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1 Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility
article 2014    
Author: Guigas, B. · Leeuw van Weenen, J.E. de · van Leeuwen, N. · Simonis-Bik, A.M. · Haeften, T.W. van · Nijpels, G. · Houwing-Duistermaat, J.J. · Beekman, M. · Deelen, J. · Havekes, L.M. · Penninx, B.W.J.H. · Vogelzangs, N. · Riet, E. van 't · Dehghan, A. · Hofman, A. · Witteman, J.C. · Uitterlinden, A.G. · Grarup, N. · Jørgensen, T. · Witte, D.R. · Lauritzen, T. · Hansen, T. · Pedersen, O. · Hottenga, J. · Romijn, J.A. · Diamant, M. · Kramer, M.H.H. · Heine, R.J. · Willemsen, G. · Dekker, J.M. · Eekhoff, E.M. · Pijl, H. · Geus, E.J. de · Slagboom, P.E. · Hart, L.M. 't
Keywords: Biology · Dopamine 2 receptor · Glucose · Insulin · Adult · Aged · Cohort analysis · Controlled study · Female · Gene locus · Genetic association · Genetic code · Genetic risk · Genetic susceptibility · Genetic variability · Genotype Human · Insulin release · Major clinical study · Male · Non insulin dependent diabetes mellitus · Pancreas islet beta cell · Population based case control study · Randomized controlled trial · Sex difference · Single nucleotide polymorphism · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

2 The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the α2-adrenergic receptors in beta cells
article 2010    
Author: Leeuw van Weenen, J.E. de · Parlevliet, E.T. · Maechler, P. · Havekes, L.M. · Romijn, J.A. · Ouwens, D.M. · Pijl, H. · Guigas, B.
Keywords: Biology · Biomedical Research · α2-Adrenergic receptor · Bromocriptine · Dopamine receptor · INS-1E cells · Insulin secretion · Mice · alpha 2 adrenergic receptor · bromocriptine · cyclic AMP · domperidone · dopamine 2 receptor stimulating agent · G protein coupled receptor · glucose · insulin · placebo · yohimbine · analytic method · animal cell · animal experiment · article · cell line · cell membrane depolarization · cell membrane potential · controlled study · drug effect · glucose clamp technique · glucose tolerance test · hyperglycemia · in vitro study · in vivo study · inhibition kinetics · insulin release · male · mouse · nonhuman · pancreas islet beta cell · priority journal · Western blotting · Animals · Bromocriptine · Cell Line · Dopamine Agonists · Dose-Response Relationship, Drug · Glucose · Insulin · Insulin-Secreting Cells · Insulinoma · Male · Mice · Mice, Inbred C57BL · Rats · Receptors, Adrenergic, alpha · Receptors, Dopamine D2
[Abstract]

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