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1 Detection of adducts formed upon treatment of DNA with cisplatin and carboplatin
bookPart 1996    
Author: Fichtinger-Schepman, A.M.J. · Welters, M.J.P. · Dijk-Knijnenburg, H.C.M. van · Sterre, M.L.T. van der · Tilby, M.J. · Berends, F. · Baan, R.A.
Keywords: Nutrition · Animal · Carboplatin · Cell Survival · CHO Cells · Cisplatin · Comparative Study · DNA · DNA Adducts · Enzyme-Linked Immunosorbent Assay · Hamsters · Kinetics · Thiourea
[Abstract]

2 Cisplatin-DNA adduct formation in rat spermatozoa and its effect on fetal development
article 2000    
Author: Hooser, S.T. · Dijk-Knijnenburg, C.M. van · Waalkens-Berendsen, I.D.H. · Smits-van Prooije, A.E. · Snoeij, N.J. · Baan, R.A. · Fichtinger-Schepman, M.J.
Keywords: Nutrition · Cisplatin · Development · DNA adducts · Embryotoxicity · Rats · Spermatozoa · Cisplatin · Animal cell · Antibody specificity · Carcinogenesis · Cell killing · Cross linking · DNA adduct · DNA binding · DNA damage · Embryotoxicity · Fetus development · Infertility · Nonhuman · Priority journal · Rat · Spermatogenesis · Spermatozoon · Animals · Body Weight · Cisplatin · DNA Adducts · DNA Damage · Embryonic and Fetal Development · Female · Fetal Death · Male · Pregnancy · Rats · Rats, Wistar · Spermatozoa · Animalia
[Abstract]

3 Effect of cisplatin exposure on platinum accumulation and growth inhibition in human neoplastic and normal squamous epithelial cells of the mucosa of the upper-aerodigestive tract
article 1999    
Author: Braakhuis, B.J.M. · Welters, M.J.P. · Cloos, J. · Pankras, J.E. · Smeets, S.J. · Fichtinger-Schepman, A.-M.J.
Keywords: Nutrition · Cisplatin · Head and neck · Keratinocytes · Non-malignant cells · Pt accumulation · Squamous cells · Cisplatin · Platinum · Adult · Antineoplastic activity · Cancer cell culture · Colorimetry · Controlled study · Drug accumulation · Epithelium cell · Female · Growth inhibition · Head and neck cancer · Human · Human cell · Keratinocyte · Male · Palate · Priority journal · Squamous cell · Squamous epithelium · Antineoplastic Agents · Carcinoma, Squamous Cell · Cell Division · Cisplatin · Epithelial Cells · Female · Head and Neck Neoplasms · Humans · Male · Middle Aged · Platinum · Tumor Cells, Cultured · Uvula
[Abstract]

4 Pharmacokinetics of cisplatin with and without amifostine in tumour- bearing nude mice
article 1998    
Author: Korst, A.E.C. · Boven, E. · Sterre, M.L.T. van der · Fichtinger-Schepman, A.M.J. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Ethyol · Pharmacokinetics · WR-2721 · Amifostine · Cisplatin · Dna · Animal cell · Animal experiment · Animal model · Animal tissue · Area under the curve · Article · Bone marrow · Controlled study · Dna adduct · Drug blood level · Drug tissue level · Female · Human · Human tissue · Intraperitoneal drug administration · Intravenous drug administration · Kidney · Liver · Mouse · Nonhuman · Nude mouse · Ovary cancer · Pharmacokinetics · Priority journal · Tumor xenograft · Amifostine · Animals · Antineoplastic Agents · Cisplatin · Drug Combinations · Drug Synergism · Female · Humans · Kidney · Liver · Mice · Neoplasm Transplantation · Ovarian Neoplasms · Platinum · Radiation-Protective Agents · Transplantation, Heterologous
[Abstract]

5 The formation and repair of cisplatin-DNA adducts in wild-type and cisplatin-resistant L1210 cells : comparison of immunocytochemical determination with detection in isolated DNA
article 1998    
Author: Blommaert, F.A. · Floot, B.G.J. · Dijk-Knijnenburg, H.C.M. van · Berends, F. · Baan, R.A. · Schornagel, J.H. · Engelse, L. den · Fichtinger-Schepman, A.M.J.
Keywords: Nutrition · Cisplatin · DNA adducts · Drug resistance · Enzyme-linked immunosorbent assay · Immunocytochemistry · antiserum · cisplatin · dna · animal cell · article · colony formation · dna adduct · dna content · dna damage · dna synthesis · drug dna binding · drug resistance · drug sensitivity · enzyme linked immunosorbent assay · growth inhibition · immunocytochemistry · mouse · nonhuman · Animals · Antineoplastic Agents · Bicarbonates · Cell Division · Cisplatin · DNA Adducts · DNA Repair · DNA, Neoplasm · Drug Resistance, Neoplasm · Enzyme-Linked Immunosorbent Assay · Immunohistochemistry · Leukemia L1210 · Mice · Sensitivity and Specificity · Thiourea · Animalia · Rodentia
[Abstract]

6 Role of metallothionein in cisplatin sensitivity of germ-cell tumours
article 2000    
Author: Meijer, C. · Timmer, A. · Vries, E.G.E.de · Groten, J.P. · Knol, A. · Zwart, N. · Dam, W.A. · Sleijfer, D.Th. · Mulder, N.H.
Keywords: Nutrition · Cisplatin · Glutathione peroxidase · Metallothionein · Protein p53 · Article · Cellular distribution · Colon carcinoma · Disease association · Drug sensitivity · Germ cell tumor · Human · Human cell · Immunohistochemistry · Priority journal · Protein expression · Testis tumor · Antineoplastic Agents · Cisplatin · Colonic Neoplasms · Drug Screening Assays, Antitumor · Germinoma · Humans · Immunohistochemistry · Male · Metallothionein · Testicular Neoplasms · Tumor Cells, Cultured · Tumor Suppressor Protein p53 · Food and Nutrition · Healthy Living
[Abstract]

7 Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2
article 2008    
Author: Wortelboer, H.M. · Balvers, M.G.J. · Usta, M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Health · Physiological Sciences · Arsenic trioxide · Cisplatin · Glutathione · Mercury chloride · MRP1 · MRP2 · Adenosine triphosphatase · Calcein · Cisplatin · Glutathione · Multidrug resistance protein 1 · Multidrug resistance protein 2 · Animal cell · Cell viability · Complex formation · Controlled study · Enzyme activity · Kidney cell · Membrane vesicle · Molecular interaction · Nonhuman · Protein expression · Transport kinetics
[Abstract]

8 Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients
article 1998    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Gall, H.E. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Creatinine · Adult · Aged · Area under the curve · Clinical article · Creatinine blood level · Dna adduct · Dna drug complex · Drug blood level · Drug effect · Drug half life · Female · Human · Intravenous drug administration · Kidney function · Male · Malignant neoplastic disease · Priority journal · Amifostine · Antineoplastic Agents · Cisplatin · DNA Adducts · Drug Interactions · Female · Half-Life · Hemofiltration · Humans · Leukocytes · Male · Middle Aged · Neoplasms · Platinum · Radiation-Protective Agents
[Abstract]

9 Effects of thiourea and ammonium bicarbonate on the formation and stability of bifunctional cisplatin-DNA adducts : consequences for the accurate quantification of adducts in (cellular) DNA
article 1995    
Author: Fichtinger-Schepman, A.M.J. · Dijk-Knijnenburg, H.C.M. van · Dijt, F.J. · Velde-Visser, S.D. van der · Berends, F. · Baan, R.A.
Keywords: Nutrition · Ammonium derivative · Bicarbonate · Cell dna · Cisplatin · Dna · Thiourea · Animal cell · Cho cell · Dna adduct · Drug determination · Drug dna interaction · Nonhuman · Animal · Bicarbonates · Cell Survival · CHO Cells · Chromatography, Ion Exchange · Cisplatin · Cricetulus · Deoxyribonucleases · DNA Adducts · Hamsters · Support, Non-U.S. Gov't · Thiourea · Animalia · Cricetinae · Cricetulus griseus
[Abstract]

10 Kinetics of the formation and removal of cisplatin-DNA adducts in blood cells and tumor tissue of cancer patients receiving chemotherapy: comparison with in vitro adduct formation
article 1990    
Author: Fichtinger-Schepman, A.M.J. · Velde van der - Visser, S.D. · Dijk van - Knijnenburg, H.C.M. · Oosterom, A.T. van · Baan, R.A. · Berends, F.
Keywords: Antineoplastic agent · Cisplatin · Endogenous compound · Adult · Blood cell · Cancer · Cancer chemotherapy · Clinical article · DNA adduct · DNA binding · Female · Human · Intravenous drug administration · Male · Priority journal · Adult · Cisplatin · Comparative Study · DNA · Female · Human · Infusions, Intravenous · Kinetics · Leukocytes · Male · Middle Age · Neoplasms · Reference Values · Support, Non-U.S. Gov't · Time Factors
[Abstract]

11 Pharmacodynamics of cisplatin in human head and neck cancer : correlation between platinum content, DNA adduct levels and drug sensitivity in vitro and in vivo
article 1999    
Author: Welters, M.J.P. · Fichtinger-Schepman, A.M.J. · Baan, R.A. · Jacobs-Bergmans, A.J. · Kegel, A. · Vijgh, W.J.F. van der · Braakhuis, B.J.M.
Keywords: Cisplatin · Cisplatin sensitivity · DNA adducts · Head and neck cancer · Platinum accumulation · DNA · phosphorus 32 · platinum · animal experiment · animal tissue · atomic absorption spectrometry · cancer cell culture · controlled study · DNA drug complex · drug sensitivity · human cell · intravenous drug administration · mouse · nonhuman · nude mouse · pharmacodynamics · radioassay · squamous cell carcinoma · tumor xenograft · Animals · Antineoplastic Agents · Carcinoma, Squamous Cell · Drug Screening Assays, Antitumor · Female · Head and Neck Neoplasms · Humans · Mice · Mice, Nude · Neoplasm Transplantation · Tumor Cells, Cultured
[PDF] [Abstract]

12 Platinum compounds with anti-tumour activity
article 1980    
Author: Plooy, A.C.M. · Lohman, P.H.M.
Keywords: Biology · Antineoplastic agent · Cisplatin · Platinum derivative · Radioisotope · Animal experiment · Cytotoxicity · DNA damage · DNA strand breakage · DNA synthesis · Drug toxicity · Endocrine system · Female genital system · Heredity · In vitro study · Intoxication · Mutagenesis · Mutagenicity · Ovary cell · Structure activity relation · Thymidine h 3 · Alkalies · Animal · Antineoplastic Agents · DNA · DNA Replication · Hamsters · In Vitro · Platinum · Structure-Activity Relationship · Support, Non-U.S. Gov't
[Abstract]

13 Prophage induction and mutagenicity of a series of anti-tumour platinum(II) and platinum(IV) co-ordination complexes
article 1982    
Author: Mattern, I.E. · Cocchiarella, L. · Kralingen, C.G. van · Lohman, P.H.M.
Keywords: Biology · Antineoplastic agent · Cisplatin · Platinum derivative · Ames test · Animal experiment · Cis platinum complex · Heredity · In vitro study · Metabolism · Mutagenicity · Prophage · Prophage induction · Salmonella · Antineoplastic Agents · Bacteriophage lambda · Histidine · Mutagenicity Tests · Mutagens · Platinum · Salmonella typhimurium · Support, Non-U.S. Gov't · Virus Activation
[Abstract]

14 The potential of platinum-DNA adduct determination in ex vivo treated tumor fragments for the prediction of sensitivity to cisplatin chemotherapy
article 1999    
Author: Welters, M.J.P. · Braakhuis, B.J.M. · Jacobs-Bergmans, A.J. · Kegel, A. · Baan, R.A. · Vijgh, W.J.F. van der · Fichtinger-Schepman, A.M.J.
Keywords: Nutrition · Ex vivo · Response · Antineoplastic agent · Animal experiment · Animal model · Cancer chemotherapy · Cancer graft · Clinical article · Head and neck carcinoma · Mouse · Nonhuman · Nude mouse · Prediction · Squamous cell carcinoma · Testis cancer · Tumor biopsy · Clinical trial · Comparative study · Culture technique · Drug resistance · Genetics · Head and neck tumor · Prediction and forecasting · Testis tumor · Adult · Aged · Antineoplastic Agents · Carcinoma, Squamous Cell · Cisplatin · Culture Techniques · DNA Adducts · Drug Resistance, Neoplasm · Female · Head and Neck Neoplasms · Humans · Male · Middle Aged · Predictive Value of Tests · Sensitivity and Specificity · Testicular Neoplasms
[Abstract]

15 Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines
article 1998    
Author: Welters, M.J.P. · Fichtinger-Schepman, A.M.J. · Baan, R.A. · Flens, M.J. · Scheper, R.J. · Braakhuis, B.J.M.
Keywords: Nutrition · Cisplatin · Glutathione · Glutathione S-transferase · Head and neck cancer · Multidrug resistance · Calcein · Glycoprotein p · Multidrug resistance protein · Cancer cell culture · Controlled study · Drug sensitivity · Drug transport · Head and neck cancer · Human cell · Immunocytochemistry · Membrane transport · Antineoplastic Agents · ATP-Binding Cassette Transporters · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Enzyme Inducti · Glutathione Transferase · Head and Neck Neoplasms · Humans · Multidrug Resistance-Associated Proteins · Neoplasm Proteins · P-Glycoprotein · Vault Ribonucleoprotein Particles
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 15 of 15 found. | Sort by date