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1 Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents
article 2010    
Author: Molhoek, E.M. · Dijk, A. van · Veldhuizen, E.J.A. · Dijk-Knijnenburg, H. · Mars-Groenendijk, R.H. · Boele, L.C.L. · Kaman-van Zanten, W.E. · Haagsman, H.P. · Bikker, F.J.
Keywords: Defence · Antibacterial activity · Biological warfare agents · Cathelicidin · Cytotoxicity · Host defence peptide · Immunomodulatory activity
[Abstract]

2 Localization of murine mammary tumor virus polypeptides on the surface of tumor cells
article 1979    
Author: Westenbrink, F. · Koornstra, W. · Creemers, P.
Keywords: Animal · Cell Line · Cell Membrane · Cytoplasm · Cytotoxicity Tests, Immunologic · Electrophoresis, Polyacrylamide Gel · Fluorescent Antibody Technique · Immunodiffusion · Immunoelectrophoresis · Mammary Neoplasms, Experimental · Mammary Tumor Virus, Mouse · Peptides · Radioimmunoassay
[Abstract]

3 Inhibition of MLC responder and stimulator function with allo-antisera in rhesus monkeys
article 1978    
Author: Widmer, M.B. · Balner, H.
Keywords: Animal · Antibody Specificity · Binding, Competitive · Cytotoxicity Tests, Immunologic · Epitopes · Haplorhini · Histocompatibility Antigens · Immune Sera · Isoantibodies · Lymphocyte Culture Test, Mixed · Macaca mulatta · Male
[Abstract]

4 Alloreactive cytotoxic T lymphocytes from aged mice express increased lysis of autologous and third-party target cells
article 1980    
Author: Kruisbeek, A.M. · Steinmeier, F.A.
Keywords: Biology · Aging · Animal · Cells, Cultured · Cross Reactions · Cytotoxicity, Immunologic · Epitopes · Isoantigens · Male · Mice · Mice, Inbred BALB C · Mice, Inbred C57BL · Mice, Inbred CBA · Mice, Inbred DBA · T-Lymphocytes · Trinitrobenzenes
[Abstract]

5 On the antifungal mode of action of metalaxyl, an inhibitor of nucleic acid synthesis in Pythium splendens
article 1981    
Author: Kerkenaar, A.
Keywords: Biology · Metalaxyl · Mithramycin · Radioisotope · Animal experiment · Bisbenzimide h 3 · Cytotoxicity · Dna synthesis · Drug absorption · Drug mechanism · Fungus · Heredity · Histology · Lipogenesis · Metalaxyl c 14 · Nucleic acid synthesis · Oomycetes · Protein synthesis · Rna synthesis
[Abstract]

6 Cytotoxic and adaptive effects in rat nasal epithelium after 3-day and 13-week exposure to low concentrations of formaldehyde vapour
article 1988    
Author: Zwart, A. · Woutersen, R.A. · Wilmer, J.W.G.M. · Spit, B.J. · Feron, V.J.
Keywords: formaldehyde · animal experiment · cytotoxicity · histology · inhalation · nonhuman · nose mucosa · priority journal · rat · Adaptation, Physiological · Animal · Cell Division · Epithelium · Female · Formaldehyde · Male · Microscopy, Electron · Mucociliary Clearance · Nose · Rats · Rats, Inbred Strains · Support, Non-U.S. Gov't · Volatilization
[Abstract]

7 Sensitivity of several cell systems to acrylamide
article 1980    
Author: Hooisma, J. · Groot, D.M.G.de · Magchielse, T. · Muijser, H.
Keywords: Pharmacology · Central nervous system · Cytotoxicity · Dose response · Drug response · Endocrine system · Female genital system · Histology · In vitro study · Intoxication · Muscle cell · Nervous system · Neuroblastoma cell · Neurotoxicity · Ovary cell · Rat · Spinal cord · Spinal ganglion · Acrylamides · Animal · Brain · Chickens · Ganglia, Spinal · Mice · Muscles · Neurons · Rabbits · Tissue Culture
[PDF] [Abstract]

8 International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity
article 2014    
Author: Teunis, M.A.T. · Spiekstra, S.W. · Smits, M. · Adriaens, E. · Eltze, T. · Galbiati, V. · Krul, C.A.M. · Landsiedel, R. · Pieters, R. · Reinders, J. · Roggen, E. · Corsini, E. · Gibbs, S.
Keywords: Health · Epidermal equivalent · In vitro · NOEL · Sensitizer potency · 1 chloro 2,4 dinitrobenzene · 2 mercaptobenzothiazole · allergen · benzocaine · cinnamaldehyde · citral · cobalt chloride · formaldehyde · interleukin 1alpha · isoeugenol · oxazolone · phenylenediamine · accuracy · assay · controlled study · cytotoxicity · epidermal equivalent sensitizer potency assay · reproducibility · skin sensitization · Biomedical Innovation · Healthy Living · Healthy Living · Themalijn
[Abstract]

9 Strategies to replace in vivo acute systemic toxicity testing: The report and recommendations of ECVAM workshop 50
article 2004    
Author: Gennari, A. · Berghe, C. van den · Casati, S. · Castell, J. · Clemedson, C. · Coecke, S. · Colombo, A. · Curren, R. · Dal Negro, G. · Goldberg, A. · Gosmore, C. · Hartung, T. · Langezaal, I. · Lessigiarska, I. · Maas, W. · Mangelsdorf, I. · Parchment, R. · Prieto, P. · Sintes, J.R. · Ryan, M. · Schmuck, G. · Stitzel, K. · Stokes, W. · Vericat, J.A. · Gribaldo, L.
Keywords: Toxicology Health · Physiological Sciences · acute toxicity · conference paper · cytotoxicity · environmental protection · European Union · in vivo study · LD 50 · priority journal · toxicity testing · Acute Toxicity Tests · Animal Testing Alternatives · Animals · Cell Death · Cosmetics · Europe · Guidelines · Lethal Dose 50 · Mouth Diseases · Registries · Reproducibility of Results · Toxicity Tests · United States

10 Glutathione depletion in rat hepatocytes : a mixture toxicity study with alpha,ß-unsaturated esters
article 2001    
Author: Freidig, A. · Hofhuis, M. · Holstijn, I. van · Hermens, J.
Keywords: Nutrition · acrolein · acrylic acid · allyl compound · ester · glutathione · methacrylic acid · animal cell · article · chemical reaction · controlled study · cytotoxicity · in vitro study · liver toxicity · male · mathematical analysis · nonhuman · protein content · rat · reaction analysis · risk assessment · Acetaldehyde · Acrolein · Animals · Cell Survival · Cells, Cultured · Dose-Response Relationship, Drug · Esters · Fumarates · Glutathione · Hepatocytes · Male · Methacrylates · Models, Statistical · Rats · Rats, Wistar · Animalia
[Abstract]

11 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparations in vitro
article 1996    
Author: Gee, J.M. · Wortley, G.M. · Johnson, I.T. · Price, K.R. · Rutten, A.A.J.J.L. · Houben, G.F. · Penninks, A.H.
Keywords: Toxicology · Alkaloid · Chaconine · Lactate dehydrogenase · Saponin · Solanine · Tomatine · Unclassified drug · Animal cell · Cell culture · Cell membrane · Cell viability · Chemical interaction · Controlled study · Cytotoxicity · Human · Human cell · In vitro study · Intestine epithelium · Intestine mucosa · Jejunum · Membrane depolarization · Membrane permeability · Nonhuman · Rat · Gypsophila spp. · Lycopersicon esculentum · Solanum tuberosum
[Abstract]

12 Short-term tests of estrogenic potential of plant stanols and plant stanol esters
article 1999    
Author: Turnbull, D. · Frankos, V.H. · Leeman, W.R. · Jonker, D.
Keywords: Nutrition · Fatty acid ester · Phytosterol · Sitostanol · Sitosterol · Body weight · Cell proliferation · Chemical structure · Cytotoxicity · Drug activity · Drug screening · Estrogen activity · Food intake · Priority journal · Structure analysis · Analysis of Variance · Animals · Breast · Cell Division · Dihydrotestosterone · Esters · Estrogens, Non-Steroidal · Female · Humans · Isoflavones · Phytoestrogens · Phytosterols · Plant Preparations · Rats · Rats, Wistar · Tumor Cells, Cultured · Uterus
[Abstract]

13 Statistically designed experiments to screen chemical mixtures for possible interactions
article 1998    
Author: Groten, J.P. · Tajima, O. · Feron, V.J. · Schoen, E.D.
Keywords: Chemistry · Bioassay · Box Behnken design · Central composite design · Factorial design · Fractionated factorial design · Mixtures · Mycotoxins · Mycotoxin · Accuracy · Analysis · Chemical interaction · Conference paper · Cytotoxicity · DNA synthesis inhibition · Factorial analysis · Fibroblast · Food contamination · Fusarium · Priority journal · Screening · Statistical analysis · Algorithms · Cell Line · Data Interpretation, Statistical · DNA · Drug Interactions · Humans · Mycotoxins · Research Design · Toxicity Tests · Fusarium
[PDF] [Abstract]

14 Platinum compounds with anti-tumour activity
article 1980    
Author: Plooy, A.C.M. · Lohman, P.H.M.
Keywords: Biology · Antineoplastic agent · Cisplatin · Platinum derivative · Radioisotope · Animal experiment · Cytotoxicity · DNA damage · DNA strand breakage · DNA synthesis · Drug toxicity · Endocrine system · Female genital system · Heredity · In vitro study · Intoxication · Mutagenesis · Mutagenicity · Ovary cell · Structure activity relation · Thymidine h 3 · Alkalies · Animal · Antineoplastic Agents · DNA · DNA Replication · Hamsters · In Vitro · Platinum · Structure-Activity Relationship · Support, Non-U.S. Gov't
[Abstract]

15 Virus-specific cytotoxic activity to mammary tumor cells of sera from normal and tumor-bearing mice with inhibition at low dilutions
article 1981    
Author: Creemers, P.
Keywords: Biology · Animal experiment · Breast · Cell culture · Cellular immunity · In vitro study · Mouse mammary tumor oncovirus · Oncovirinae · Animal · Antigen-Antibody Complex · Cytotoxicity, Immunologic · Dose-Response Relationship, Immunologic · Female · Mammary Neoplasms, Experimental · Mammary Tumor Virus, Mouse · Mice · Mice, Inbred AKR · Mice, Inbred BALB C · Mice, Inbred C3H · Mice, Inbred C57BL · Mice, Inbred DBA · Rauscher Virus
[Abstract]

16 Comparative sensitivity of histo-pathology and specific lung parameters in the detection of lung injury
article 1988    
Author: Hooftman, R.N. · Kuper, C.F. · Appelman, L.M.
Keywords: Medicine · Geneeskunde · Pathology · Gamma glutamyltransferase · Nitrogen dioxide · Animal cell · Animal experiment · Cytotoxicity · Histology · Histopathology · Inhalational drug administration · Lung alveolus macrophage · Lung toxicity · Nonhuman · Phagocytosis · Rat · Administration, Inhalation · Alkaline Phosphatase · Animal · Body Weight · Bronchoalveolar Lavage Fluid · Cell Survival · Comparative Study · gamma-Glutamyltransferase · Lactate Dehydrogenase · Lung Diseases · Macrophages · Male · Nitrogen Dioxide · Phagocytosis · Proteins · Rats · Rats, Inbred Strains
[Abstract]

17 A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity
article 2019    
Author: Desprez, B. · Birk, B. · Blaauboer, B. · Boobis, A. · Carmichael, P. · Cronin, M.T.D. · Curie, R. · Daston, G. · Hubesch, B. · Jennings, P. · Klaric, M. · Kroese, D. · Mahony, C. · Ouédraogo, G. · Piersma, A. · Richarz, A.N. · Schwarz, M. · Benthem, J. van · Water, B. van de · Vinken, M.
Keywords: Adverse outcome pathway · Mode-of-action · Ontology model · Repeated dose toxicity · Cosmetic · Adverse outcome · Biotransformation · Chemical parameters · Chemical structure · Cytotoxicity · Exposure · Human · Kinetics · Metabolism · Mode of action · Nonhuman · Note · Ontology · Organ distribution · Physical chemistry · Repeated dose toxicity · Safety · Toxicity testing · Toxicology · Workflow
[Abstract]

18 Lack of clastogenic effects in cultured human lymphocytes treated with hydroquinone
article 2003    
Author: Roza, L. · Vogel, N. de · Delft, J.H.M. van
Keywords: Biology Health · Physiological Sciences · Antimutagen · Clastogenicity · Human lymphocytes · Hydroquinone · Mutagenicity · hydrogen peroxide · hydroquinone · hydroquinone derivative · mutagenic agent · oxidizing agent · article · concentration response · controlled study · cytotoxicity · genotoxicity · human · human cell · lymphocyte culture · male · metabolic activation · mutagenicity · normal human · structural chromosome aberration · animal · biotransformation · cell culture · chromatid · chromosome aberration · drug effect · in vitro study · liver · lymphocyte · metabolism · mutagen testing · rat · Wistar rat · Animalia · Animals · Biotransformation · Cells, Cultured · Chromatids · Chromosome Aberrations · Humans · Hydrogen Peroxide · Hydroquinones · Liver · Lymphocytes · Male · Mutagenicity Tests · Mutagens · Oxidants · Rats · Rats, Wistar
[Abstract]

19 Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization
article 2011    
Author: Molhoek, E.M. · Dijk, A. van · Veldhuizen, E.J.A. · Haagsman, H.P. · Bikker, F.J.
Keywords: Chicken cathelicidin-2 · Cyclization · d-Amino acid substitution · Host defense peptide · Stability · Bacterial protein · Bacterium lipopolysaccharide · Cathelicidin · Cathelicidin 2 · Phenylalanine · Proteinase · Tryptophan · Unclassified drug · Amino acid substitution · Antibacterial activity · Article · Bactericidal activity · Controlled study · Cyclization · Cytotoxicity · Human · Human cell · Nonhuman · Peptide synthesis · Peripheral blood mononuclear cell · Priority journal · Protein degradation · Protein engineering · Protein modification · Protein stability · Protein variant · Bacteria (microorganisms) · Life · CBRN - CBRN Protection · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Detection of hormonal anabolic compounds in calf urine and unverified growth-promoting preparations : application of the AR-LUX bioassay for screening and determination of androgenic activity
article 2003    
Author: Blankvoort, B.M.G. · Aarts, J.M.M.J.G. · Schilt, R. · Geerdink, P. · Spenkelink, B. · Rodenburg, R.J.T.
Keywords: Biology · Analytical research · Anabolic agent · Androgen · Boldenone · Drug residue · Luciferase · Androgen receptor mediated luciferase expression system · Animal · Animal experiment · Bioassay · Body growth · Cattle · Cell line · Conference paper · Controlled study · Cytotoxicity · Drug determination · Enzyme assay · European Union · Female · Food contamination · Gene expression · Human · Human cell · Liquid liquid extraction · Male · Methodology · Nonhuman · Reporter gene · Tumor cell line · Urine · Urine level · Anabolic Agents · Animals · Biological Assay · Cattle · Cell Line, Tumor · Drug Residues · Female · Food Contamination · Humans · Luciferases
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 38 found. Next | Sort by date