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1 A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity
article 2019    
Author: Desprez, B. · Birk, B. · Blaauboer, B. · Boobis, A. · Carmichael, P. · Cronin, M.T.D. · Curie, R. · Daston, G. · Hubesch, B. · Jennings, P. · Klaric, M. · Kroese, D. · Mahony, C. · Ouédraogo, G. · Piersma, A. · Richarz, A.N. · Schwarz, M. · Benthem, J. van · Water, B. van de · Vinken, M.
Keywords: Adverse outcome pathway · Mode-of-action · Ontology model · Repeated dose toxicity · Cosmetic · Adverse outcome · Biotransformation · Chemical parameters · Chemical structure · Cytotoxicity · Exposure · Human · Kinetics · Metabolism · Mode of action · Nonhuman · Note · Ontology · Organ distribution · Physical chemistry · Repeated dose toxicity · Safety · Toxicity testing · Toxicology · Workflow
[Abstract]

2 Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data
article 2014    
Author: Veen, J.W. van der · Soeteman-Hernández, L.G. · Ezendam, J. · Stierum, R. · Kuper, F.C. · Loveren, H. van
Keywords: Biology · Adverse outcome pathway · Allergic contact dermatitis · Human in vitro systems · Mechanisms of toxicity · Molecular map · Skin sensitization · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Pathways of Toxicity : t4 workshop
article 2014    
Author: Kleensang, A. · Maertens, A. · Rosenberg, M. · Fitzpatrick, S. · Lamb, J. · Auerbach, S. · Brennan, R. · Crofton, K.M. · Gordon, B. · Fornace Jr., A.J. · Gaido, K. · Gerhold, D. · Haw, R. · Henney, A. · Ma’ayan, A. · McBride, M. · Monti, S. · Ochs, M.F. · Pandey, A. · Sharan, R. · Stierum, R. · Tugendreich, Z. · Willett, C. · Wittwehr, C. · Xia, J. · Patton, G.W. · Arvidson, K. · Bouhifd, M. · Hogberg, H.T. · Luechtefeld, T. · Smirnova, L. · Zhao, L. · Adeleye,Y. · Kanehisa, M. · Carmichael, P. · Andersen, M.E. · Hartung, T.
Keywords: Toxicology · Systems toxicology · Pathways of toxicity · Adverse outcome pathways · In vitro toxicology · Human toxome · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins
article 2017    
Author: Bilsen, J.H.M. van · Sienkiewicz-Szłapka, E. · Lozano-Ojalvo, D. · Willemsen, L.E.M. · Antunes, C.M. · Molina, E. · Smit, J.J. · Wróblewska, B. · Wichers, H.J. · Knol, E.F. · Ladics, G.S. · Pieters, R.H.H. · Denery-Papini, S. · Vissers, Y.M. · Bavaro, S.L. · Larré, C. · Verhoeckx, K.C.M. · Roggen, E.L.
Keywords: Biology · Adverse outcome pathway · Food allergy · Food proteins · Key event relations · Key events · Mechanistic understanding · Molecular initiating event · Sensitization · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

5 Adverse outcome pathways: opportunities, limitations and open questions
article 2017    
Author: Leist, M. · Ghallab, A. · Graepel, R. · Marchan, R. · Hassan, R. · Bennekou, S.H. · Limonciel, A. · Vinken, M. · Schildknecht, S. · Waldmann, T. · Danen, E. · Ravenzwaay, B. van · Kamp, H. · Gardner, I. · Godoy, P. · Bois, F.Y. · Braeuning, A. · Reif, R. · Oesch, F. · Drasdo, D. · Höhme, S. · Schwarz, M. · Hartung, T. · Braunbeck, T. · Beltman, J. · Vrieling, H. · Sanz, F. · Forsby, A. · Gadaleta, D. · Fisher, C. · Kelm, J. · Fluri, D. · Ecker, G. · Zdrazil, B. · Terron, A. · Jennings, P. · Burg, B. van der · Dooley, S. · Meijer, A.H. · Willighagen, E. · Martens, M. · Evelo, C. · Mombelli, E. · Taboureau, O. · Mantovani, A. · Hardy, B. · Koch, B. · Escher, S. · van Thriel, C. · Cadenas, C. · Kroese, D. · Water, B. van de · Hengstler, J.G.
Keywords: Biology · Binning of events · CCl4 · Computational toxicology · Interspecies extrapolation · Liver fibrosis · Metabolism · Multi-scale integration · Multiple hit events · Paracetamol · Pathway unidirectionality · Prioritization of compounds · Proof of non-toxicity · Regulatory toxicology · Systems biology · Tumor promotion · Vinyl acetate · Adverse outcome · Adverse outcome pathway · Ecotoxicology · Epidemiological data · Human · Nonhuman · Plasticity · Risk assessment · Signal transduction · Toxicity assay · Toxicokinetics · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Read-across approaches - Misconceptions, promises and challenges ahead
article 2014    
Author: Patlewicz, G. · Ball, N. · Becker, R.A. · Booth, E.D. · Cronin, M.T.D. · Kroese, D. · Steup, D. · Ravenzwaay, B. van · Hartung, T.
Keywords: Biology · (Q)SARs · Adverse outcome pathways (AOP) · Analogue approach · Category approach · Scientific confidence framework · Chemical compound · Awareness · Data processing · Ecotoxicology · Human · Information processing · Nonhuman · Quantitative structure activity relation · Read across approach · Toxicity · Toxicology · Uncertainty · Validity · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies
article 2019    
Author: Lozano-Ojalvo, D. · Benede, S. · Antunes, C.M. · Bavaro, S.L. · Bouchaud, G. · Costa, A. · Denery-Papini, S. · Diaz-Perales, A. · Garrido-Arandia, M. · Gavrovic-Jankulovic, M. · Hayen, S. · Martinez-Blanco, M. · Molina, E. · Monaci, L. · Pieters, R.H.H. · Villemin, C. · Wichers, H.J. · Wroblewska, B. · Willemsen, L.E.M. · Roggen, E.L. · Bilsen, J.H.M. van
Keywords: Nutrition · Adverse outcome pathway · Dendritic cells · Epithelial cells · IgE-mediated food allergy · In vitro models · T and B cells · Allergies · Cytology · Immune system · Proteins · Risk assessment · Adverse outcomes · B cells · Dendritic cells · Epithelial cells · Food allergies · In-vitro models · Cells · Life · RAPID - Risk Analysis for Products in Development
[Abstract]

8 Cost-effectiveness of planned birth in a birth centre compared with alternative planned places of birth: results of the Dutch Birth Centre study
article 2017    
Author: Hitzert, M. · Hermus, M.M. · Boesveld, I.I. · Franx, A. · Pal-de Bruin, K.K. van der · Steegers, E.E. · Akker-van Marle, E.M. van den
Keywords: Health · Birth centre · Economic evaluation · Maternity care; · Optimality index · Adult · Adverse outcome · Cost effectiveness analysis · Female · Home delivery · Human · Major clinical study · Maternal care · Multipara · Netherlands · Nullipara · Traditional birth attendant · Healthy for Life · Healthy Living · Life · CH - Child Health · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

9 Double-blind placebo-controlled food challenges in children with alleged cow's milk allergy: Prevention of unnecessary elimination diets and determination of eliciting doses
article 2013    
Author: Dambacher, W.M. · Kort, E.H.M. de · Blom, W.M. · Houben, G.F. · Vries, E. de
Keywords: Health · Cow's milk allergy · Cow's milk protein · Double-blind placebo-controlled provocation · Milk hypersensitivity · Minimum eliciting dose · food allergen · milk protein · abdominal pain · adverse outcome · allergic reaction · article · artificial milk · child · colic · constipation · controlled study · diarrhea · diet · double blind procedure · dyspnea · eczema · feeding disorder · female · human · infant · infant feeding · major clinical study · male · milk allergy · pathological crying · preschool child · prospective study · provocation test · randomized controlled trial · rash · rectum hemorrhage · school child · swelling · urticaria · vomiting · wheezing · Food and Nutrition · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

10 Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raisingA systematic review and meta-analysis of relevant preclinical studies and clinical trials
article 2015    
Author: Kühnast, S. · Fiocco, M. · Hoorn, J.W.A. van der · Princen, H.M.G. · Jukema, J.W.
Keywords: Biology · 3Leiden.CETP mice · ABCA1 degradation inhibitors · APOE · Apolipoprotein A-I inducer · Apolipoprotein A-I Milano · Apolipoprotein A-I mimetic · Atherosclerosis · Cardiovascular disease · CETP inhibition · Clinical outcome · Clinical trials · Delipidated HDL · Fibrates · Glitazones · Hamster · HDL-cholesterol · LCAT · LDL-cholesterol · Mouse · Myocardial infarction · Niacin · Non-HDL-cholesterol · PPAR agonists · Rabbit · Reconstituted HDL · SR-BI inhibitor · Agents affecting lipid metabolism · ATP binding cassette A1 degradation inhibitor · Cardiovascular agent · Cholesterol ester transfer protein · Cholesterol ester transfer protein inhibitor · Dalcetrapib · Fibric acid derivative · Glitazar derivative · Glitazone derivative · High density lipoprotein cholesterol · Liver X receptor agonist · Low density lipoprotein cholesterol · Nicotinic acid · Peptide derivative · Peroxisome proliferator activated receptor agonist · Placebo · Receptor blocking agent · Scavenger receptor BI inhibitor · Unclassified drug · Adverse outcome · Cardiovascular risk · Cholesterol blood level · Clinical trial (topic) · Disease association · Drug effect · Drug targeting · Heart infarction · Human · Meta analysis · Mortality · Nonhuman · Protein expression · Randomized controlled trial (topic) · Risk management · Risk reduction · Systematic review · Treatment response · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 10 of 10 found. | Sort by date