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1 Effects of fenofibrate on hyperlipidemia and postprandial triglyceride metabolism in human apolipoprotein C1 transgenic mice
article 1998    
Author: Jong, M.C. · Dahlmans, V.E.H. · Princen, H.M.G. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Apo C · LDL-receptor · Transgenic mice · Triglycerides · Animals · Antilipemic Agents · Apolipoproteins C · Humans · Hyperlipidemias · Mice · Mice, Transgenic · Procetofen · Triglycerides
[Abstract]

2 Plant sterol intakes and colorectal cancer risk in the Netherlands : cohort study on diet and cancer
article 2001    
Author: Normén, A.L. · Brants, H.A.M. · Voorrips, L.E. · Andersson, H.A. · Brandt, P.A. van den
Keywords: Nutrition · Aged · Antilipemic Agents · Bread · Case-Control Studies · Cholesterol · Cohort Studies · Colorectal Neoplasms · Confounding Factors (Epidemiology) · Dietary Fats · Female · Follow-Up Studies · Fruit · Humans · Male · Middle Aged · Netherlands · Phytosterols · Prospective Studies · Questionnaires · Rectal Neoplasms · Risk Factors · Sitosterols · Stigmasterol · Vegetables
[Abstract]

3 Studies on the role of PPAR in the fibrate-modulated gene expression of apolipoprotein A-I, plasminogen activator inhibitor 1, and fibrinogen in primary hepatocyte cultures from cynomolgus monkey
article 1996    
Author: Kockx, M. · Princen, H.M.G. · Kooistra, T.
Keywords: Animals · Antilipemic Agents · Apolipoprotein A-I · Cells, Cultured · Female · Fibrinogen · Gene Expression Regulation · Macaca fascicularis · Male · Microbodies · Plasminogen Activator Inhibitor 1 · Pyrimidines · Receptors, Cytoplasmic and Nuclear · Transcription Factors · Animalia · Macaca fascicularis
[Abstract]

4 Lack of predictability of classical animal models for hypolipidemic activity: A good time for mice?
article 1998    
Author: Krause, B.R. · Princen, H.M.G.
Keywords: Health · Classic models · HMG-CoA reductase · Hypolipidemic activity · 3 (2,4 difluorophenyl) 1 heptyl 1 (4 neopentylbenzyl)urea · Animals · Antilipemic Agents · Disease Models, Animal · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hyperlipidemias · Lipids · Lipoproteins · Mice · Niacin
[Abstract]

5 Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-α
article 1999    
Author: Kockx, M. · Gervois, P.P. · Poulain, P. · Derudas, B. · Peters, J.M. · Gonzalez, F.J. · Princen, H.M.G. · Kooistra, T. · Staels, B.
Keywords: Biology · Antilipemic Agents · Cells, Cultured · Clofibrate · Clofibric Acid · DNA-Binding Proteins · Fibrinogen · Gene Expression Regulation · Kinetics · Liver · Male · Mice · Mice, Knockout · Peroxisome Proliferators · Procetofen · Rats · Rats, Sprague-Dawley · Rats, Wistar · Receptors, Cytoplasmic and Nuclear · RNA, Messenger · Transcription Factors · Transcription, Genetic · Triglycerides
[Abstract]

6 Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes. Role of the peroxisome proliferator-activated receptor-α
article 1998    
Author: Kockx, M. · Princen, H.M.G. · Kooistra, T.
Keywords: Health · Animals · Antilipemic Agents · Apolipoprotein A-I · Cells, Cultured · Clofibrate · Clofibric Acid · Dimerization · Female · Fibrinogen · Gemfibrozil · Gene Expression Regulation · Genes, Reporter · Liver · Macaca fascicularis · Male · Peroxisome Proliferators · Plasminogen Activator Inhibitor 1 · Procetofen · Pyrimidines · Receptors, Cytoplasmic and Nuclear · Receptors, Retinoic Acid · Retinoid X Receptors · Trans-Activation (Genetics) · Transcription Factors · Tretinoin
[Abstract]

7 Apolipoprotein E1-Hammersmith (Lys146 → Asn;Arg147 → Trp), due to a dinucleotide substitution, is associated with early manifestation of dominant type III hyperlipoproteinaemia
article 1996    
Author: Hoffer, M.J.V. · Niththyananthan, S. · Naoumova, R.P. · Kibirige, M.S. · Frants, R.R. · Havekes, L.M. · Thompson, G.R.
Keywords: Biology · Dyslipidaemia · Cclofibrate · Colestyramine · Mercaptamine · Atherosclerosis · Case report · Adult · Anticholesteremic Agents · Antilipemic Agents · Apolipoproteins E · Child · Child, Preschool · Cholesterol · Cholestyramine · Cysteamine · Dinucleotide Repeats · DNA · Electrophoresis · Exons · Female · Genotype · Humans · Hyperlipoproteinemia Type III · Immunoblotting · Male · Nuclear Family · Phenotype · Point Mutation · Procetofen · Radiation-Protective Agents · Triglycerides
[Abstract]

8 Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia
article 1997    
Author: Maat, M.P.M. de · Knipscheer, H.C. · Kastelein, J.J.P. · Kluft, C.
Keywords: Biology · C reactive protein · Ciprofibrate · Acute phase response · Cardiovascular disease · Clinical trial · Controlled clinical trial · Controlled study · Drug effect · Drug mechanism · Fibrinogen blood level · Genetic polymorphism · Hypercholesterolemia · Major clinical study · Oral drug administration · Randomized controlled trial · Risk factor · Adult · Antilipemic Agents · Clofibric Acid · Female · Fibrinogen · Gemfibrozil · Humans · Hyperlipidemias · Male · Middle Aged
[Abstract]

9 Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression
article 2001    
Author: Post, S.M. · Duez, H. · Gervois, P.P. · Staels, B. · Kuipers, F. · Princen, H.M.G.
Keywords: Animals · Antilipemic Agents · Bile Acids and Salts · Cells, Cultured · Cholesterol · Cholesterol 7-alpha-Hydroxylase · Clofibric Acid · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Down-Regulation · Hepatocytes · Mice · Mice, Knockout · Pyrimidines · Rats · Receptors, Cytoplasmic and Nuclear · RNA, Messenger · Steroid Hydroxylases · Transcription Factors · Transcription, Genetic
[Abstract]

10 Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation
article 2003    
Author: Kleemann, R. · Gervois, P.P. · Verschuren, L. · Staels, B. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Animals · Antilipemic Agents · Bezafibrate · C-Reactive Protein · CCAAT-Enhancer-Binding Protein-beta · Cell Nucleus · Clofibric Acid · Down-Regulation · Hepatocytes · Humans · Interleukin-1 · Mice · Mice, Knockout · NF-kappa B · NF-kappa B p50 Subunit · Protein Binding · Receptors, Cytoplasmic and Nuclear · Transcription Factors · Transcription, Genetic · Transfection
[Abstract]

11 Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression
article 2007    
Author: Hoogt, C.C. van der · Haan, W. de · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Romijn, J.A. · Princen, H.M.G. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · Fibrate · High density lipoprotein · Peroxisome proliferator-activated receptor α · Transgenic mice · apolipoprotein E · cholesterol ester transfer protein · fenofibrate · high density lipoprotein cholesterol · very low density lipoprotein · animal experiment · cholesterol transport · controlled study · drug mechanism · food intake · gene expression · lipid metabolism · mouse · nonhuman · priority journal · protein expression · protein function · steady state · transgene · Animals · Antilipemic Agents · Apolipoproteins B · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Gene Expression · Humans · Liver · Male · Mice · Mice, Transgenic · Procetofen · RNA, Messenger
[PDF] [Abstract]

12 Cholestrol content of the rat lens is lowered by administration of simvastatin, but not pravastatin
article 1993    
Author: Vries, A.C.J. de · Vermeer, M.A. · Bredman, J.J. · Bar, P.R. · Cohen, L.H.
Keywords: Pharmacology · 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors · hypocholesterolaemic drugs · antilipemic agent · drug derivative · hydroxymethylglutaryl coenzyme A reductase inhibitor · hypocholesterolemic agent · mevinolin · animal experiment · cholesterol metabolism · oral drug administration · biosynthesis · dose response · drug effect · enzymology · liver microsome · metabolism · organ culture · rat strain · time · Aging · Animal · Anticholesteremic Agents · Antilipemic Agents · Cholesterol · Dose-Response Relationship, Drug · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lens, Crystalline · Lovastatin · Microsomes, Liver · Organ Culture · Pravastatin · Rats · Rats, Wistar · Simvastatin · Time Factors
[Abstract]

13 Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients
article 1997    
Author: Kockx, M. · Maat, M.P.M. de · Knipscheer, H.C. · Kastelein, J.P. · Kluft, C. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Antigen · Antilipemic agent · Cholesterol · Ciprofibrate · Fibrinogen · Gemfibrozil · Plasminogen activator inhibitor · Tissue plasminogen activator · Triacylglycerol · Adult · Blood level · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Double blind procedure · Drug effect · Enzyme immunoassay · Female · Fibrinogen blood level · Hyperlipidemia · Major clinical study · Male · Priority journal · Triacylglycerol blood level · Aged · Antilipemic Agents · Cholesterol · Clofibric Acid · Double-Blind Method · Female · Fibrinogen · Gemfibrozil · Humans · Hyperlipoproteinemia Type II · Male · Middle Aged · Plasminogen Activator Inhibitor 1 · Smoking · Tissue Plasminogen Activator · Treatment Outcome
[Abstract]

14 Studies on the mechanism of fibrate-inhibited expression of plasminogen activator inhibitor-1 in cultured hepatocytes from cynomolgus monkey
article 1997    
Author: Arts, J. · Kooistra, T.
Keywords: Biology · 9-cis retinoic acid · fibrates · hepatocytes · peroxisome proliferator-activated receptor · plasminogen activator inhibitor-1 · 2 [1 (3 amidinothiopropyl) 1h indol 3 yl] 3 (1 methyl 1h indol 3 yl)maleimide · alitretinoin · antilipemic agent · epidermal growth factor · fibric acid derivative · gemfibrozil · peroxisome proliferator · phorbol 13 acetate 12 myristate · plasminogen activator inhibitor 1 · protein kinase C · protein kinase C inhibitor · retinoid X receptor · transforming growth factor beta · animal cell · controlled study · dose time effect relation · drug mechanism · enzyme activity · gene expression · hyperlipidemia · liver cell culture · monkey · nonhuman · Animals · Antilipemic Agents · Cells, Cultured · Dose-Response Relationship, Drug · Liver · Macaca fascicularis · Plasminogen Activator Inhibitor 1 · RNA, Messenger
[Abstract]

15 Fenofibrate reduces atherogenesis in ApoE*3Leiden mice: Evidence for multiple antiatherogenic effects besides lowering plasma cholesterol
article 2006    
Author: Kooistra, T. · Verschuren, L. · Vries de-Weij, J.van der · Koenig, W. · Toet, K. · Princen, H.M.G. · Kleemann, R.
Keywords: Biology · Biomedical Research · Atherosclerosis · Fibrates · Inflammation · Pleiotrop · Reverse cholesterol transport · ABC transporter A1 · Cholesterol · Fenofibrate · Granulocyte macrophage colony stimulating factor · Immunoglobulin enhancer binding protein · Intercellular adhesion molecule 1 · Monocyte chemotactic protein 1 · Serum amyloid A · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta atherosclerosis · Atherogenesis · Cholesterol blood level · Cholesterol diet · Cholesterol transport · Controlled study · Disease severity · Drug effect · Macrophage · Mouse · Nonhuman · Protein blood level · Protein expression · Transgenic mouse · Upregulation · Animals · Antilipemic Agents · Aorta · Aortic Valve · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Cholesterol · Female · Inflammation · Lipids · Lipoproteins · Mice · Mice, Transgenic · Procetofen
[Abstract]

16 Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids
article 2009    
Author: Kersten, S. · Lichtenstein, L. · Steenbergen, E. · Mudde, K. · Hendriks, H.F.J. · Hesselink, M.K. · Schrauwen, P. · Müller, M.
Keywords: Nutrition · Biomedical Research · ANGPTL4 · Caloric restriction · Free fatty acids · angiopoietin · angiopoietin like protein 4 · beta adrenergic receptor stimulating agent · fatty acid · unclassified drug · ANGPTL4 protein, human · Angptl4 protein, mouse · antilipemic agent · Fiaf protein, rat · lipid emulsion · messenger RNA · salbutamol · adult · animal cell · article · blood sampling · caloric restriction · cell strain HepG2 · controlled study · enzyme linked immunosorbent assay · exercise · fatty acid blood level · female · gene expression · genetic variability · hepatoma cell · human · human cell · human experiment · intestine cell · male · mouse · muscle cell · nonhuman · normal human · priority journal · protein blood level · rat · animal · blood · cell culture · clinical trial · controlled clinical trial · genetic transfection · genetics · heart muscle cell · intestine · liver tumor · metabolism · middle aged · randomized controlled trial · time · upregulation · Adrenergic beta-Agonists · Adult · Albuterol · Angiopoietins · Animals · Antilipemic Agents · Caloric Restriction · Cells, Cultured · Enzyme-Linked Immunosorbent Assay · Exercise · Fat Emulsions, Intravenous · Fatty Acids, Nonesterified · Humans · Intestines · Liver Neoplasms · Male · Mice · Middle Aged · Myocytes, Cardiac · Rats · RNA, Messenger · Time Factors · Transfection · Up-Regulation · Young Adult
[Abstract]

17 Mouse models for atherosclerosis and pharmaceutical modifiers
article 2007    
Author: Zadelaar, A.S.M. · Kleemann, R. · Verschuren, L. · Vries-van der Weij, J. de · Hoorn, J. van der · Princen, H.M. · Kooistra, T.
Keywords: Biology · Biomedical Research · ACE inhibitors · AT1 receptor antagonists · Atherosclerosis · LXR · Mouse models · Pharmaceutical drugs · PPAR · Statins · atorvastatin · avasimibe · candesartan · captopril · cholesterol acyltransferase inhibitor · dipeptidyl carboxypeptidase inhibitor · hydralazine · hydroxymethylglutaryl coenzyme A reductase inhibitor · irbesartan · losartan · ly 465608 · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · olmesartan · perindopril · peroxisome proliferator activated receptor alpha agonist · pirinixic acid · pitavastatin · pravastatin · quinapril · ramipril · rosuvastatin · simvastatin · telmisartan · temocapril · unindexed drug · valsartan · zofenopril · antihypertensive agent · antilipemic agent · apolipoprotein E · atherosclerosis · pathophysiology · sensitivity and specificity · Animals · Antihypertensive Agents · Antilipemic Agents · Apolipoproteins E · Atherosclerosis · Disease Models, Animal · Dose-Response Relationship, Drug · Drug Administration Schedule · Dyslipidemias · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypertension · Male · Mice · Mice, Knockout · Mice, Transgenic · Sensitivity and Specificity
[Abstract]

18 Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice
article 2008    
Author: Hoorn, J.W.A. van der · Haan, W. de · Berbée, J.P.P. · Havekes, L.M. · Jukema, J.W. · Rensen, P.C. · Princen, H.M.G.
Keywords: APOE*3Leiden.CETP transgenic mice · CETP · HDL-cholesterol · Hyperlipidemia · Niacin · cholesterol · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · low density lipoprotein cholesterol · nicotinic acid · triacylglycerol · antilipemic agent · CETP protein, human · messenger RNA · animal experiment · animal model · animal tissue · blood level · cholesterol blood level · controlled study · dose response · drug dose comparison · drug mechanism · female · gene activity · gene expression regulation · hypercholesterolemia · hypertriglyceridemia · kidney · lipid transport · lipoprotein blood level · liver · mouse · mouse strain · nonhuman · particle size · plasma clearance · priority journal · protein blood level · protein function · protein transport · transgenic mouse · triacylglycerol blood level · atherosclerosis · bile · blood · chemistry · disease model · drug effect · fat intake · feces · genetics · metabolism · time · upregulation · Animals · Antilipemic Agents · Apolipoprotein A-I · Apolipoprotein E3 · Atherosclerosis · Bile · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Dietary Fats · Disease Models, Animal · Dose-Response Relationship, Drug · Feces · Female · Humans · Liver · Mice · Mice, Transgenic · Niacin · RNA, Messenger · Time Factors · Triglycerides · Up-Regulation
[Abstract]

19 Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-α Activator Fenofibrate
article 2004    
Author: Gervois, P. · Kleemann, R. · Pilon, A. · Percevault, F. · Koenig, W. · Staels, B. · Kooistra, T.
Keywords: Biology · Biomedical Research · Biological organs · Enzyme kinetics · Lipids · Metabolism · Patient treatment · Plasmas · Acute phase response (APR) · Gene expression · Genetic engineering · Albumin · Alpha 2 macroglobulin · CCAAT enhancer binding protein · CCAAT enhancer binding protein alpha · CCAAT enhancer binding protein beta · CCAAT enhancer binding protein delta · Fenofibrate · Fibrinogen · Interleukin 6 · peroxisome proliferator activated receptor agonist · peroxisome proliferator activated receptor alpha · serum amyloid A · STAT3 protein · Stress activated protein kinase · Transcription factor · Unclassified drug · Acute phase response · Animal experiment · Animal tissue · Clinical article · Controlled study · Down regulation · Enzyme activation · Fibrinogen blood level · Gene expression regulation · Hyperlipidemia · In vivo study · Knockout mouse · Liver · Long term care · Male · Mouse · Nonhuman · Protein expression · Protein function · Protein phosphorylation · Transcription regulation · Wild type · Acute-Phase Reaction · Animals · Antilipemic Agents · Apolipoproteins · Down-Regulation · Fibrinogen · Haptoglobins · Humans · Interleukin-6 · Mice · Procetofen · Receptors, Cytoplasmic and Nuclear · Serum Amyloid A Protein · Signal Transduction · Transcription Factors · Animalia · Eukaryota
[PDF] [Abstract]

20 Apolipoprotein E*3-Leiden transgenic mice mode for hypolipidaemic drugs
article 1998    
Author: Vlijmen, B.J.M. van · Pearce, N.J. · Bergö, M. · Staels, B. · Yates, J.W. · Gribble, A.D. · Bond, B.C. · Hofker, M.H. · Havekes, L.M. · Groot, P.H.E.
Keywords: Pharmacology · ±(3R*,5S*)3-Carboxy-11-(2,4-dichlorophenyl)-3,5-dihydroxyundecanoic acid, 5-ring lactone · CAS 154566-12-8 · Gemfibrozil · Hypolipidaemic drugs, testing in transgenic mice · Lovastatin · SB 204990, hypolipidaemic effect · 3 carboxy 11 (2,4 dichlorophenyl) 3,5 dihydroxyundecanoic acid · Antilipemic agent · Apolipoprotein c3 · Apolipoprotein e3 · Cholesterol · Gemfibrozil · High density lipoprotein · Lipoprotein lipase · Low density lipoprotein · Messenger rna · Mevinolin · Sb 204990 · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Anticoagulant agent · Apolipoprotein E · Apolipoprotein E3 · Heparin · Lactone · Lipid · Messenger RNA · SB 204990 · Animal model · Animal tissue · Atherosclerosis · Cholesterol blood level · Controlled study · Dose response · Drug effect · Enzyme activity · Gene expression · Hyperlipidemia · Lipoprotein blood level · Male · Mouse · Nonhuman · Oral drug administration · Transgenic mouse · Animal · Biosynthesis · Blood · C57BL mouse · Drug screening · Genetics · Liver · Metabolism · hysiology · Animals · Anticoagulants · Antilipemic Agents · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Drug Evaluation, Preclinical · Gemfibrozil · Heparin · Lactones · Lipids · Lipoprotein Lipase · Liver · Lovastatin · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · RNA, Messenger · Triglycerides
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 20 found. | Sort by date