens · Animals · Dermatitis, Allergic Contact · Dose-Response Relationship, Drug · Guidelines · Humans · Molecular Weight · No-Observed-Adverse-Effect Level · Occupational Exposure · Respiratory Hypersensitivity · Risk Assessment · Skin Tests · Animalia · Cavia porcellus · Dermatophagoides farinae · Dermatophagoides pteronyssinus
[Abstract]

16 The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
article 2008    
Author: Kuper, C.F. · Stierum, R.H. · Boorsma, A. · Schijf, M.A. · Prinsen, M. · Bruijntjes, J.P. · Bloksma, N. · Arts, J.H.E.
Keywords: Health · Dinitrochlorobenzene · LLNA · MCP-1 · MIP1-beta · Respiratory allergy · Skin allergy · 1 chloro 2,4 dinitrobenzene · CD4 antigen · immunoglobulin G · macrophage inflammatory protein 1beta · monocyte chemotactic protein 1 · monocyte chemotactic protein 3 · thymus and activation regulated chemokine · animal experiment · animal model · animal tissue · article · controlled study · female · lung function · lung lavage · lung parenchyma · male · microarray analysis · nonhuman · Norway · nucleotide sequence · priority journal · rat · respiratory tract allergy · skin allergy · skin irritation · skin sensitization · Th2 cell · upregulation · Administration, Cutaneous · Allergens · Animals · Dermatitis, Allergic Contact · Dinitrochlorobenzene · Female · Immunoglobulin E · Immunoglobulin G · Inhalation Exposure · Irritants · Local Lymph Node Assay · Lung · Lymph Nodes · Male · Rats · Rats, Inbred BN · Rats, Wistar · Respiratory Function Tests · Respiratory Hypersensitivity · Th2 Cells · Animalia · Rattus · Rattus norvegicus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 16 of 16 found. | Sort by date