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1 Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression
article 1999    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Winther, M.P.J. de · Hof, B. van 't · Zee, A. van der · Boom, H. van der · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Hypertriglyceridemia · LDL receptor · LDL receptor-related protein · VLDL triglyceride lipolysis · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol, VLDL · Gene Expression · Hypertriglyceridemia · Lipolysis · Mice · Mice, Knockout · Point Mutation · Receptors, LDL · Triglycerides
[Abstract]

2 Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease
article 1996    
Author: Bronzova, J. · Duijn, C.M. van · Havekes, L.M. · Knijff, P. de · Broeckhoven, C. van · Hofman, A.
Keywords: Biology · Apolipoprotein E gene · Apolipoprotein e · Apolipoprotein e4 · Adult · Allele · Clinical feature · Disease course · Genotype · Major clinical study · Myoclonus · Rigidity · Risk · Seizure · Tremor · Alleles · Alzheimer Disease · Apolipoproteins · Female · Humans · Male · Middle Aged · Prognosis
[Abstract]

3 Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
article 2003    
Author: Gerritsen, G. · Kypreos, K.E. · Zee, A. van der · Teusink, B. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E4 · Apolipoproteins E · Cholesterol · Humans · Hyperlipidemias · Lipids · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · Protein Structure, Tertiary · Triglycerides
[PDF] [Abstract]

4 Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
article 1998    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Zee, A. van der · Hof, B. van 't · Boom, H. van der · Kobayashi, K. · Chan, L. · Havekes, L.M. · Hofker, M.H.
Keywords: Health · ApoE variants · Atherosclerosis · Gene therapy · VLDL receptor · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Female · Gene Transfer Techniques · Humans · Hypercholesterolemia · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Triglycerides
[Abstract]

5 Binding of β-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas apoE only modulates binding affinity
article 1999    
Author: Beer, F. de · Hendriks, W.L. · Vark, L.C. van · Kamerling, S.W.A. · Dijk, K.W. van · Hofker, M.H. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Biology · β-VLDL · apoE · Heparan sulfate proteoglycans · Lipoprotein lipase · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Binding, Competitive · Cell Line · Cholesterol, VLDL · Heparan Sulfate Proteoglycans · Iodine Radioisotopes · Lipoprotein Lipase · Macrophages · Mice · Mice, Knockout
[Abstract]

6 Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice
article 1999    
Author: Winther, M.P.J. de · Gijbels, M.J.J. · Dijk, K.W. van · Gorp, P.J.J. van · Suzuki, H. · Kodama, T. · Frants, R.R. · Havekes, L.M. · Hofker, M.H.
Keywords: Biology · Apolipoprotein E · Atherosclerosis · Mouse models · Animals · Aorta, Thoracic · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Diet, Atherogenic · Female · Humans · Male · Membrane Proteins · Mice · Mice, Knockout · Mice, Transgenic · Receptors, Immunologic · Receptors, Lipoprotein · Receptors, Scavenger · Risk Factors · Scavenger Receptors, Class B
[Abstract]

7 Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase
article 1998    
Author: Man, F.H.A.F. de · Beer, F. de · Laarse, A. van der · Smelt, A.H.M. · Leuven, J.A.G. · Havekes, L.M.
Keywords: Health · Atherosclerosis · Familial dysbetalipoproteinemia · Metabolism · Triglyceride · VLDL · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Female · Heparan Sulfate Proteoglycans · Heterozygote · Homozygote · Humans · Hyperlipoproteinemia Type III · Lipolysis · Lipoprotein Lipase · Lipoproteins, VLDL · Male · Middle Aged
[Abstract]

8 Apolipoprotein E2 (Lys146→Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides
article 2000    
Author: Beer, F. de · Dijk, K.W. van · Jong, M.C. · Vark, L.C. van · Zee, A. van der · Hofker, M.H. · Fallaux, F.J. · Hoeben, R.C. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Adenoviridae · Alleles · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Gene Expression · Gene Transfer Techniques · Humans · Hydrolysis · Hyperlipoproteinemia Type III · Hypertriglyceridemia · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · Point Mutation · RNA, Messenger · Triglycerides
[Abstract]

9 Interactions between lifestyle-related factors and the ApoE polymorphism on plasma lipids and apolipoproteins: The ears study
article 1997    
Author: Boer, J.M.A. · Ehnholm, C. · Menzel, H.J. · Havekes, L.M. · Rosseneu, M. · O'Reilly, D.S.J. · Tiret, L.
Keywords: Biology · Adiposity · Apolipoprotein · Apolipoprotein E polymorphism · Lifestyle · Lipids · Apolipoprotein · Apolipoprotein b · Apolipoprotein e · Apolipoprotein e2 · Apolipoprotein e3 · Cholesterol · Cholesterol oleate · Linoleic acid · Lipid · Polyunsaturated fatty acid · Saturated fatty acid · Triacylglycerol · Adult · Alcohol consumption · Anthropometry · Body mass · Cigarette smoking · Controlled study · Female · Genetic polymorphism · Human · Lifestyle · Lipid blood level · Major clinical study · Male · Phenotype · Physical activity · Priority journal · Adolescent · Adult · Apolipoprotein E4 · Apolipoproteins · Apolipoproteins B · Apolipoproteins E · Body Mass Index · Cholesterol Esters · Coronary Arteriosclerosis · Female · Heterozygote · Humans · Life Style · Lipids · Male · Polymorphism, Genetic · Risk Factors
[Abstract]

10 Quantitative assessment of aortic atherosclerosis in APOE*3 leiden transgenic mice and its relationship to serum cholesterol exposure
article 1996    
Author: Groot, P.H.E. · Vlijmen, B.J.M. van · Benson, G.M. · Hofker, M.H. · Schiffelers, R. · Vidgeon-Hart, M. · Havekes, L.M.
Keywords: Biology · animal model · apolipoprotein E · diet · familial dyslipoproteinemia · hyperlipidemia · apolipoprotein e · cholesterol · animal experiment · animal model · animal tissue · aorta atherosclerosis · aorta sinus · article · atherosclerosis · cholesterol blood level · cholesterol diet · controlled study · dyslipoproteinemia · feeding · female · hyperlipidemia · hypolipemia · lipid diet · male · mouse · nonhuman · priority journal · transgenic mouse · Animals · Aortic Diseases · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Cholesterol · Cholesterol, Dietary · Dietary Fats · Female · Hyperlipidemias · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Sinus of Valsalva
[Abstract]

11 Combined Association and Linkage Analysis Applied to the APOE Locus
article 2004    
Author: Beekman, M. · Posthuma, D. · Heijmans, B.T. · Lakenberg, N. · Suchiman, H.E.D. · Snieder, H. · Knijff, P. de · Frants, R.R. · Ommen, G.J.B. van · Kluft, C. · Vogler, G.P. · Slagboom, P.E. · Boomsma, D.I.
Keywords: ApoE level · Fine-mapping · Quantitative trait locus · Twin pairs · chromosome 19 · cohort analysis · gene locus · gene mapping · genetic association · genetic linkage · genetic polymorphism · genotype · linkage analysis · lipoprotein blood level · quantitative trait locus · short tandem repeat · twins · Adolescent · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoprotein E4 · Apolipoproteins E · Chromosomes, Human, Pair 19 · Cohort Studies · Female · Genotype · Humans · Linkage (Genetics) · Lod Score · Male · Netherlands · Polymorphism, Genetic · Quantitative Trait, Heritable · Genetta
[Abstract]

12 Serum apolipoprotein e level is not increased in Alzheimer's disease : The Rotterdam study
article 1998    
Author: Slooter, A.J.C. · Knijff, P. de · Hofman, A. · Cruts, M. · Breteler, M.M.B. · Broeckhoven, C. van · Havekes, L.M. · Duijn, C.M. van
Keywords: Health · Alzheimer's disease · Apolipoprotein E · Atherosclerosis · Dementia · Plasma · Serum level · Aged · Aged, 80 and over · Alzheimer Disease · Apolipoproteins E · Cohort Studies · Female · Genotype · Humans · Male · Middle Aged
[Abstract]

13 Atherosclerosis in APOE(*)3-Leiden transgenic mice from proliferative to atheromatous stage
article 1999    
Author: Lutgens, E. · Daemen, M. · Kockx, M. · Doevendans, P. · Hofker, M. · Havekes, L. · Wellens, H. · Muinck, E.D. de
Keywords: Biology · Apoptosis · Atherosclerosis · Genetics · Animals · Apolipoprotein E3 · Apolipoproteins E · Apoptosis · Arteriosclerosis · Diet, Atherogenic · Disease Models, Animal · Disease Progression · DNA · Female · Foam Cells · Male · Mice · Mice, Transgenic · Phenotype
[Abstract]

14 Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4
article 1998    
Author: Mulder, M. · Ravid, R. · Kloet, J.E.R. de · Haasdijk, E.D. · Julk, J. · Boom, J. van der · Havekes, L.M.
Keywords: Biology · Cerebrospinal fluid · Lipids · Aged · Aged, 80 and over · Alzheimer Disease · Apolipoprotein E4 · Apolipoproteins E · Brain · Cholesterol · Fatty Acids · Female · Genotype · Homeostasis · Humans · Male · Phospholipids · Reference Values
[Abstract]

15 Use of transgenic mice in lipoprotein metabolism and atherosclerosis research
article 1997    
Author: Havekes, L.M. · Vlijmen, B.J.M. van · Jong, M.C. · Dijk, K.W. van · Hofker, M.H.
Keywords: Biology · Age Factors · Animals · Apolipoprotein E3 · Apolipoproteins C · Apolipoproteins E · Arteriosclerosis · Cholesterol · Female · Humans · Lipids · Lipoproteins · Lipoproteins, VLDL · Male · Mice · Mice, Transgenic · Sex Factors · Animalia · Mus musculus
[Abstract]

16 Mice expressing only the mutant APOE3Leiden gene show impaired VLDL secretion
article 2001    
Author: Mensenkamp, A.R. · Teusink, B. · Baller, J.F.W. · Wolters, H. · Havinga, R. · Dijk, K.W. van · Havekes, L.M. · Kuipers, F.
Keywords: Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Fatty Liver · Lipid Metabolism · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · RNA, Messenger · Triglycerides
[Abstract]

17 Acute inhibition of hepatic β-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity
article 2005    
Author: Duivenvoorden, I. · Teusink, B. · Rensen, P.C.N. · Kuipers, F. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acids · Glucose metabolism · Steatosis · Triglycerides · Very low density lipoprotein · 3 hydroxybutyrate dehydrogenase · carnitine palmitoyltransferase inhibitor · cholesterol · insulin · palmoxiric acid · triacylglycerol · very low density lipoprotein · apolipoprotein E · apolipoprotein E3 · apolipoprotein E3 (Leidein) · fatty acid · messenger RNA · analytic method · animal cell · animal experiment · article · cholesterol blood level · comparative study · controlled study · fatty acid oxidation · gluconeogenesis · insulin blood level · insulin sensitivity · ketogenesis · mouse · nonhuman · transgenic mouse · animal · blood · genetics · insulin resistance · metabolism · oxidation reduction reaction · physiology · secretion · Animals · Apolipoprotein E3 · Apolipoproteins E · Fatty Acids, Nonesterified · Insulin Resistance · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Transgenic · Oxidation-Reduction · RNA, Messenger
[PDF] [Abstract]

18 Accelerated atherosclerosis and calcification in vein grafts: A study in APOE*3 Leiden transgenic mice
article 2002    
Author: Lardenoye, J.H.P. · Vries, M.R. de · Löwik, C.W.G.M. · Xu, Q. · Dhore, C.R. · Cleutjens, J.P.M. · Hinsbergh, V.W.M. van · Bockel, J.H. van · Quax, P.H.A.
Keywords: Animals · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Calcinosis · Foam Cells · Graft Rejection · Hypercholesterolemia · Kinetics · Lipids · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Veins
[Abstract]

19 A rapid micromethod for apolipoprotein E phenotyping directly in serum
article 1987    
Author: Havekes, L.M. · Knijff, P. de · Beisiegel, U. · Havinga, J. · Smit, M. · Klasen, E.
Keywords: Apolipoprotein e · Blood and hemopoietic system · Human cell · Immunoblotting · Isoelectric focusing · Methodology · Micrometer · Serum · Apolipoproteins E · Chloroform · Guanidine · Guanidines · Human · Hyperlipoproteinemia Type III · Isoelectric Focusing · Methanol · Phenotype
[PDF] [Abstract]

20 Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.
article 2010    
Author: Kleemann, R. · Erk, M. van · Verschuren, L. · Hoek, A.M. van den · Koek, M. · Wielinga, P.Y. · Jie, A. · Pellis, L. · Bobeldijk-Pastorova, I. · Kelder, T. · Toet, K. · Wopereis, S. · Cnubben, N. · Evelo, C. · Ommen, B. van · Kooistra, T.
Keywords: Biology · Biomedical Research · Apolipoprotein E3 · Fatty acid · Blood · DNA microarray · Genetics · Obesity · physiology · transgenic mouse · Western blotting · Adiposity · Animals · Apolipoprotein E3 · Blotting, Western · Fatty Acids, Nonesterified · Glucose Tolerance Test · Insulin Resistance · Male · Mice · Mice, Transgenic · Oligonucleotide Array Sequence Analysis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 105 found. Next | Sort by date