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1 Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver
article 1999    
Author: Mensenkamp, A.R. · Jong, M.C. · Goor, H. van · Luyn, M.J.A. van · Bloks, V. · Havinga, R. · Voshol, P.J. · Hofker, M.H. · Dijk, K.W. van · Havekes, L.M. · Kuipers, F.
Keywords: Biology · Animals · Apolipoproteins E · Cells, Cultured · Cholesterol · Crosses, Genetic · Fatty Acids, Nonesterified · Glycerol · Homeostasis · Humans · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Mice, Transgenic · Microscopy, Immunoelectron · Phytosterols · Sitosterols · Sterols · Triglycerides · Tritium
[PDF] [Abstract]

2 Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.
article 2010    
Author: Kleemann, R. · Erk, M. van · Verschuren, L. · Hoek, A.M. van den · Koek, M. · Wielinga, P.Y. · Jie, A. · Pellis, L. · Bobeldijk-Pastorova, I. · Kelder, T. · Toet, K. · Wopereis, S. · Cnubben, N. · Evelo, C. · Ommen, B. van · Kooistra, T.
Keywords: Biology · Biomedical Research · Apolipoprotein E3 · Fatty acid · Blood · DNA microarray · Genetics · Obesity · physiology · transgenic mouse · Western blotting · Adiposity · Animals · Apolipoprotein E3 · Blotting, Western · Fatty Acids, Nonesterified · Glucose Tolerance Test · Insulin Resistance · Male · Mice · Mice, Transgenic · Oligonucleotide Array Sequence Analysis · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

3 Effect of two breakfasts, different in carbohydrate composition, on hunger and satiety and mood in healthy men
article 2003    
Author: Pasman, W.J. · Blokdijk, V.M. · Bertina, F.M. · Hopman, W.P.M. · Hendriks, H.F.J.
Keywords: Nutrition · Physiological Sciences · Breakfast · Carbohydrate · Mood · Obesity · Satiety · carbohydrate · cholecystokinin · fatty acid · glucose · insulin · triacylglycerol · adult · article · carbohydrate analysis · carbohydrate diet · cholecystokinin blood level · clinical article · clinical trial · controlled clinical trial · controlled study · crossover procedure · fatty acid blood level · glucose blood level · human · hunger · insulin blood level · male · meal · mood · priority journal · psychophysiology · randomized controlled trial · satiety · scoring system · triacylglycerol blood level · Adult · Affect · Blood Glucose · Cholecystokinin · Cross-Over Studies · Dietary Carbohydrates · Fatty Acids, Nonesterified · Humans · Hunger · Insulin · Male · Middle Aged · Satiation
[Abstract]

4 Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
article 2003    
Author: Voshol, P.J. · Haemmerle, G. · Ouwens, D.M. · Zimmermann, R. · Zechner, R. · Teusink, B. · Maassen, J.A. · Havekes, L.M. · Romijn, J.A.
Keywords: Health · Glucose · Hormone sensitive lipase · Insulin receptor · Protein kinase B · Triacylglycerol · Triacylglycerol lipase · Unclassified drug · Animal tissue · Controlled study · Enzyme activity · Enzyme deficiency · Enzyme mechanism · Enzyme phosphorylation · Fatty acid blood level · Gluconeogenesis · Glucose transport · Hormone sensitivity · Hyperinsulinemia · Insulin sensitivity · Knockout mouse · Lipid liver level · Lipolysis · Mouse · Nonhuman · Western blotting · Adiponectin · Animals · Blood Glucose · Cholesterol · Cholesterol Esterase · Fasting · Fatty Acids, Nonesterified · Glucose · Insulin · Intercellular Signaling Peptides and Proteins · Liver · Male · Mice · Mice, Knockout · Muscle, Skeletal · Proteins · Receptor, Insulin · Triglycerides
[Abstract]

5 Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production
article 2006    
Author: Boer, M.A.M. den · Voshol, P.J. · Kuipers, F. · Romijn, J.A. · Havekes, L.M.
Keywords: Biology · Biomedical Research · Euglycemic hyperinsulinemic clamp · Fatty acid · Very-low-density lipoprotein · Insulin · Adipose tissue · Animal experiment · Aanimal model · Controlled study · Drug effect · Drug inhibition · Fatty acid blood level · Gluconeogenesis · Glucose infusion · Glucose transport · Hyperinsulinemia · Insulin blood level · Insulin resistance · Insulin sensitivity · Lipolysis · Liver function · Mouse · Nonhuman · Animals · Blood Glucose · Dose-Response Relationship, Drug · Fatty Acids, Nonesterified · Glucose · Glucose Clamp Technique · Hypoglycemic Agents · Insulin · Kinetics · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Inbred C57BL · Triglycerides
[Abstract]

6 Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification
article 2007    
Author: Westerterp, M. · Berbée, J.F.P. · Delsing, D.J.M. · Jong, M.C. · Gijbels, M.J.J. · Dahlmans, V.E.H. · Offerman, E.H. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Lipoprotein · Lipoprotein lipase · Skin · Triglyceride · very low density lipoprotein · animal cell · animal experiment · animal tissue · controlled study · electricity · esterification · female · in vitro study · mouse · nonhuman · phenotype · skin transplantation · wild type · Animals · Apolipoprotein C-I · Cells, Cultured · Enzyme-Linked Immunosorbent Assay · Esterification · Fatty Acids, Nonesterified · Female · Humans · Lipoproteins, VLDL · Macrophages · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Oleic Acid · Phenotype · Protein Binding · Skin · Skin Abnormalities · Skin Transplantation
[PDF] [Abstract]

7 A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice
article 2002    
Author: Muurling, M. · Jong, M.C. · Mensink, R.P. · Hornstra, G. · Dahlmans, V.E.H. · Pijl, H. · Voshol, P.J. · Havekes, L.M.
Keywords: Biology Health · fat · fatty acid · glucose · high density lipoprotein · insulin · intermediate density lipoprotein · low density lipoprotein · triacylglycerol · very low density lipoprotein · animal experiment · animal model · article · body weight · caloric intake · controlled study · energy metabolism · feeding · glucose tolerance · insulin blood level · insulin dependent diabetes mellitus · insulin resistance · insulin sensitivity · lipid diet · lipid metabolism · low fat diet · male · mouse · non insulin dependent diabetes mellitus · nonhuman · obesity · priority journal · Animals · Blood Glucose · Body Weight · Cholesterol · Dietary Fats · Energy Intake · Fatty Acids, Nonesterified · Glucose Tolerance Test · Insulin · Insulin Resistance · Lipids · Lipoproteins · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Inbred C57BL · Polyethylene Glycols · Triglycerides
[Abstract]

8 Leptin deficiency per se dictates body composition and insulin action in ob/ob mice
article 2008    
Author: Hoek, A.M. van den · Teusink, B. · Voshol, P.J. · Havekes, L.M. · Romijn, J.A. · Pijl, H.
Keywords: Biology · Adiposity hormone · Brain · Insulin resistance · Metabolism · Type 2 diabetes mellitus · glucose · insulin · leptin · animal experiment · animal tissue · article · body composition · body weight · caloric restriction · controlled study · diet restriction · female · gluconeogenesis · glucose clamp technique · glucose metabolism · hormone deficiency · insulin resistance · insulin sensitivity · lean body weight · leptin deficiency · male · mouse · mouse strain · nonhuman · obesity · pathophysiology · priority journal · quantitative analysis · signal transduction · wild type · Animals · Blood Glucose · Body Composition · Body Weight · Fatty Acids, Nonesterified · Female · Food Deprivation · Glucose · Glucose Clamp Technique · Growth and Development · Insulin · Leptin · Male · Mice · Mice, Inbred C57BL · Mice, Obese · Mice, Transgenic · Obesity
[Abstract]

9 Acute inhibition of hepatic β-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity
article 2005    
Author: Duivenvoorden, I. · Teusink, B. · Rensen, P.C.N. · Kuipers, F. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acids · Glucose metabolism · Steatosis · Triglycerides · Very low density lipoprotein · 3 hydroxybutyrate dehydrogenase · carnitine palmitoyltransferase inhibitor · cholesterol · insulin · palmoxiric acid · triacylglycerol · very low density lipoprotein · apolipoprotein E · apolipoprotein E3 · apolipoprotein E3 (Leidein) · fatty acid · messenger RNA · analytic method · animal cell · animal experiment · article · cholesterol blood level · comparative study · controlled study · fatty acid oxidation · gluconeogenesis · insulin blood level · insulin sensitivity · ketogenesis · mouse · nonhuman · transgenic mouse · animal · blood · genetics · insulin resistance · metabolism · oxidation reduction reaction · physiology · secretion · Animals · Apolipoprotein E3 · Apolipoproteins E · Fatty Acids, Nonesterified · Insulin Resistance · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Transgenic · Oxidation-Reduction · RNA, Messenger
[PDF] [Abstract]

10 The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis
article 2004    
Author: Goudriaan, J.R. · Espirito Santo, S.M.S. · Voshol, P.J. · Teusink, B. · Dijk, K.W. van · Vlijmen, B.J.M. van · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Adipose tissue · Free fatty acids · Lipoprotein lipase · Postprandial lipid metabolism · Transgenic mice · Very low density lipoprotein-like emulsion · Albumin · Carbon 14 · Chylomicron · Fatty acid · Lipoprotein lipase · Triacylglycerol · Very low density lipoprotein · Very low density lipoprotein receptor · Animal experiment · Animal tissue · Bolus injection · Continuous infusion · Controlled study · Diet restriction · Emulsion · Enzyme activity · Fatty acid transport · Female · Half life time · Lipid blood level · Lipid hydrolysis · Lipid metabolism · Lipolysis · Mouse · Nonhuman · Plasma clearance · Postprandial state · Protein expression · Transgenic mouse · Adipose Tissue · Albumins · Animals · Chylomicrons · Fatty Acids, Nonesterified · Mice · Receptors, LDL · Triglycerides
[PDF] [Abstract]

11 CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance
article 2005    
Author: Goudriaan, J.R. · oer, M.A.M. den · Rensen, P.C.N. · Febbraio, M. · Kuipers, F. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acid transport · Free fatty acids · Postprandial lipid metabolism · Transgenic mice · Triglyceride hydrolysis · CD36 antigen · Glycerol · Heparin · Triacylglycerol · Very low density lipoprotein · Animal experiment · Animal tissue · Body fat · CD36 deficiency · Controlled study · Enzyme inhibition · Enzyme metabolism · Half life time · In vitro study · Isotope labeling · Lipid metabolism · Mouse · Nonhuman · Protein deficiency · Protein function · Protein hydrolysis · Transgenic mouse · Tiacylglycerol blood level · Wild type · Animals · Antigens, CD36 · Eating · Fatty Acids, Nonesterified · Female · Intestinal Absorption · Lipoprotein Lipase · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Inbred C57BL · Triglycerides
[PDF] [Abstract]

12 Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM
article 1997    
Author: Brussaard, H.E. · Gevers Leuven, J.A. · Frölich, M. · Kluft, C. · Krans, H.M.J.
Keywords: Biology · Coagulation factors · Glucose regulation · Hepatic glucose production · Insulin sensitivity · Lipoprotein profiles · Non-insulin-dependent diabetes mellitus · Oestrogen therapy · Apolipoprotein a1 · Apolipoprotein b · Blood clotting factor · Glycosylated hemoglobin · High density lipoprotein cholesterol · Insulin · Low density lipoprotein cholesterol · Plasminogen activator · Adult · Aged · Cardiovascular disease · Cardiovascular risk · Clinical article · Estrogen therapy · Glucogenesis · Non insulin dependent diabetes mellitus · Postmenopause · C-Peptide · Cholesterol · Diabetes Mellitus, Type 2 · Double-Blind Method · Estradiol · Estrogen Replacement Therapy · Fatty Acids, Nonesterified · Female · Fibrinolysis · Hemoglobin A, Glycosylated · Humans · Insulin Resistance · Lipids · Lipoproteins · Middle Aged · Plasminogen Activator Inhibitor 1 · Postmenopause · Tissue Plasminogen Activator · Triglycerides
[Abstract]

13 Hyperlipidaemia is associated with increased insulin-mediated glucose metabolism, reduced fatty acid metabolism and normal blood pressure in transgenic mice overexpressing human apolipoprotein C1
article 2001    
Author: Koopmans, S.J. · Jong, M.C. · Que, I. · Dahlmans, V.E.H. · Pijl, H. · Radder, J.K. · Frölich, M. · Havekes, L.M.
Keywords: Biology · APOC1 · Hypertension · Insulin resistance · Insulin resistance syndrome · Lipoprotein · NEFA · Fatty acid · Palmitic acid · Triacylglycerol · Tritium · Very low density lipoprotein · Adipose tissue · Animal model · Animal tissue · Blood pressure · Cholesterol blood level · Clearance · Controlled study · Fatty acid metabolism · Gene overexpression · Glucose blood level · Glucose clamp technique · Glucose metabolism · Glycogen synthesis · Glycolysis · Heart rate · Hyperinsulinemia · Hyperlipidemia · Hypertension · In vivo study · Infusion · Insulin resistance · Lipid transport · Lipogenesis · Mean arterial pressure · Mouse · Nonhuman · Skeletal muscle · Transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins C · Blood Glucose · Blood Pressure · Cholesterol · Fatty Acids, Nonesterified · Gene Expression · Glucose · Glucose Clamp Technique · Glycogen · Humans · Hyperlipidemias · Insulin · Lipid Metabolism · Liver · Mice · Mice, Transgenic · Muscle, Skeletal · Palmitic Acid · Triglycerides · Tritium
[Abstract]

14 Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids
article 2009    
Author: Kersten, S. · Lichtenstein, L. · Steenbergen, E. · Mudde, K. · Hendriks, H.F.J. · Hesselink, M.K. · Schrauwen, P. · Müller, M.
Keywords: Nutrition · Biomedical Research · ANGPTL4 · Caloric restriction · Free fatty acids · angiopoietin · angiopoietin like protein 4 · beta adrenergic receptor stimulating agent · fatty acid · unclassified drug · ANGPTL4 protein, human · Angptl4 protein, mouse · antilipemic agent · Fiaf protein, rat · lipid emulsion · messenger RNA · salbutamol · adult · animal cell · article · blood sampling · caloric restriction · cell strain HepG2 · controlled study · enzyme linked immunosorbent assay · exercise · fatty acid blood level · female · gene expression · genetic variability · hepatoma cell · human · human cell · human experiment · intestine cell · male · mouse · muscle cell · nonhuman · normal human · priority journal · protein blood level · rat · animal · blood · cell culture · clinical trial · controlled clinical trial · genetic transfection · genetics · heart muscle cell · intestine · liver tumor · metabolism · middle aged · randomized controlled trial · time · upregulation · Adrenergic beta-Agonists · Adult · Albuterol · Angiopoietins · Animals · Antilipemic Agents · Caloric Restriction · Cells, Cultured · Enzyme-Linked Immunosorbent Assay · Exercise · Fat Emulsions, Intravenous · Fatty Acids, Nonesterified · Humans · Intestines · Liver Neoplasms · Male · Mice · Middle Aged · Myocytes, Cardiac · Rats · RNA, Messenger · Time Factors · Transfection · Up-Regulation · Young Adult
[Abstract]

15 Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice
article 2006    
Author: Duivenvoorden, I. · Voshol, P.J. · Rensen, P.C.N. · Duyvenvoorde, W. van · Romijn, J.A. · Emeis, J.J. · Havekes, L.M. · Nieuwenhuizen, W.F.
Keywords: Health Biology · Food technology · APOE*3Leiden mice · Cholesterol · Free fatty acids · Sphingolipids · Steatosis · Triacylglycerol · alanine aminotransferase · amyloid · apolipoprotein E3 · cholesterol · cholesterol ester · fatty acid · messenger RNA · phytosphingosine · RNA · sphingolipid · triacylglycerol · apolipoprotein E · apolipoprotein E3 (Leidein) · very low density lipoprotein · animal experiment · animal model · animal tissue · article · cholesterol blood level · cholesterol metabolism · controlled study · diet supplementation · dose response · drug effect · drug structure · fatty liver · female · gene expression · hepatitis · lipogenesis · lipolysis · mouse · nonhuman · nutritional assessment · plasma clearance · prophylaxis · animal · blood · chemistry · cholesterol intake · enzymology · feces · genetics · intestine absorption · lipid metabolism · liver · metabolism · physiology · randomization · transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Cholesterol, Dietary · Dose-Response Relationship, Drug · Fatty Acids, Nonesterified · Fatty Liver · Feces · Female · Gene Expression · Intestinal Absorption · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Random Allocation · RNA · Sphingolipids · Triglycerides
[Abstract]

16 Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
article 2005    
Author: Heijboer, A.C. · Hoek, A.M. van den · Pijl, H. · Voshol, P.J. · Havekes, L.M. · Romijn, J.A. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Brain · Diabetes · Glut4 · Insulin resistance · Metabolism · Neuropeptides · Glucose transporter 4 · Hormone receptor stimulating agent · Insulin · Melanocortin 3 receptor · Melanocortin 4 receptor · Melanotan II · Messenger RNA · Placebo · Tritium · Unclassified drug · Water · Animal experiment · Animal tissue · Body weight · Brain lateral ventricle · Controlled study · Distillation · Drug effect · Food intake · Gluconeogenesis · Glucose blood level · Glucose clamp technique · Glucose metabolism · Hyperinsulinemia · Insulin sensitivity · Isotope labeling · Mouse · Mouse strain · Nonhuman · Skeletal muscle · Alpha-MSH · Animals · Blood Glucose · Corticosterone · Fatty Acids, Nonesterified · Glucose · Glucose Clamp Technique · Glucose Transporter Type 4 · Injections, Intraventricular · Insulin · Insulin Resistance · Kinetics · Liver · Male · Mice · Mice, Inbred C57BL · Monosaccharide Transport Proteins · Muscle Proteins · Peptides, Cyclic · Receptor, Melanocortin, Type 3 · Receptor, Melanocortin, Type 4 · RNA, Messenger
[Abstract]

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Showing 1 to 16 of 16 found. | Sort by date