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1 Regulatory acceptance and use of the extended one generation reproductive toxicity study within Europe
article 2015    
Author: Schiffelers, M.J.W.A. · Blaauboer, B.J. · Bakker, W.E. · Hendriksen, C.F.M. · Krul, C.
Keywords: Barriers and drivers · EOGRTS · REACH · Regulatory acceptance and use · Reproductive toxicity testing · Animalia · Rattus · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

2 The long-term study in rodents for identifying carcinogens: Some controversies and suggestions for improvements
article 1986    
Author: Feron, V.J. · Kroes, R.
Keywords: Animal experiment · Carcinogen testing · Chemical carcinogenesis · Intoxication · Mouse · Nonhuman · Rat · Rodent · Toxicity testing · Animal · Drug Administration Schedule · International Cooperation · Mutagenicity Tests · Rodentia · Zoology · Medicine · Geneeskunde · Pathology
[Abstract]

3 Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay
article 2012    
Author: Strikwold, M. · Woutersen, R.A. · Spenkelink, B. · Punt, A. · Rietjens, I.M.C.M.
Keywords: Alternative toxicity testing · Developmental toxicity · Embryonic stem cell test · Embryotoxicity · Potency ranking · Substituted phenols · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 A neurofunctional test battery for evaluating the effects of long-term exposure to chemicals
article 1989    
Author: Kulig, B.M.
Keywords: Nutrition · Acrylamide · Hexane · Styrene · Animal experiment · Animal model · Chronic toxicity · Inhalation · Learning · Nerve conduction · Neurotoxicity · Nonhuman · Rat · Screening test · Toxicity testing

5 Toxicology in the 21st century - Working our way towards a visionary reality
article 2011    
Author: Berg, N. · Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Roggen, E.L.
Keywords: Health · -Omics · 21st Century vision · 3Rs · Computational · In vitro · Replacement · Testing strategy · Toxicity testing · Validation · article · biological model · education · Europe · ex vivo study · financial management · in vitro study · in vivo study · interpersonal communication · leadership · medical research · practice guideline · risk assessment · standardization · systems biology · toxicity testing · toxicology · validation process · Animalia · Healthy living · Biomedical Innovations · Themalijn
[Abstract]

6 Assessment of human exposure to fumonisin B1
article 1998    
Author: Nijs, M. de · Egmond, H.P. van · Nauta, M. · Rombouts, F.M. · Notermans, S.H.W.
Keywords: Nutrition · Exposure assessment · Fumonisin B1 · Public health · Carcinogenicity · Celiac disease · Dermatitis herpetiformis · Esophagus cancer · Maize · Mycotoxin · Netherlands · Toxicity testing · Carboxylic Acids · Fumonisins · Humans · Mycotoxins · Netherlands · Risk Management · Zea mays · Fungi · Fusarium · Zea mays
[Abstract]

7 Significance of the dog as 'second animal species' in toxicity testing for establishing the lowest 'no-toxic-effect level'
article 1986    
Author: Appelman, L.M. · Feron, V.J.
Keywords: Animal experiment · Comparative toxicology · Dog · Economic aspect · Intoxication · No toxic effect level · Nonhuman · Rat · Toxicity testing · Animal · Dogs · Drug Toxicity · Food Additives · Maximum Allowable Concentration · Pesticides · Rats · Species Specificity · Support, Non-U.S. Gov't
[Abstract]

8 State of the art on alternative methods to animal testing from an industrial point of view: ready for regulation?
article 2014    
Author: Ashton, R. · Wever, B. de · Fuchs, H.W. · Gaca, M. · Hill, E. · Krul, C.A.M. · Poth, A. · Roggen, E.L.
Keywords: Health · Non-animal testing · Legislation · Regulation · In vitro modeling · Harmonization · Standardization · Analytic method · Animal testing alternative · Conference paper · Industry · Law · Toxicity testing · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

9 Toxicological profile for o-phenylphenol and its sodium salt
article 1998    
Author: Stouten, H.
Keywords: Toxicology · Effects · Hazard assessment · Kinetics · O-phenylphenol · Review · Sodium o-phenylphenol · Toxicity · Disinfectant agent · Hydroxybiphenyl · Phenol derivative · Cleaning · Drug toxicity · Health care personnel · Health hazard · Hospital · Human · Occupational exposure · Occupational toxicology · Risk assessment · Toxicity testing · Toxicology · Administration, Cutaneous · Administration, Oral · Animals · Biphenyl Compounds · Disinfectants · Dogs · Humans · Mice · Mutagenicity Tests · Rats · Reproduction · Skin · Tissue Distribution · Toxicity Tests
[Abstract]

10 A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity
article 2019    
Author: Desprez, B. · Birk, B. · Blaauboer, B. · Boobis, A. · Carmichael, P. · Cronin, M.T.D. · Curie, R. · Daston, G. · Hubesch, B. · Jennings, P. · Klaric, M. · Kroese, D. · Mahony, C. · Ouédraogo, G. · Piersma, A. · Richarz, A.N. · Schwarz, M. · Benthem, J. van · Water, B. van de · Vinken, M.
Keywords: Adverse outcome pathway · Mode-of-action · Ontology model · Repeated dose toxicity · Cosmetic · Adverse outcome · Biotransformation · Chemical parameters · Chemical structure · Cytotoxicity · Exposure · Human · Kinetics · Metabolism · Mode of action · Nonhuman · Note · Ontology · Organ distribution · Physical chemistry · Repeated dose toxicity · Safety · Toxicity testing · Toxicology · Workflow
[Abstract]

11 Safety evaluation of synthetic β-carotene
article 1999    
Author: Woutersen, R.A. · Wolterbeek, A.P.M. · Appel, M.J. · Berg, H. van den · Goldbohm, R.A. · Feron, V.J.
Keywords: Toxicology · Absorption · Cancer prevention · Distribution · Lung cancer · Toxicity · beta carotene · cancer risk · carcinogenicity · chronic toxicity · drug absorption · drug distribution · drug safety · drug transport · genotoxicity · human · nonhuman · reproductive toxicity · review · toxicity testing · Absorption · Animals · Antioxidants · beta Carotene · Cell Transformation, Neoplastic · Chemoprevention · Drug Interactions · Humans · Intervention Studies · Lung Neoplasms · Mice · Rats · Rats, Sprague-Dawley · Skin Neoplasms · Smoking · Animalia
[Abstract]

12 Cryopreservation of precision-cut rat liver slices using a computer-controlled freezer
article 2000    
Author: Maas, W.J.M. · Leeman, W.R. · Groten, J.P. · Sandt, J.J.M. van de
Keywords: Computer-controlled freezing · Cryopreservation · Rat liver slices · Animal tissue · Computer · Controlled study · Cryopreservation · Dehydration · Liver slice · Nonhuman · Rat · Species difference · Technique · Thawing · Toxicity testing · Adenosine Triphosphate · Animal · Cell Separation · Cell Survival · Computer Systems · Cryopreservation · Dinitrochlorobenzene · Formazans · Freezing · Glutathione · Glutathione Transferase · Hepatocytes · Lactate Dehydrogenase · Liver · Male · Organ Preservation · Proteins · Rats · Rats, Wistar · Support, Non-U.S. Gov't · Testosterone · Tetrazolium Salts · Time Factors · Urea
[Abstract]

13 Induction of hyperplasia in the bladder epithelium of rats by a dietary excess of acid or base: Implications for toxicity/carcinogenicity testing
article 1988    
Author: Groot, A.P. de · Feron, V.J. · Immel, H.R.
Keywords: acid · alkali · ammonium chloride · glutamate sodium · potassium bicarbonate · acid base balance · animal experiment · bladder epithelium · bladder hyperplasia · carcinogen testing · diet · male · nonhuman · rat · toxicity testing · urine ph · Acid-Base Equilibrium · Ammonium Chloride · Animal · Bladder · Carbonates · Circadian Rhythm · Diet · Epithelium · Hydrogen-Ion Concentration · Hyperplasia · Male · Mutagenicity Tests · Potassium · Rats · Urine
[Abstract]

14 Relevance of parameters related to fertility and reproduction in toxicity testing
article 1983    
Author: Koëter, H.B.W.M.
Keywords: Antibiotic agent · Chemical agent · Chlorinated hydrocarbon · Heavy metal · Insecticide · Chemical teratogenesis · Drug toxicity · Female genital system · Fertility · Fetus · Intoxication · Male genital system · Nonhuman · Pregnancy · Reproduction · Short survey · Toxicity testing · Animal · Drug Evaluation, Preclinical · Female · Fertility · Pregnancy · Rats · Reproduction · Support, Non-U.S. Gov't · Toxicology · Zoology · Medicine · Geneeskunde · Pharmacology
[Abstract]

15 Evaluation of potential neurotoxic effects of occupational exposure to (L)-Lactates
article 2001    
Author: Clary, J.J. · Feron, V.J. · Velthuijsen, J.A. van
Keywords: Toxicology · Chronic neurotoxicity · Chronic toxic encephalopathy · Lactate esters · Organo psycho syndrome · Solvents · 2 ethylhexanol · 2 propanol · alcohol · butanol · isobutanol · lactic acid derivative · methanol · propanol · animal experiment · article · brain disease · disease association · hydrolysis · mouse · neurotoxicity · nonhuman · occupational exposure · priority journal · rat · risk assessment · toxicity testing · Alcohols · Animals · Esters · Humans · Hydrolysis · Lactates · Neurotoxicity Syndromes · No-Observed-Adverse-Effect Level · Occupational Exposure · Solvents · Toxicity Tests · Volatilization
[Abstract]

16 Use of read-across and tiered exposure assessment in risk assessment under REACH - A case study on a phase-in substance
article 2010    
Author: Vink, S.R. · Mikkers, J. · Bouwman, T. · Marquart, H. · Kroese, E.D.
Keywords: Biology · Biomedical Research · Grouping · REACH · Read-across · Risk assessment · Tiered exposure assessment · 1 methoxypropan 2 ol · chemical compound · unclassified drug · analytic method · article · chemical analysis · data analysis · European Union · experimental animal welfare · health hazard · occupational exposure · physical chemistry · priority journal · qualitative analysis · quantitative analysis · risk assessment · standardization · statistical model · toxicity testing · Animalia
[Abstract]

17 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

18 Alternative acute inhalation toxicity testing by determination of the concentration-time-mortality relationship : experimental comparison with standard LC50 testing
article 1992    
Author: Zwart, A. · Arts, J.H.E. · Berge, W.F. ten · Appelman, L.M.
Keywords: Biology · Biology · Medicine · Geneeskunde · Pharmacology · Toxicology · Animal experiment · Article · Inhalation · Lc 50 · Nonhuman · Rat · Toxicity · Toxicity testing · Administration · Inhalation · Animal · Comparative Study · Environmental Exposure · Female · Lethal Dose 50 · Male · Mortality · Rats · Reference Values · Research Design · Support, Non-U.S. Gov't · Time Factors · Toxicology · Animalia
[Abstract]

19 The acute toxicity of selected alkylphenols to young and adult Daphnia magna
article 1998    
Author: Gerritsen, A. · Hoeven, N. van der · Pielaat, A.
Keywords: alkylphenol · alkyphenol · elimination rate · mortality rate · no-observed-effect concentration · toxicity · article · daphnia · ecotoxicity · ecotoxicology · nonhuman · statistical analysis · survival · toxicity testing · Animals · Chromatography, High Pressure Liquid · Daphnia · Female · Hazardous Substances · Hydrogen-Ion Concentration · Phenols · Structure-Activity Relationship · Toxicity Tests · Cladocera · Daphnia · Daphnia magna · Daphnia pulex · Pulex
[Abstract]

20 Strategies to replace in vivo acute systemic toxicity testing: The report and recommendations of ECVAM workshop 50
article 2004    
Author: Gennari, A. · Berghe, C. van den · Casati, S. · Castell, J. · Clemedson, C. · Coecke, S. · Colombo, A. · Curren, R. · Dal Negro, G. · Goldberg, A. · Gosmore, C. · Hartung, T. · Langezaal, I. · Lessigiarska, I. · Maas, W. · Mangelsdorf, I. · Parchment, R. · Prieto, P. · Sintes, J.R. · Ryan, M. · Schmuck, G. · Stitzel, K. · Stokes, W. · Vericat, J.A. · Gribaldo, L.
Keywords: Toxicology Health · Physiological Sciences · acute toxicity · conference paper · cytotoxicity · environmental protection · European Union · in vivo study · LD 50 · priority journal · toxicity testing · Acute Toxicity Tests · Animal Testing Alternatives · Animals · Cell Death · Cosmetics · Europe · Guidelines · Lethal Dose 50 · Mouth Diseases · Registries · Reproducibility of Results · Toxicity Tests · United States

Search results also available in MS Excel format.

Showing 1 to 20 of 58 found. Next | Sort by date