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Showing 1 to 14 of 14 found. | Sort by date

1 Increasing nerve agent treatment efficacy by P-glycoprotein inhibition
article 2016    
Author: Joosen, M.J.A. · Vester, S.M. · Hamelink, J. · Klaassen, S.D. · Berg, R.M. van den
Keywords: Atropine · Oxime · p-Glycoprotein · Seizures · Soman · Tariquidar · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

2 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

3 A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents
article 1978    
Author: Kepner, L.A. · Wolthuis, O.L.
Keywords: Biology · Atropine · Cholinesterase reactivator · Oxime · Soman · 1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl ether · Animal experiment · Breathing · Drug comparison · Drug intoxication · Drug response · Intoxication · Intraperitoneal drug administration · Mouse · Muscle · Musculoskeletal system · Neuromuscular transmission · Organophosphate poisoning · Rat · Respiratory system · Subcutaneous drug administration · Animal · Atropine · Comparative Study · Drug Synergism · Female · Male · Mice · Neuromuscular Junction · Organophosphorus Compounds · Oximes · Rats · Rats, Inbred Strains · Respiration · Soman
[Abstract]

4 The dependence of the blood level of the oxime HS 6 on the severity of organophosphate poisoning
article 1976    
Author: Wolthuis, O.L. · Clason-van der Wiel, H.J. · Visser, R.P.L.S.
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Atropine · Cholinesterase inhibitor · Dimethyl ether · Soman · Drug analysis · Drug blood level · Drug intoxication · Intoxication · Intravenous drug administration · Pharmacokinetics · Plasma · Pralidoxime derivative · Rat · Respiratory failure · Theoretical study · Animal · Antidotes · Atropine · Dose-Response Relationship, Drug · Lethal Dose 50 · Male · Organophosphorus Compounds · Oximes · Rats · Soman
[Abstract]

5 Effects of innervation by ciliary ganglia on developing muscle in vitro
article 1979    
Author: Slaaf, D.W. · Hooisma, J. · Meeter, E. · Stevens, W.F.
Keywords: Biology · Acetylcholine · Acetylcholinesterase · Tetrodotoxin · Animal experiment · Chicken · Ciliary ganglion · Endplate potential · In vitro study · Muscle · Neuromuscular synapse · Tissue culture · Animal · Atropine · Cells, Cultured · Chick Embryo · Electric Stimulation · Ganglia, Parasympathetic · Membrane Potentials · Motor Endplate · Muscles · Physostigmine · Tetrodotoxin · Tubocurarine
[Abstract]

6 Persistence of the anti-cholinesterase soman in rats: Antagonism with a non-toxic simulator of this organophosphate
article 1981    
Author: Wolthuis, O.L. · Benschop, H.P. · Berends, F.
Keywords: Biology · Acetylcholinesterase · Atropine · Soman · Animal experiment · Controlled study · Drug intoxication · Intoxication · Intravenous drug administration · Rat · Simulator · Sustained release preparation · Acetylcholinesterase · Animal · Male · Organophosphorus Compounds · Pyridinium Compounds · Rats · Soman · Time Factors
[Abstract]

7 Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning
article 2009    
Author: Joosen, M.J.A. · Jousma, E. · Boom, T.M. van den · Kuijpers, W.C. · Smit, A.B. · Lucassen, P.J. · Helden, H.P.M. van
Keywords: Toxicology · Learning · Memory · Neurogenesis · Olanzapine · Organophosphate · Soman · acetylcholine · acetylcholinesterase · atropine · doublecortin · olanzapine · soman · animal experiment · animal model · animal tissue · article · body weight · cell survival · cognitive defect · controlled study · corpus striatum · developmental disorder · drug efficacy · drug treatment failure · histopathology · learning disorder · male · maze test · memory disorder · nervous system development · neurotoxicity · nonhuman · osmotic minipump · priority journal · rat · recurrent disease · seizure · Acetylcholine · Acetylcholinesterase · Animals · Atropine · Benzodiazepines · Cholinesterase Reactivators · Corpus Striatum · Hippocampus · Male · Maze Learning · Neurogenesis · Pyridinium Compounds · Rats · Rats, Sprague-Dawley · Seizures · Soman · Animalia · Rattus
[Abstract]

8 Beneficial effects of TCP on soman intoxication in guinea pigs : seizures, brain damage and learning behaviour
article 2001    
Author: Groot, D.M.G. de · Bierman, E.P.B. · Bruijnzeel, P.L.B. · Carpentier, P. · Kulig, B.M. · Lallement, G. · Melchers, B.P.C. · Philippens, I.H.C.H.M. · Huygevoort, A.H.B.M. van
Keywords: Toxicology · 1 (1 (2 thienyl)cyclohexyl)piperidine · 1-(1-(2-thienyl)cyclohexyl)piperidine · Atropine · Chemical warfare agent · Drug derivative · Muscarinic receptor blocking agent · N methyl dextro aspartic acid receptor · Neuroprotective agent · Chemically induced disorder · Discrimination learning · Drug effect · Pathology · Physiology · Animals · Atropine · Behavior, Animal · Brain · Chemical Warfare Agents · Cholinesterase Inhibitors · Discrimination Learning · Electroencephalography · Guinea Pigs · Male · Muscarinic Antagonists · Neuroprotective Agents · Phencyclidine · Pyridostigmine Bromide · Receptors, N-Methyl-D-Aspartate · Seizures · Soman
[Abstract]

9 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

10 Successful oxime therapy one hour after soman intoxication in the rat
article 1978    
Author: Wolthuis, O.L. · Kepner, L.A.
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Atropine · Cholinesterase · Oxime · Radioisotope · Soman · Acetylcholine h 3 · Aging · Animal experiment · Breathing · Cytology · Diaphragm · Drug comparison · Drug intoxication · In vitro study · Intoxication · Muscle · Neuromuscular transmission · Peripheral nervous system · Phrenic nerve · Rat · Respiratory failure · Respiratory system · Animal · Atropine · Cholinesterases · Diaphragm · Male · Muscle Contraction · Organophosphorus Compounds · Oximes · Phrenic Nerve · Rats · Soman · Time Factors
[Abstract]

11 Increasing oxime efficacy by blood-brain barrier modulation
article 2011    
Author: Joosen, M.J.A. · Schans, M.J. van der · Dijk, C.G.M. van · Kuijpers, W.C. · Wortelboer, H.M. · Helden, H.P.M. van
Keywords: HI6 · Nerve agent · P-glycoprotein · Seizures · Tariquidar · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Acetylcholinesterase · Atropine · Tariquidar · Animal experiment · Animal model · Article · Blood brain barrier · Blood level · Brain blood volume · Controlled study · Convulsion · Drug effect · Drug efficacy · Drug intoxication · Drug penetration · Male · Microdialysis · Modulation · Nerve agent poisoning · Nonhuman · Priority journal · Quantitative analysis · Rat · Seizure · Rattus · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether, 34433-31-3 · Acetylcholinesterase, 9000-81-1 · Atropine, 51-55-8, 55-48-1 · Tariquidar, 206873-63-4 · Tradenames: hi 6, TNO; xr 9576, avaant · Manufacturers: TNO; avaant · Life · CBRN - CBRN Protection PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

12 Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
article 2003    
Author: Schans, M.J. van der · Lander, B.J. · Wiel, H. van der · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Chiral HPLC · Hairless guinea pigs · Intravenous · Marmosets · Percutaneous · Persistence · Stereospecificity · Toxicokinetics · Treatment · Carbamic acid · Oxime · Volatile agent · Anesthesia · Animal experiment · Animal model · Bioavailability · Blood level · Dose response · Enantiomer · Guinea pig · Intoxication · Marmoset · Nonhuman · Primate · Toxicokinetics · Administration, Topical · Anesthesia · Animals · Atropine · Callithrix · Chemical Warfare Agents · Chromatography, Gas · Chromatography, High Pressure Liquid · Electrochemistry · Injections, Intravenous · Kinetics · Lethal Dose 50 · Male · Muscarinic Antagonists · Organothiophosphorus Compounds · Stereoisomerism · Animalia · Cavia · Cavia porcellus · Primates · Sus scrofa · Acetylcholinesterase, 9000-81-1 · Carbamic acid, 463-77-4 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Sarin, 107-44-8 · Soman, 96-64-0 · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Muscarinic antagonists · Organothiophosphorus compounds · VX, 50782-69-9
[Abstract]

13 Ingrowth of aorta wall into stent grafts impregnated with basic fibroblast growth factor: A porcine in vivo study of blood vessel prosthesis healing
article 2004    
Author: Bas, J.M.A. van der · Quax, P.H.A. · Berg, A.C. van den · Visser, M.J.T. · Linden, E. van der · Bockel, J.H. van
Keywords: Biology · Atropine · Basic fibroblast growth factor · Heparin · Isoflurane · Nitric oxide · Pancuronium bromide · Thiopental · Warfarin · Aneurysm surgery · Animal experiment · Animal tissue · Aorta prosthesis · Aorta wall · Blood vessel graft · Blood vessel prosthesis · Comparative study · Controlled study · Electron microscopy · Endoleak · Endovascular surgery · Nonhuman · Pathogenesis · Postoperative complication · Swine disease · Treatment outcome · Wound healing · Animals · Aorta · Blood Vessel Prosthesis · Blood Vessel Prosthesis Implantation · Coated Materials, Biocompatible · Collagen · Fibroblast Growth Factor 2 · Growth Substances · Heparin · Microscopy · Models, Animal · Myoblasts, Smooth Muscle · Polyethylene Terephthalates · Prosthesis Failure · Stents · Surgical Procedures, Minimally Invasive · Swine · Wound Healing
[Abstract]

14 Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes
article 1979    
Author: Benschop, H.P. · Berg, G.R. van den · Hooidonk, C. van · Jong, L.P.A. de · Kientz, C.E. · Berends, F. · Kepner, L.A. · Meeter, E. · Visser, R.P.L.S.
Keywords: Biology · Acetylcholinesterase · Antidote · Atropine · Cholinesterase reactivator · Diacetyl oxime · Enzyme · Obidoxime P · Paraoxon · Sarin · Tri ortho cresyl phosphate · 1,2,3 thiadiazole 5 carboxaldoxime · 2 (hydroximinomethyl) 1 methylpyridinium salt · 2 methyl 1,2,3 thiadiazolium salt carboxaldoxime · 3 methyl 1,2,3 thiadiazolium salt 5 carboxaldoxime · Animal experiment · Blood · Blood and hemopoietic system · Dose response · Drug administration · Drug analysis · Drug blood level · Drug comparison · Drug elimination · Drug half life · Drug interaction · Drug intoxication · Drug metabolism · Drug response · Drug screening · Drug synthesis · Drug tolerance · Drug toxicity · Drug urine level · Goat · Guinea pig · High performance liquid chromatography · Hydroximinoacetone · In vitro study · Intoxication · Intraperitoneal drug administration · Intravenous drug administration · Mouse · Nuclear magnetic resonance · Oral drug administration · Organophosphate intoxication · Pharmacokinetics · Prevention · Prophylaxis · Rabbit · Rat · Subcutaneous drug administration · Theoretical study · Therapy · Thiadiazole 5 carboxaldoxime derivative · Ultraviolet spectrophotometry · Urine · Acetylcholinesterase · Animal · Antidotes · Body Temperature · Cattle · Chemistry · Dose-Response Relationship, Drug · Enzyme Reactivators · Female · Goats · Guinea Pigs · Half-Life · In Vitro · Lethal Dose 50 · Male · Mice · Organophosphorus Compounds · Oximes · Rabbits · Rats · Rats, Inbred Strains · Sarin · Solubility · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date