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Showing 1 to 12 of 12 found. | Sort by date

1 Urine profile analysis by field desorption mass spectrometry, a technique for detecting metabolites of xenobiotics. Application to 3,5-dinitro-2-hydroxytoluene
article 1983    
Author: Greef, J. van der · Leegwater, D.C.
Keywords: Nutrition · Dinitro ortho cresol · Drug metabolite · Radioisotope · Xenobiotic agent · Dinitro ortho cresol c 14 · Drug analysis · Drug determination · Mass spectrometry · Methodology · Nonhuman · Thin layer chromatography · Urine · Animal · Biotransformation · Cresols · Dinitrocresols · Male · Rats · Rats, Inbred Strains · Spectrum Analysis, Mass
[Abstract]

2 Criteria to distinguish between natural situations and illegal use of boldenone, boldenone esters and boldione in cattle. 1. Metabolite profiles of boldenone, boldenone esters and boldione in cattle urine
article 2006    
Author: Le Bizec, B. · Courant, F. · Gaudin, I. · Bichon, E. · Destrez, B. · Schilt, R. · Draisci, R. · Monteau, F. · André, F.
Keywords: Biology · Analytical research · Anabolic · Boldenone · Endogenous · 17 Beta boldenone · Biological marker · Boldione · Drug metabolite · Unclassified drug · Animal experiments · Comparative study · Controlled study · Drug abuse · Drug metabolism · Drug urine level · Androstadienes · Cattle · Esters · Gas Chromatography-Mass Spectrometry · Testosterone · Animalia · Bos taurus
[Abstract]

3 Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development
article 2006    
Author: Greef, J. van der · Adourian, A. · Muntendam, P. · McBurney, R.N.
Keywords: Biology · Analytical research · biological marker · drug metabolite · new drug · bioinformatics · body fluid · data base · decision making · drug determination · drug efficacy · drug marketing · drug research · drug safety · human · medical technology · metabolomics · multiple sclerosis · non insulin dependent diabetes mellitus · nonhuman · osteoarthritis · phenotype · postmarketing surveillance · proteomics · review · serology · structure activity relation
[Abstract]

4 Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, L. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Androstenedione · Boldenone · Drug metabolite · Animal tissue · Cattle · Conference paper · Drug feces level · Drug metabolism · Drug urine level · Gas chromatography · Liver cell · Liver microsome · Mass spectrometry · Nonhuman · Animals · Cells, Cultured · Feces · Gas Chromatography-Mass Spectrometry · Liver · Male · Microsomes, Liver · Testosterone
[PDF] [Abstract]

5 Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept
article 2014    
Author: Mooij, M.G. · Duijn, E. van · Knibbe, C.A.J. · Windhorst, A.D. · Hendrikse, N.H. · Vaes, W.H.J. · Spaans, E. · Fabriek, B.O. · Sandman, H. · Grossouw, D. · Hanff, L.M. · Janssen, P.J.J.M. · Koch, B.C.P. · Tibboel, D. · Wildt, S.N. de
Keywords: Nutrition · Carbon 14 · Drug metabolite · Paracetamol · Accelerator mass spectrometry · Blood sampling · Child · Clinical article · Drug blood level · Drug metabolism · Female · Human · Indwelling catheter · Infant · Limit of quantitation · Liquid chromatography · Male · Mass spectrometry · Maximum plasma concentration · Newborn · Open study · Pharmacokinetics · Pilot study · Preschool child · Priority journal · Single drug dose · Time to maximum plasma concentration · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 A thirteen week dietary toxicity study with 7-hydroxymatairesinol potassium acetate (HMRlignan) in rats
article 2005    
Author: Lina, B. · Korte, H. · Nyman, L. · Unkila, M.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · 7-Hydroxymatairesinol · Enterolactone · Lignan · Safety · Sub-chronic · Toxicity · 7 hydroxyenterolactone · 7 hydroxymatairesinol potassium acetate · drug metabolite · enterolactone · lignan · matairesinol · phospholipid · triacylglycerol · unclassified drug · animal experiment · animal tissue · article · body weight · cholesterol blood level · chronic toxicity · cognition · controlled study · diet · dose response · drug blood level · estrus cycle · female · food intake · histopathology · kidney disease · leukocyte count · male · motor activity · nonhuman · ophthalmoscopy · organ weight · ovary · palatability · priority journal · rat · sex difference · thrombocyte count · toxicity testing · triacylglycerol blood level · weight reduction · 4-Butyrolactone · Animals · Body Weight · Diet · Female · Lignans · Male · Motor Activity · No-Observed-Adverse-Effect Level · Organ Size · Potassium Acetate · Rats · Rats, Wistar · Mammalia · Rattus norvegicus
[Abstract]

7 Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: A toxicogenomics approach
article 2006    
Author: Kienhuis, A.S. · Wortelboer, H.M. · Hoflack, J.C. · Moonen, E.J. · Kleinjans, J.C.S. · Ommen, B. van · Delft, J.H.M. van · Stierum, R.H.
Keywords: Biology · Biomedical Research · beta naphthoflavone · coumarin · cytochrome P450 · dexamethasone · drug metabolite · enzyme inducing agent · phenobarbital · animal cell · animal experiment · animal model · animal tissue · article · controlled study · culture medium · cytotoxicity · drug activation · drug metabolism · enzyme activity · experimental rat · gene expression · histopathology · in vitro study · in vivo study · liver cell · liver toxicity · male · nonhuman · nucleotide sequence · prediction · principal component analysis · priority journal · rat · signal transduction · toxicogenetics · Alanine Transaminase · Animals · Aspartate Aminotransferases · Cell Culture Techniques · Cells, Cultured · Cholesterol · Coumarins · gamma-Glutamyltransferase · Gene Expression Profiling · Hepatocytes · Liver · Male · Oligonucleotide Array Sequence Analysis · Rats · Rats, Wistar · Toxicogenetics
[Abstract]

8 Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy
article 2006    
Author: Chang, W.T. · Thissen, U. · Ehlert, K.A. · Koek, M.M. · Jellema, R.H. · Hankemeier, T. · Greef, J. van der · Wang, M.
Keywords: Biology · Analytical research · ANOVA-simultaneous component analysis · ASCA · GC-MS · Herbal medicine · Metabolite profiling · Principal component analysis · Processing of traditional Chinese medicine · Quality control · Rehmannia glutinosa L. · Drug metabolite · Herbaceous agent · Natural product · Rehmannia glutinosa extract · Analysis of variance · Chinese medicine · Drug determination · Drug manufacture · Drug quality · Gas chromatography · Mass spectrometry · Nonhuman · Plant growth · Plant metabolism · Plant root · Principal component analysis · Quality control · Rehmannia · Rehmannia glutinosa · Climate · Drugs, Chinese Herbal · Gas Chromatography-Mass Spectrometry · Humans · Phytotherapy · Principal Component Analysis · Quality Control · Rehmannia · Soil · Rehmannia · Rehmannia glutinosa
[Abstract]

9 Higher mass loadability in comprehensive two-dimensional gas chromatography-mass spectrometry for improved analytical performance in metabolomics analysis
article 2008    
Author: Koek, M.M. · Muilwijk, B. · Stee, L.L.P. van · Hankemeier, T.
Keywords: Biology · Column diameter · Comprehensive two-dimensional gas chromatography · GC × GC-TOFMS · Mass loadability · Metabolic profiling · Metabolites · Metabolomics · Overloading · Sample capacity · Stationary phase film thickness · Time-of-flight mass spectrometry · Concentration (process) · Film thickness · Gas chromatography · Mass spectrometry · Sampling · Column diameter · Comprehensive two-dimensional gas chromatography · Metabolic profiling · Sample capacity · Stationary phase film thickness · Time-of-flight mass spectrometry · Metabolites · drug metabolite · analytic method · article · autoanalysis · comparative study · concentration (parameters) · feasibility study · film · gas chromatography · mass · mass fragmentography · metabolomics · priority journal · sample · Animals · Cattle · Gas Chromatography-Mass Spectrometry · Glucose · Molecular Weight · Reference Standards · Serum

10 Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of α,β-unsaturated carbonyl compounds
article 2005    
Author: Wortelboer, H.M. · Usta, M. · Zanden, J.J. van · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Nutrition · Biomedical Research · α,β-Unsaturated carbonyl compounds · Inhibition · MRP1 · MRP2 · 2 hexenal · acrolein · caffeic acid phenethyl ester · calcein · carbonyl derivative · cinnamaldehyde · citral · crotonaldehyde · curcumin · cyclosporin A · demethoxycurcumin · didemethoxycurcumin · drug metabolite · glutathione · multidrug resistance protein 1 · multidrug resistance protein 2 · thiol derivative · unclassified drug · verlukast · animal cell · article · cell isolation · cell metabolism · conjugate · controlled study · dog · drug efficacy · drug metabolism · drug potency · drug protein binding · glutathione metabolism · kidney cell · membrane vesicle · modulation · molecular model · molecular stability · nonhuman · priority journal · protein expression · protein transport · Aldehydes · Animals · Biological Transport · Cell Line · Curcumin · Dogs · Fluoresceins · Humans · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Transfection
[Abstract]

11 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

12 Disposition of [14C]γ-cyclodextrin in germ-free and conventional rats
article 1998    
Author: Bie, A.T.H.J. de · Ommen, B. van · Bär, A.
Keywords: Nutrition · Carbon 14 · Carbon dioxide · Drug metabolite · Gamma cyclodextrin · Carbon · Cyclodextrin · Gamma cyclodextrin derivative · Gamma-cyclodextrin · Animal experiment · Animal tissue · Carcass · Controlled study · Dose response · Drug bile level · Drug blood level · Drug disposition · Drug feces level · Drug identification · Drug metabolism · Drug saliva level · Drug tissue level · Drug urine level · Female · Gastrointestinal tract · Germfree animal · High performance liquid chromatography · Intravenous drug administration · Isotope labeling · Male · Nonhuman · Oral drug administration · Priority journal · Rat · Animal · Animal food · Bile · Breath analysis · Chemistry · Comparative study · Digestive system · Feces · Intestine absorption · Metabolism · Wistar rat · Administration, Oral · Animal Feed · Animals · Breath Tests · Carbon Dioxide · Carbon Radioisotopes · Cyclodextrins · Digestive System · Feces · Female · gamma-Cyclodextrins · Germ-Free Life · Injections, Intravenous · Intestinal Absorption · Male · Rats · Rats, Wistar
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date