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Showing 1 to 18 of 18 found. | Sort by date

1 Influence of growth factors and medium composition on benzo[a]pyrene- and vitamin A-induced cell proliferation and differentiation in hamster tracheal epithelium in organ culture
article 1996    
Author: Wolterbeek, A.P.M. · Ciotti, M.A.L.T. · Schoevers, E.J. · Roggeband, R. · Baan, R.A. · Feron, V.J. · Rutten, A.A.J.J.L.
Keywords: Toxicology · benzo[a]pyrene · calcium chloride · epidermal growth factor · growth factor · nicotinamide adenine dinucleotide · nicotinamide adenine dinucleotide phosphate · retinol · transferrin · animal cell · article · cell differentiation · cell proliferation · controlled study · culture medium · epithelium cell · hamster · male · nonhuman · squamous cell metaplasia · trachea mucosa
[Abstract]

2 Determination of the B2 vitamer flavin-adenine dinucleotide in whole blood by high-performance liquid chromatography with fluorometric detection
article 1982    
Author: Speek, A.J. · Schaik, F. van · Schrijver, J. · Schreurs, W.H.P.
Keywords: Nutrition · Flavine adenine nucleotide · Flavine nucleotide · Riboflavin · Nicotinamide adenine dinucleotide · Blood · Blood and hemopoietic system · Drug blood level · Drug determination · Fluorometry · High performance liquid chromatography · Human · Human cell · In vitro study · Methodology · Normal human · Normal value · Preliminary communication · Theoretical study · Article · Chemistry · Spectrofluorometry · Chromatography, High Pressure Liquid · Human · Microchemistry · NAD · Spectrometry, Fluorescence
[Abstract]

3 Inhibition of zaleplon metabolism by cimetidine in the human liver : in vitro studies with subcellular fractions and precision-cut liver slices
article 2002    
Author: Renwick, A.B. · Ball, S.E. · Tredger, J.M. · Price, R.J. · Walters, D.G. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition · Aldehyde oxidase · Cimetidine · Cytochrome P450 3A · Reduced nicotinamide adenine dinucleotide phosphate · Zaleplon · Cell fractionation · Drug inhibition · Drug metabolism · Human · Human cell · Human tissue · In vitro study · Liver metabolism · Liver microsome · Liver slice · Acetamides · Cimetidine · Cytosol · Dose-Response Relationship, Drug · Drug Interactions · Enzyme Inhibitors · Humans · Hypnotics and Sedatives · Inhibitory Concentration 50 · Kinetics · Liver · Models, Chemical · Pyrimidines · Subcellular Fractions · Staphylococcus phage 3A
[Abstract]

4 Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14
article 2000    
Author: Werf, M.J. van der · Boot, A.M.
Keywords: Nutrition · Carveol · Carvone · Dihydrocarveol · Monoterpene metabolism · Rhodococcus erythropolis · Bacterial enzyme · Carveol · Carvone · Dihydrocarveol · Hexanoic acid derivative · Isomerase · Nicotinamide adenine dinucleotide · Oxepane derivative · Oxidoreductase · Oxygenase · Unclassified drug · Bacterial metabolism · Controlled study · Enzyme activity · Nonhuman · Priority journal · Rhodococcus · Stereoisomerism · 2,6-Dichloroindophenol · Alcohol Oxidoreductases · Anaerobiosis · Biodegradation, Environmental · Cyclohexenes · Hydrolases · Isomerases · Monoterpenes · Rhodococcus · Stereoisomerism · Terpenes · Actinobacteria (class) · Bacteria (microorganisms) · Erythropolis · Rhodococcus erythropolis · Uncultured actinomycete
[Abstract]

5 Effect of the acquisition enhancing drug piracetam on rat cerebral energy metabolism. Comparison with naftidrofuryl and methamphetamine
article 1976    
Author: Nickolson, V.J. · Wolthuis, O.L.
Keywords: Biology · Adenine nucleotide · Adenylate kinase · Methamphetamine · Naftidrofuryl · Piracetam · Brain · Energy transfer · Histochemistry · In vitro study · Rat · Theoretical study · Adenosine Diphosphate · Adenosine Monophosphate · Adenosine Triphosphate · Adenylate Kinase · Animal · Cerebral Cortex · Comparative Study · Energy Metabolism · Furans · In Vitro · Male · Methamphetamine · Nafronyl · Piracetam · Pyrrolidinones · Rats
[Abstract]

6 The expression of type III hyperlipoproteinemia: Involvement of lipolysis genes
article 2009    
Author: Henneman, P. · Sman-de Beer, F. van der · Moghaddam, P.H. · Huijts, P. · Stalenhoef, A.F.H. · Kastelein, J.J.P. · Duijn, C.M. van · Havekes, L.M. · Frants, R.R. · Dijk, K.W. van · Smelt, A.H.M.
Keywords: Biology · Biomedical Research · adenine · apolipoprotein A5 · apolipoprotein C3 · apolipoprotein E2 · cytosine · guanine · lipoprotein lipase · liver triacylglycerol lipase · thymine · adult · aged · article · controlled study · disease severity · female · gene expression · gene frequency · gene function · gene linkage disequilibrium · genetic association · genetic polymorphism · genetic variability · human · human cell · hyperlipidemia · hyperlipoproteinemia type 3 · hypertriglyceridemia · lipolysis · lipoprotein blood level · major clinical study · male · mutational analysis · Netherlands · priority journal
[Abstract]

7 Increased resistance to 14α-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14α-demethylase (cyp51) and the A. Niger cytochrome P450 reductase (cprA) genes
article 1996    
Author: Brink, H.J.M. van den · Nistelrooy, H.J.G.M. van · Waard, M.A. de · Hondel, C.A.M.J.J. van den · Gorcom, R.F.M. van
Keywords: Biology · Ergosterol · NADPH cytochrome P450 reductase · Sterol 14α-demethylation inhibitors · Drug products · Fungicides · Genes · Demethylase inhibitors (DMI) · Gene encoding · Genetic engineering · Cytochrome p450 reductase · Reduced nicotinamide adenine dinucleotide phosphate ferrihemoprotein reductase · Enzyme synthesis · Fungal genetics · Nonhuman · Penicillium · Priority journal · Aspergillus niger · Cytochrome P-450 Enzyme System · Drug Resistance, Microbial · Enzyme Inhibitors · Gene Expression Regulation, Fungal · NADH, NADPH Oxidoreductases · NADPH-Ferrihemoprotein Reductase · Oxidoreductases · Penicillium · Recombinant Proteins · Transformation, Genetic · Aspergillus niger · Fungi · Penicillium · Penicillium italicum
[Abstract]

8 Cloning and characterization of the NADPH cytochrome P450 oxidoreductase gene from the filamentous fungus Aspergillus niger
article 1995    
Author: Brink, J.M. van den · Zeijl, C.M.J. van · Brons, J.F. · Hondel, C.A.M.J.J. van den · Gorcom, R.F.M. van
Keywords: Nutrition · Benzoic acid derivative · Reduced nicotinamide adenine dinucleotide phosphate ferrihemoprotein reductase · Amino acid sequence · Aspergillus niger · Gene isolation · Gene sequence · Genetic analysis · Hybridization · Molecular cloning · Nonhuman · Nucleotide sequence · Polymerase chain reaction · Priority journal · Sequence analysis · Structure activity relation · Amidohydrolases · Amino Acid Sequence · Aspergillus niger · Base Sequence · Benzoates · Benzoic Acid · Cloning, Molecular · Conserved Sequence · Enzyme Induction · Gene Dosage · Gene Expression Regulation, Fungal · Genes, Structural, Fungal · Molecular Sequence Data · NADPH-Ferrihemoprotein Reductase · Polymerase Chain Reaction · Restriction Mapping · Sequence Alignment · Sequence Analysis, DNA · Transformation, Genetic
[Abstract]

9 Tissue culture and neurotoxicology
article 1982    
Author: Hooisma, J.
Keywords: Biology · Acrylamide · Colchicine · Glutathione · Nicotinamide adenine dinucleotide · Animal cell · Brain cell · Central nervous system · Dose response · Drug comparison · Drug mechanism · Drug mixture · Drug response · Drug screening · In vitro study · Intoxication · Methodology · Nervous system · Neurotoxicity · Nonhuman · Rat · Tissue culture · Acrylamide · Acrylamides · Animal · Axons · Colchicine · Female · Ganglia, Spinal · Glutathione · Male · NAD · Nervous System Diseases · Rats · Rats, Inbred Strains · Support, Non-U.S. Gov't · Tissue Culture · Toxicology
[Abstract]

10 K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study
article 2003    
Author: Brink, M. · Goeij, A.F.P.M. de · Weijenberg, M.P. · Roemen, G.M.J.M. · Lentjes, M.H.F.M. · Pachen, M.M.M. · Smits, K.M. · Bruïne, A.P. de · Goldbohm, R.A. · Brandt, P.A. van den
Keywords: Health Biology · Food and Chemical Risk Analysis · adenine · DNA fragment · guanine · thymine · adult · aged · cancer cell culture · cancer growth · cancer localization · cancer risk · cancer staging · cancer tissue · codon · cohort analysis · colon carcinogenesis · colorectal cancer · controlled study · correlation analysis · DNA purification · environmental factor · exon · familial cancer · family history · female · gene mutation · gene sequence · histopathology · human · human cell · human tissue · incidence · major clinical study · male · mutational analysis · Netherlands · nucleic acid base substitution · oncogene K ras · polymerase chain reaction · priority journal · reproducibility · review · tumor biopsy · tumor differentiation · validation process · Base Sequence · Cohort Studies · Colorectal Neoplasms · DNA Primers · Genes, ras · Humans · Mutation · Netherlands
[Abstract]

11 Calreticulin transacetylase mediates the acetylation of nitric oxide synthase by polyphenolic acetate
article 2008    
Author: Bansal, S. · Gaspari, M. · Raj, H.G. · Kumar, A. · Cuda, G. · Verheij, E. · Tyagi, Y.K. · Ponnan, P. · Rastogi, R.C. · Parmar, V.S.
Keywords: Nanotechnology · Calreticulin · Nitric oxide synthase · Polyphenolic acetates · Protein acetylation · Transacetylase · Acetylation · Binding sites · Cell membranes · Enzyme activity · Proteins · Calreticulin · Polyphenolic acetates · Protein acetylation · Transacetylase · Nitric oxide · 7,8 diacetoxy 4 methylcoumarin · acyltransferase · calreticulin · calreticulin transacetylase · coumarin derivative · lysine · nitric oxide synthase · polyphenol acetate · polyphenol derivative · reduced nicotinamide adenine dinucleotide phosphate · acetylation · amino acid sequence · article · binding affinity · catalysis · controlled study · enzyme purification · human · human tissue · mass spectrometry · protein domain · Acetates · Acetylation · Acetyltransferases · Amino Acid Sequence · Amino-Acid N-Acetyltransferase · Calcium-Binding Protein, Vitamin D-Dependent · Chromatography, Liquid · Female · Flavonoids · Humans · Lysine · Molecular Sequence Data · Nanotechnology · Nitric Oxide Synthase Type I · Peptides · Phenols · Placenta · Pregnancy · Tandem Mass Spectrometry
[Abstract]

12 Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma
article 2006    
Author: Dijk, B.A.C. van · Schouten, L.J. · Oosterwijk, E. · Hulsbergen van de · Kaa, C.A. · Kiemeney, L.A.L.M. · Goldbohm, R.A. · Schalken, J.A. · Brandt, P.A. van den
Keywords: Health · Food and Chemical Risk Analysis · Cigarette smoking · Cohort study · Renal cell carcinoma · The Netherlands · Von Hippel-Lindau gene mutations · adenine · cytosine · guanine · thymine · adult · aged · article · cigarette smoking · clear cell carcinoma · cohort analysis · dose response · female · follow up · gene · gene mutation · human · human tissue · kidney carcinoma · major clinical study · male · Netherlands · nucleic acid base substitution · priority journal · risk factor · von hippel lindau gene · Aged · Carcinoma, Renal Cell · Cohort Studies · Female · Humans · Japan · Kidney Neoplasms · Male · Middle Aged · Multivariate Analysis · Mutation · Risk Factors · Smoking · Von Hippel-Lindau Tumor Suppressor Protein
[PDF] [Abstract]

13 Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study
article 2004    
Author: Brink, M. · Weijenberg, M.P. · Goeij, A.F.P.M. de · Schouten, L.J. · Koedijk, F.D.H. · Roemen, G.M.J.M. · Lentjes, M.H.F.M. · Bruïne, A.P. de · Goldbohm, R.A. · Brandt, P.A. van den
Keywords: Health · Food and Chemical Risk Analysis · adenine · fat · guanine · K ras protein · linoleic acid · monounsaturated fatty acid · polyunsaturated fatty acid · thymine · unsaturated fatty acid · adult · aged · article · cancer incidence · cancer patient · cancer risk · cohort analysis · colon cancer · colon carcinogenesis · colorectal cancer · confidence interval · controlled study · data analysis · fat intake · female · follow up · gene mutation · human · major clinical study · male · mutational analysis · Netherlands · nucleic acid base substitution · oncogene K ras · priority journal · rectum cancer · risk factor · Aged · Cohort Studies · Colonic Neoplasms · Diet · Fats · Female · Follow-Up Studies · Genes, ras · Humans · Male · Middle Aged · Mutation · Netherlands · Rectal Neoplasms
[Abstract]

14 Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways
article 2000    
Author: Werf, M.J. van der
Keywords: Nutrition · Carvone · Flavoprotein · Limonene · Menthol · Regioselectivity · Bacterial enzyme · Carvone · Cyclohexanone derivative · Heptanoic acid derivative · Limonene · Menthone · Terpene · Unspecific monooxygenase · Amino acid sequence · Amino terminal sequence · Biodegradation · Enzyme activity · Enzyme analysis · Enzyme purification · Enzyme specificity · Enzyme structure · Molecular weight · Nonhuman · Priority journal · Rhodococcus · Sequence homology · Stereochemistry · Aldehydes · Amino Acid Sequence · Biodegradation, Environmental · Catalysis · Cyclohexanones · Enzyme Induction · Enzyme Inhibitors · Flavin-Adenine Dinucleotide · Hydrogen-Ion Concentration · Menthol · Metals · Molecular Sequence Data · Molecular Weight · Oxygenases · Rhodococcus · Sequence Alignment · Sequence Homology, Amino Acid · Spectrum Analysis · Stereoisomerism · Substrate Specificity · Temperature · Terpenes
[Abstract]

15 Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450
article 1998    
Author: Bessems, J.G.M. · Groot, M.J. de · Baede, E.J. · Koppele, J.M. te · Vermeulen, N.P.E.
Keywords: Nutrition · Analgesic agent · Cytochrome p450 · Horseradish peroxidase · Hydrogen peroxide · Paracetamol · Reduced nicotinamide adenine dinucleotide phosphate · Analgesia · Animal experiment · Animal tissue · Biotransformation · Catalysis · Drug metabolism · Electron spin resonance · Enzyme activity · Liver microsome · Male · Nonhuman · Oxidation · Rat · Acetaminophen · Animals · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP2B1 · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Electron Spin Resonance Spectroscopy · Free Radicals · Horseradish Peroxidase · Hydrogen · Male · Microsomes, Liver · NADP · Oxidation-Reduction · Rats · Rats, Wistar · Thermodynamics · Animalia · Armoracia rusticana · Rickettsia sp. PAR
[Abstract]

16 Synthesis and biological evaluation of disubstituted N6- cyclopentyladenine analogues: The search for a neutral antagonist with high affinity for the adenosine A1 receptor
article 2004    
Author: Ligt, R.A.F. de · Klein, P.A.M. van der · Frijtag Drabbe Künzel, J.K. von · Lorenzen, A. · El Maate, F.A. · Fujikawa, S. · Westhoven, R. van · Hoven, T. van den · Brussee, J. · Ijzerman, A.P.
Keywords: Biology Toxicology · Physiological Sciences · [35S]GTPγS binding · Adenosine A1 receptor · Inverse agonism · N-0840 derivatives · Neutral antagonist · 8 bromo 9 methyladenine · 8 bromo n 6 cyclopentyl 9 methyladenine · 8 bromo n 6 cyclopentyl 9 propyladenine · 9 allyl 8 bromo n 6 cyclopentyladenine · 9 allyl n 6 cyclopentyl 8 methoxyadenine · adenine derivative · adenosine A1 receptor antagonist · luf 5666 · luf 5668 · luf 5669 · luf 5674 · n 0840 · n 6 cyclopentyl 8 (ethylthio) 9 methyladenine · n 6 cyclopentyl 8 (n ethyl n butylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methyl n ethylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methyl n propylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methylisopropylamino) 9 methyladenine · n 6 cyclopentyl 8 (n piperidino) 9 methyladenine · n 6 cyclopentyl 8 (n pyrrolidino) 9 methyladenine · n 6 cyclopentyl 8 (n,n diethylamino) 9 methyladenine · n 6 cyclopentyl 8 ethoxy 9 methyladenine · n 6 cyclopentyl 8 isopropoxy 9 methyladenine · n 6 cyclopentyl 8 methoxy 9 methyladenine · n 6 cyclopentyl 8 methoxy 9 propyladenine · n 6 cyclopentyl 9 methyl 8 oxoadenine · n 6 cyclopentyl 9 methyl 8 propoxyadenine · n 6 cyclopentyl 9 methyladenine · unclassified drug · article · binding affinity · drug determination · drug synthesis · drug tolerability · receptor affinity · substitution reaction · Adenine · Adenosine · Animals · Cell Line · CHO Cells · Cricetinae · Drug Evaluation, Preclinical · Humans · Receptor, Adenosine A1
[Abstract]

17 Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity
article 2006    
Author: Boerboom, A.M.J.F. · Vermeulen, M. · Woude, H. van der · Bremer, B.I. · Lee-Hilz, Y.Y. · Kampman, E. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Aarts, J.M.M.J.G.
Keywords: Biology · Benzyl isothiocyanate · Fisetin · Glutathione transferase · Kaempferol · Luteolin · Myricetin · Quercetin · Reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone) · Taxifolin · Tert butylhydroquinone · Animal cell · Antioxidant activity · Cancer cell culture · Cancer screening · Chemoprophylaxis · Controlled study · Drug potency · Drug structure · Electrophile responsive element mediated gene · Enzyme induction · Gene · Gene activation · Gene expression · Gene induction · Genetic transcription · Human cell · Molecular interaction · Mouse · Nonhuman · Reporter gene · Screening test · Stereospecificity · Structure activity relation · Tandem repeat · Transcription initiation · Validation study · Animals · Base Sequence · Cell Line · DNA Primers · Enzyme Induction · Flavonoids · Gene Expression · Genes, Reporter · Humans · Luciferases · Mice · Plasmids · Structure-Activity Relationship · Transcription, Genetic · Benzyl isothiocyanate · Electrophile-responsive element (EpRE) · Hepa-1c1c7 cells · Stable luciferase reporter cell lines · Transient transfection
[Abstract]

18 The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro
article 2005    
Author: Parnham, M.J. · Bogaards, J.J.P. · Schrander, F. · Schut, M.W. · Orešković, K. · Mildner, B.
Keywords: Health Pharmacology · Physiological Sciences · Cytochrome P450 · Metabolism · PLD-118 · 2 amino 4 methylenecyclopentanecarboxylic acid · alpha naphthoflavone · amino acid · antifungal agent · bufuralol · chlorzoxazone · coumarin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2B6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · cytochrome P450 3A · diclofenac · diethyldithiocarbamic acid · ethoxyresorufin · ketoconazole · mephenytoin · monoclonal antibody · monoclonal antibody 2B6 · quinidine · reduced nicotinamide adenine dinucleotide phosphate · resorufin · sulfaphenazole · testosterone · umbelliferone · unclassified drug · unindexed drug · analytic method · animal tissue · article · candidiasis · concentration response · controlled study · derivatization · dog · drug structure · enzyme assay · enzyme inhibition · enzyme stability · enzyme substrate · fluorescence analysis · high performance liquid chromatography · human · human tissue · in vitro study · liver homogenate · liver microsome metabolism · nonhuman · rat · structure analysis · Administration, Oral · Animals · Antifungal Agents · Chemistry, Pharmaceutical · Cycloleucine · Cytochrome P-450 Enzyme System · Dogs · Drug Evaluation, Preclinical · Humans · Microsomes, Liver · Rats · Ribosomal Proteins
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 18 of 18 found. | Sort by date