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Showing 1 to 18 of 18 found. | Sort by date

1 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes
article 2008    
Author: Price, R.J. · Scott, M.P. · Giddings, A.M. · Walters, D.G. · Stierum, R.H. · Meredith, C. · Lake, B.G.
Keywords: Biology · Physiological Sciences · Butylated hydroxytoluene · Curcumin · CYP induction · Cytochrome P450 (CYP) · Human hepatocytes · Propyl gallate · Thiabendazole · butylcresol · curcumin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2B6 · cytochrome P450 3A4 · ethoxyresorufin deethylase · gallic acid propyl ester · messenger RNA · tiabendazole · adult · aged · article · controlled study · enzyme activity · human · human cell · liver cell · male · Aged · Anthelmintics · Antioxidants · Butylated Hydroxytoluene · Cells, Cultured · Curcumin · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP1A2 · Cytochrome P-450 CYP3A · Cytochrome P-450 Enzyme System · Hepatocytes · Humans · Male · Middle Aged · Propyl Gallate · RNA, Messenger · Steroid Hydroxylases · Thiabendazole
[Abstract]

2 Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450
article 1998    
Author: Bessems, J.G.M. · Groot, M.J. de · Baede, E.J. · Koppele, J.M. te · Vermeulen, N.P.E.
Keywords: Nutrition · Analgesic agent · Cytochrome p450 · Horseradish peroxidase · Hydrogen peroxide · Paracetamol · Reduced nicotinamide adenine dinucleotide phosphate · Analgesia · Animal experiment · Animal tissue · Biotransformation · Catalysis · Drug metabolism · Electron spin resonance · Enzyme activity · Liver microsome · Male · Nonhuman · Oxidation · Rat · Acetaminophen · Animals · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP2B1 · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Electron Spin Resonance Spectroscopy · Free Radicals · Horseradish Peroxidase · Hydrogen · Male · Microsomes, Liver · NADP · Oxidation-Reduction · Rats · Rats, Wistar · Thermodynamics · Animalia · Armoracia rusticana · Rickettsia sp. PAR
[Abstract]

3 Cytochrome P450 enzyme systems in fungi
article 1998    
Author: Brink, H.M. van den · Gorcom, R.F.M. van · Hondel, C.A.M.J.J. van den · Punt, P.J.
Keywords: Nutrition · Bioconversion · Biotransformation · CPR · CYP · Cytochrome P450 · Index descriptors · Cytochrome p450 · Biotransformation · Fungal genetics · Fungus · Molecular genetics · Nonhuman · Priority journal · Review · Saccharomyces cerevisiae · Cytochrome P-450 Enzyme System · Fungi · Genes, Plant · Multigene Family · Saccharomyces cerevisiae
[Abstract]

4 The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
article 2017    
Author: Li, M. · Graaf, I.A.M. de · Steeg, E. van de · Jager, M.H. de · Groothuis, G.M.M.
Keywords: Biology · CYP3A4 · Ex vivo · Interplay · P-glycoprotein · Precision-cut intestinal slice · Selective P-gp inhibitor · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

5 Testosterone 15β-hydroxylation by solvent tolerant Pseudomonas putida S12
article 2007    
Author: Ruijssenaars, H.J. · Sperling, E.M.G.M. · Wiegerinck, P.H.G. · Brands, F.T.L. · Wery, J. · Bont, J.A.M.de
Keywords: Biology · Biotechnology · CYP106A2 · Fer · Pseudomonas putida · Solvent tolerance · Steroid synthesis · Whole cell biocatalyst · Biocatalysts · Enzyme kinetics · Hydroxylation · Optimization · Solvents · Pseudomonas putida · Solvent tolerance · Steroid synthesis · Whole cell biocatalysts · Drug products · 15 beta hydroxylase · bacterial protein · cytochrome P450 · organic solvent · steroid monooxygenase · testosterone · threonine · valine · 15beta hydroxylase CYP106A2, Bacillus megaterium · 15beta-hydroxylase CYP106A2, Bacillus megaterium · solvent · article · Bacillus subtilis · biocatalyst · biotransformation · chemical structure · controlled study · high performance liquid chromatography · nonhuman · nuclear magnetic resonance · priority journal · protein expression · Pseudomonas putida · steroid hydroxylation · steroidogenesis · biological model · enzyme specificity · evaluation · gene expression regulation · genetics · hydroxylation · metabolism · site directed mutagenesis · transgenic organism · Bacillus megaterium · Bacillus subtilis · Pseudomonas putida · Bacterial Proteins · Cytochrome P-450 Enzyme System · Gene Expression Regulation, Bacterial · Hydroxylation · Models, Biological · Mutagenesis, Site-Directed · Organisms, Genetically Modified · Pseudomonas putida · Solvents · Substrate Specificity · Testosterone
[Abstract]

6 Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression
article 2001    
Author: Post, S.M. · Duez, H. · Gervois, P.P. · Staels, B. · Kuipers, F. · Princen, H.M.G.
Keywords: Animals · Antilipemic Agents · Bile Acids and Salts · Cells, Cultured · Cholesterol · Cholesterol 7-alpha-Hydroxylase · Clofibric Acid · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Down-Regulation · Hepatocytes · Mice · Mice, Knockout · Pyrimidines · Rats · Receptors, Cytoplasmic and Nuclear · RNA, Messenger · Steroid Hydroxylases · Transcription Factors · Transcription, Genetic
[Abstract]

7 Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase in rat hepatocytes
article 1997    
Author: Post, S.M. · Wit, E.C.M. de · Princen, H.M.G.
Keywords: Animals · Bile Acids and Salts · Cholesterol · Cholesterol 7-alpha-Hydroxylase · Cholesterol Esters · Coffee · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Diterpenes · Enzyme Induction · Heat · Hydroxymethylglutaryl CoA Reductases · Hydroxymethylglutaryl-CoA Synthase · Hypercholesterolemia · Liver · Male · Rats · Rats, Wistar · Receptors, LDL · RNA, Messenger · Steroid Hydroxylases · Terpenes · Transcription, Genetic · Triglycerides
[Abstract]

8 Polymorphisms in genes related to activation or detoxification of carcinogens might interact with smoking to increase renal cancer risk: Results from The Netherlands Cohort Study on diet and cancer
article 2008    
Author: Smits, K.M. · Schouten, L.J. · Dijk, B.A.C. van · Houwelingen, K. van · Hulsbergen-Kaa, C.A. van de · Kiemeney, L.A.L.M. · Houwelingen, K. van · Goldbohm, R.A. · Oosterwijk, E. · Brandt, P.A. van den
Keywords: Health · Leefomgeving en gezondheid · CYP1A1 genotype · Gene-environment interaction · GSTμ1 genotype · Renal cell cancer · Smoking · carcinogen · cytochrome P450 1A1 · DNA · glutathione S-transferase M1 · glutathione transferase · glutathione transferase M1 · agar gel electrophoresis · aged · article · biotransformation · comparative study · female · follow up · genetic polymorphism · genetics · genotype · human · incidence · kidney carcinoma · kidney tumor · male · middle aged · Netherlands · polymerase chain reaction · prospective study · risk factor · smoking · Aged · Biotransformation · Carcinogens · Carcinoma, Renal Cell · Cytochrome P-450 CYP1A1 · DNA, Neoplasm · Electrophoresis, Agar Gel · Female · Follow-Up Studies · Genotype · Glutathione Transferase · Humans · Incidence · Kidney Neoplasms · Male · Middle Aged · Netherlands · Polymerase Chain Reaction · Polymorphism, Genetic · Prospective Studies · Risk Factors · Smoking · Healthy for Life · Healthy Living
[Abstract]

9 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

10 Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals
article 2004    
Author: Hofman, M.K. · Groenendijk, M. · Verkuijlen, P.J.J.H. · Jonkers, I.J.A.M. · Mohrschladt, M.F. · Smelt, A.H.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · CYP7A1 · Hyperlipidaemia · Modifier gene · Polymorphism · Triglycerides · apolipoprotein E3 · cholesterol · cholesterol 7alpha monooxygenase · isoprotein · lipid · low density lipoprotein · triacylglycerol · very low density lipoprotein · controlled study · DNA polymorphism · familial hypercholesterolemia · gene control · homozygosity · hyperlipidemia · hyperlipoproteinemia type 3 · lipid blood level · major clinical study · promoter region · triacylglycerol blood level · Adult · Aged · Cholesterol 7-alpha-Hydroxylase · Female · Gene Frequency · Genotype · Humans · Hypertriglyceridemia · Male · Middle Aged · Polymorphism, Genetic · Promoter Regions (Genetics) · Triglycerides
[Abstract]

11 Differential effects of 17α-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat
article 1999    
Author: Koopen, N.R. · Post, S.M. · Wolters, H. · Havinga, R. · Stellaard, F. · Boverhof, R. · Kuipers, F. · Princen, H.M.G.
Keywords: Δ-<sup>22</sup>-β-muricholate · Bile · Cholestasis · Cholesterol-7α- hydroxylase · Enterohepatic circulation · Estrogens · Sterol-27-hydroxylase · Wistar rat · Animals · Aryl Hydrocarbon Hydroxylases · Bile Acids and Salts · Chenodeoxycholic Acid · Cholates · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Enterohepatic Circulation · Ethinyl Estradiol · Hydrogen-Ion Concentration · Liver · Male · Rats · Rats, Wistar · RNA, Messenger · Steroid 12-alpha-Hydroxylase · Steroid Hydroxylases
[PDF] [Abstract]

12 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

13 Persistent alterations in regional brain glial fibrillary acidic protein and synaptophysin levels following pre- and postnatal polychlorinated biphenyl exposure
article 1996    
Author: Morse, D.C. · Plug, A. · Wesseling, W. · Berg, K.J. van den · Brouwer, A.
Keywords: Toxicology · aroclor 1254 · calcineurin · ethoxyresorufin deethylase · glial fibrillary acidic protein · polychlorinated biphenyl · synaptophysin · animal experiment · animal tissue · article · brain · brain region · brain stem · brain weight · cerebellum · controlled study · corpus striatum · dose response · female · fetus · fetus weight · immunochemistry · liver microsome · male · neurotoxicity · newborn · nonhuman · olfactory tract · prefrontal cortex · pregnancy · rat · sex difference · Animals · Animals, Newborn · Antithyroid Agents · Aroclor 1254 · Aroclors · Biological Markers · Body Weight · Brain · Brain Stem · Ca(2+)-Calmodulin Dependent Protein Kinase · Cerebellum · Cytochrome P-450 CYP1A1 · Female · Glial Fibrillary Acidic Protein · Male · Organ Size · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Reproduction · Synaptophysin · Animalia
[Abstract]

14 Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10
article 1996    
Author: Kappers, W.A. · Groene, E.M. de · Kleij, L.A. · Witkamp, R.F. · Zweers-Zeilmaker, W.M. · Feron, V.J. · Horbach, G.J.
Keywords: Toxicology · CYP2C9 protein, human · cytochrome P450 · diclofenac · enzyme inhibitor · flurbiprofen · ketoprofen · mixed function oxidase · nonsteroid antiinflammatory agent · phenylbutazone · sulfaphenazole · tolbutamide · tolbutamide 4 hydroxylase · tolbutamide 4-hydroxylase · unspecific monooxygenase · animal · article · cell line · Cricetulus · drug interaction · gene expression · genetic transfection · genetics · hamster · human · hydroxylation · lung · metabolism · methylation · Animals · Anti-Inflammatory Agents, Non-Steroidal · Aryl Hydrocarbon Hydroxylases · Cell Line · Cricetinae · Cricetulus · Cytochrome P-450 Enzyme System · Diclofenac · Drug Interactions · Enzyme Inhibitors · Flurbiprofen · Gene Expression · Humans · Hydroxylation · Ketoprofen · Lung · Methylation · Mixed Function Oxygenases · Phenylbutazone · Sulfaphenazole · Tolbutamide · Transfection
[Abstract]

15 Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole
article 2008    
Author: Stierum, R. · Conesa, A. · Heijne, W. · Ommen, B.v. · Junker, K. · Scott, M.P. · Price, R.J. · Meredith, C. · Lake, B.G. · Groten, J.
Keywords: Nutrition · Toxicology and Applied Pharmacology · Butylated hydroxytoluene · Curcumin · Drug metabolism · Mixtures · p53 · Peroxisome proliferation · Propyl gallate · Rat · Thiabendazole · Toxicogenomics · butylcresol · complementary DNA · curcumin · cyanide · cytochrome P450 · cytochrome P450 2B1 · cytochrome P450 2B2 · cytochrome P450 2C6 · cytochrome p450 3a9 · cytochrome p450 4a3 · enoyl coenzyme A hydratase · enzyme · gallic acid propyl ester · glutathione transferase · growth arrest and DNA damage inducible protein 45 · palmitoyl coenzyme A · phytanoyl coenzyme a dioxygenase · protein kinase C beta · protein p53 · RNA · serum albumin · tiabendazole · transcriptome · animal tissue · article · controlled study · diet · DNA microarray · food poisoning · gene expression · gene expression profiling · liver · male · metabolism · nonhuman · nucleotide sequence · rat · real time polymerase chain reaction · Western blotting · Animals · Aryl Hydrocarbon Hydroxylases · Body Weight · Butylated Hydroxytoluene · Curcumin · Cytochrome P-450 CYP1A2 · Cytochrome P-450 CYP2B1 · Data Interpretation, Statistical · Diet · DNA, Complementary · Food Additives · Gene Expression · Gene Expression Profiling · Glutathione Transferase · Liver · Male · Organ Size · Oxidation-Reduction · Palmitoyl Coenzyme A · Propyl Gallate · Rats · Rats, Sprague-Dawley · Reverse Transcriptase Polymerase Chain Reaction · Steroid Hydroxylases · Thiabendazole · Rattus
[Abstract]

16 Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs
article 2014    
Author: Beker van Woudenberg, A. · Snel, C. · Rijkmans, E. · Groot, D. de · Bouma, M. · Hermsen, S. · Piersma, A. · Menke, A. · Wolterbeek, A.
Keywords: Biology · Antiepileptic drugs · Behavior · Developmental (neuro)toxicity · Gene expression · Histopathology · Integrated test strategy · Kinetics · Zebrafish embryotoxicity test (ZET) · Anticonvulsive agent · Carbamazepine · Cytochrome P450 26A1 · Ethosuximide · Etiracetam · Valproic acid · ALDH1A2 gene · Animal cell · Animal experiment · Animal model · Animal tissue · Case study · Cell vacuole · Concentration (parameters) · Controlled study · CYP26A1 gene · Demo case study · Developmental toxicity · Edema · Embryo · Embryotoxicity · Experimental design · Female · Gene · Gene expression · Histopathology · In situ hybridization · Larva · Liver cell · Male · Morphology · Motor activity · Nerve degeneration · Neurotoxicity · Nonhuman · Nucleotide sequence · Pericardial disease · Pericardial edema · Phenotype · Predictive value · Sensitivity analysis · Swimming · Toxicity testing · Toxicokinetics · Whole mount in situ hybridization · Zebra fish · Zebrafish embryotoxicity test · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

17 Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products
article 2007    
Author: Jeurissen, S.M.F. · Claassen, F.W. · Havlik, J. · Bouwmans, E.E. · Cnubben, N.H.P. · Sudhölter, E.J.R. · Rietjens, I.M.C.M. · Beek, T.A. van
Keywords: Biomedical Research · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · Bioassay · Cytology · Enzyme inhibition · Fluorescence · Metabolites · Screening · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · High performance liquid chromatography · basil extract · cytochrome P450 1A2 · cytochrome P450 1A2 inhibitor · cytochrome P450 inhibitor · fluvoxamine · furafylline · kava extract · methoxyresorufin · naringenin · natural product · plant extract · propranolol · resorufin · resorufin derivative · tacrine · article · assay · basil · demethylation · fluorescence · high performance liquid chromatography · metabolite · methoxyresorufin O demethylation assay · minimum detectable amount · online analysis · parameter · priority journal · screening · Biological Products · Chromatography, High Pressure Liquid · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Humans · Inhibitory Concentration 50 · Kava · Methanol · Ocimum basilicum · Online Systems · Oxidoreductases · Plant Extracts · Spectrometry, Fluorescence · Spectrophotometry, Ultraviolet · Ocimum basilicum · Piper methysticum
[Abstract]

18 Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes
article 2004    
Author: Price, R.J. · Scott, M.P. · Walters, D.G. · Stierum, R.H. · Groten, J.P. · Meredith, C. · Lake, B.G.
Keywords: Nutrition · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · BHT · Butylated hydroxytoluene · CDNB · CH · Cumene hydroperoxide · CYP · Cytochrome P450 · DCNB · Enzyme induction · GSH S-transferase · Rat liver · Thiabendazole · Xenobiotic metabolism · apoprotein · butylcresol · cytochrome P450 1A · cytochrome P450 1A1 · cytochrome P450 1A2 · cytochrome P450 2B · cytochrome P450 2B1 · cytochrome P450 2B2 · glutathione transferase · messenger RNA · tiabendazole · animal cell · animal experiment · article · controlled study · dose response · drug megadose · enzyme activation · enzyme activity · enzyme induction · enzyme metabolism · enzyme substrate · liver microsome metabolism · liver mitochondrion · liver weight · male · nonhuman · nucleotide sequence · protein blood level · rat · xenobiotic metabolism · Acyltransferases · Administration, Oral · Animals · Antinematodal Agents · Antioxidants · Butylated Hydroxytoluene · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Glutathione Transferase · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Thiabendazole
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 18 of 18 found. | Sort by date