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1 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3
article 2003    
Author: Laan, W.H. van der · Quax, P.H.A. · Seemayer, C.A. · Huisman, L.G.M. · Pieterman, E.J. · Grimbergen, J.M. · Verheijen, J.H. · Breedveld, F.C. · Gay, R.E. · Gay, S. · Huizinga, T.W.J. · Pap, T.
Keywords: Adenoviridae · Animals · Arthritis, Rheumatoid · Cartilage, Articular · Cell Division · Fibroblasts · Gene Expression · Gene Therapy · Genetic Vectors · Humans · Matrix Metalloproteinases · Mice · Mice, SCID · Synovial Membrane · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Adenoviridae · Animalia
[Abstract]

2 Temporal changes in collagen composition and metabolism during rodent palatogenesis
article 2000    
Author: Mansell, J.P. · Kerrigan, J. · McGill, J. · Bailey, J. · TeKoppele, J. · Sandy, J.R.
Keywords: Biomedical Research · Collagen · Cross-linking · Matrix metalloproteinase · MMP · Palate · TIMP · gelatinase A · pyridinium derivative · pyridinoline · stromelysin · tissue inhibitor of metalloproteinase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · animal experiment · animal tissue · article · calcification · collagen metabolism · collagen synthesis · controlled study · cross linking · embryo · embryo development · enzyme activity · extracellular matrix · fetus · mouse · nonhuman · ossification · palate · priority journal · Animal · Calcification, Physiologic · Collagen · Cross-Linking Reagents · Embryo and Fetal Development · Female · Gelatinase A · Male · Palate · Rats · Rats, Wistar · Stromelysin 1 · Tissue Inhibitor-of Metalloproteinase-2 · Tissue-Inhibitor of Metalloproteinase-1 · Rodentia · Trixis
[Abstract]

3 Matrix metalloproteinases in premature coronary atherosclerosis: influence of inhibitors, inflammation, and genetic polymorphisms
article 2007    
Author: Nanni, S. · Melandri, G. · Hanemaaijer, R. · Cervi, V. · Tomasi, L. · Altimari, A. · Lent, N. van · Tricoci, P. · Bacchi, L. · Branzi, A.
Keywords: Health · Biomedical Research · biological marker · gelatinase A · gelatinase B · glucose · haptoglobin · matrix metalloproteinase · stromelysin · tissue inhibitor of metalloproteinase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · adult · article · controlled study · coronary artery atherosclerosis · correlation analysis · enzyme activity · enzyme blood level · exon · genetic polymorphism · glucose blood level · human · human tissue · inflammation · major clinical study · male · metabolic disorder · pathogenesis · priority journal · protein expression · protein localization
[Abstract]

4 Extracellular matrix components and regulators in the airway smooth muscle in asthma
article 2008    
Author: Araujo, B.B. · Dolhnikoff, M. · Silva, L.F.F. · Elliot, J. · Lindeman, J.H.N. · Ferreira, D.S. · Mulder, A. · Gomes, H.A.P. · Fernezlian, S.M. · James, A. · Mauad, T.
Keywords: Airway smooth muscle · Extracellular matrix · Fatal asthma · Metalloproteinases · Remodelling · Tissue inhibitor of metalloproteinase · Adolescent · Adult · Asthma · Bronchi · Case-Control Studies · Extracellular Matrix · Female · Humans · Male · Matrix Metalloproteinases · Middle Aged · Muscle, Smooth · Tissue Inhibitor of Metalloproteinases
[Abstract]

5 A novel and simple immunocapture assay for determination of gelatinase-B (MMP-9) activities in biological fluids : Saliva from patients with Sjögren's syndrome contain increased latent and active gelatinase-B levels
article 1998    
Author: Hanemaaijer, R. · Visser, H. · Konttinen, Y.T. · Koolwijk, P. · Verheijen, J.H.
Keywords: Health · Activity assay · Gelatinase B · Matrix metalloproteinases (MMP) · Sjogren's syndrome · Urokinase · Animals · Antibodies, Monoclonal · Antibody Specificity · Collagenases · Female · Humans · Immunoassay · Matrix Metalloproteinase 9 · Mice · Mice, Inbred BALB C · Saliva · Sensitivity and Specificity · Sjogren's Syndrome · Tissue Inhibitor of Metalloproteinase-2 · Animalia
[Abstract]

6 Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix
article 2003    
Author: Collen, A. · Hanemaaijer, R. · Lupu, F. · Quax, P.H.A. · Lent, N. van · Grimbergen, J. · Peters, E. · Koolwijk, P. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Adenoviridae · Aprotinin · Cells, Cultured · Collagen · Culture Media · Defective Viruses · Drug Synergism · Endothelial Growth Factors · Endothelium, Vascular · Fibrin · Fibroblast Growth Factor 2 · Genetic Vectors · Heart Diseases · Humans · Intercellular Signaling Peptides and Proteins · Lymphokines · Matrix Metalloproteinase 1 · Matrix Metalloproteinase 2 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Neovascularization, Pathologic · Neovascularization, Physiologic · Phenylalanine · Protease Inhibitors · Thiophenes · Thrombosis · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Tumor Necrosis Factor-alpha · Vascular Endothelial Growth Factor A · Vascular Endothelial Growth Factors
[Abstract]

7 MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
article 2005    
Author: Tchetverikov, I. · Lohmander, L.S. · Verzijl, N. · Huizinga, T.W.J. · TeKoppele, J.M. · Hanemaaijer, R. · Groot, J. de
Keywords: Biomedical Research · alpha 2 macroglobulin · interstitial collagenase · matrix metalloproteinase · prointerstitial collagenase · prostromelysin · stromelysin · tissue inhibitor of metalloproteinase 3 · unclassified drug · arthritis · controlled study · enzyme activation · enzyme activity · enzyme inhibition · human · immunoassay · joint injury · knee · major clinical study · osteoarthritis · priority journal · protein determination · pseudogout · quantitative analysis · synovial fluid level · Acute Disease · Adult · alpha-Macroglobulins · Arthritis · Chondrocalcinosis · Cross-Sectional Studies · Female · Humans · Knee Injuries · Male · Matrix Metalloproteinases · Middle Aged · Osteoarthritis, Knee · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

8 Effect of the anti-tumor necrosis factor-α antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease
article 2007    
Author: Meijer, M.J. · Mieremet-Ooms, M.A.C. · Duijn, W. van · Zon, A.M. van der · Hanemaaijer, R. · Verheijen, J.H. · Hogezand, R.A. van · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biomedical Research · Inflammatory bowel disease · Infliximab · Matrix metalloproteinase · Tissue inhibitor of metalloproteinase · Tumor necrosis factor-alpha · azathioprine · cyclosporin · gelatinase A · gelatinase B · infliximab · interstitial collagenase · mesalazine · messenger RNA · pokeweed mitogen · steroid · stromelysin · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · tumor necrosis factor alpha antibody · adolescent · adult · aged · article · clinical article · controlled study · Crohn disease · drug effect · enteritis · explant · female · genotype · human · human tissue · intestine mucosa · male · priority journal · protein degradation · protein expression · single nucleotide polymorphism · ulcerative colitis · Adolescent · Adult · Aged · Antibodies, Monoclonal · Colitis, Ulcerative · Crohn Disease · Down-Regulation · Female · Humans · Intestinal Mucosa · Male · Matrix Metalloproteinases · Middle Aged · Phenotype · Polymorphism, Single Nucleotide · Reverse Transcriptase Polymerase Chain Reaction · Tissue Culture Techniques · Tissue Inhibitor of Metalloproteinases · Tumor Necrosis Factor-alpha
[Abstract]

9 A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
article 2010    
Author: Eefting, D. · Seghers, L. · Grimbergen, J.M. · Vries, M.R. de · Boer, H.C. de · Lardenoye, J.W.H.P. · Jukema, J.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Health · Biomedical Research · Gene therapy · Matrix metalloproteinases · Plasmin(ogen) · Vascular surgery · Vein graft disease · apolipoprotein E3 · aprotinin · hybrid protein · matrix metalloproteinase · matrix metalloproteinase inhibitor · plasmin · plasmin inhibitor · plasminogen activator · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 1 amino terminal fragment of urokinase type plasminogen activator bovine pancreas trypsin inhibitor · unclassified drug · urokinase receptor · animal cell · animal experiment · animal model · animal tissue · article · carotid artery · cell surface · controlled study · electroporation · expression vector · female · gene overexpression · gene targeting · genetic transfection · human · human tissue · hypercholesterolemia · in vivo culture · intima · male · mouse · nonhuman · nonviral gene delivery system · priority journal · vein graft disease
[Abstract]

10 Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer
article 2006    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Duijn, W. van · Griffioen, G. · Hanemaaijer, R. · Velde, C.J.H. van de · Krieken, J.H.J.M. van · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Health · Biomedical Research · Gelatinases · MMP-7 · MMP-8 · MMP-9 · TIMP · Tissue inhibitor of metalloproteinases · gelatinase A · gelatinase B · matrilysin · neutrophil collagenase · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 2 · bioassay · cancer classification · cancer patient · cancer staging · cancer survival · cancer tissue · comparative study · controlled study · correlation analysis · enzyme analysis · enzyme assay · enzyme linked immunosorbent assay · histopathology · human tissue · major clinical study · prognosis · protein variant · stomach cancer · stomach mucosa · tissue section · world health organization · Adult · Aged · Aged, 80 and over · Enzyme-Linked Immunosorbent Assay · Female · Humans · Male · Matrix Metalloproteinase 2 · Middle Aged · Predictive Value of Tests · Prognosis · Stomach Neoplasms · Survival Analysis
[PDF] [Abstract]

11 Involvement of Membrane-Type Matrix Metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial Cells: Role of MT3-MMP
article 2004    
Author: Plaisier, M. · Kapiteijn, K. · Koolwijk, P. · Fijten, C. · Hanemaaijer, R. · Grimbergen, J.M. · Mulder-Stapel, A. · Quax, P.H.A. · Helmerhorst, F.M. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Fibrin · Gelatinase A · Immunoglobulin G · Interstitial collagenase · Matrix metalloproteinase · Matrix metalloproteinase inhibitor · Membrane type 3 metalloproteinase · Membrane type 4 metalloproteinase · Messenger RNA · Unclassified drug · Urokinase · Adenovirus · Capillary · Cell culture · Controlled study · Endometrium cell · Endothelium cell · Enzyme inhibition · Enzyme regulation · Genetic transduction · Human cell · Immunohistochemistry · Prepuce · Protein expression · Vascular endothelium · Adenoviridae · Cells, Cultured · Collagen Type I · Endometrium · Endothelial Cells · Female · Humans · Matrix Metalloproteinase 16 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Neovascularization, Physiologic · Plasmin · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Urinary Plasminogen Activator · Adenoviridae
[Abstract]

12 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma
article 2005    
Author: Lamfers, M.L.M. · Gianni, D. · Tung, C.H. · Idema, S. · Schagen, F.H.E. · Carette, J.E. · Quax, P.H.A. · Beusechem, V.W. van · Top, W.P. van der · Dirven, C.M.F. · Chiocca, E.A. · Gerritsen, W.R.
Keywords: Biomedical Research · oncolytic adenovirus · oncolytic virus · tissue inhibitor of metalloproteinase 3 · Adenovirus · animal experiment · animal model · animal tissue · antineoplastic activity · article · cancer cell culture · cancer model · cancer survival · cell proliferation · cell strain HEK293 · controlled study · culture medium · drug efficacy · enzyme activity · enzyme inhibition · female · gene deletion · gene expression · gene insertion · gene transfer · glioblastoma · glioma cell · human · human cell · mouse · nonhuman · priority journal · protein expression · survival time · transgene · tumor xenograft · Adenoviridae · Animals · Cell Growth Processes · Cell Line, Tumor · Gene Transfer Techniques · Glioma · Humans · Matrix Metalloproteinase 2 · Mice · Mice, Nude · Tissue Inhibitor of Metalloproteinase-3 · Virus Replication · Xenograft Model Antitumor Assays
[Abstract]

13 MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis
article 2004    
Author: Tchetverikov, I. · Ronday, H.K. · El, B. van · Kiers, G.H. · Verzijl, N. · TeKoppele, J.M. · Huizinga, T.W.J. · Groot, J. de · Hanemaaijer, R.
Keywords: alpha 2 macroglobulin · biological marker · gelatinase A · gelatinase B · hydroxyproline · interstitial collagenase · matrix metalloproteinase · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · aged · circulation · clinical article · collagen degradation · concentration (parameters) · controlled study · correlation analysis · enzyme activity · enzyme assay · enzyme linked immunosorbent assay · female · high performance liquid chromatography · human · male · osteoarthritis · priority journal · rheumatoid arthritis · sampling · serum · statistical significance · synovial fluid · Adult · Aged · alpha-Macroglobulins · Arthritis, Rheumatoid · Case-Control Studies · Collagenases · Enzyme Precursors · Enzyme-Linked Immunosorbent Assay · Female · Humans · Hydroxyproline · Male · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Matrix Metalloproteinases · Metalloendopeptidases · Middle Aged · Osteoarthritis, Knee · Statistics, Nonparametric · Synovial Fluid · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

14 Relaxin stimulates MMP-2 and α-smooth muscle actin expression by human periodontal ligament cells
article 2008    
Author: Henneman, S. · Bildt, M.M. · Groot, J. de · Kuijpers-Jagtman, A.M. · Von den Hoff, J.W.
Keywords: Biology Nutrition · α-SMA · Fibroblasts · MMP · Periodontal ligament · Relaxin · Gelatinase · Matrix metalloproteinase · Relaxin · Tissue inhibitor of metalloproteinase · Article · Cell culture · Chemistry · Cytology · Drug effect · Enzymology · Female · Fibroblast · Gene expression · Genetics · Human · Male · Metabolism · Periodontal ligament · Cells, Cultured · Female · Fibroblasts · Gelatinases · Gene Expression · Humans · Male · Matrix Metalloproteinases · Periodontal Ligament · Relaxin · Tissue Inhibitor of Metalloproteinases
[Abstract]

15 Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer
article 2007    
Author: Kubben, F.J.G.M. · Sier, C.F.M. · Hawinkels, L.J.A.C. · Tschesche, H. · Duijn, W. van · Zuidwijk, K. · Reijden, J.J. van der · Hanemaaijer, R. · Griffioen, G. · Lamers, C.B.H.W. · Verspaget, H.W.
Keywords: Biology · Biomedical Research · Activity assay · Cancer · Metalloproteinase · Prognosis · gelatinase B · lipocalin · matrix metalloproteinase inhibitor · tissue inhibitor of metalloproteinase 1 · adult · aged · article · autolysis · cancer survival · disease classification · enzyme activity · enzyme degradation · epithelium cell · female · human · human tissue · immunohistochemistry · major clinical study · male · multivariate analysis · priority journal · protein function · stomach cancer · tumor · univariate analysis · world health organization
[Abstract]

16 Fluorogenic MMP activity assay for plasma including MMPs complexed to α2-macroglobulin
article 1999    
Author: Beekman, B. · Drijfhout, J.W. · Ronday, H.K. · TeKoppele, J.M.
Keywords: Health · Biomedical Research · Alpha 2 macroglobulin · Batimastat · Fluorescein · Matrix metalloproteinase · Arthritis · Cancer · Collagen degradation · Conference paper · Controlled study · Enzyme active site · Enzyme activity · Enzyme assay · Fluorescence analysis · Human · Molecular weight · Alpha-Macroglobulins · Collagen · Collagenases · Fluorescent Dyes · Humans · Kinetics · Matrix Metalloproteinase 13 · Metalloendopeptidases · Phenylalanine · Protease Inhibitors · Substrate Specificity · Thiophenes · Tissue Inhibitor of Metalloproteinase-1
[Abstract]

17 Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis
article 2007    
Author: Sanders, J.S.F. · Huitema, M.G. · Hanemaaijer, R. · Goor, H. van · Kallenberg, C.G.M. · Stegeman, C.A.
Keywords: Biology · ANCA-associated vasculitis · Crescentic glomerulonephritis · Immunohistochemistry · MMP-2 · MMP-9 · Plasma levels · TIMP-1 · Urinary levels · C reactive protein · Adult · Aged · Aged, 80 and over · Antibodies, Antineutrophil Cytoplasmic · C-Reactive Protein · Creatine · Enzyme-Linked Immunosorbent Assay · Female · Humans · Immunohistochemistry · Kidney Diseases · Kidney Glomerulus · Male · Matrix Metalloproteinases · Middle Aged · Proteinuria · Tissue Inhibitor of Metalloproteinase-1 · Vasculitis
[Abstract]

18 Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha
article 1995    
Author: Bart, A.C.W. de · Quax, P.H.A. · Löwik, C.W.G.M. · Verheijen, J.H.
Keywords: Health · collagenase · gelatinase · interleukin 1alpha · messenger rna · metalloproteinase · plasminogen · stromelysin · tissue inhibitor of metalloproteinase · urokinase · animal cell · animal tissue · article · bone matrix · bone turnover · calvaria · cattle · controlled study · extracellular matrix · human · human cell · mouse · nonhuman · osteolysis · osteosarcoma · protein degradation · Extracellular Matrix · Human · Interleukin-1 · Metalloendopeptidases · Osteoblasts · Osteosarcoma · Plasminogen Activators · Plasminogen Inactivators · Support, Non-U.S. Gov't · Tumor Cells, Cultured · Urinary Plasminogen Activator
[Abstract]

19 Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
article 2009    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Verheijen, J.H. · Bockel, J.H. van · Geelkerken, R.H. · Lindeman, J.H.N.
Keywords: Biology · Biomedical Research · antihypertensive agent · antithrombocytic agent · cystatin C · cysteine proteinase · doxycycline · gelatinase B · hydroxymethylglutaryl coenzyme A reductase inhibitor · messenger RNA · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · abdominal aorta aneurysm · adult · aged · aorta wall · article · clinical article · clinical trial · controlled clinical trial · controlled study · dose response · drug effect · drug megadose · drug tolerability · enzyme activity · enzyme assay · female · gene expression · human · human tissue · immunohistochemistry · low drug dose · male · neutrophil · polymerase chain reaction · priority journal · protein degradation · quantitative analysis · randomized controlled trial · treatment duration · Western blotting · Aged · Aged, 80 and over · Aorta, Abdominal · Aortic Aneurysm, Abdominal · Cardiovascular Agents · Cystatin C · Cysteine Endopeptidases · Dose-Response Relationship, Drug · Doxycycline · Female · Gene Expression Regulation, Enzymologic · Humans · Male · Matrix Metalloproteinases · Middle Aged · Neutrophil Infiltration · Neutrophils · Prospective Studies · Protease Inhibitors · RNA, Messenger · Time Factors · Tissue Inhibitor of Metalloproteinase-1 · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

20 Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction
article 2009    
Author: Borne, S.W.M. van den · Cleutjens, J.P.M. · Hanemaaijer, R. · Creemers, E.E. · Smits, J.F.M. · Daemen, M.J.A.P. · Blankesteijn, W.M.
Keywords: Biology · Biomedical Research · Infarct rupture · Inflammation · Matrix metalloproteinases · MMP activity assay · MMP immunohistochemistry · Myocardial infarction · gelatinase A · gelatinase B · neutrophil collagenase · tissue inhibitor of metalloproteinase 1 · adult · aged · article · clinical article · controlled study · enzyme activity · female · heart · heart disease · heart infarction · human · human tissue · immunohistochemistry · infarct rupture · inflammatory cell · male · priority journal · zymography · Aged · Aged, 80 and over · Cell Count · Female · Heart Rupture, Post-Infarction · Humans · Immunohistochemistry · Male · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 8 · Matrix Metalloproteinase 9 · Middle Aged · Myocardial Infarction · Myocarditis
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 28 found. Next | Sort by date