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1 Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis
article 2015    
Author: Sticova, E. · Lodererova, A. · Steeg, E. van de · Frankova, S. · Kollar, M. · Lanska, V. · Kotalova, R. · Dedic, T. · Schinkel, A.H. · Jirsa, M.
Keywords: Biology · Bilirubin · Cholestasis · Immunohistochemistry · Liver disease · Organic anion transporter · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

2 Uniform procedure of 1H NMR analysis of rat urine and toxicometabonomics Part II : Comparison of NMR profiles classification of hepatotoxicity
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.-P.H.T.M. · Smit, M.J. · Zandberg, P. · Horbach, G.J. · Mellema, J.-R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Cholestasis · Hepatotoxicity · Metabonomics · Necrosis · NMR · Steatosis · Urinalysis · 1 naphthyl isothiocyanate · biological marker · bromobenzene · carbon tetrachloride · chlorpromazine · ethinylestradiol · ibuprofen · iproniazid · isoniazid · methyltestosterone · mianserin · paracetamol · phenobarbital · placebo · tetracycline · thioacetamide · animal experiment · animal tissue · article · controlled study · diagnostic accuracy · diagnostic value · drug blood level · drug urine level · early diagnosis · fatty liver · histopathology · intermethod comparison · intrahepatic cholestasis · liver necrosis · liver toxicity · male · nonhuman · pattern recognition · prediction · principal component analysis · proton nuclear magnetic resonance · rat · urinalysis · Animals · Biological Markers · Cholestasis · Fatty Liver · Hepatitis, Toxic · Liver · Magnetic Resonance Spectroscopy · Male · Necrosis · Pattern Recognition, Automated · Principal Component Analysis · Rats · Rats, Wistar · Urine · Animalia · Rattus
[Abstract]

3 Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs
article 2018    
Author: Notenboom, S. · Weigand, K.M. · Proost, J.H. · Lipzig, M.M.H. van · Steeg, E. van de · Broek, P.H.H. van den · Greupink, R. · Russel, F.G.M. · Groothuis, G.M.M.
Keywords: Biology · Bile acid handling · Biokinetic model · BSEP · Cholestasis · Human · In silico · NTCP · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ADME - ADME/DMPK · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[PDF] [Abstract]

4 Differential effects of 17α-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat
article 1999    
Author: Koopen, N.R. · Post, S.M. · Wolters, H. · Havinga, R. · Stellaard, F. · Boverhof, R. · Kuipers, F. · Princen, H.M.G.
Keywords: Δ-<sup>22</sup>-β-muricholate · Bile · Cholestasis · Cholesterol-7α- hydroxylase · Enterohepatic circulation · Estrogens · Sterol-27-hydroxylase · Wistar rat · Animals · Aryl Hydrocarbon Hydroxylases · Bile Acids and Salts · Chenodeoxycholic Acid · Cholates · Cholesterol 7-alpha-Hydroxylase · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Enterohepatic Circulation · Ethinyl Estradiol · Hydrogen-Ion Concentration · Liver · Male · Rats · Rats, Wistar · RNA, Messenger · Steroid 12-alpha-Hydroxylase · Steroid Hydroxylases
[PDF] [Abstract]

5 Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
article 2015    
Author: Mesens, N. · Crawfordb, A.D. · Menke, A. · Hung, P.D. · Goethem, F. van · Nuyts, R. · Hansen, E. · Wolterbeek, A. · Gompel, J. van · Witte, P. de · Esguerra, C.V.
Keywords: Nutrition · Zebrafish larvae · Screening assay · Lfabp10a · Hepatotoxicity · DILI · Alpidem · Amiodarone · Bosentan · Buspirone · Diclofenac · Fatty acid binding protein · Fatty acid binding protein 10a · Glycogen · Ketorolac · Nefazodone · Paracetamol · Reactive oxygen metabolite · Rosiglitazone · Tacrine · Tamoxifen · Tetracycline · Troglitazone · Unclassified drug · Zolpidem · Adult · Animal tissue · Cell vacuole · Cholestasis · Circulation · Concentration response · Controlled study · Drug safety · Female · Glycogen analysis · Heart rate · Histology · Histopathology · In situ hybridization · Larval stage · Liver cell · Liver level · Liver size · Liver toxicity · Male · Mitochondrial membrane · Mitochondrial toxicity · Molecular cloning · Nonhuman · Protein expression · Steatosis · Toxicity testing · Zebra fish · Danio rerio · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 5 of 5 found. | Sort by date