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Showing 1 to 8 of 8 found. | Sort by date

1 Developing computational model-based diagnostics to analyse clinical chemistry data
article 2010    
Author: Schalkwijk, D.B. van · Bochove, K. van · Ommen, B. van · Freidig, A.P. · Someren, E.P. van · Greef, J. van der · Graaf, A.A. de
Keywords: Biology · Biomedical Research · Clinical chemistry · Clinical diagnostics · Computational modelling · Lipoprotein metabolism · Particle profiler · Probabilistic and deterministic modelling · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

2 13-Week oral toxicity study with isomaltulose (Palatinose®) in rats
article 2002    
Author: Jonker, D. · Lina, B.A.R. · Kozianowski, G.
Keywords: Toxicology and Applied Pharmacology · Isomaltulose · Oral administration · Rat · Safety · Subchronic toxicity study · Palatinose · Animal experiment · Animal tissue · Behavior · Blood analysis · Body weight · Carbohydrate analysis · Chronic toxicity · Clinical chemistry · Controlled study · Diet · Female · Fluid intake · Food analysis · Food intake · Histopathology · Immunotoxicity · Ingestion · Male · Motor activity · Neurologic examination · Nonhuman · Cphthalmoscopy · Organ weight · Rat · Safety · Urinalysis · Animals · Blood Coagulation · Body Weight · Diet · Eating · Erythrocyte Count · Erythrocyte Indices · Female · Isomaltose · Leukocyte Count · Male · Organ Size · Rats · Rats, Wistar · Rattus norvegicus
[Abstract]

3 Evaluation of the toxicity of concentrated barley β-glucan in a 28-day feeding study in Wistar rats
article 2003    
Author: Delaney, B. · Carlson, T. · Frazer, S. · Zheng, T. · Hess, R. · Ostergren, K. · Kierzek, K. · Haworth, J. · Knutson, N. · Junker, K. · Jonker, D.
Keywords: Toxicology · Toxicology and Applied Pharmacology · β-Glucan · Barley · Lymphocytes · Soluble fiber · beta glucan · cholesterol · animal experiment · animal model · animal tissue · article · barley · blood clotting · cholesterol blood level · clinical chemistry · controlled study · erythrocyte · feeding · female · fluid intake · food intake · food poisoning · growth · male · nonhuman · organ weight · rat · sex difference · stomach emptying · Animal Feed · Animals · Behavior, Animal · Blood Chemical Analysis · Body Weight · Diet · Dietary Fiber · Drinking · Eating · Erythrocyte Count · Female · Glucans · Hordeum · Leukocyte Count · Male · Nervous System Diseases · Organ Size · Rats · Rats, Wistar · Animalia · Avena · Hordeum vulgare subsp. vulgare · Rattus norvegicus · Rodentia
[Abstract]

4 Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats
article 2003    
Author: Jonker, D. · Kuper, C.F. · Fraile, N. · Estrella, A. · Rodríguez Otero, C.
Keywords: Toxicology · Toxicology and Applied Pharmacology · Diet · Lycopene · NOEL · Oral · Subchronic toxicity · Wistar rat · lycopene · animal experiment · animal tissue · article · blood examination · body weight · calculation · clinical chemistry · clinical observation · cognition · dietary intake · female · food intake · functional assessment · fungal biomass · histopathology · male · motor activity · nonhuman · ophthalmoscope · organ weight · priority journal · rat · urinalysis · Administration, Oral · Animals · Antioxidants · Behavior, Animal · Biomass · Body Weight · Carotenoids · Chemistry, Clinical · Diet · Dose-Response Relationship, Drug · Female · Hematologic Tests · Male · Motor Activity · Mucorales · No-Observed-Adverse-Effect Level · Rats · Rats, Wistar · Blakeslea trispora · Helianthus · Rattus norvegicus
[Abstract]

5 The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
article 2014    
Author: Mierlo, G.J.D. van · Cnubben, N.H.P. · Wouters, D. · Wolbink, G.J. · Hart, M.H.L. · Rispens, T. · Ganderup, N.C. · Kuper, C.F. · Aarden, L. · Penninks, A.H.
Keywords: Biology · Adalimumab · Alternative model · Anti-drug antibodies · Immunogenicity · Infliximab · Minipig · Pharmacokinetics Ddrug antibody · Animal experiment · Animal model · Animal tissue · Antibody response · Antibody titer · Area under the curve · Body weight · Clinical chemistry · Clinical feature · Clinical observation · Controlled study · Drug blood level · Drug clearance · Drug half life · Drug megadose · Female · Hematological parameters · Histopathology · Immune function test · Immune system · Low drug dose · Maximum plasma concentration · Mean residence time · Nonhuman · Organ weight · Predictive value · Priority journal · Time to maximum plasma concentration · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Sensitivity of 1H NMR analysis of rat urine in relation to toxicometabonomics. Part I: Dose-dependent toxic fffects of Bromobenzene and paracetamol
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.P.H.T.M. · Horbach, G.J. · Smit, M.J. · Zandberg, P. · Mellema, J.R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Biomarkers · Bromobenzene · Hepatotoxicity · Metabonomics · Necrosis · Paracetamol · Urinalysis · alanine aminotransferase · aspartate aminotransferase · biological marker · bromobenzene · paracetamol · alanine aminotransferase blood level · animal experiment · animal tissue · article · aspartate aminotransferase blood level · clinical chemistry · controlled study · diagnostic accuracy · diagnostic value · dose response · drug blood level · drug urine level · early diagnosis · histopathology · intermethod comparison · liver dysfunction · liver necrosis · liver toxicity · male · non invasive measurement · nonhuman · pattern recognition · principal component analysis · proton nuclear magnetic resonance · rat · sensitivity analysis · spectrometer · urinalysis · Acetaminophen · Alanine Transaminase · Analgesics, Non-Narcotic · Animals · Aspartate Aminotransferases · Bromobenzenes · Dose-Response Relationship, Drug · Hepatitis, Toxic · Kidney · Liver · Magnetic Resonance Spectroscopy · Necrosis · Principal Component Analysis · Rats · Rattus
[Abstract]

7 Within-animal variation as an indication of the minimal magnitude of the critical effect size for continuous toxicological parameters applicable in the benchmark dose approach
article 2006    
Author: Dekkers, S. · Telman, J. · Rennen, M.A.J. · Appel, M.J. · Heer, C.de
Keywords: Biology · Food and Chemical Risk Analysis · Adverse effect · Benchmark approach · Critical effect size · Within-animal variation · Benchmarking · Biodiversity · Data reduction · Error analysis · Parameter estimation · Risk assessment · Adverse effects · Benchmark approach · Critical effect size (CES) · Within-animal variation · Toxicity · Intraspecific variation · Rodent · Temporal variation · Toxicity · Variance analysis · Analysis of variance · Animal experiment · Circadian rhythm · Clinical chemistry · Controlled study · Effect size · Female · Hematology · Male · Nonhuman · Rat · Review · Sex difference · Toxicity testing · Toxicological parameters · Analysis of Variance · Animals · Data Interpretation, Statistical · Dogs · Dose-Response Relationship, Drug · Female · Male · Poisons · Rats · Rats, Wistar · Risk Assessment · Toxicology · Animalia
[Abstract]

8 Evaluation of a subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats
article 2000    
Author: Hempenius, R.A. · Lina, B.A.R. · Haggitt, R.C.
Keywords: Arachidonic acid oil · Clinical chemistry · Haematology · Histopathology · Organ weights · Rat · Reproductive indices · Safety · alkaline phosphatase · arachidonic acid · cholesterol · corn oil · creatinine · docosahexaenoic acid · fat droplet · oil · phospholipid · triacylglycerol · urea · animal experiment · article · cell vacuole · controlled study · enzyme activity · fertility · food intake · food poisoning · food safety · histopathology · lactation · lipid composition · lipogranuloma · mating · Mortierella alpina · neurotoxicity · nonhuman · organ weight · pregnancy · prenatal exposure · rat · toxicity testing · weaning · weight gain · Administration, Oral · Animals · Arachidonic Acids · Body Weight · Docosahexaenoic Acids · Dose-Response Relationship, Drug · Female · Fermentation · Fish Oils · Humans · Infant Food · Infant Nutrition Physiology · Infant, Newborn · Liver · Male · Mortierella · Mutagenicity Tests · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Reproduction · Animalia · Ara · Fungi · Mortierella alpina · Rodentia · Zea mays
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 8 of 8 found. | Sort by date