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Showing 1 to 19 of 19 found. | Sort by date

1 Factor V antigen levels and venous thrombosis: Risk profile, interaction with factor V leiden, and relation with factor VII antigen levels
article 2000    
Author: Kamphuisen, P.W. · Rosendaal, F.R. · Eikenboom, J.C.J. · Bos, R. · Bertina, R.M.
Keywords: Adolescent · Adult · Aged · Drug Resistance · Factor V · Factor VIII · Female · Humans · Male · Middle Aged · Protein C · Risk Factors · Venous Thrombosis
[Abstract]

2 The formation and repair of cisplatin-DNA adducts in wild-type and cisplatin-resistant L1210 cells : comparison of immunocytochemical determination with detection in isolated DNA
article 1998    
Author: Blommaert, F.A. · Floot, B.G.J. · Dijk-Knijnenburg, H.C.M. van · Berends, F. · Baan, R.A. · Schornagel, J.H. · Engelse, L. den · Fichtinger-Schepman, A.M.J.
Keywords: Nutrition · Cisplatin · DNA adducts · Drug resistance · Enzyme-linked immunosorbent assay · Immunocytochemistry · antiserum · cisplatin · dna · animal cell · article · colony formation · dna adduct · dna content · dna damage · dna synthesis · drug dna binding · drug resistance · drug sensitivity · enzyme linked immunosorbent assay · growth inhibition · immunocytochemistry · mouse · nonhuman · Animals · Antineoplastic Agents · Bicarbonates · Cell Division · Cisplatin · DNA Adducts · DNA Repair · DNA, Neoplasm · Drug Resistance, Neoplasm · Enzyme-Linked Immunosorbent Assay · Immunohistochemistry · Leukemia L1210 · Mice · Sensitivity and Specificity · Thiourea · Animalia · Rodentia
[Abstract]

3 Evaluation of 99mTc-UBI 29-41 scintigraphy for specific detection of experimental multidrug-resistant Staphylococcus aureus bacterial endocarditis
article 2010    
Author: Brouwer, C.P.J.M. · Gemmel, F.F.A.Y. · Welling, M.M.
Keywords: Nutrition · Food technology · Drug resistance · Endocarditis, bacterial · Technetium 99m ubiquicidin(29-41) · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients
article 2006    
Author: Brand, W. · Schutte, M.E. · Williamson, G. · Zanden, J.J. van · Cnubben, N.H.P. · Groten, J.P. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · ATP binding cassette (ABC) transport proteins · Flavonoids · Intestinal transcellular transport · Animals · ATP-Binding Cassette Transporters · Biological Availability · Biological Transport · Drug Resistance, Multiple · Flavonoids · Humans · Intestines
[Abstract]

5 Glutathione conjugation of the cytostatic drug ifosfamide and the role of human glutathione S-transferases
article 1995    
Author: Dirven, H.A.A.M. · Megens, L. · Oudshoorn, M.J. · Dingemanse, M.A. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione transferase · Ifosfamide · Cancer chemotherapy · Drug conjugation · Drug detoxification · Drug resistance · Enzyme activity · Human · Human tissue · Leukemia · Lymphoma · Solid tumor · Antineoplastic Agents, Alkylating · Biotransformation · Chromatography, High Pressure Liquid · Drug Resistance, Neoplasm · Glutathione · Glutathione Transferase · Human · Ifosfamide · Isoenzymes · Magnetic Resonance Spectroscopy · Metabolic Detoxication, Drug · Spectrometry, Mass, Fast Atom Bombardment · Support, Non-U.S. Gov't
[Abstract]

6 Differential binding of methyl benzimidazol 2 yl carbamate to fungal tubulin as a mechanism of resistance to this antimiotic agent in mutant strains of Aspergillus nidulans
article 1977    
Author: Davidse, L.C. · Flach, W.
Keywords: benomyl · carbon 14 · colchicine · fuberidazole · mebendazole · nocodazole · r 17 934 · radioisotope · tiabendazole · aspergillus nidulans · colchicine h 3 · drug binding · drug protein binding · drug resistance · microorganism · mutant · theoretical study · Aspergillus nidulans · Benzimidazoles · Binding, Competitive · Carbamates · Colchicine · Drug Resistance · Glycoproteins · Griseofulvin · Hydrogen-Ion Concentration · Melatonin · Mutation · Podophyllotoxin · Receptors, Drug · Temperature · Tubulin · Vinblastine
[Abstract]

7 Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
article 1996    
Author: Zaman, G.J.R. · Cnubben, N.H.P. · Bladeren, P.J. van · Evers, R. · Borst, P.
Keywords: Adenosine Monophosphate · ATP-Binding Cassette Transporters · Biological Transport · Carcinoma, Non-Small-Cell Lung · Cell Membrane · Drug Resistance, Multiple · Ethacrynic Acid · Glutathione · Humans · Kinetics · Lung Neoplasms · Multidrug Resistance-Associated Proteins · Recombinant Proteins · Saccharomyces cerevisiae · Sulfinpyrazone · Transfection · Tumor Cells, Cultured
[PDF] [Abstract]

8 Antimalarial activity of the bisquinoline trans-N1,N2-bis (7- chloroquinolin-4-yl)cyclohexane-1,2-diamine: Comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737
article 1997    
Author: Ridley, R.G. · Matile, H. · Jaquet, C. · Dorn, A. · Hofheinz, W. · Leupin, W. · Masciadri, R. · Theil, F.P. · Richter, W.F. · Girometta, M.A. · Guenzi, A. · Urwyler, H. · Gocke, E. · Potthast, J.M. · Csato, M. · Thomas, A. · Peters, W.
Keywords: Health · Plasmodium berghei · Subcutaneous drug administration · Animals · Antimalarials · Chloroquine · Cyclohexylamines · Dogs · Drug Resistance · Half-Life · Heme · Malaria, Vivax · Male · Mice · Plasmodium falciparum · Plasmodium vivax · Quinolines · Rats · Rats, Wistar · Stereoisomerism
[Abstract]

9 Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin
article 2005    
Author: Zanden, J.J. van · Mul, A. de · Wortelboer, H.M. · Usta, M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology · Physiological Sciences · Flavonoids · MRP1 · MRP2 · Multidrug resistance · Myricetin · Vincristine · antineoplastic agent · flavonoid · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · vincristine · animal cell · article · cell line · cell proliferation · chemotherapy · concentration (parameters) · controlled study · drug resistance · drug transport · genetic transfection · IC 50 · in vitro study · nonhuman · priority journal · Animals · Cell Line · Cell Proliferation · Dogs · Dose-Response Relationship, Drug · Drug Resistance, Neoplasm · Flavonoids · Humans · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Vincristine
[Abstract]

10 Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines
article 1998    
Author: Welters, M.J.P. · Fichtinger-Schepman, A.M.J. · Baan, R.A. · Flens, M.J. · Scheper, R.J. · Braakhuis, B.J.M.
Keywords: Nutrition · Cisplatin · Glutathione · Glutathione S-transferase · Head and neck cancer · Multidrug resistance · Calcein · Glycoprotein p · Multidrug resistance protein · Cancer cell culture · Controlled study · Drug sensitivity · Drug transport · Head and neck cancer · Human cell · Immunocytochemistry · Membrane transport · Antineoplastic Agents · ATP-Binding Cassette Transporters · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Enzyme Inducti · Glutathione Transferase · Head and Neck Neoplasms · Humans · Multidrug Resistance-Associated Proteins · Neoplasm Proteins · P-Glycoprotein · Vault Ribonucleoprotein Particles
[PDF] [Abstract]

11 The potential of platinum-DNA adduct determination in ex vivo treated tumor fragments for the prediction of sensitivity to cisplatin chemotherapy
article 1999    
Author: Welters, M.J.P. · Braakhuis, B.J.M. · Jacobs-Bergmans, A.J. · Kegel, A. · Baan, R.A. · Vijgh, W.J.F. van der · Fichtinger-Schepman, A.M.J.
Keywords: Nutrition · Ex vivo · Response · Antineoplastic agent · Animal experiment · Animal model · Cancer chemotherapy · Cancer graft · Clinical article · Head and neck carcinoma · Mouse · Nonhuman · Nude mouse · Prediction · Squamous cell carcinoma · Testis cancer · Tumor biopsy · Clinical trial · Comparative study · Culture technique · Drug resistance · Genetics · Head and neck tumor · Prediction and forecasting · Testis tumor · Adult · Aged · Antineoplastic Agents · Carcinoma, Squamous Cell · Cisplatin · Culture Techniques · DNA Adducts · Drug Resistance, Neoplasm · Female · Head and Neck Neoplasms · Humans · Male · Middle Aged · Predictive Value of Tests · Sensitivity and Specificity · Testicular Neoplasms
[Abstract]

12 Functional analysis of three plasmids from Lactobacillus plantarum
article 2005    
Author: Kranenburg, R. van · Golic, N. · Bongers, R. · Leer, R.J. · Vos, W.M. de · Siezen, R.J. · Kleerebezem, M.
Keywords: Biology · Biotechnology · Biomarkers · Genes · Plants (botany) · Functional analysis · Bacteria · Carnobacterium maltaromaticum · Arsenates · Arsenites · Base Sequence · Chromosome Mapping · DNA Replication · DNA, Bacterial · Drug Resistance, Bacterial · Gene Dosage · Genes, Bacterial · Lactobacillus plantarum · Molecular Sequence Data · Plasmids · Replicon · Sequence Homology, Nucleic Acid · Transfection · Bacillus subtilis · Carnobacterium maltaromaticum · Lactobacillus plantarum · Lactococcus lactis · Lactococcus plantarum
[PDF] [Abstract]

13 Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.
article 2005    
Author: Cnubben, N.H. · Wortelboer, H.M. · Zanden, J.J. van · Rietjens, I.M. · Bladeren, P.J. van
Keywords: Health Pharmacology · Physiological Sciences · ABC transporter · cyclosporin derivative · dibenzo[a,d]cycloheptene derivative · glycoprotein P · quinoline derivative · valspodar · zosuquidar · drug antagonism · drug design · drug effect · genetics · human · metabolism · multidrug resistance · review · RNA interference · transport at the cellular level · ATP-Binding Cassette Transporters · Biological Transport · Cyclosporins · Dibenzocycloheptenes · Drug Design · Drug Resistance, Multiple · Humans · P-Glycoproteins · Quinolines · RNA Interference
[Abstract]

14 Differences in dexamethasone-sensitivity between lymphocytes from patients with Alzheimer's disease and patients with multi-infarct dementia
article 1996    
Author: Nijhuis, E.W.P. · Oostervink, F. · Hinloopen, B. · Rozing, J. · Nagelkerken, L.
Keywords: Health · Glucocorticoid receptor · Clinical article · Cognitive defect · Drug sensitivity · Human cell · Lymphocyte · Mononuclear cell · Multiinfarct dementia · Screening · Aged · Aged, 80 and over · Alzheimer Disease · Apoptosis · Cells, Cultured · Dementia, Multi-Infarct · Dexamethasone · Drug Resistance · Female · Gene Expression Regulation · Humans · Immunosuppressive Agents · Interleukin-2 · Interleukin-4 · Lymphocyte Activation · Male · Phytohemagglutinins · Proto-Oncogene Proteins c-bcl-2 · Receptors, Glucocorticoid · T-Lymphocytes
[Abstract]

15 The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa
article 1995    
Author: Dirven, H.A.A.M. · Dictus, E.L.J.T. · Broeders, N.L.H.L. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione reductase · Tepa · Thiotepa · Conformational transition · Drug conformation · Drug conjugation · Drug protein binding · Drug resistance · Enzyme activity · Priority journal · Chromatography, High Pressure Liquid · Female · Glutathione · Glutathione Transferase · Human · Isoenzymes · Kinetics · Liver · Magnetic Resonance Spectroscopy · Placenta · Pregnancy · Support, Non-U.S. Gov't · Thiotepa
[Abstract]

16 Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells
article 2004    
Author: Zanden, J.J. van · Geraets, L. · Wortelboer, H.M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology Toxicology · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · 50% inhibition concentration · CDNB · DNP-SG · Glutathione · Glutathione conjugate · Glutathione S-transferase · GS-X · GSH · GST · IC50 · MRP · Multidrug resistance associated protein · P-gp · S-(2,4-dinitrophenyl)glutathione · 3',4' dihydroxyflavone · carbon · catechin · catechol derivative · eriodictyol · flavanoid · flavone derivative · galanin · glutathione transferase · hydroxyl group · kaempferol · luteolin · morin · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · quercetin · taxifolin · unclassified drug · animal cell · article · breast cancer · cell strain MCF 7 · chemical bond · controlled study · drug activity · drug potency · enzyme activity · enzyme inhibition · genetic transfection · human · human cell · IC 50 · lipophilicity · nonhuman · priority journal · structure activity relation · toxicokinetics · Biological Transport · Breast Neoplasms · Carrier Proteins · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Flavonoids · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Structure-Activity Relationship · Tumor Cells, Cultured
[Abstract]

17 Interplay between MRP Inhibition and Metabolism of MRP Inhibitors: The Case of Curcumin
article 2003    
Author: Wortelboer, H.M. · Usta, M. · Velde, A.E. van der · Boersma, M.G. · Spenkelink, B. · Zanden, J.J. van · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Physiological Sciences · curcumin · glutathione · glutathionylcurcumin · multidrug resistance protein 1 · multidrug resistance protein 2 · protein inhibitor · unclassified drug · animal cell · article · controlled study · drug effect · IC 50 · inhibition kinetics · insect cell · intracellular transport · membrane vesicle · metabolism · monolayer culture · nonhuman · protein expression · protein transport · Animals · ATP-Binding Cassette Transporters · Baculoviridae · Cell Line · Curcumin · Cyclosporine · Dinitrochlorobenzene · Dose-Response Relationship, Drug · Drug Resistance, Multiple · Ethacrynic Acid · Fluoresceins · Glutathione · Glutathione Transferase · Humans · P-Glycoprotein · P-Glycoproteins · Propionates · Quinolines · Recombinant Proteins · Spodoptera · Animalia · Apus apus · Insecta
[Abstract]

18 Increased resistance to 14α-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14α-demethylase (cyp51) and the A. Niger cytochrome P450 reductase (cprA) genes
article 1996    
Author: Brink, H.J.M. van den · Nistelrooy, H.J.G.M. van · Waard, M.A. de · Hondel, C.A.M.J.J. van den · Gorcom, R.F.M. van
Keywords: Biology · Ergosterol · NADPH cytochrome P450 reductase · Sterol 14α-demethylation inhibitors · Drug products · Fungicides · Genes · Demethylase inhibitors (DMI) · Gene encoding · Genetic engineering · Cytochrome p450 reductase · Reduced nicotinamide adenine dinucleotide phosphate ferrihemoprotein reductase · Enzyme synthesis · Fungal genetics · Nonhuman · Penicillium · Priority journal · Aspergillus niger · Cytochrome P-450 Enzyme System · Drug Resistance, Microbial · Enzyme Inhibitors · Gene Expression Regulation, Fungal · NADH, NADPH Oxidoreductases · NADPH-Ferrihemoprotein Reductase · Oxidoreductases · Penicillium · Recombinant Proteins · Transformation, Genetic · Aspergillus niger · Fungi · Penicillium · Penicillium italicum
[Abstract]

19 Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with L-lysine
article 2001    
Author: Peschel, A. · Jack, R.W. · Otto, M. · Collins, L.V. · Staubitz, P. · Nicholson, G. · Kalbacher, H. · Nieuwenhuizen, W.F. · Jung, G. · Tarkowski, A. · Kessel, K.P.M. van · Strijp, J.A.G. van
Keywords: Toxicology · Host defense peptides · Innate immunity · Oxygen-independent killing · Phospholipids · Staphylococcus aureus virulence · antibiotic agent · defensin · gallidermin · gramicidin D · gramicidin S · lysine · magainin 2 · melittin · membrane lipid · nisin · phosphatidylglycerol · protegrin · tachyplesin · unclassified drug · virulence factor · virulence factor mprf · animal model · antibiotic resistance · article · bacterial count · bactericidal activity · controlled study · Enterococcus faecalis · female · gene inactivation · mouse · Mycobacterium tuberculosis · neutrophil · nonhuman · nucleotide sequence · pathogenicity · priority journal · Pseudomonas aeruginosa · Staphylococcus aureus · surface charge · alpha-Defensins · Amino Acid Sequence · Animals · Anti-Bacterial Agents · Bacterial Proteins · Base Sequence · Cell Membrane · Defensins · DNA, Bacterial · Drug Resistance, Microbial · Esterification · Genes, Bacterial · Humans · Lysine · Molecular Sequence Data · Neutrophils · Peptides · Phosphatidylglycerols · Staphylococcus aureus · Swine · Virulence
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date