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1 Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: State of the science
article 2010    
Author: Breier, J.M. · Gassmann, K. · Kayser, R. · Stegeman, H. · Groot, D.de · Fritsche, E. · Shafer, T.J.
Keywords: Biology · Biotechnology · Cell culture · Developmental neurotoxicity screening · High-throughput screening · Neuroprogenitor cells · Neurosphere · Stem cell
[Abstract]

2 The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man
article 2010    
Author: Louisse, J. · Jong, E. de · Sandt, J.J.M. van de · Blaauboer, B.J. · Woutersen, R.A. · Piersma, A.H. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Nutrition · Biomedical Research · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Glycol ethers · Physiologically based kinetic modeling
[Abstract]

3 Adipose stem cells for intervertebral disc regeneration: Current status and concepts for the future: Tissue Engineering Review Series
article 2008    
Author: Hoogendoorn, R.J.W. · Lu, Z.F. · Kroeze, R.J. · Bank, R.A. · Wuisman, P.I. · Helder, M.N.
Keywords: Adipose tissue · Intervertebral disc degeneration · Mesenchymal stem cells · Regeneration · Scaffold · Stem cell selection · Adipocyte · In vitro study · Intervertebral disk · Mesenchymal stem cell transplantation · Pathology · Pathophysiology · Spine disease · Spine fusion · Tissue engineering · Transplantation · Adipocytes · Animals · Humans · Intervertebral Disk · Mesenchymal Stem Cell Transplantation · Regeneration · Spinal Diseases · Spinal Fusion · Tissue Engineering · Animalia · Capra hircus
[PDF] [Abstract]

4 Factors determining cell killing by chemotherapeutic agents In Vivo-II : Melphalan, chlorambucil and nitrogen mustard
article 1971    
Author: Putten, L.M. van · Lelieveld, P.
Keywords: Drug effect · female · hematopoietic stem cell · metabolism · Animal · Bone Marrow · Bone Marrow Cells · Cell Survival · Chlorambucil · Cyclophosphamide · DNA · Female · Hematopoietic Stem Cells · Male · Mechlorethamine · Melphalan · Mice · Spleen
[Abstract]

5 Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay
article 2012    
Author: Strikwold, M. · Woutersen, R.A. · Spenkelink, B. · Punt, A. · Rietjens, I.M.C.M.
Keywords: Alternative toxicity testing · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · Potency ranking · Substituted phenols · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

6 Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity
article 2011    
Author: Louisse, J. · Gönen, S. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Pharmacology · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · In vitro · Retinoids · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 Oral polymorphonuclear neutrophil characteristics in relation to oral health: A cross-sectional, observational clinical study
article 2016    
Author: Rijkschroeff, P. · Jansen, I.D.C. · Weijden, F.A. van der · Keijser, B.J.F. · Loos, B.G. · Nicu, E.A.
Keywords: Biology · Mesenchymal stem cell · Multi-differentiation · Myoblast · Oral mucosa · Three-dimensional culture · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants
article 2013    
Author: Piersma, A.H. · Bosgra, S. · Duursen, M.B.M. van · Hermsen, S.A.B. · Jonker, L.R.A. · Kroese, E.D. · Linden, S.C. van der · Man, H. · Roelofs, M.J.E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Westerhout, J. · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative assay · Aromatase · CALUX · Embryonic stem cell test · ReProGlo · Test battery · Toxicokinetics · Zebrafish embryotoxicity assay · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[Abstract]

9 Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human
article 2013    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Biology · Alternative for animal testing · Embryonic stem cell test (EST) · In vitro-in vivo (IVIV) extrapolation · Phenol · Physiologically based kinetic (PBK) modelling · Risk assessment · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

10 In vitro proliferation of haemopoietic cells in the presence of adherent cell layers. I. Culture conditions and strain dependence
article 1979    
Author: Reimann, J. · Burger, H.
Keywords: Animal · Bone Marrow Cells · Cell Division · Cells, Cultured · Colony-Forming Units Assay · Hematopoietic Stem Cell Transplantation · Hematopoietic Stem Cells · Mice · Mice, Inbred BALB C · Mice, Inbred C3H · Mice, Inbred Strains · Time Factors · Transplantation, Homologous · Transplantation, Isogeneic
[Abstract]

11 Factors affecting the transduction of pluripotent hematopoietic stem cells: Long-term expression of a human adenosine deaminase gene in mice
article 1993    
Author: Einerhand, M.P.W. · Bakx, T.A. · Kukler, A. · Valerio, D.
Keywords: Adenosine deaminase · Interleukin 1alpha · Interleukin 3 · Animal cell · Bone marrow cell · Cell transplantation · Colony forming unit s · Controlled study · Gene expression · Gene transfer · Genetic transduction · Hematopoietic stem cell · Human · Mouse · Nonhuman · Retrovirus · Adenosine Deaminase · Animal · Bone Marrow · Bone Marrow Cells · Bone Marrow Transplantation · Cells, Cultured · Fluorouracil · Gene Expression · Genetic Vectors · Hematopoietic Cell Growth Factors · Hematopoietic Stem Cells · Interleukin-1 · Interleukin-3 · Mice · Mice, Inbred C57BL · Mice, Inbred CBA · Retroviridae · Spleen · Stem Cell Factor · Transfection
[Abstract]

12 Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds
article 2009    
Author: Jong, E. de · Louisse, J. · Verwei, M. · Blaauboer, B.J. · Sandt, J.J.M. van de · Woutersen, R.A. · Rietjens, I.M.C.M. · Piersma, A.H.
Keywords: Chemistry · Toxicology and Applied Pharmacology · Alternatives to animal testing · Developmental toxicology · Embryonic stem cells · Glycol ethers · butoxyacetic acid · ethoxyacetic acid · glycol ether alkoxy acid metabolite · methoxyacetic acid · phenoxyacetic acid · toxin · unclassified drug · animal cell · article · cell differentiation · chemical analysis · chemical structure · concentration response · controlled study · cytotoxicity test · developmental disorder · developmental toxicity · embryonic stem cell · embryonic stem cell test · embryotoxicity · heart muscle cell · in vivo study · mouse · nonhuman · sensitivity analysis · toxicokinetics · Animal Testing Alternatives · Animals · Biotransformation · Cell Differentiation · Cell Survival · Dose-Response Relationship, Drug · Embryonic Development · Embryonic Stem Cells · Glycols · Kinetics · Mice · Models, Statistical · Myocytes, Cardiac · Predictive Value of Tests · Reference Standards · Structure-Activity Relationship · Teratogens · Animalia
[Abstract]

13 Vascular Growth in Ischemic Limbs: A Review of Mechanisms and Possible Therapeutic Stimulation
article 2008    
Author: Weel, V. van · Tongeren, R.B. van · Hinsbergh, V.W.M. van · Bockel, J.H. van · Quax, P.H.A.
Keywords: Health · Biomedical Research · adenovirus vector · angiogenic factor · fibrin · fibroblast growth factor · fibroblast growth factor 4 · granulocyte macrophage colony stimulating factor · placebo · plasmid vector · protein · scatter factor · vasculotropin · vasculotropin 121 · vasculotropin 165 · vasculotropin A · vasculotropin C · angiogenesis · autologous bone marrow transplantation · bone marrow · Buerger disease · cell therapy · clinical trial · comprehension · coronary artery disease · diabetes mellitus · gene therapy · human · immune system · inflammatory cell · intermittent claudication · introspection · limb ischemia · neovascularization (pathology) · nonhuman · pain · peripheral occlusive artery disease · priority journal · review · stem cell · stenosis · stimulation · Angiogenesis Inducing Agents · Animals · Collateral Circulation · Gene Therapy · Humans · Ischemia · Leg · Neovascularization, Physiologic · Stem Cell Transplantation · Vascular Endothelial Growth Factor A
[Abstract]

14 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context
article 2015    
Author: Kroese, E.D. · Bosgra, S. · Buist, H.E. · Lewin, G. · Linden, S.C. van der · Man, H.Y. · Piersma, A.H. · Rorije, E. · Schulpen, S.H.W. · Schwarz, M. · Uibel, F. · Vugt-Lussenburg, B.M.A. van · Wolterbeek, A.P.M. · Burg, B. van der
Keywords: Biology · Alternative model · CALUX · Developmental toxicity · Embryonic stem cell test · Grouping · Read across · ReProGlo · Zebrafish embryotoxicity assay · 2 ethylhexanoic acid · 2 methylhexanoic acid · Dibutyltin dichloride · monobutyltin trichloride · Monoethylhexyl phthalate · Monomethyl phthalate · Toxic substance · Tributyltin chloride · Unclassified drug · Valproic acid · Analytic method · Animal cell · Assay · CALUX battery · Chemical analysis · Chemical procedures · Chemical structure · Controlled study · Developmental toxicity · Dosimetry · Embryonic stem cell test · Embryotoxicity · Fertilization · In vitro study · Morphology · Mouse · Nonhuman · ReProGlo assay · Toxicokinetics · Zebrafish embryotoxicity test · Animalia · Danio rerio · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate
article 2009    
Author: Dartel, D.A.M. van · Pennings, J.L.A. · Hendriksen, P.J.M. · Schooten, F.J. van · Piersma, A.H.
Keywords: Alternative test method · Differentiation · Embryonic stem cells · Monobutyl phthalate · Transcriptomics · monobutyl phthalic acid · oligonucleotide · phthalic acid · RNA · Unclassified drug · Animal cell · Cell differentiation · Cell proliferation · Controlled study · Embryonic stem cell · Gene control · Heart muscle cell · Mesoderm · Microarray analysis · Modulation · Mouse · Nonhuman · Pluripotent stem cell · Animals · Cell Differentiation · Cell Proliferation · Cells, Cultured · Dose-Response Relationship, Drug · Embryonic Stem Cells · Gene Expression Profiling · Gene Expression Regulation, Developmental · Gene Regulatory Networks · Mice · Muscle Contraction · Myocytes, Cardiac · Oligonucleotide Array Sequence Analysis · Phthalic Acids · Risk Assessment · Time Factors · Toxicity Tests
[Abstract]

16 Endogenous collagen influences differentiation of human multipotent mesenchymal stromal cells
article 2010    
Author: Fernandes, H. · Mentink, A. · Bank, R. · Stoop, R. · Blitterswijk, C. van · Boer, J. de
Keywords: Biology · Biomedical Research · Adipogenesis · Adipogenic · Ascorbic acids · Bone formation · Chondrogenesis · Chondrogenic · Collagen synthesis · Collagen type I · Collagenous matrix · Expansion phase · Extracellular matrices · Gene expression profiling · In-line · In-vitro · In-vivo · Matrix remodeling · Mesenchymal stromal cells · Multipotent cells · Osteoclastogenesis · Osteogenesis · Osteogenic · Proliferation rate · Stem cell · Cell culture · Collagen · Ketones · Organic acids · Stem cells · Gene expression
[Abstract]

17 Predominant recognition of species-specific determinants of the GroES homologues from Mycobacterium leprae and M. tuberculosis
article 1998    
Author: Chua-Intra, B. · Ivanyi, J. · Hills, A. · Thole, J. · Moreno, C. · Vordermeier, H.M.
Keywords: Health · Animal experiment · Animal model · Antibody specificity · Antigen recognition · Bacterial membrane · Controlled study · Delayed hypersensitivity · Hybridoma · Mouse · Mycobacterium leprae · Mycobacterium tuberculosis · Nonhuman · Pleura fluid · Species difference · Stem cell · Amino Acid Sequence · Animals · Antigens, Bacterial · B-Lymphocytes · Chaperonin 10 · Epitope Mapping · Epitopes · Female · H-2 Antigens · Mice · Mice, Inbred Strains · Mycobacterium leprae · Mycobacterium tuberculosis · Peptide Fragments · Species Specificity · T-Lymphocytes
[Abstract]

18 Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
article 2006    
Author: Verwei, M. · Burgsteden, J.A. van · Krul, C.A.M. · Sandt, J.J.M. van de · Freidig, A.P.
Keywords: Biology · Biomedical Research · Alternative test method · Developmental toxicity · Embryonic stem cells · PBPK model · 2 ethoxyethanol · 2 methoxyethanol · acetic acid derivative · ethoxyacetic acid · fluorouracil · methotrexate · methoxyacetic acid · retinoic acid · unclassified drug · animal cell · article · computer model · controlled study · embryo · embryo development · embryonic stem cell · embryotoxicity · exposure · metabolism · mouse · nonhuman · prediction · priority journal · risk assessment · rodent · Animal Testing Alternatives · Animals · Cell Line · Cell Survival · Dose-Response Relationship, Drug · Embryo · Mice · Models, Biological · Predictive Value of Tests · Rats · Risk Assessment · Stem Cells · Teratogens · Toxicity Tests · Rodentia
[Abstract]

19 Differential effects of bone morphogenetic protein-2 and transforming growth factor-β1 on gene expression of collagen-modifying enzymes in human adipose tissue-derived mesenchymal stem cells
article 2009    
Author: Knippenberg, M. · Helder, M.N. · Doulabi, B.Z. · Bank, R.A. · Wuisman, P.I.J.M. · Klein-Nulend, J.
Keywords: Biology · Biomedical Research · Adipose tissue · Alkaline phosphatase activity · Bone morphogenetic protein-2 · Bone tissue · Bone tissue engineering · Differential effect · Extracellular matrices · Growth factor · Human adipose tissue · Hydroxylases · Lysyl oxidase · Mesenchymal stem cell · Osteogenic differentiation · Physical and mechanical properties · Post-translational modifications · Procollagen · Transforming growth factors · Type I collagen · Bioactivity · Biomechanics · Bone · Catalysts · Cell culture · Cells · Collagen · Enzyme activity · Enzyme inhibition · Enzymes · Flowcharting · Gene expression · Mechanical properties · Peptides · Tissue engineering
[Abstract]

20 Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo
article 2015    
Author: Higuera, G.A. · Fernandes, H. · Spitters, T.W.G.M. · Peppel, J. van de · Aufferman, N. · Truckenmueller, R. · Escalante · Stoop, R. · Leeuwen, J.P. van · Boer, J. de · Subramaniam, V. · Karperien, M. · Blitterswijk, C. van · Boxtel, A. van · Moroni, L.
Keywords: Biology · Angiogenesis · ECM (extracellular matrix) · Mesenchymal stromal cells · Microarchitecture · Molecular gradients · Blood vessels · Cell death · Cell proliferation · Cells · Cytology · Flowcharting · Gene expression · Genes · Nutrients · Cell culture · Hypocalcin · Animal cell · Animal experiment · Bone marrow derived mesenchymal stem cell · Cell adhesion · Controlled study · Hypoxia · In vitro study · In vivo study · Mouse · Nonhuman · Nutrient availability · Nutrient limitation · Phenotype · Protein expression · Spatiotemporal analysis · Surface area · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 27 found. Next | Sort by date