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1 Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates
article 1999    
Author: Beek, E. van · Pieterman, E. · Cohen, L. · Löwik, C. · Papapoulos, S.
Keywords: Animals · Brain · Carbon Radioisotopes · Carbon-Carbon Double Bond Isomerases · Cattle · Dimethylallyltranstransferase · Diphosphonates · Enzyme Inhibitors · Indoles · Mevalonic Acid · Bovinae
[Abstract]

2 Inhibition of matrix metalloproteinases by bisphosphonates may in part explain their effects in the treatment of multiple myeloma [6]
article 2000    
Author: Teronen, O. · Laitinen, M. · Salo, T. · Hanemaaijer, R. · Heikkilä, P. · Konttinen, Y.T. · Sorsa, T.
Keywords: Pharmacology · Antineoplastic Agents · Breast Neoplasms · Diphosphonates · Down-Regulation · Enzyme Inhibitors · Female · Humans · Male · Matrix Metalloproteinases · Multiple Myeloma · Neoplasm Metastasis

3 Lack of interaction between orlistat and oral contraceptives
article 1996    
Author: Hartmann, D. · Güzelhan, C. · Zuiderwijk, P.B.M. · Odink, J.
Keywords: Nutrition · Biology · Contraception · Contraceptive Methods--pharmacodynamics · Contraceptive Mode Of Action · Developed Countries · Double-blind Studies · Drug Interactions · Drugs · Enzyme Inhibitors--pharmacodynamics · Enzymes And Enzyme Inhibitors · Europe · Family Planning · Netherlands · Oral Contraceptives, Combined--pharmacodynamics · Oral Contraceptives--pharmacodynamics · Ovulation Suppression · Physiology · Research Methodology · Research Report · Studies · Treatment · Western Europe · Adult · Analysis of Variance · Contraceptives, Oral, Combined · Drug Interactions · Enzyme Inhibitors · Female · Humans · Lactones · Luteinizing Hormone · Progesterone · Radioimmunoassay
[Abstract]

4 Oral matrix metalloproteinase inhibition and arterial remodeling after balloon dilation: An intravascular ultrasound study in the pig
article 2001    
Author: Sierevogel, M.J. · Pasterkamp, G. · Velema, E. · Jaegere, P.P.T.de · Smet, B.J.G.L.de · Verheijen, J.H. · Kleijn, D.P.V.de · Borst, C.
Keywords: Health · Angioplasty · Metalloproteinases · Remodeling · Stenosis · Ultrasonics · Administration, Oral · Animals · Arteries · Balloon Dilatation · Enzyme Inhibitors · Hydroxamic Acids · Hyperplasia · Matrix Metalloproteinases · Swine · Tunica Intima · Ultrasonography, Interventional
[Abstract]

5 Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7α-hydroxylase in cultured rat hepatocytes and in vivo in the rat
article 1999    
Author: Post, S.M. · Paul Zoeteweij, J. · Bos, M.H.A. · Wit, E.C.M. de · Havinga, R. · Kuipers, F. · Princen, H.M.G.
Keywords: Biology · Acetates · Animals · Anticholesteremic Agents · Bile Acids and Salts · Cells, Cultured · Cholesterol · Cholesterol 7-alpha-Hydroxylase · Cholesterol Esters · Enzyme Induction · Enzyme Inhibitors · Liver · Male · Rats · Rats, Wistar · RNA, Messenger · Sterol O-Acyltransferase · Sulfonic Acids · Triglycerides
[Abstract]

6 Synthesis of a novel fluorescent ceramide analogue and its use in the characterization of recombinant ceramidase from Pseudomonas aeruginosa PA01
article 2002    
Author: Nieuwenhuizen, W.F. · Leeuwen, S. van · Götz, F. · Egmond, M.R.
Keywords: Nutrition · Amidohydrolases · Binding Sites · Ceramides · Enzyme Inhibitors · Fluorescent Dyes · Hydrogen-Ion Concentration · Kinetics · Magnetic Resonance Spectroscopy · Molecular Structure · Phosphatidylcholines · Pseudomonas aeruginosa · Recombinant Proteins · Bacteria (microorganisms) · Mammalia · Pseudomonas · Pseudomonas aeruginosa
[Abstract]

7 Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells: Regulation by tumor necrosis factor-α and doxycycline
article 1997    
Author: Hanemaaijer, R. · Sorsa, T. · Konttinen, Y.T. · Ding, Y. · Sutinen, M. · Visser, H. · Hinsbergh, V.W.M. van · Helaakoski, T. · Kainulainen, T. · Rönkä, H. · Tschesche, H. · Salo, T.
Keywords: Arthritis, Rheumatoid · Catalysis · Cells, Cultured · Collagenases · Doxycycline · Endothelium · Endothelium, Vascular · Enzyme Inhibitors · Fibroblasts · Glycosylation · Humans · Matrix Metalloproteinase 8 · RNA, Messenger · Synovial Membrane · Tetradecanoylphorbol Acetate · Tumor Necrosis Factor-alpha · Up-Regulation
[PDF] [Abstract]

8 Identification of multiple target sites for a glutathione conjugate on glutathione-S-transferase by matrix-assisted laser desorption/ionization mass spectrometry
article 1996    
Author: Jespersen, S. · Ploemen, J.H.T.M. · Bladeren, P.J. · Niessen, W.M.A. · Tjaden, U.R. · Greef, J. van der
Keywords: Nutrition · GSTCBQ target residues · Mapping site-specific mutagenesis · Binding Sites · Chloranil · Enzyme Inhibitors · Glutathione · Glutathione Transferase · Molecular Weight · Mutagenesis, Site-Directed · Peptide Mapping · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
[Abstract]

9 Inhibition of zaleplon metabolism by cimetidine in the human liver : in vitro studies with subcellular fractions and precision-cut liver slices
article 2002    
Author: Renwick, A.B. · Ball, S.E. · Tredger, J.M. · Price, R.J. · Walters, D.G. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition · Aldehyde oxidase · Cimetidine · Cytochrome P450 3A · Reduced nicotinamide adenine dinucleotide phosphate · Zaleplon · Cell fractionation · Drug inhibition · Drug metabolism · Human · Human cell · Human tissue · In vitro study · Liver metabolism · Liver microsome · Liver slice · Acetamides · Cimetidine · Cytosol · Dose-Response Relationship, Drug · Drug Interactions · Enzyme Inhibitors · Humans · Hypnotics and Sedatives · Inhibitory Concentration 50 · Kinetics · Liver · Models, Chemical · Pyrimidines · Subcellular Fractions · Staphylococcus phage 3A
[Abstract]

10 Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro
article 2003    
Author: Nieuw Amerongen, G.P. van · Koolwijk, P. · Versteilen, A. · Hinsbergh, V.W.M. van
Keywords: Amides · Capillaries · Cell Culture Techniques · Cell Movement · Cells, Cultured · Cytoskeleton · Endothelial Growth Factors · Endothelium, Vascular · Enzyme Activation · Enzyme Inhibitors · Fibrin · Humans · Intercellular Signaling Peptides and Proteins · Lymphokines · Male · Neovascularization, Physiologic · Penis · Pyridines · rho GTP-Binding Proteins · rhoA GTP-Binding Protein · Signal Transduction · Umbilical Veins · Vascular Endothelial Growth Factor A · Vascular Endothelial Growth Factors
[Abstract]

11 Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1′-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells
article 2008    
Author: Jeurissen, S.M.F. · Punt, A. · Delatour, T. · Rietjens, I.M.C.M.
Keywords: Alkenylbenzenes · DNA adducts · Estragole · Ocimum basilicum · Sulfotransferases · 1' hydroxyestragole · Animals · Anisoles · Biotransformation · Carcinoma, Hepatocellular · Cell Line, Tumor · Cell Survival · Chromatography, High Pressure Liquid · Deoxyguanosine · DNA Adducts · DNA Repair · Enzyme Inhibitors · Humans · Liver · Liver Neoplasms · Ocimum basilicum · Plant Extracts · Rats · Risk Assessment · Spectrometry, Mass, Electrospray Ionization · Subcellular Fractions · Sulfotransferases · Tetrazolium Salts · Thiazoles · Ocimum · Ocimum basilicum · Rattus
[Abstract]

12 Angiotensin converting enzyme inhibiting therapy is associated with lower vitreous vascular endothelial growth factor concentrations in patients with proliferative diabetic retinopathy
article 2002    
Author: Hogeboom Buggenum, I.M. van · Polak, B.C.P. · Reichert-Thoen, J.W.M. · Vries de - Knoppert, W.A.E.J. · Hinsbergh, V.W.M. van · Tangelder, G.J.
Keywords: Biology · Adult · Age of Onset · Aged · Aged, 80 and over · Angiotensin-Converting Enzyme Inhibitors · Blood Pressure · Diabetes Mellitus, Type 1 · Diabetes Mellitus, Type 2 · Diabetic Retinopathy · Enalapril · Endothelial Growth Factors · Female · Humans · Intraocular Pressure · Lymphokines · Male · Middle Aged · Vascular Endothelial Growth Factor A · Vascular Endothelial Growth Factors · Vitreous Body
[Abstract]

13 Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction.
article 2000    
Author: Nieuw Amerongen, G.P. van · Vermeer, M.A. · Hinsbergh, V.W. van
Keywords: Biology · Amides · Calcium · Cell Membrane Permeability · Cells, Cultured · Cyclic AMP · Cytoskeleton · Dose-Response Relationship, Drug · Endothelium, Vascular · Enzyme Activation · Enzyme Inhibitors · Horseradish Peroxidase · Humans · Intracellular Signaling Peptides and Proteins · Myosin Light Chains · Phosphatidic Acids · Phosphorylation · Protein-Serine-Threonine Kinases · Pyridines · rhoA GTP-Binding Protein · Thrombin · Time Factors · Umbilical Veins
[Abstract]

14 Vastatins have a distinct effect on sterol synthesis and progesterone secretion in human granulosa cells in vitro
article 1996    
Author: Vliet, A.K. van · Thiel, G.C.F. van · Naaktgeboren, N. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitor · Progesterone secretion · Simvastatin · Sterol synthesis · Cholesterol · Low density lipoprotein · Methysticin · Cholesterol synthesis · Controlled study · Human cell · Cells, Cultured · Cholesterol · Culture Media · Enzyme Inhibitors · Female · Follicle Stimulating Hormone · Granulosa Cells · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lovastatin · Luteinizing Hormone · Pravastatin · Progesterone · Simvastatin
[Abstract]

15 Inhibition of glutathione S-transferase activity in human melanoma cells by alfa, beta-unsaturated carbonyl derivatives : effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
article 1996    
Author: Iersel, M.L.P.S. van · Ploemen, J.P.H.T.M. · Struik, I. · Amersfoort, C. van · Keyzer, A.E. · Schefferlie, J.G. · Bladeren, P.J. van
Keywords: Health · Cells · Glutathione S-transferases · Inhibition · Ketones · 2 hexenal · Cinnamaldehyde · Citral · Crotonaldehyde · Controlled study · Enzyme activity · Enzyme inhibition · High performance liquid chromatography · Human · Human cell · Melanoma cell · Acrolein · Aldehydes · Chromatography, High Pressure Liquid · Curcumin · Enzyme Inhibitors · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Melanoma · Monoterpenes · Skin Neoplasms · Terpenes · Tumor Cells, Cultured
[Abstract]

16 Activation of rhoa by thrombin in endothelial hyperpermeability: Role of rho kinase and protein tyrosine kinases
article 2000    
Author: Nieuw Amerongen, G.P. van · Delft, S.V. · Vermeer, M.A. · Collard, J.G. · Hinsbergh, V.W.M. van
Keywords: Amides · Calcium · Cell Membrane Permeability · Cells, Cultured · Cytoskeleton · Endothelium, Vascular · Enzyme Activation · Enzyme Inhibitors · Hemostatics · Humans · Intracellular Signaling Peptides and Proteins · Myosin Light Chains · Phosphorylation · Protein Binding · Protein-Serine-Threonine Kinases · Protein-Tyrosine Kinases · Proto-Oncogene Proteins c-akt · Pyridines · rhoA GTP-Binding Protein · Thrombin · Umbilical Veins
[Abstract]

17 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

18 The role of α-amylase in the perception of oral texture and flavour in custards
article 2004    
Author: Wijk, R.A.de · Prinz, J.F. · Engelen, L. · Weenen, H.
Keywords: Nutrition · Physiological Sciences · α-Amylase · Acarbose · CMC · Creaminess · Enzymatic starch breakdown · Flavour release · Humans · Oral texture sensations · acarbose · amylase · amylase inhibitor · carboxymethylcellulose · starch · article · cream · flavor · food · food quality · human · human experiment · melting point · normal human · perception · priority journal · saliva · sensation · task performance · Vanilla · viscosity · Acarbose · Adolescent · Adult · alpha-Amylase · Dose-Response Relationship, Drug · Enzyme Inhibitors · Female · Food · Humans · Male · Mouth · Saliva · Starch · Taste · Viscosity
[Abstract]

19 Increased resistance to 14α-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14α-demethylase (cyp51) and the A. Niger cytochrome P450 reductase (cprA) genes
article 1996    
Author: Brink, H.J.M. van den · Nistelrooy, H.J.G.M. van · Waard, M.A. de · Hondel, C.A.M.J.J. van den · Gorcom, R.F.M. van
Keywords: Biology · Ergosterol · NADPH cytochrome P450 reductase · Sterol 14α-demethylation inhibitors · Drug products · Fungicides · Genes · Demethylase inhibitors (DMI) · Gene encoding · Genetic engineering · Cytochrome p450 reductase · Reduced nicotinamide adenine dinucleotide phosphate ferrihemoprotein reductase · Enzyme synthesis · Fungal genetics · Nonhuman · Penicillium · Priority journal · Aspergillus niger · Cytochrome P-450 Enzyme System · Drug Resistance, Microbial · Enzyme Inhibitors · Gene Expression Regulation, Fungal · NADH, NADPH Oxidoreductases · NADPH-Ferrihemoprotein Reductase · Oxidoreductases · Penicillium · Recombinant Proteins · Transformation, Genetic · Aspergillus niger · Fungi · Penicillium · Penicillium italicum
[Abstract]

20 Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle
article 1996    
Author: Vliet, A.K. van · Nègre-Arrariou, P. · Thiel, G.C.F. van · Bolhuis, P.A. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitors · Human myoblasts · Sterol synthesis · Adenosine triphosphate · Hydroxymethylglutaryl coenzyme a reductase inhibitor · Mevinolin · Mitochondrial enzyme · Cell culture · Cell proliferation · Cell viability · Concentration response · Controlled study · Dna synthesis · Human cell · Human tissue · Muscle biopsy · Myoblast · Myopathy · Skeletal muscle · Acetic Acid · Adenosine Triphosphate · Anticholesteremic Agents · Cell Division · Cell Survival · Cells, Cultured · DNA · Enzyme Inhibitors · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lovastatin · Mitochondria · Muscle, Skeletal · Oxidoreductases · Pravastatin · Simvastatin · Sterols
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 39 found. Next | Sort by date