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1 Hepatocyte-specifi c IKK- β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice
article 2011    
Author: Diepen, J.A.V. · Wong, M.C. · Guigas, B. · Bos, J. · Stienstra, R. · Hodson, L. · Shoelson, S.E. · Jimmy F. P. Berbée · Rensen, P.C.N. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Health · I k B kinase β · Lipid metabolism · Liver · Nuclear factor kappa B · Very low density lipoprotein · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

2 CETP expression reverses the reconstituted HDL-induced increase in VLDL
article 2011    
Author: Wang, Y. · Berbée, J.F.P. · Stroes, E.S. · Smit, J.W.A. · Havekes, L.M. · Romijn, J.A. · Rensen, P.C.N.
Keywords: Health · Cholesterol · Cholesteryl ester transfer protein · High density lipoprotein · Transgenic mice · Triglycerides · Very low density lipoprotein production · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

3 The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis
article 2004    
Author: Goudriaan, J.R. · Espirito Santo, S.M.S. · Voshol, P.J. · Teusink, B. · Dijk, K.W. van · Vlijmen, B.J.M. van · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Adipose tissue · Free fatty acids · Lipoprotein lipase · Postprandial lipid metabolism · Transgenic mice · Very low density lipoprotein-like emulsion · Albumin · Carbon 14 · Chylomicron · Fatty acid · Lipoprotein lipase · Triacylglycerol · Very low density lipoprotein · Very low density lipoprotein receptor · Animal experiment · Animal tissue · Bolus injection · Continuous infusion · Controlled study · Diet restriction · Emulsion · Enzyme activity · Fatty acid transport · Female · Half life time · Lipid blood level · Lipid hydrolysis · Lipid metabolism · Lipolysis · Mouse · Nonhuman · Plasma clearance · Postprandial state · Protein expression · Transgenic mouse · Adipose Tissue · Albumins · Animals · Chylomicrons · Fatty Acids, Nonesterified · Mice · Receptors, LDL · Triglycerides
[PDF] [Abstract]

4 The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI
article 2008    
Author: Hu, L. · Hoogt, C.C. van der · Espirito Santo, S.M.S. · Out, R. · Kypreos, K.E. · Vlijmen, B.J.M. van · Berkel, T.J.C. van · Romijn, J.A. · Havekes, L.M. · Dijk, K.W. van · Rensen, P.C.N.
Keywords: Biology · Apolipoprotein · Denovirus-mediated gene transfer · Lipoprotein lipase · Low density lipoprotein receptor · Low density lipoprotein receptor-related protein · Transgenic mice · Triglyceride-rich emulsion particles · Very low density lipoprotein receptor · apolipoprotein E · cell surface protein · cholesterol · lipoprotein lipase · low density lipoprotein receptor · low density lipoprotein receptor related protein · proteoglycan · proteoheparan sulfate · scavenger receptor BI · triacylglycerol · very low density lipoprotein · very low density lipoprotein receptor · CD36 antigen · ligand · very low density lipoprotein cholesterol · Adenovirus · animal cell · animal experiment · animal tissue · article · cell isolation · cell surface · controlled study · enzyme activity · in vitro study · in vivo study · internalization · lipid analysis · liver cell · male · mouse · nonhuman · priority journal · protein expression · regulatory mechanism · animal · blood · emulsion · genetics · liver · metabolism · mouse mutant · Animals · Antigens, CD36 · Cholesterol, VLDL · Emulsions · LDL-Receptor Related Proteins · Ligands · Lipoprotein Lipase · Liver · Male · Mice · Mice, Knockout · Proteoglycans · Receptors, LDL · Healthy for Life · Healthy Living
[Abstract]

5 Insulin suppresses apolipoprotein(a) synthesis in cultured cynomolgus monkey hepatocytes
article 1999    
Author: Princen, H.M.G.
Keywords: Biology · Apolipoprotein a · Apolipoprotein b · Cholesterol · Insulin · Lipoprotein a · Very low density lipoprotein · Animal cell · Drug half life · Hepatoma cell · Human · Hyperinsulinemia · Insulin dependent diabetes mellitus · Letter · Lipoprotein synthesis · Liver cell · Monkey · Nonhuman

6 Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet
article 2011    
Author: Diepen, J.A. van · Vroegrijk, I.O.C.M. · Berbée, J.F.P. · Shoelson, S.E. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N. · Voshol, P.J.
Keywords: Biology · Inflammation · Lipid metabolism · Very low-density lipoprotein · acetylsalicylic acid · apolipoprotein C1 · immunoglobulin enhancer binding protein · transcription factor RelA · triacylglycerol · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · controlled study · drug mechanism · drug targeting · enzyme inhibition · gene expression · hypertriglyceridemia · in vivo study · lipid diet · lipogenesis · lipoprotein blood level · male · metabolic syndrome X · mouse · nonhuman · priority journal · protein expression · risk factor · triacylglycerol blood level · aspirin · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

7 Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice
article 2004    
Author: Bovenschen, N. · Dijk, K.W. van · Havekes, L.M. · Mertens, K. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Clearance · Factor VIII · Knockout mice · Low-density lipoprotein receptor-related protein · Very low-density lipoprotein receptor · blood clotting factor 8 · cholesterol · triacylglycerol · very low density lipoprotein receptor · animal experiment · article · catabolism · cholesterol blood level · controlled study · knockout mouse · male · mouse · nonhuman · plasma clearance · priority journal · triacylglycerol blood level · Animals · Factor VIII · Integrases · LDL-Receptor Related Proteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

8 Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
article 2005    
Author: Berbée, J.F.P. · Hoogt, C.C. van der · Sundararaman, D. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein C-I · Fatty acids · Lipid metabolism · Lipoprotein lipase · Triglycerides · Very low density lipoprotein · Lipoprotein receptor · Tritium · Very low density lipoprotein · Animal experiment · Animal model · Cholesterol blood level · Controlled study · Enzyme activity · Half life time · Hyperlipidemia · Hyperlipoproteinemia type 3 · Lipolysis · Mouse · Nonhuman · Pathophysiology · Protein expression · Transgenic mouse · Animals · Apolipoproteins · Apolipoproteins C · Apolipoproteins E · Humans · Hypertriglyceridemia · Lactoferrin · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phenotype · Time Factors
[PDF] [Abstract]

9 Acute inhibition of hepatic β-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity
article 2005    
Author: Duivenvoorden, I. · Teusink, B. · Rensen, P.C.N. · Kuipers, F. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acids · Glucose metabolism · Steatosis · Triglycerides · Very low density lipoprotein · 3 hydroxybutyrate dehydrogenase · carnitine palmitoyltransferase inhibitor · cholesterol · insulin · palmoxiric acid · triacylglycerol · very low density lipoprotein · apolipoprotein E · apolipoprotein E3 · apolipoprotein E3 (Leidein) · fatty acid · messenger RNA · analytic method · animal cell · animal experiment · article · cholesterol blood level · comparative study · controlled study · fatty acid oxidation · gluconeogenesis · insulin blood level · insulin sensitivity · ketogenesis · mouse · nonhuman · transgenic mouse · animal · blood · genetics · insulin resistance · metabolism · oxidation reduction reaction · physiology · secretion · Animals · Apolipoprotein E3 · Apolipoproteins E · Fatty Acids, Nonesterified · Insulin Resistance · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Transgenic · Oxidation-Reduction · RNA, Messenger
[PDF] [Abstract]

10 Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL
article 2006    
Author: Westerterp, M. · Haan, W. de · Berbée, J.F.P. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Lipases transgenic mouse models · Very low density lipoprotein · apolipoprotein B · cholesterol · fatty acid · heparin · lipid · olive oil · triacylglycerol · very low density lipoprotein · animal experiment · animal tissue · cholesterol blood level · concentration response · controlled study · enzyme inhibition · gene dosage · gonad · hyperlipidemia · intestine absorption · knockout mouse · lipid absorption · lipid blood level · lipid metabolism · lipolysis · mouse · nonhuman · postprandial state · protein expression · triacylglycerol blood level · white adipose tissue · Animals · Apolipoprotein C-I · Apolipoproteins C · Apolipoproteins E · Cholesterol · Hyperlipidemias · Intestines · Lipase · Lipoprotein Lipase · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Postprandial Period
[PDF] [Abstract]

11 Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein
article 2007    
Author: Gautier, T. · Tietge, U.J.F. · Boverhof, R. · Perton, F.G. · Le Guern, N. · Masson, D. · Rensen, P.C.N. · Havekes, L.M. · Lagrost, L. · Kuipers, F.
Keywords: Biology · Biomedical Research · Bile · Cholesterol · Triglycerides · bile acid · cholesterol · cholesterol ester transfer protein · high density lipoprotein · triacylglycerol · very low density lipoprotein · animal model · bile secretion · cholesterol blood level · controlled study · insulin metabolism · lipid metabolism · lipid storage · mouse · nonhuman · stress · Animals · Apolipoprotein C-I · Cholesterol Ester Transfer Proteins · Gallbladder · Lipids · Liver · Mice · Mice, Inbred C57BL · Mice, Knockout · Polymerase Chain Reaction · RNA
[PDF] [Abstract]

12 Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1
article 1996    
Author: Jong, M.C. · Dahlmans, V.E.H. · Gorp, P.J.J. van · Breuer, M.L. · Mol, M.J.T.M. · Zee, A. van der · Frants, R.R. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Transgenic mice · Triacylglycerol · Very low density lipoprotein · Animal experiment · Animal model · Atherosclerosis · Cholesterol blood level · Controlled study · Female · Lipolysis · Liver clearance · Liver metabolism · Male · Nonhuman · Protein transport · Transgenic mouse · Triacylglycerol blood level · Animals · Apolipoprotein C-I · Apolipoprotein E3 · Apolipoproteins C · Apolipoproteins E · Arteriosclerosis · Cholesterol · Cholesterol, Dietary · Gene Expression · Humans · Hyperlipoproteinemias · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Triglycerides
[Abstract]

13 Reduced very-low-density lipoprotein fractional catabolic rate in apolipoprotein C1-deficient mice
article 1997    
Author: Jong, M.C. · Ree, J.H. van · Dahlmans, V.E.H. · Frants, R.R. · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · very low density lipoprotein · animal experiment · catabolism · controlled study · human · hyperlipoproteinemia · lipolysis · metabolism · mouse · nonhuman · priority journal · protein degradation · protein metabolism · transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins B · Apolipoproteins C · Cholesterol, Dietary · Female · Lipolysis · Lipoproteins, VLDL · Mice · Mice, Mutant Strains · Triglycerides · Ultracentrifugation · Animalia · Mus musculus
[Abstract]

14 Apolipoprotein AV: Low concentration, high impact
article 2005    
Author: Rensen, P.C.N. · Dijk, K.W. van · Havekes, L.M.
Keywords: Biomedical Research · Apolipoprotein A5 · High density lipoprotein · Lipoprotein lipase · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · APOA5 protein, human · Editorial · Enzyme linked immunosorbent assay · Homeostasis · Ischemic heart disease · Lipid metabolism · Nonhuman · Protein assembly · Triacylglycerol blood level · Animal · Blood · Metabolism · Note · Physiology · Animals · Apolipoproteins · Apolipoproteins A · Homeostasis · Humans · Hypertriglyceridemia · Triglycerides
[Abstract]

15 Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment
article 1993    
Author: Lombardi, P. · Mulder, M. · Boom, H. van der · Frants, R.R. · Havekes, L.M.
Keywords: Cholesterol acyltransferase · Lipoprotein · Lipoprotein receptor · Low density lipoprotein · Triacylglycerol · Very low density lipoprotein · Cholesterol blood level · Density gradient centrifugation · Endosome · Enzyme activity · Homeostasis · Human cell · Lipid transport · Protein binding · Protein degradation · Biological Transport · Cell Compartmentation · Cell Line · Cholesterol · Endocytosis · Esterification · Human · Lipoprotein Lipase · Lipoproteins, LDL · Lipoproteins, VLDL · Lysosomes · Sterol O-Acyltransferase · Support, Non-U.S. Gov't · Triglycerides
[PDF] [Abstract]

16 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice
article 2008    
Author: Haan, W. de · Hoogt, C.C. van der · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Princen, H.M.G. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · CETP · High-density lipoprotein · HMGCoA reductase · Statin · Transgenic mice · ABC transporter A1 · apolipoprotein A1 · apolipoprotein E3 · atorvastatin · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · messenger RNA · phospholipid transfer protein · scavenger receptor BI · very low density lipoprotein · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · cholesterol diet · controlled study · drug effect · gene expression · hypercholesterolemia · lipoprotein blood level · lipoprotein metabolism · male · mouse · nonhuman · priority journal · protein expression · transgenic mouse · Animals · Apolipoprotein E3 · Cholesterol Ester Transfer Proteins · Cholesterol, Dietary · Cholesterol, HDL · Cholesterol, VLDL · Dose-Response Relationship, Drug · Female · Gene Expression · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypercholesterolemia · Liver · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Pyrroles · RNA, Messenger
[Abstract]

17 Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue
article 2006    
Author: Boer, M.A.M. den · Berbée, J.F.P. · Reiss, P. · Valk, M. van der · Voshol, P.J. · Kuipers, F. · Havekes, L.M. · Rensen, P.C.N. · Romijn, J.A.
Keywords: Dyslipidemia · FA metabolism · Protease inhibitor · TG metabolism · Transgenic mice · Albumin · Lipoprotein lipase · Proteinase inhibitor · Ritonavir · Triacylglycerol · Triolein · Very low density lipoprotein · Anticoagulant agent · Apolipoprotein E · Apolipoprotein E3 (Leidein) · Diagnostic agent · Fatty acid · Heparin · Tritium · Very low density lipoprotein cholesterol · Adipose tissue · Animal tissue · Clearance · Controlled study · Drug mechanism · Emulsion · Enzyme activity · Fat intake · Fatty acid metabolism · Fatty acid transport · Half life time · Hypertriglyceridemia · Lipid diet · Lipodystrophy · Lipolysis · Mouse · Nonhuman · Postprandial state · Transgenic mouse · Triacylglycerol blood level · Biosynthesis · Blood · Chemically induced disorder · Drug effect · Enzyme activation · Genetics · Human immunodeficiency virus infection · Metabolism · Adipose Tissue · Animals · Anticoagulants · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Emulsions · Enzyme Activation · Fatty Acids · Female · Heparin · HIV Infections · HIV Protease Inhibitors · Hypertriglyceridemia · Lipolysis · Lipoprotein Lipase · Mice · Mice, Transgenic · Postprandial Period · Ritonavir · Triglycerides · Triolein · Tritium
[Abstract]

18 Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
article 2005    
Author: Espirito Santo, S.M.S. · Rensen, P.C.N. · Goudriaan, J.R. · Bensadoun, A. · Bovenschen, N. · Voshol, P.J. · Havekes, L.M. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Apolipoprotein E · Hepatic lipase · Hyperlipidemia · Lipoprotein lipase · Low density lipoprotein receptor · Postprandial response · Transgenic mice · Very low density lipoprotein receptor · Very low density lipoproteins · Lipid · Low density lipoprotein receptor · Low density lipoprotein receptor related protein · Triacylglycerol lipase · Very low density lipoprotein receptor · Leucine responsive regulatory protein · Lipoprotein · Transcription factor · Animal experiment · Animal model · Animal tissue · Controlled study · Female · gene deletion · Hyperlipidemia · Lipid blood level · Lipid diet · Male · Mouse · Nonhuman · Protein defect · Species comparison · Triacylglycerol blood level · Triacylglycerol lipase blood level · Wild type · Chemistry · Genetics · Metabolism · Pathology · Physiology · Polymerase chain reaction · Time · Transgenic mouse · Alleles · Animals · Cholesterol · DNA-Binding Proteins · Genotype · Hyperlipidemias · Leucine-Responsive Regulatory Protein · Lipid Metabolism · Lipoproteins · Mice · Mice, Transgenic · Polymerase Chain Reaction · Receptors, LDL · Time Factors · Transcription Factors · Triglycerides
[PDF] [Abstract]

19 Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression
article 2007    
Author: Hoogt, C.C. van der · Haan, W. de · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Romijn, J.A. · Princen, H.M.G. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · Fibrate · High density lipoprotein · Peroxisome proliferator-activated receptor α · Transgenic mice · apolipoprotein E · cholesterol ester transfer protein · fenofibrate · high density lipoprotein cholesterol · very low density lipoprotein · animal experiment · cholesterol transport · controlled study · drug mechanism · food intake · gene expression · lipid metabolism · mouse · nonhuman · priority journal · protein expression · protein function · steady state · transgene · Animals · Antilipemic Agents · Apolipoproteins B · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Gene Expression · Humans · Liver · Male · Mice · Mice, Transgenic · Procetofen · RNA, Messenger
[PDF] [Abstract]

20 Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification
article 2007    
Author: Westerterp, M. · Berbée, J.F.P. · Delsing, D.J.M. · Jong, M.C. · Gijbels, M.J.J. · Dahlmans, V.E.H. · Offerman, E.H. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Lipoprotein · Lipoprotein lipase · Skin · Triglyceride · very low density lipoprotein · animal cell · animal experiment · animal tissue · controlled study · electricity · esterification · female · in vitro study · mouse · nonhuman · phenotype · skin transplantation · wild type · Animals · Apolipoprotein C-I · Cells, Cultured · Enzyme-Linked Immunosorbent Assay · Esterification · Fatty Acids, Nonesterified · Female · Humans · Lipoproteins, VLDL · Macrophages · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Oleic Acid · Phenotype · Protein Binding · Skin · Skin Abnormalities · Skin Transplantation
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 54 found. Next | Sort by date