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1 Inter-individual variability in the oxidation of 1,2-dibromoethane: Use of heterologously expressed human cytochrome P450 and human liver microsomes
article 1996    
Author: Wormhoudt, L.W. · Ploemen, J.H.T.M. · Waziers, I. de · Commandeur, J.N.M. · Beaune, P.H. · Bladeren, P.J. van · Vermeulen, N.P.E.
Keywords: Acetaldehyde · Carcinogens · Cytochrome P-450 Enzyme System · Ethylene Dibromide · Humans · Hydroxylation · Isoenzymes · Kinetics · Microsomes, Liver · Oxidation-Reduction · Structure-Activity Relationship
[Abstract]

2 Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes
article 1995    
Author: Bogaards, J.J.P. · Ommen, B. van · Wolf, C.R. · Bladeren, P.J. van
Keywords: Toxicology · Cell Line · Chlorobenzenes · Chlorzoxazone · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethanolamines · Human · Oxazines · Oxidation-Reduction · Substrate Specificity · Testosterone · Transfection
[Abstract]

3 Cytochrome P450 enzyme systems in fungi
article 1998    
Author: Brink, H.M. van den · Gorcom, R.F.M. van · Hondel, C.A.M.J.J. van den · Punt, P.J.
Keywords: Nutrition · Bioconversion · Biotransformation · CPR · CYP · Cytochrome P450 · Index descriptors · Cytochrome p450 · Biotransformation · Fungal genetics · Fungus · Molecular genetics · Nonhuman · Priority journal · Review · Saccharomyces cerevisiae · Cytochrome P-450 Enzyme System · Fungi · Genes, Plant · Multigene Family · Saccharomyces cerevisiae
[Abstract]

4 Moderate cholecalciferol supplementation depresses intestinal calcium absorption in growing dogs
article 2002    
Author: Tryfonidou, M.A. · Stevenhagen, J.J. · Bemd, G.J.C.M. van den · Oosterlaken-Dijksterhuis, M.A. · Deluca, H.F. · Mol, J.A. · Brom, W.E. van den · Leeuwen, J.P.T.M. van · Hazewinkel, H.A.W.
Keywords: Nutrition · Animals · Calcitriol · Calcium · Calcium Radioisotopes · Calcium, Dietary · Cholecalciferol · Cytochrome P-450 Enzyme System · Dogs · Down-Regulation · Female · Gene Expression Regulation, Enzymologic · Intestinal Absorption · Intestines · Kidney · Male · Metabolic Clearance Rate · Models, Animal · Phosphates · Receptors, Calcitriol · Steroid Hydroxylases · Animalia · Canis familiaris
[Abstract]

5 Conversion of pentahalogenated phenols by microperoxidase-8/H2O2 to benzoquinone-type products
article 1998    
Author: Osman, A.M. · Posthumus, M.A. · Veeger, C. · Bladeren, P.J. van · Laane, C. · Rietjens, I.M.C.M.
Keywords: Nutrition · Benzoquinone derivative · Halophenol · Peroxidase · Catalyst · Chemical analysis · Chemical reaction · Chlorination · Dechlorination · Dehalogenation · Ascorbic Acid · Benzoquinones · Catalysis · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Gas Chromatography-Mass Spectrometry · Hydrogen Peroxide · Molecular Conformation · Peroxidases · Phenols · Protein Binding
[Abstract]

6 Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression
article 2001    
Author: Post, S.M. · Duez, H. · Gervois, P.P. · Staels, B. · Kuipers, F. · Princen, H.M.G.
Keywords: Animals · Antilipemic Agents · Bile Acids and Salts · Cells, Cultured · Cholesterol · Cholesterol 7-alpha-Hydroxylase · Clofibric Acid · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Down-Regulation · Hepatocytes · Mice · Mice, Knockout · Pyrimidines · Rats · Receptors, Cytoplasmic and Nuclear · RNA, Messenger · Steroid Hydroxylases · Transcription Factors · Transcription, Genetic
[Abstract]

7 The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: A longitudinal study
article 1994    
Author: Groen, K. · Breimer, D.D. · Jansen, E.J. · Bezooijen, C.F.A. van
Keywords: Health · 3 hydroxymethylphenazone · 4 hydroxyphenazone · Norphenazone · Phenazone · Adolescent · Aged · Body weight · Controlled study · Drug blood level · Drug clearance · Drug metabolism · Drug urine level · Enantiomer · Enzyme activity · Enzyme specificity · High performance liquid chromatography · Nonhuman · Survival rate · Aging · Animal · Antipyrine · Cytochrome P-450 Enzyme System · Enzyme Induction · Hexobarbital · Longitudinal Studies · Male · Metabolic Clearance Rate · Phenobarbital · Rats · Rats, Inbred BN · Stereoisomerism
[Abstract]

8 Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol
article 1996    
Author: Bessems, J.G.M. · Koppele, J.M. te · Dijk, P.A. van · Stee, L.L.P. van · Commandeur, J.N.M. · Vermeulen, N.P.E.
Keywords: Toxicology · beta naphthoflavone · cytochrome p450 · glutathione · paracetamol · paracetamol derivative · phenobarbital · animal tissue · article · controlled study · drug oxidation · liver microsome · male · nonhuman · rat · Acetaminophen · Animals · Benzoquinones · beta-Naphthoflavone · Cytochrome P-450 Enzyme System · Gas Chromatography-Mass Spectrometry · Glutathione · Imines · Kinetics · Male · Microsomes, Liver · Oxidation-Reduction · Rats · Rats, Wistar · Spectrophotometry, Ultraviolet · Animalia · Armoracia rusticana
[Abstract]

9 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · (Anti)carcinogenic · Biotransformation · Dietary compound · Modulation · Cytochrome p450 · Glutathione transferase · Biotransformation · Cancer risk · Carcinogenesis · Drug detoxification · Enzyme activity · Genetic polymorphism · Human · Nutrition · Priority journal · Review · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Diet · Gene Expression Regulation, Neoplastic · Glutathione Transferase · Humans · Kinetics · Neoplasms · Variation (Genetics) · Xenobiotics
[Abstract]

10 Expression of cytochromes P450 in mammalian cells.
article 1998    
Author: Groene, E.M. de
Keywords: Pharmacology · Complementary DNA · Cytochrome P450 · RNA · Animal · Cell strain 3T3 · Gene vector · Genetics · Human · Metabolism · Methodology · Molecular cloning · Mouse · Retrovirus · Animals · Cloning, Molecular · Cytochrome P-450 Enzyme System · DNA, Complementary · Genetic Vectors · Humans · Mice · NIH 3T3 Cells · Retroviridae · RNA

11 An improved colony-PCR method for filamentous fungi for amplification of pcr-fragments of several kilobases
article 1998    
Author: Zeijl, C.M.J. van · Kamp, E.H.M. van de · Punt, P.J. · Selten, G.C.M. · Hauer, B. · Gorcom, R.F.M. van · Hondel, C.A.M.J.J. van den
Keywords: Nutrition · Colony-PCR method · Filamentous fungi · Rapid screening · Fungi · Colony-PCR method · Filamentous fungi · Biotechnology · Aspergillus niger · Bacterium transformation · Fungus · Gene disruption · Genetic transformation · Mycelium · Nonhuman · Plasmid · Polymerase chain reaction · Priority journal · Aspergillus niger · Cytochrome P-450 Enzyme System · DNA Mutational Analysis · DNA, Fungal · Enzymes · Glucan 1,4-alpha-Glucosidase · Plasmids · Transformation, Genetic · Aspergillus niger · Bacteria (microorganisms) · Bassiana · Beauveria · Cordyceps bassiana · Fungi
[Abstract]

12 Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase in rat hepatocytes
article 1997    
Author: Post, S.M. · Wit, E.C.M. de · Princen, H.M.G.
Keywords: Animals · Bile Acids and Salts · Cholesterol · Cholesterol 7-alpha-Hydroxylase · Cholesterol Esters · Coffee · Cytochrome P-450 CYP27A1 · Cytochrome P-450 Enzyme System · Diterpenes · Enzyme Induction · Heat · Hydroxymethylglutaryl CoA Reductases · Hydroxymethylglutaryl-CoA Synthase · Hypercholesterolemia · Liver · Male · Rats · Rats, Wistar · Receptors, LDL · RNA, Messenger · Steroid Hydroxylases · Terpenes · Transcription, Genetic · Triglycerides
[Abstract]

13 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

14 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

15 Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment
article 1996    
Author: Hissink, A.M. · Oudshoorn, M.J. · Ommen, B. van · Haenen, G.R.M.M. · Bladeren, P.J. van
Keywords: 1,2 dichlorobenzene · ascorbic acid · cytochrome p450 · epoxide hydrolase · glutathione · glutathione transferase · isoniazid · phenobarbital · animal cell · animal experiment · article · biotransformation · conjugation · controlled study · covalent bond · human · human cell · hydrolysis · liver microsome metabolism · liver toxicity · male · nonhuman · rat · Animals · Biotransformation · Chlorobenzenes · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Humans · Insecticides · Isoenzymes · Male · Microsomes, Liver · Protein Binding · Rats · Rats, Inbred F344 · Rats, Sprague-Dawley · Rats, Wistar · Risk Assessment · Species Specificity · Spectrophotometry, Ultraviolet · Animalia · Rattus norvegicus
[Abstract]

16 Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1′-hydroxysafrole
article 2004    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Awad, H.M. · Boersma, M.G. · Brand, W. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · 1' hydroxysafrole · carcinogen · cytochrome P450 · cytochrome P450 2A6 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · safrole · unclassified drug · animal cell · article · enzyme activation · enzyme specificity · human · insect cell · microsome · nonhuman · reaction analysis · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Humans · Microsomes, Liver · Risk Assessment · Safrole · Statistics, Nonparametric · Substrate Specificity · Animalia · Insecta
[Abstract]

17 Xanthobacter sp. C20 contains a novel bioconversion pathway for limonene
article 2000    
Author: Werf, M.J. van der · Keijzer, P.M. · Schaft, P.H. van der
Keywords: Biology · Cytochrome P-450 · Limonene-8,9-epoxide · Oxidation · Stereospecificity · Terpene bioconversion · Bacteria · Biopolymers · Carbon · Cell culture · Enzyme inhibition · Reaction kinetics · Cyclohexane · Cytochrome · Limonene · Bioconversion · cytochrome P450 · limonene · limonene 8,9 epoxide · terpene · unclassified drug · article · bacterium identification · bacterium isolation · biotransformation · enantiomer · nonhuman · nuclear magnetic resonance spectroscopy · priority journal · reaction analysis · river · sediment · stereoisomerism · Xanthobacter · Cyclohexanes · Cyclohexenes · Cytochrome P-450 Enzyme System · Food Microbiology · Ginger · Industrial Microbiology · Menthol · Monoterpenes · Oxidation-Reduction · Plants, Medicinal · Stereoisomerism · Terpenes · Xanthobacter · Xanthobacter sp.
[PDF] [Abstract]

18 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

19 A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide : relevance of extrahepatic metabolism
article 2000    
Author: Hissink, A.M. · Wormhoudt, L.W. · Sherratt, P.J. · Hayes, J.D. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Ethylene dibromide · Extrapolation · Glutathione S-transferase · Interindividual variation · PBPK · Risk assessment · 1,2 dibromoethane · cytochrome P450 · glutathione · glutathione transferase · animal experiment · animal model · article · biotransformation · controlled study · male · nonhuman · pharmacokinetics · prediction · rat · risk assessment · toxicity testing · xenobiotic metabolism · Administration, Oral · Animals · Area Under Curve · Biotransformation · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethylene Dibromide · Glutathione Transferase · Humans · Injections, Intravenous · Liver · Male · Models, Biological · Rats · Rats, Wistar · Risk Assessment
[Abstract]

20 Isolation and molecular characterisation of the gene encoding eburicol 14α-demethylase (CYP51) from Penicillium italicum
article 1996    
Author: Nistelrooy, J.G.M. van · Brink, J.M. van den · Kan, J.A.L. van · Gorcom, R.F.M. van · Waard, M.A. de
Keywords: Biology · 14α-demethylase · Cytochrome P450 · Fungicides · Penicillium italicum · Sterol biosynthesis inhibitors · Cytochrome p450 isoenzyme · Enilconazole · Etaconazole · Fenarimol · Fungicide · Unclassified drug · Article · Controlled study · Gene isolation · Genetic analysis · Molecular cloning · Molecular genetics · Nonhuman · Penicillium · Priority journal · Sterol synthesis · Yeast · Amino Acid Sequence · Base Sequence · Blotting, Northern · Cloning, Molecular · Cytochrome P-450 Enzyme System · DNA Primers · Fungal Proteins · Fungicides, Industrial · Genes, Fungal · Lanosterol · Molecular Sequence Data · Oxidoreductases · Penicillium · Pyrimidines · Restriction Mapping · Sequence Analysis, DNA · Sequence Homology, Amino Acid
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 39 found. Next | Sort by date