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Showing 1 to 14 of 14 found. | Sort by date

1 Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates
article 1999    
Author: Beek, E. van · Pieterman, E. · Cohen, L. · Löwik, C. · Papapoulos, S.
Keywords: Animals · Brain · Carbon Radioisotopes · Carbon-Carbon Double Bond Isomerases · Cattle · Dimethylallyltranstransferase · Diphosphonates · Enzyme Inhibitors · Indoles · Mevalonic Acid · Bovinae
[Abstract]

2 Diagnosis and dosimetry of exposure to sulfur mustard: Development of a standard operating procedure for mass spectrometric analysis of haemoglobin adducts - Exploratory research on albumin and keratin adducts
article 2000    
Author: Noort, D. · Fidder, A. · Hulst, A.G. · Jong, L.P.A. de · Benschop, H.P.
Keywords: Adducts · Albumin · Dosimetry · Haemoglobin · Keratin · Mass spectrometry · Sulfur mustard · Albuminoid · Carbon · Diagnostic agent · Hemoglobin · Keratin · Mustard gas · Article · Chemistry · Culture technique · Differential diagnosis · Drug effect · Human · Intoxication · Liquid chromatography · Mass spectrometry · Pathology · Reference value · Skin · Albumins · Carbon Radioisotopes · Cell Culture Techniques · Chromatography, Liquid · Diagnosis, Differential · Hemoglobins · Humans · Mass Spectrometry · Poisoning · Reference Values · Skin · Carbon Radioisotopes · Keratins, 68238-35-7 · Mustard Gas, 505-60-2
[Abstract]

3 Biomonitoring of exposure to lewisite based on adducts to haemoglobin
article 2000    
Author: Fidder, A. · Noort, D. · Hulst, A.G. · Jong, L.P.A.de · Benschop, H.P.
Keywords: Toxicology · Adducts · Electrospray mass spectroscopy · Gas chromatography-mass spectroscopy · Haemoglobin · 2 chlorovinylarsonous acid · Arsenic acid derivative · Beta globin · Dimercaprol · Hemoglobin · Imidazole derivative · Lewisite · Unclassified drug · Animal experiment · Biological monitoring · Chemical warfare · Controlled study · Erythrocyte · Gas chromatography · Guinea pig · Health hazard · Human · Human cell · Male · Mass spectrometry · Nonhuman · Radioactivity · Urinalysis · Animals · Arsenicals · Binding Sites · Carbon Radioisotopes · Chelating Agents · Dimercaprol · Environmental Exposure · Erythrocytes · Gas Chromatography-Mass Spectrometry · Globins · Guinea Pigs · Hemoglobins · Humans · Imidazoles · Male · Protein Binding · Mass spectrometry · Electrospray ionization · 1-(heptafluorobutyryl)imidazole, 32477-35-3 · 2-chlorovinylarsonous acid · Arsenicals · Carbon radioisotopes · Chelating agents · Dimercaprol, 59-52-9 · Globins, 9004-22-2 · Hemoglobins · Imidazoles · Lewisite, 541-25-3
[Abstract]

4 Transport of D-xylose in Lactobacillus pentosus, Lactobacillus casei, and Lactobacillus plantarum: Evidence for a mechanism of facilitated diffusion via the phosphoenolpyruvate:mannose phosphotransferase system
article 1999    
Author: Chaillou, S. · Pouwels, P.H. · Postma, P.W.
Keywords: Nutrition · Mannose · Phosphoenolpyruvate sugar phosphotransferase · Xylose · Bacterial growth · Carbohydrate transport · Diffusion · Enzyme mechanism · Fermentation · Lactobacillus · Lactobacillus casei · Lactobacillus pentosus · Lactobacillus plantarum · Nonhuman · Priority journal · Adenosine Triphosphate · Biological Transport, Active · Carbon Radioisotopes · Diffusion · Genetic Complementation Test · Kinetics · Lactobacillus casei · Mannose · Mutation · Phosphoenolpyruvate · Phosphoenolpyruvate Sugar Phosphotransferase System · Plasmids · Species Specificity · Transformation, Genetic · Xylose
[Abstract]

5 Occupational exposure of hairdressers to [14C]-para-phenylenediamine-containing oxidative hair dyes: A mass balance study
article 2007    
Author: Hueber-Becker, F. · Nohynek, G.J. · Dufour, E.K. · Meuling, W.J.A. · Bie, A.T.H.J.de · Toutain, H. · Bolt, H.M.
Keywords: Biomedical Research · Bladder cancer · CAS 106-50-3 · Hair dyes · Hairdresser · Occupational exposure · para-Phenylenediamine, PPD · Sensitisation · carbon 14 · hair dye · phenylenediamine · adult · ambient air · article · blood level · blood sampling · controlled study · equipment · female · glove · hair · hairdresser · hand washing · human · human experiment · male · normal human · occupational exposure · personal monitoring · protective clothing · urinalysis · urinary excretion · Adult · Beauty Culture · Carbon Radioisotopes · Environmental Monitoring · Female · Gloves, Protective · Hair Dyes · Handwashing · Humans · Male · Middle Aged · Occupational Exposure · Phenylenediamines
[Abstract]

6 Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye
article 2004    
Author: Nohynek, G.J. · Skare, J.A. · Meuling, W.J.A. · Hein, D.W. · Bie, A.T.H.J. de · Toutain, H.
Keywords: Health · Physiological Sciences · Arylamines · CAS No.: 106-50-3 · Hair dyes · Human volunteers · N-acetyltransferase 2 · Para-phenylenediamine · Skin metabolism · arylamine acetyltransferase · carbon 14 · glucuronic acid · hair dye · phenylenediamine · acetylation · adult · aerobic metabolism · article · genotype · human · male · metabolism · metabolite · molecular weight · normal human · radioactivity · urinalysis · urine level · Absorption · Acetylation · Administration, Topical · Adolescent · Adult · Arylamine N-Acetyltransferase · Carbon Radioisotopes · Genetic Predisposition to Disease · Genotype · Hair Dyes · Humans · Male · Phenylenediamines · Pilot Projects · Urinary Bladder Neoplasms · Mammalia
[Abstract]

7 Disposition of 14C-erythritol in germfree and conventional rats
article 1996    
Author: Ommen, B. van · Bie, B. de · Bar, A.
Keywords: Toxicology · erythritol · carbon · carbon dioxide · diagnostic agent · sweetening agent · animal experiment · article · controlled study · drug disposition · drug elimination · drug metabolism · female · germfree animal · male · nonhuman · priority journal · rat · absorption · animal · body weight · intestine · kidney · metabolism · microbiology · physiology · tissue distribution · urine · Wistar rat · Absorption · Animals · Body Weight · Carbon Dioxide · Carbon Radioisotopes · Erythritol · Female · Germ-Free Life · Intestines · Kidney · Male · Rats · Rats, Wistar · Sweetening Agents · Tissue Distribution
[Abstract]

8 Pediatric Mïcrodose and Microtracer Studies Using 14C in Europe
article 2015    
Author: Turner, M.A. · Mooij, M.G. · Vaes, W.H.J. · Windhorst, A.D. · Hendrikse, N.H. · Knibbe, C.A.J. · Körgvee, L.T. · Maruszak, W. · Grynkiewicz, G. · Garner, R.C. · Tibbocl, D. · Park, B.K. · Wildt, S.N. de
Keywords: Nutrition · Carbon · Drug · Age · Dose calculation · Dose response · Drug-Related Side Effects and Adverse Reactions · Economics · Ethics · Legislation and jurisprudence · Metabolism · Newborn · Phase 1 clinical trial (topic) · Preschool child · Age Factors · Carbon Radioisotopes · Child · Child, Preschool · Clinical Trials, Phase I as Topic · Dose-Response Relationship, Drug · Drug Approval · Drug Costs · Drug Dosage Calculations · Drug-Related Side Effects and Adverse Reactions · Europe · Government Regulation · Humans · Infant · Infant, Newborn · Patient Safety · Pharmaceutical Preparations · Pharmacokinetics · Risk Assessment · Risk Factors · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro
article 2005    
Author: Buist, H.E. · Sandt, J.J.M. van de · Burgsteden, J.A. van · Heer, C. de
Keywords: Chemistry Safety · Biomedical Research · Biocidal active substances · Dermal absorption · Quaternary ammonium chlorides · Repeated exposure · Risk assessment · Single exposure · Skin barrier · ammonium derivative · biocide · boric acid · deltamethrin · formaldehyde · permethrin · piperonyl butoxide · quaternary ammonium derivative · sodium bromide · tebuconazole · unclassified drug · water · adult · article · controlled study · dilution · exposure · female · human · human tissue · intermethod comparison · priority journal · quantitative analysis · risk assessment · skin absorption · skin function · skin penetration · skin permeability · statistical significance · titrimetry · Adult · Benzalkonium Compounds · Carbon Radioisotopes · Detergents · Deuterium Oxide · Dose-Response Relationship, Drug · Female · Humans · Middle Aged · Perfusion · Permeability · Propoxur · Quaternary Ammonium Compounds · Skin Absorption · Skin Physiology
[Abstract]

10 Disposition of 14C-α-cyclodextrin in germ-free and conventional rats
article 2004    
Author: Ommen, B. van · Bie, A.T.H.J. de · Bär, A.
Keywords: Biology · Physiological Sciences · alpha cyclodextrin · carbon 14 · alpha cyclodextrin derivative · alpha-cyclodextrin · carbon · cyclodextrin · animal experiment · animal tissue · article · blood analysis · carcass · controlled study · dietary fiber · female · fermentation · gastrointestinal tract · germfree animal · high performance liquid chromatography · intestine flora · isotope labeling · kidney tubule excretion · lung alveolus carbon dioxide tension · male · metabolic regulation · nonhuman · priority journal · radioisotope distribution · rat · rat strain · small intestine absorption · species comparison · stomach content · animal · blood · drug detoxification · intravenous drug administration · oral drug administration · tissue distribution · urine · Wistar rat · Mammalia · Microbiota · Rattus norvegicus · Administration, Oral · alpha-Cyclodextrins · Animals · Carbon Radioisotopes · Cyclodextrins · Female · Germ-Free Life · Injections, Intravenous · Male · Metabolic Detoxication, Drug · Rats · Rats, Wistar · Tissue Distribution
[Abstract]

11 Transdermal administration of radiolabelled [14C]rotigotine by a patch formulation: A mass balance trial
article 2007    
Author: Cawello, W. · Wolff, H.M. · Meuling, W.J.A. · Horstmann, R. · Braun, M.
Keywords: Biomedical Research · carbon 14 · dopamine receptor stimulating agent · rotigotine · silicone · adult · article · clinical trial · diarrhea · dizziness · drug absorption · drug clearance · drug delivery system · drug distribution · drug elimination · drug formulation · drug metabolism · drug penetration · drug release · drug structure · drug tolerability · fatigue · human · human experiment · isotope labeling · liquid chromatography · liquid scintillation counting · male · mass balance · normal human · phase 1 clinical trial · priority journal · radioactivity · single drug dose · tandem mass spectrometry · Administration, Cutaneous · Adolescent · Adult · Carbon Radioisotopes · Chromatography, Liquid · Dopamine Agonists · Humans · Male · Middle Aged · Tandem Mass Spectrometry · Tetrahydronaphthalenes · Thiophenes
[Abstract]

12 Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
article 2015    
Author: Vlaming, M.L. · Duijn, E. van · Dillingh, M.R. · Brands, R. · Windhorst, A.D. · Hendrikse, N.H. · Bosgra, S. · Burggraaf, J. · Koning, M.C. de · Fidder, A. · Mocking, J.A. · Sandman, H. · Ligt, R.A. de · Fabriek, B.O. · Pasman, W.J. · Seinen, W. · Alves, T. · Carrondo, M. · Peixoto, C. · Peeters, P.A. · Vaes, W.H.
Keywords: Biology · Alkaline phosphatase, placental · Carbon · Glycosylphosphatidylinositol anchored protein · Isoenzyme · Recombinant protein · Area under the curve · Biological model · Clinical trial · Controlled study · Dose calculation · Double blind procedure · Half life time · Intravenous drug administration · Phase 1 clinical trial · Procedures · Randomized controlled trial · Statistical model · Administration, Intravenous · Adolescent · Adult · Alkaline Phosphatase · Area Under Curve · Carbon Radioisotopes · Double-Blind Method · Drug Dosage Calculations · GPI-Linked Proteins · Half-Life · Healthy Volunteers · Humans · Isoenzymes · Linear Models · Male · Mass Spectrometry · Metabolic Clearance Rate · Models, Biological · Netherlands · Recombinant Proteins · Young Adult · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ARPC - Analytical Research (Pharm & Chemistry) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

13 Tumor necrosis factor α induces endothelial galactosyl transferase activity and verocytotoxin receptors. Role of specific tumor necrosis factor receptors and protein kinase C
article 1995    
Author: Kar, N.C.A.J. van de · Kooistra, T. · Vermeer, M. · Lesslauer, W. · Monnens, L.A.H. · Hinsbergh, V.W.M. van
Keywords: Toxicology · 1 (5 isoquinolinesulfonyl) 2 methylpiperazine · 2 [1 (3 amidinothiopropyl) 1h indol 3 yl] 3 (1 methyl 1h indol 3 yl)maleimide · endothelial leukocyte adhesion molecule 1 · galactosyltransferase · globotriaosylceramide · interleukin 1 · n (2 guanidinoethyl) 5 isoquinolinesulfonamide · phorbol 13 acetate 12 myristate · phorbol ester · plasminogen activator inhibitor 1 · protein kinase C · protein kinase C inhibitor · recombinant interleukin 1beta · recombinant tumor necrosis factor alpha · tumor necrosis factor receptor · verotoxin · article · autoradiography · controlled study · endothelium cell · endothelium injury · gene expression · hemolytic uremic syndrome · human · human cell · priority journal · protein synthesis inhibition · signal transduction · umbilical vein · Autoradiography · Bacterial Toxins · Carbon Radioisotopes · Cell Adhesion Molecules · Cells, Cultured · Cytotoxins · E-Selectin · Endothelium, Vascular · Enzyme Induction · Galactose · Galactosyltransferases · Glucose · Glycolipids · Human · Kinetics · Protein Kinase C · Receptors, Cell Surface · Receptors, Tumor Necrosis Factor · Shiga-Like Toxin I · Support, Non-U.S. Gov't · Tumor Necrosis Factor · Umbilical Veins
[Abstract]

14 Disposition of [14C]γ-cyclodextrin in germ-free and conventional rats
article 1998    
Author: Bie, A.T.H.J. de · Ommen, B. van · Bär, A.
Keywords: Nutrition · Carbon 14 · Carbon dioxide · Drug metabolite · Gamma cyclodextrin · Carbon · Cyclodextrin · Gamma cyclodextrin derivative · Gamma-cyclodextrin · Animal experiment · Animal tissue · Carcass · Controlled study · Dose response · Drug bile level · Drug blood level · Drug disposition · Drug feces level · Drug identification · Drug metabolism · Drug saliva level · Drug tissue level · Drug urine level · Female · Gastrointestinal tract · Germfree animal · High performance liquid chromatography · Intravenous drug administration · Isotope labeling · Male · Nonhuman · Oral drug administration · Priority journal · Rat · Animal · Animal food · Bile · Breath analysis · Chemistry · Comparative study · Digestive system · Feces · Intestine absorption · Metabolism · Wistar rat · Administration, Oral · Animal Feed · Animals · Breath Tests · Carbon Dioxide · Carbon Radioisotopes · Cyclodextrins · Digestive System · Feces · Female · gamma-Cyclodextrins · Germ-Free Life · Injections, Intravenous · Intestinal Absorption · Male · Rats · Rats, Wistar
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date