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Showing 1 to 13 of 13 found. | Sort by date

1 Animal behavioral methods in neurotoxicity assessment : SGOMSEC joint report
article 1996    
Author: Kulig, B. · Alleva, E. · Bignami, G. · Cohn, J. · Cory-Slechta, D. · Landa, V. · O'donoghue, J. · Peakall, D.
Keywords: Toxicology · Animals · Behavior, Animal · Cognition · Drug Evaluation, Preclinical · Ethology · Motor Activity · Nervous System Diseases · Neurotoxins · Risk Assessment · Toxicity Tests
[Abstract]

2 The chicken enucleated eye test (CEET) : a practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials
article 1996    
Author: Prinsen, M.K.
Keywords: Toxicology · Animal Testing Alternatives · Animals · Chickens · Cornea · Corneal Opacity · Drug Evaluation, Preclinical · Epithelium · Eye Enucleation · Irritants · Rabbits · Toxicity Tests · Animalia · Gallus gallus · Oryctolagus cuniculus
[Abstract]

3 Mutagenicity screening: General principles and minimal criteria. Report of a committee of the European Environmental Mutagen Society
article 1978    
Author: Kilbey, B.J. · Igali, S. · Lohman, P.H.M.
Keywords: Biology · Chemical mutagen · Animal experiment · Methodology · Mutagen testing · Mutagenesis · Short survey · Bacteriological Techniques · Drug Evaluation, Preclinical · Escherichia coli · Genetic Techniques · Mutagens · Saccharomyces cerevisiae · Salmonella typhimurium
[Abstract]

4 The role of the low-density lipoprotein receptor-related protein (LRP) in the plasma clearance and liver uptake of recombinant single-chain urokinase-type plasminogen activator in rats
article 1997    
Author: Kaaden, M.E. van der · Rijken, D.C. · Kruijt, J.K. · Berkel, T.J.C. van · Kuiper, J.
Keywords: Animals · Drug Evaluation, Preclinical · Iodine Radioisotopes · Kupffer Cells · LDL-Receptor Related Protein 1 · Liver · Male · Metabolic Clearance Rate · Plasminogen Activators · Rats · Rats, Wistar · Receptors, Immunologic · Receptors, LDL · Recombinant Proteins · Tissue Distribution · Urinary Plasminogen Activator
[Abstract]

5 Short-term tests in the framework of carcinogen risk assessment to man
article 1983    
Author: Kroes, R.
Keywords: Carcinogen · Mutagenic agent · Chemical carcinogenesis · Etiology · Human · Methodology · Netherlands · Nonhuman · Risk · Short survey · Animal · Article · Bioassay · Biological model · Drug screening · Mutagen testing · Species difference · Animal · Biological Assay · Carcinogens · Drug Evaluation, Preclinical · Models, Biological · Mutagenicity Tests · Mutagens · Risk · Species Specificity
[Abstract]

6 Angiogenesis: An improved in vitro biological system and automated image-based workflow to aid identification and characterization of angiogenesis and angiogenic modulators
article 2008    
Author: Santos, A.F. · Zaltsman, A.B. · Martin, R.C. · Kuzmin, A. · Alexandrov, Y. · Roquemore, E.P. · Jessop, R.A. · Erck, M.G.M.V. · Verheijen, J.H.
Keywords: angiogenesis modulator · bevacizumab · suramin · angiogenesis · article · automation · controlled study · human · human cell · image analysis · in vitro study · instrumentation · Angiogenesis Modulating Agents · Antibodies, Monoclonal · Automation · Cells, Cultured · Dose-Response Relationship, Drug · Drug Evaluation, Preclinical · Fibrinogen · Fluorescent Dyes · Humans · Image Processing, Computer-Assisted · Immunohistochemistry · Neovascularization, Pathologic · Neovascularization, Physiologic · Suramin · Tissue Fixation · Tumor Necrosis Factor-alpha · Vascular Endothelial Growth Factor A
[Abstract]

7 Relevance of parameters related to fertility and reproduction in toxicity testing
article 1983    
Author: Koëter, H.B.W.M.
Keywords: Antibiotic agent · Chemical agent · Chlorinated hydrocarbon · Heavy metal · Insecticide · Chemical teratogenesis · Drug toxicity · Female genital system · Fertility · Fetus · Intoxication · Male genital system · Nonhuman · Pregnancy · Reproduction · Short survey · Toxicity testing · Animal · Drug Evaluation, Preclinical · Female · Fertility · Pregnancy · Rats · Reproduction · Support, Non-U.S. Gov't · Toxicology · Zoology · Medicine · Geneeskunde · Pharmacology
[Abstract]

8 Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys
article 2001    
Author: Brok, H.P.M. · Tekoppele, J.M. · Hakimi, J. · Kerwin, J.A. · Nijenhuist, E.M. · Groot, C.W.de · Bontrop, R.E. · Hart 't, B.A.
Keywords: Biology · Biomedical Research · Animal model · Inflammation · Joint destruction · Nonhuman primate · Rheumatoid arthritis · Collagen · Interleukin 2 receptor · Interleukin 2 receptor antibody · Monoclonal antibody · Animal experiment · Animal model · Autoimmune disease · Controlled study · Drug blood level · Drug half life · Immunization · Immunogenicity · Inflammation · Joint destruction · Male · Nonhuman · Priority journal · Prophylaxis · Rhesus monkey · Rheumatoid arthritis · Animals · Antibodies, Monoclonal · Antibody Specificity · Arthritis, Rheumatoid · Autoantibodies · Autoimmune Diseases · C-Reactive Protein · Collagen · Disease Models, Animal · Drug Evaluation, Preclinical · Humans · Hydroxyproline · Immunization · Immunoglobulin G · Macaca mulatta · Male · Receptors, Interleukin-2 · Weight Loss
[Abstract]

9 Drug-eluting stents studies in mice: Do we need atherosclerosis to study restenosis?
article 2006    
Author: Pires, N.M.M. · Jukema, J.W. · Daemen, M.J.A.P. · Quax, P.H.A.
Keywords: Health · Biomedical Research · (Histo)Pathology · Animal models · Atherosclerosis · Drug-eluting stents · Restenosis · 7 hexanoyltaxol · Dactinomycin · Dexamethasone · Everolimus · Paclitaxel · Paclitaxel derivative · Qp 2 · Rapamycin · Tacrolimus · Thalidomide · Unclassified drug · Artery intima proliferation · Atherosclerosis · Blood pressure variability · Clinical trial · Coronary stent · Cost effectiveness analysis · Disease exacerbation · Disease model · Drug efficacy · Drug eluting stent · Drug release · Drug safety · Evaluation · Healing impairment · Hypersensitivity reaction · In-stent restenosis · Mouse strain · Nonhuman · Pain · Rash · Respiratory tract disease · Restenosis · Side effect · Thrombosis · Animals · Atherosclerosis · Coronary Restenosis · Disease Models, Animal · Drug Delivery Systems · Drug Evaluation, Preclinical · Humans · Mice · Paclitaxel · Sirolimus · Stents
[Abstract]

10 Rescuing drug discovery: In vivo systems pathology and systems pharmacology
article 2005    
Author: Greef, J. van der · McBurney, R.N.
Keywords: Pharmacology Health · Analytical research · 5' methoxyhydnocarpin · berberine · biological marker · ginseng extract · herbaceous agent · Hypericum extract · paroxetine · unclassified drug · article · bioinformatics · cardiovascular disease · clinical trial · cost benefit analysis · cost control · cost effectiveness analysis · data base · depression · drug approval · drug design · drug efficacy · drug indication · drug industry · drug information · drug marketing · drug research · drug response · drug safety · drug screening · drug targeting · growth inhibition · health care · health care cost · health program · human · in vivo study · non insulin dependent diabetes mellitus · nonhuman · patient compliance · prediction · prescription · priority journal · productivity · quantitative analysis · standard · system analysis · validation process · animal · diagnosis · economics · mass communication · review · Animals · Cost-Benefit Analysis · Diagnosis · Diffusion of Innovation · Drug Approval · Drug Design · Drug Evaluation · Drug Evaluation, Preclinical · Drug Industry · Humans
[Abstract]

11 Synthesis and biological evaluation of disubstituted N6- cyclopentyladenine analogues: The search for a neutral antagonist with high affinity for the adenosine A1 receptor
article 2004    
Author: Ligt, R.A.F. de · Klein, P.A.M. van der · Frijtag Drabbe Künzel, J.K. von · Lorenzen, A. · El Maate, F.A. · Fujikawa, S. · Westhoven, R. van · Hoven, T. van den · Brussee, J. · Ijzerman, A.P.
Keywords: Biology Toxicology · Physiological Sciences · [35S]GTPγS binding · Adenosine A1 receptor · Inverse agonism · N-0840 derivatives · Neutral antagonist · 8 bromo 9 methyladenine · 8 bromo n 6 cyclopentyl 9 methyladenine · 8 bromo n 6 cyclopentyl 9 propyladenine · 9 allyl 8 bromo n 6 cyclopentyladenine · 9 allyl n 6 cyclopentyl 8 methoxyadenine · adenine derivative · adenosine A1 receptor antagonist · luf 5666 · luf 5668 · luf 5669 · luf 5674 · n 0840 · n 6 cyclopentyl 8 (ethylthio) 9 methyladenine · n 6 cyclopentyl 8 (n ethyl n butylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methyl n ethylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methyl n propylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methylamino) 9 methyladenine · n 6 cyclopentyl 8 (n methylisopropylamino) 9 methyladenine · n 6 cyclopentyl 8 (n piperidino) 9 methyladenine · n 6 cyclopentyl 8 (n pyrrolidino) 9 methyladenine · n 6 cyclopentyl 8 (n,n diethylamino) 9 methyladenine · n 6 cyclopentyl 8 ethoxy 9 methyladenine · n 6 cyclopentyl 8 isopropoxy 9 methyladenine · n 6 cyclopentyl 8 methoxy 9 methyladenine · n 6 cyclopentyl 8 methoxy 9 propyladenine · n 6 cyclopentyl 9 methyl 8 oxoadenine · n 6 cyclopentyl 9 methyl 8 propoxyadenine · n 6 cyclopentyl 9 methyladenine · unclassified drug · article · binding affinity · drug determination · drug synthesis · drug tolerability · receptor affinity · substitution reaction · Adenine · Adenosine · Animals · Cell Line · CHO Cells · Cricetinae · Drug Evaluation, Preclinical · Humans · Receptor, Adenosine A1
[Abstract]

12 The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro
article 2005    
Author: Parnham, M.J. · Bogaards, J.J.P. · Schrander, F. · Schut, M.W. · Orešković, K. · Mildner, B.
Keywords: Health Pharmacology · Physiological Sciences · Cytochrome P450 · Metabolism · PLD-118 · 2 amino 4 methylenecyclopentanecarboxylic acid · alpha naphthoflavone · amino acid · antifungal agent · bufuralol · chlorzoxazone · coumarin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2B6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · cytochrome P450 3A · diclofenac · diethyldithiocarbamic acid · ethoxyresorufin · ketoconazole · mephenytoin · monoclonal antibody · monoclonal antibody 2B6 · quinidine · reduced nicotinamide adenine dinucleotide phosphate · resorufin · sulfaphenazole · testosterone · umbelliferone · unclassified drug · unindexed drug · analytic method · animal tissue · article · candidiasis · concentration response · controlled study · derivatization · dog · drug structure · enzyme assay · enzyme inhibition · enzyme stability · enzyme substrate · fluorescence analysis · high performance liquid chromatography · human · human tissue · in vitro study · liver homogenate · liver microsome metabolism · nonhuman · rat · structure analysis · Administration, Oral · Animals · Antifungal Agents · Chemistry, Pharmaceutical · Cycloleucine · Cytochrome P-450 Enzyme System · Dogs · Drug Evaluation, Preclinical · Humans · Microsomes, Liver · Rats · Ribosomal Proteins
[Abstract]

13 Apolipoprotein E*3-Leiden transgenic mice mode for hypolipidaemic drugs
article 1998    
Author: Vlijmen, B.J.M. van · Pearce, N.J. · Bergö, M. · Staels, B. · Yates, J.W. · Gribble, A.D. · Bond, B.C. · Hofker, M.H. · Havekes, L.M. · Groot, P.H.E.
Keywords: Pharmacology · ±(3R*,5S*)3-Carboxy-11-(2,4-dichlorophenyl)-3,5-dihydroxyundecanoic acid, 5-ring lactone · CAS 154566-12-8 · Gemfibrozil · Hypolipidaemic drugs, testing in transgenic mice · Lovastatin · SB 204990, hypolipidaemic effect · 3 carboxy 11 (2,4 dichlorophenyl) 3,5 dihydroxyundecanoic acid · Antilipemic agent · Apolipoprotein c3 · Apolipoprotein e3 · Cholesterol · Gemfibrozil · High density lipoprotein · Lipoprotein lipase · Low density lipoprotein · Messenger rna · Mevinolin · Sb 204990 · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Anticoagulant agent · Apolipoprotein E · Apolipoprotein E3 · Heparin · Lactone · Lipid · Messenger RNA · SB 204990 · Animal model · Animal tissue · Atherosclerosis · Cholesterol blood level · Controlled study · Dose response · Drug effect · Enzyme activity · Gene expression · Hyperlipidemia · Lipoprotein blood level · Male · Mouse · Nonhuman · Oral drug administration · Transgenic mouse · Animal · Biosynthesis · Blood · C57BL mouse · Drug screening · Genetics · Liver · Metabolism · hysiology · Animals · Anticoagulants · Antilipemic Agents · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Drug Evaluation, Preclinical · Gemfibrozil · Heparin · Lactones · Lipids · Lipoprotein Lipase · Liver · Lovastatin · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · RNA, Messenger · Triglycerides
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date