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Showing 1 to 19 of 19 found. | Sort by date

1 Automated TV based system for open field studies: Effects of methamphetamine
article 1978    
Author: Tanger, H.J. · Vanwersch, R.A.P. · Wolthuis, O.L.
Keywords: Biology · Methamphetamine · Animal experiment · Automation · Central nervous system · Dose response · Drug response · Intraperitoneal drug administration · Motor activity · Open field behavior · Rat · Television · Animal · Male · Methamphetamine · Motor Activity · Rats · Television · Time Factors
[Abstract]

2 Putting pharmacogenetics into practice
article 2006    
Author: Hopkins, M.M. · Ibarreta, D. · Gaisser, S. · Enzing, C.M. · Ryan, J. · Martin, P.A. · Lewis, G. · Detmar, S. · Akker-van Marle, M.E. van den · Hedgecoe, A.M. · Nightingale, P. · Dreiling, M. · Hartig, K.J. · Vullings, W. · Forde, T.
Keywords: Health · c=Clinical practice · Drug efficacy · Drug response · Drug safety · Health care system · Pharmacogenomics · Policy · Review · Vocational education · Biotechnology · Drug Approval · Drug Design · Drug Industry · Pharmacogenetics · Research · United States

3 Sensitivity of several cell systems to acrylamide
article 1980    
Author: Hooisma, J. · Groot, D.M.G.de · Magchielse, T. · Muijser, H.
Keywords: Pharmacology · Central nervous system · Cytotoxicity · Dose response · Drug response · Endocrine system · Female genital system · Histology · In vitro study · Intoxication · Muscle cell · Nervous system · Neuroblastoma cell · Neurotoxicity · Ovary cell · Rat · Spinal cord · Spinal ganglion · Acrylamides · Animal · Brain · Chickens · Ganglia, Spinal · Mice · Muscles · Neurons · Rabbits · Tissue Culture
[PDF] [Abstract]

4 Behavioral effects of etiracetam in rats
article 1981    
Author: Wolthuis, O.L.
Keywords: Biology · Etiracetam · Piracetam · 2 Pyrrolidone derivative · Drug derivative · Animal experiment · Avoidance behavior · Behavior · Central nervous system · Conditioning · Drug comparison · Drug response · Intraperitoneal drug administration · Rat · Animal · Animal behavior · Drug effect · Electric shock · Male · Motor activity · Perceptive discrimination · Perceptive threshold · Rat strain · Animal · Avoidance Learning · Behavior, Animal · Discrimination (Psychology) · Electroshock · Male · Motor Activity · Piracetam · Pyrrolidinones · Rats · Rats, Inbred Strains · Sensory Thresholds
[Abstract]

5 A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents
article 1978    
Author: Kepner, L.A. · Wolthuis, O.L.
Keywords: Biology · Atropine · Cholinesterase reactivator · Oxime · Soman · 1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl ether · Animal experiment · Breathing · Drug comparison · Drug intoxication · Drug response · Intoxication · Intraperitoneal drug administration · Mouse · Muscle · Musculoskeletal system · Neuromuscular transmission · Organophosphate poisoning · Rat · Respiratory system · Subcutaneous drug administration · Animal · Atropine · Comparative Study · Drug Synergism · Female · Male · Mice · Neuromuscular Junction · Organophosphorus Compounds · Oximes · Rats · Rats, Inbred Strains · Respiration · Soman
[Abstract]

6 Extrapulmonary colony formation after intravenous injection of tumour cells into heparin treated animals
article 1978    
Author: Maat, B.
Keywords: fibrin · animal experiment · blood and hemopoietic system · blood clotting · cancer graft · colony formation · dose response · drug comparison · drug response · intraperitoneal drug administration · intravenous drug administration · lung · metastasis · mouse · respiratory system · theoretical study · Animal · Cell Count · Heparin · Lung Neoplasms · Mice · Neoplasm Circulating Cells · Neoplasm Metastasis · Neoplasms, Experimental · Rats · Thoracic Neoplasms
[PDF] [Abstract]

7 Acute inhalation toxicity study of ammonia in rats with variable exposure periods
article 1982    
Author: Appelman, L.M. · Berge, W.F. ten · Reuzel, P.G.J.
Keywords: Nutrition · Ammonia · Adverse drug reaction · Animal experiment · Dose response · Drug response · Drug toxicity · Epidemiology · Inhalation · Inhalational drug administration · Intoxication · Mortality · Respiratory system · Animal · Dose-Response Relationship, Drug · Female · Lethal Dose 50 · Male · Rats · Rats, Inbred Strains · Regression Analysis · Sex Factors · Support, Non-U.S. Gov't · Time Factors
[Abstract]

8 Repeated exposure to alpha-ethylacrolein vapour: Subacute toxicity study in rats
article 1981    
Author: Appelman, L.M. · Hendriksen, C.F.M. · Feron, V.J.
Keywords: Adverse drug reaction · Alpha ethylacrolein · Animal experiment · Dose response · Drug response · Drug toxicity · Inhalational drug administration · Intoxication · Rat · Acrolein · Aldehydes · Animal · Behavior, Animal · Blood · Eating · Female · Hyperplasia · Lung · Male · Organ Weight · Rats · Rats, Inbred Strains · Support, Non-U.S. Gov't · Volatilization
[Abstract]

9 Tissue culture and neurotoxicology
article 1982    
Author: Hooisma, J.
Keywords: Biology · Acrylamide · Colchicine · Glutathione · Nicotinamide adenine dinucleotide · Animal cell · Brain cell · Central nervous system · Dose response · Drug comparison · Drug mechanism · Drug mixture · Drug response · Drug screening · In vitro study · Intoxication · Methodology · Nervous system · Neurotoxicity · Nonhuman · Rat · Tissue culture · Acrylamide · Acrylamides · Animal · Axons · Colchicine · Female · Ganglia, Spinal · Glutathione · Male · NAD · Nervous System Diseases · Rats · Rats, Inbred Strains · Support, Non-U.S. Gov't · Tissue Culture · Toxicology
[Abstract]

10 In vitro evaluation of some latent radioprotective compounds
article 1976    
Author: Vos, O. · Budke, L. · Grant, G.A.
Keywords: Biology · 2 (3 aminopropylamino)ethanethiol · Ae 48527 · Amifostine · Cystafos · Cystamine · Cysteamine derivative · Glycolic acid derivative · Mercaptamine · Phosphorothioic acid derivative · Thiol derivative · Unclassified drug · Cell culture · Cysteamine s sulfonic acid · Dose response · Drug comparison · Drug response · In vitro study · Kidney cell · Mouse · Radiation protection · Theoretical study · Tissue culture · Amifostine · Animal · Blood · Cell Line · Cell Survival · Culture Media · Cystamine · Cysteamine · Dose-Response Relationship, Drug · Dose-Response Relationship, Radiation · Female · Hydrolysis · In Vitro · Mercaptoethylamines · Mice · Organothiophosphorus Compounds · Radiation-Protective Agents · Rats · X-Rays
[Abstract]

11 Modifying effect of vitamin A on benzo[a]pyrene-induced respiratory tract tumours in hamsters
article 1984    
Author: Beems, R.B.
Keywords: Benzo[a]pyrene · Retinol · Animal experiment · Animal model · Chemical carcinogenesis · Dose response · Drug administration · Drug blood level · Drug efficacy · Drug mechanism · Drug response · Electron microscopy · Epidemiology · Fatality · Mortality · Nonhuman · Oral drug administration · Prevention · Respiratory system · Respiratory tract tumor · Sex difference · Animal · Benzo(a)pyrene · Benzopyrenes · Body Weight · Dose-Response Relationship, Drug · Drug Interactions · Eating · Female · Hamsters · Male · Mesocricetus · Precancerous Conditions · Respiratory Tract Neoplasms · Sex Factors · Support, Non-U.S. Gov't · Vitamin A
[Abstract]

12 ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis : Results from the PERTINENT study
article 2009    
Author: Ceconi, C. · Fox, K.M. · Remme, W.J. · Simoons, M.L. · Deckers, J.W. · Bertrand, M. · Parrinello, G. · Kluft, C. · Blann, A. · Cokkinos, D. · Ferrari, R.
Keywords: Health · Biomedical Research · ACE inhibition · Coronary artery disease · Inflammation · Perindopril · Thrombosis · biological marker · C reactive protein · D dimer · dipeptidyl carboxypeptidase inhibitor · fibrinogen · perindopril · placebo · tumor necrosis factor alpha · article · atherosclerosis · clinical trial · controlled clinical trial · controlled study · coronary artery disease · drug effect · drug efficacy · drug response · endothelial dysfunction · human · inflammation · major clinical study · prediction · priority journal · prognosis · survival · thrombosis · treatment duration · treatment outcome · treatment response · Angiotensin-Converting Enzyme Inhibitors · Biological Markers · C-Reactive Protein · Cardiovascular Diseases · Coronary Artery Disease · Coronary Thrombosis · Double-Blind Method · Europe · Fibrin Fibrinogen Degradation Products · Fibrinogen · Humans · Inflammation · Inflammation Mediators · Kaplan-Meiers Estimate · Perindopril · Proportional Hazards Models · Risk Assessment · Risk Factors · Time Factors · Treatment Outcome · Tumor Necrosis Factor-alpha
[Abstract]

13 The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man
article 1981    
Author: Wolthuis, O. · Vanwersch, R.A.P. · Wiel, H.J. van der
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · [(3 isobutyryl 1 pyridiniomethyl) (2 hydroxyiminomethyl 1 pyridiniomethyl)] ether · Sarin · Soman · Tubocurarine chloride · Unclassified drug · Animal experiment · Bispyridinium oxime · Diaphragm · Dog · Dose response · Drug comparison · Drug response · Guinea pig · Human cell · In vitro study · Intercostal muscle · Intravenous drug administration · Neuromuscular transmission · Rat · Adult · Aged · Animal · Antidotes · Chorionic Gonadotropin · Comparative Study · Dogs · Electric Stimulation · Female · Guinea Pigs · Human · In Vitro · Male · Middle Age · Neuromuscular Junction · Organophosphorus Compounds · Pralidoxime Compounds · Pyridinium Compounds · Rats · Sarin · Soman · Species Specificity · Synaptic Transmission
[Abstract]

14 PAF-acether-induced release of tissue-type plasminogen activator from vessel walls
article 1985    
Author: Emeis, J.J. · Kluft, C.
Keywords: Biology · 3 amino 1 (3 trifluoromethylphenyl) 2 pyrazoline · 4 bromophenacyl bromide · Acetylsalicylic acid · Diethylcarbamazine · Docebenone · Endetic acid · Indometacin · Mepacrine · Nordihydroguaiaretic acid · Plasminogen activator · Thrombocyte activating factor · Tissue plasminogen activator · Animal experiment · Biological model · Blood and hemopoietic system · Blood clotting · Blood vessel wall · Cardiovascular system · Dose response · Drug accumulation · Drug analysis · Drug blood level · Drug comparison · Drug determination · Drug identification · Drug inhibition · Drug isolation · Drug mechanism · Drug response · Histology · Intravenous drug administration · Nonhuman · Peripheral vascular system · Regional perfusion · Spectrophotometry · Thrombocyte aggregating factor · Animal · Blood Vessels · Calcium · Cyclooxygenase Inhibitors · Fibrinolysis · Lipoxygenase Inhibitors · Male · Phospholipases · Plasminogen Activators · Platelet Activating Factor · Rats · Rats, Inbred Strains · Support, Non-U.S. Gov't
[Abstract]

15 Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes
article 2015    
Author: Liang, W. · Verschuren, L. · Mulder, P. · Hoorn, J.W.A. van der · Verheij, J. · Dam, A.D. van · Boon, M.R. · Princen, H.M.G. · Havekes, L.M. · Kleemann, R. · Hoek, A.M. van den
Keywords: Biology · Alanine aminotransferase · Aspartate aminotransferase · Glucose · High density lipoprotein cholesterol · Insulin · Interleukin 6 · Low density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Salsalate · Triacylglycerol · Alanine aminotransferase blood level · Animal cell · Animal experiment · Animal model · Animal tissue · Aspartate aminotransferase blood level · Body weight · Controlled study · Down regulation · Drug efficacy · Drug response · Dyslipidemia · Energy metabolism · Fatty acid oxidation · Fatty liver · Gene expression · Glucose blood level · Glycemic control · Hepatitis · Insulin blood level · Insulin resistance · Lipid metabolism · Lipogenesis · Male · Mouse · Nonalcoholic fatty liver · Nonhuman · Treatment duration · Treatment outcome · Triacylglycerol blood level · Upregulation · Weight gain · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Nutritional effects of alkali treated soyprotein in rats
article 1974    
Author: Beek, L. van · Feron, V.J. · Groot, A.P. de
Keywords: ketone body · protein · alanine aminotransferase blood level · alkaline phosphatase blood level · aspartate aminotransferase blood level · body weight · dose response · drug response · erythrocyte count · feeding behavior · glucosuria · growth · histology · kidney · kidney calcification · leukocyte count · microscopy · oral drug administration · organ · proteinuria · rat · sex · sex difference · soybean · theoretical study · urine · urine ph · Alanine Transaminase · Alkaline Phosphatase · Animal · Animal Nutrition · Aspartate Aminotransferases · Body Weight · Comparative Study · Dietary Proteins · Female · Hydrogen-Ion Concentration · Kidney · Male · Nephrocalcinosis · Organ Weight · Phosphorus · Rats · Sex Factors · Soybeans · Vegetable Proteins · production · technology · food · Medicine · Geneeskunde · Health · Gezondheid · Dietetics · Voedingsleer
[Abstract]

17 Rescuing drug discovery: In vivo systems pathology and systems pharmacology
article 2005    
Author: Greef, J. van der · McBurney, R.N.
Keywords: Pharmacology Health · Analytical research · 5' methoxyhydnocarpin · berberine · biological marker · ginseng extract · herbaceous agent · Hypericum extract · paroxetine · unclassified drug · article · bioinformatics · cardiovascular disease · clinical trial · cost benefit analysis · cost control · cost effectiveness analysis · data base · depression · drug approval · drug design · drug efficacy · drug indication · drug industry · drug information · drug marketing · drug research · drug response · drug safety · drug screening · drug targeting · growth inhibition · health care · health care cost · health program · human · in vivo study · non insulin dependent diabetes mellitus · nonhuman · patient compliance · prediction · prescription · priority journal · productivity · quantitative analysis · standard · system analysis · validation process · animal · diagnosis · economics · mass communication · review · Animals · Cost-Benefit Analysis · Diagnosis · Diffusion of Innovation · Drug Approval · Drug Design · Drug Evaluation · Drug Evaluation, Preclinical · Drug Industry · Humans
[Abstract]

18 Interferon-β therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis
article 2007    
Author: Zafranskaya, M. · Oschmann, P. · Engel, R. · Weishaupt, A. · Noort, J.M. van · Jomaa, H. · Eberl, M.
Keywords: Health · Biomedical Research · Autoimmunity · CFSE (5- (and 6-) carboxyfluorescein diacetate succinimidyl ester) · Disease progression · Immunotherapy · Myelin antigens · T-cell responses · beta1a interferon · CD45RO antigen · cytokine · interferon beta serine · myelin oligodendrocyte glycoprotein · adult · article · CD4+ T lymphocyte · CD8+ T lymphocyte · cell proliferation · clinical article · controlled study · correlation analysis · drug response · ex vivo study · female · functional status · human · human cell · immunotherapy · in vitro study · male · memory cell · multiple sclerosis · phenotype · prevalence · priority journal · Adult · Antigens, CD45 · CD4-Positive T-Lymphocytes · CD8-Positive T-Lymphocytes · Cell Proliferation · Cells, Cultured · Cytokines · Disease Progression · Flow Cytometry · Humans · Immunologic Memory · Immunophenotyping · Immunosuppressive Agents · Interferon-beta · Lymphocyte Activation · Middle Aged · Multiple Sclerosis, Relapsing-Remitting · Myelin-Associated Glycoprotein · T-Lymphocyte Subsets
[Abstract]

19 Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes
article 1979    
Author: Benschop, H.P. · Berg, G.R. van den · Hooidonk, C. van · Jong, L.P.A. de · Kientz, C.E. · Berends, F. · Kepner, L.A. · Meeter, E. · Visser, R.P.L.S.
Keywords: Biology · Acetylcholinesterase · Antidote · Atropine · Cholinesterase reactivator · Diacetyl oxime · Enzyme · Obidoxime P · Paraoxon · Sarin · Tri ortho cresyl phosphate · 1,2,3 thiadiazole 5 carboxaldoxime · 2 (hydroximinomethyl) 1 methylpyridinium salt · 2 methyl 1,2,3 thiadiazolium salt carboxaldoxime · 3 methyl 1,2,3 thiadiazolium salt 5 carboxaldoxime · Animal experiment · Blood · Blood and hemopoietic system · Dose response · Drug administration · Drug analysis · Drug blood level · Drug comparison · Drug elimination · Drug half life · Drug interaction · Drug intoxication · Drug metabolism · Drug response · Drug screening · Drug synthesis · Drug tolerance · Drug toxicity · Drug urine level · Goat · Guinea pig · High performance liquid chromatography · Hydroximinoacetone · In vitro study · Intoxication · Intraperitoneal drug administration · Intravenous drug administration · Mouse · Nuclear magnetic resonance · Oral drug administration · Organophosphate intoxication · Pharmacokinetics · Prevention · Prophylaxis · Rabbit · Rat · Subcutaneous drug administration · Theoretical study · Therapy · Thiadiazole 5 carboxaldoxime derivative · Ultraviolet spectrophotometry · Urine · Acetylcholinesterase · Animal · Antidotes · Body Temperature · Cattle · Chemistry · Dose-Response Relationship, Drug · Enzyme Reactivators · Female · Goats · Guinea Pigs · Half-Life · In Vitro · Lethal Dose 50 · Male · Mice · Organophosphorus Compounds · Oximes · Rabbits · Rats · Rats, Inbred Strains · Sarin · Solubility · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date