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Showing 1 to 7 of 7 found. | Sort by date

1 The introduction of toxicogenomics; potential new markers of hepatotoxicity.
article 2005    
Author: Heijne, W.H. · Stierum, R.H. · Leeman, W.R. · Ommen, B. van
Keywords: Toxicology · Physiological Sciences · biological marker · drug · animal · biological model · chemically induced disorder · drug toxicity · gene expression profiling · genetics · human · liver disease · methodology · review · toxicogenetics · toxicology · Animals · Biological Markers · Drug Toxicity · Gene Expression Profiling · Humans · Liver Diseases · Models, Biological · Pharmaceutical Preparations · Toxicogenetics · Toxicology

2 Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: A toxicogenomics approach
article 2006    
Author: Kienhuis, A.S. · Wortelboer, H.M. · Hoflack, J.C. · Moonen, E.J. · Kleinjans, J.C.S. · Ommen, B. van · Delft, J.H.M. van · Stierum, R.H.
Keywords: Biology · Biomedical Research · beta naphthoflavone · coumarin · cytochrome P450 · dexamethasone · drug metabolite · enzyme inducing agent · phenobarbital · animal cell · animal experiment · animal model · animal tissue · article · controlled study · culture medium · cytotoxicity · drug activation · drug metabolism · enzyme activity · experimental rat · gene expression · histopathology · in vitro study · in vivo study · liver cell · liver toxicity · male · nonhuman · nucleotide sequence · prediction · principal component analysis · priority journal · rat · signal transduction · toxicogenetics · Alanine Transaminase · Animals · Aspartate Aminotransferases · Cell Culture Techniques · Cells, Cultured · Cholesterol · Coumarins · gamma-Glutamyltransferase · Gene Expression Profiling · Hepatocytes · Liver · Male · Oligonucleotide Array Sequence Analysis · Rats · Rats, Wistar · Toxicogenetics
[Abstract]

3 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

4 A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Jong, C.H.C. de · Gottschalk, R. · Herwijnen, M. van · Boorsma, A. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Biology · Biomedical Research · Coumarin · Gene expression profiling · Hepatotoxicity · Parallelogram approach · Primary human hepatocytes · Species difference · Toxicogenomics · Coumarin · Adult · Aged · Blood clotting · Concentration response · Controlled study · Disorders of mitochondrial functions · Down regulation · Energy consumption · Female · Gene expression profiling · Genomics · Human · Human cell · Liver cell · Liver toxicity · Male · Species difference · Toxicogenetics · Transcriptomics · Animalia · Rattus
[Abstract]

5 Parallelogram approach using rat-human In vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Wortelboer, H. · Herwijnen, M. van · Gottschalk, R. · Jong, C.H.C. de · Boorsma, A. · Paules, R.S. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Toxicology · Biotechnology · Acetaminophen · Gene expression profiling · Hepatocyte-based in vitro models · Interspecies extrapolation · Liver injury · T-profiler · oxidoreductase · paracetamol · adult · aged · animal cell · animal experiment · animal model · animal tissue · article · biological activity · cell function · chemical analysis · controlled study · energy consumption · enzyme activity · female · gene expression profiling · gene repression · human · human cell · human tissue · human versus animal comparison · in vitro study · in vivo study · liver cell · liver metabolism · liver mitochondrion · liver toxicity · male · nonhuman · rat · species comparison · toxicogenetics · Acetaminophen · Adult · Aged · Analgesics, Non-Narcotic · Animals · Cell Survival · Cells, Cultured · Female · Hepatitis, Toxic · Hepatocytes · Humans · In Situ Hybridization · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Rats, Wistar · RNA · Species Specificity · Toxicogenetics · Rattus · Rodentia
[Abstract]

6 Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat
article 2007    
Author: Hendriksen, P.J.M. · Freidig, A.P. · Jonker, D. · Thissen, U. · Bogaards, J.J.P. · Mumtaz, M.M. · Groten, J.P. · Stierum, R.H.
Keywords: Biology · Analytical research · Biomedical research · Benzene · Mercury · Microarrays · Mixtures · Toxicogenomics · Trichloroethylene · benzene · biological marker · messenger RNA · methylmercury · trichloroethylene · animal experiment · animal tissue · apoptosis · article · Ccng1 gene · cell proliferation · cell viability · controlled study · gene · gene expression profiling · gene induction · id2 gene · liver toxicity · long term exposure · male · MDM2 gene · microarray analysis · nephrotoxicity · NFKB1 gene · nonhuman · Nr2f6 gene · rat · stress · tissue specificity · tnfrsf1a gene · toxicogenetics · transcriptomics · Animals · Benzene · Cell Survival · Drug Interactions · Drug Synergism · Environmental Pollutants · Gene Expression Profiling · Gene Expression Regulation · Kidney · Liver · Male · Methylmercury Compounds · No-Observed-Adverse-Effect Level · Oligonucleotide Array Sequence Analysis · Rats · Rats, Inbred F344 · RNA, Messenger · Toxicity Tests · Trichloroethylene · Rattus
[Abstract]

7 The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays
article 2008    
Author: Vinken, M. · Doktorova, T. · Ellinger-Ziegelbauer, H. · Ahr, H.-J. · Lock, E. · Carmichael, P. · Roggen, E. · Delft, J. van · Kleinjans, J. · Castell, J. · Bort, R. · Donato, T. · Ryan, M. · Corvi, R. · Keun, H. · Ebbels, T. · Athersuch, T. · Sansone, S.-A. · Rocca-Serra, P. · Stierum, R. · Jennings, P. · Pfaller, W. · Gmuender, H. · Vanhaecke, T. · Rogiers, V.
Keywords: Biology · Physiological Sciences · carcinoGENOMICS · Chemical carcinogenesis · FP6 project · Genomics · Genotoxic carcinogen · Metabolomics · Metabonomics · Model compounds · Non-genotoxic carcinogen · REACH · Selection criteria · 1,3 butadiene · 2 nitrofluorene · 2,3,7,8 tetrachlorodibenzo para dioxin · aflatoxin B1 · alkanone · arsenate sodium · asbestos · benzo[a]pyrene · bromodichloromethane · cadmium derivative · chemical compound · chloroprene · chlorothalonil · dichromate sodium · dimethylnitrosamine · isobutyl nitrite · methapyrilene · monuron · nifedipine · ochratoxin · phenobarbital · phorbol 13 acetate 12 myristate · piperonyl butoxide · pirinixic acid · potassium bromate · s (1,2 dichlorovinyl)cysteine · streptozocin · tolbutamide · unindexed drug · vinyl chloride · carcinogenicity · genomics · human · in vitro study · medical information · medical research · model · nonhuman · priority journal · review · screening · Animal Testing Alternatives · Carcinogenicity Tests · European Union · Gene Expression Profiling · Genomics · Hazardous Substances · International Cooperation · Toxicogenetics · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 7 of 7 found. | Sort by date