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Showing 1 to 14 of 14 found. | Sort by date

1 Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
article 1998    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Zee, A. van der · Hof, B. van 't · Boom, H. van der · Kobayashi, K. · Chan, L. · Havekes, L.M. · Hofker, M.H.
Keywords: Health · ApoE variants · Atherosclerosis · Gene therapy · VLDL receptor · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Female · Gene Transfer Techniques · Humans · Hypercholesterolemia · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Triglycerides
[Abstract]

2 A novel strategy for the isolation of defined pyrG mutants and the development of a site-specific integration system for Aspergillus awamori
article 1995    
Author: Gouka, R.J. · Hessing, J.G.M. · Stam, H. · Musters, W. · Hondel, C.A.M.J.J. van den
Keywords: Biology · Amino Acid Sequence · Aspergillus · Base Sequence · DNA, Fungal · Gene Transfer Techniques · Genes, Fungal · Genetic Vectors · Molecular Sequence Data · Mutagenesis, Site-Directed · Restriction Mapping · Transformation, Genetic · Aspergillus awamori · Aspergillus niger · Fungi
[Abstract]

3 An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins
article 1999    
Author: Vlijmen, B.J.M. van · Rohlmann, A. · Page, S.T. · Bensadoun, A. · Bos, I.S.T. · Berkel, T.J.C. van · Havekes, L.M. · Herz, J.
Keywords: Animals · Binding Sites · Cholesterol · Chylomicrons · Detergents · Gene Transfer Techniques · Heymann Nephritis Antigenic Complex · Immunoblotting · LDL-Receptor Related Protein 1 · Lipase · Lipoprotein Lipase · Liver · Membrane Glycoproteins · Mice · Mice, Transgenic · Polyethylene Glycols · Rats · Receptors, Immunologic · Receptors, LDL · Time Factors · Transfection · Triglycerides
[PDF] [Abstract]

4 Apolipoprotein E2 (Lys146→Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides
article 2000    
Author: Beer, F. de · Dijk, K.W. van · Jong, M.C. · Vark, L.C. van · Zee, A. van der · Hofker, M.H. · Fallaux, F.J. · Hoeben, R.C. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Adenoviridae · Alleles · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Gene Expression · Gene Transfer Techniques · Humans · Hydrolysis · Hyperlipoproteinemia Type III · Hypertriglyceridemia · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · Point Mutation · RNA, Messenger · Triglycerides
[Abstract]

5 Adenovirus-mediated transfer of the 39 kD receptor-associated protein increases fibrinolytic capacity
article 2001    
Author: Goedde, M.F. · Grimbergen, J.M. · Toet, K.H. · Sitter, T. · Quax, P.H. · Kooistra, T.
Keywords: Adenoviridae · Carrier Proteins · Cells, Cultured · Culture Media, Conditioned · Down-Regulation · Drug Stability · Epithelial Cells · Fibrinolysis · Gene Transfer Techniques · Genetic Vectors · Glycoproteins · Humans · Immunoblotting · LDL-Receptor Related Protein-Associated Protein · Peritoneum · Peritonitis · Time Factors · Tissue Extracts · Tissue Plasminogen Activator
[Abstract]

6 Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo
article 2008    
Author: Haan, W. de · Out, R. · Berbée, J.F.P. · Hoogt, C.C. van der · Dijk, K.W.v. · Berkel, T.J.C. van · Romijn, J.A. · Wouter Jukema, J. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Physiological Sciences · High density lipoprotein · Oxidized LDL · SR-BI · Transgenic mice · cholesterol ester · high density lipoprotein cholesterol · scavenger receptor BI · Adenovirus · animal cell · cholesterol metabolism · dose response · in vivo study · liver cell · mouse · nonhuman · particle size · protein expression · Adenoviridae · Animals · Apolipoprotein C-I · Cholesterol, HDL · Gene Transfer Techniques · Hepatocytes · Humans · Mice · Mice, Knockout · Scavenger Receptors, Class B · Adenoviridae · Murinae · Mus · Mus musculus
[Abstract]

7 In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI
article 2001    
Author: Lamfers, M.L.M. · Lardenoye, J.H.P. · Vries, M.R. de · Aalders, M.C. · Engelse, M.A. · Grimbergen, J.M. · Hinsbergh, V.W.M. van · Quax, P.H.A.
Keywords: Adenoviridae · Angioplasty, Balloon · Animals · Aprotinin · Carotid Arteries · Carotid Stenosis · Cell Culture Techniques · Gene Expression · Gene Therapy · Gene Transfer Techniques · Genetic Vectors · Humans · Male · Peptide Fragments · Plasmin · Rats · Rats, Sprague-Dawley · Recurrence · RNA, Messenger · Tunica Intima · Tunica Media · Urinary Plasminogen Activator · Adenoviridae · Animalia · Bovinae
[Abstract]

8 Gene transfer of the urokinase-type plasminogen activator receptor-targeted matrix metalloproteinase inhibitor TIMP-1.ATF suppresses neointima formation more efficiently than tissue inhibitor of metalloproteinase-1
article 2002    
Author: Lamfers, M.L.M. · Grimbergen, J.M. · Aalders, M.C. · Havenga, M.J. · Vries, M.R. de · Huisman, L.G.M. · Hinsbergh, V.W.M. van · Quax, P.H.A.
Keywords: Biology · Adenovirus · Matrix metalloproteinases · Neointima formation · Plasmin(ogen) · Urokinase-type plasminogen activator · Adenovirus · Adenoviridae · Animals · Cell Division · Cell Membrane · Cell Movement · Cells, Cultured · CHO Cells · Collagenases · Cricetinae · Culture Media, Conditioned · Enzyme Activation · Flow Cytometry · Gene Transfer Techniques · Humans · Matrix Metalloproteinase 13 · Muscle, Smooth, Vascular · Protein Structure, Tertiary · Receptors, Cell Surface · Recombinant Fusion Proteins · RNA, Messenger · Saphenous Vein · Tissue Inhibitor of Metalloproteinase-1 · Tunica Intima · Urinary Plasminogen Activator
[Abstract]

9 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma
article 2005    
Author: Lamfers, M.L.M. · Gianni, D. · Tung, C.H. · Idema, S. · Schagen, F.H.E. · Carette, J.E. · Quax, P.H.A. · Beusechem, V.W. van · Top, W.P. van der · Dirven, C.M.F. · Chiocca, E.A. · Gerritsen, W.R.
Keywords: Biomedical Research · oncolytic adenovirus · oncolytic virus · tissue inhibitor of metalloproteinase 3 · Adenovirus · animal experiment · animal model · animal tissue · antineoplastic activity · article · cancer cell culture · cancer model · cancer survival · cell proliferation · cell strain HEK293 · controlled study · culture medium · drug efficacy · enzyme activity · enzyme inhibition · female · gene deletion · gene expression · gene insertion · gene transfer · glioblastoma · glioma cell · human · human cell · mouse · nonhuman · priority journal · protein expression · survival time · transgene · tumor xenograft · Adenoviridae · Animals · Cell Growth Processes · Cell Line, Tumor · Gene Transfer Techniques · Glioma · Humans · Matrix Metalloproteinase 2 · Mice · Mice, Nude · Tissue Inhibitor of Metalloproteinase-3 · Virus Replication · Xenograft Model Antitumor Assays
[Abstract]

10 The relevance of gene transfer to the safety of food and feed derived from genetically modified (GM) plants
article 2004    
Author: Eede, G. van den · Aarts, H. · Buhk, H.J. · Corthier, G. · Flint, H.J. · Hammes, W. · Jacobsen, B. · Midtvedt, T. · Vossen, J. van der · Wright, A. von · Wackernagel, W. · Wilcks, A.
Keywords: Biology · Biotechnology · Aantibiotic resistance · Agrobacterium tumefaciens · Biosafety · Conjugation · DNA degradation · DNA integration · Gene transfer · GMO · Horizontal gene transfer · Marker gene removal · Marker genes · Marker rescue · risk assessment · safety assessment · Transformation · plasmid vector · conference paper · DNA modification · electroporation · food analysis · food safety · gene delivery system · gene expression · gene function · gene transfer · genetically modified food · human · marker gene · medical information · nonhuman · promoter region · public health · risk assessment · tissue specificity · Animal Feed · Animals · Consumer Product Safety · European Union · Food Analysis · Food Supply · Gene Transfer Techniques · Gene Transfer, Horizontal · Genetic Engineering · Humans · International Cooperation · Plants, Genetically Modified · Risk Assessment · Agrobacterium · Agrobacterium tumefaciens
[Abstract]

11 ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglycerides (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis
article 2004    
Author: Schaap, F.G. · Rensen, P.C.N. · Voshol, P.J. · Vrins, C. · Vliet, H.N. van der · Chamuleau, R.A.F.M. · Havekes, L.M. · Groen, A.K. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · Data reduction · Enzymes · Gene transfer · Metabolism · Reaction kinetics · Lipolytic conversion · Lipoproteins · Biochemistry · Apolipoprotein A · Apolipoprotein a5 · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Animal experiment · APO5 gene · Gene · Gene transfer · Hydrolysis · Hyperlipidemia · Hypertriglyceridemia · Lipid blood level · Lipid metabolism · Lipoprotein blood level · Mouse · Nonhuman · Triacylglycerol blood level · Adenoviridae · Adipose Tissue · Animals · Apolipoproteins · Dose-Response Relationship, Drug · Gene Transfer Techniques · Hydrolysis · Kinetics · Lipids · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Inbred C57BL · Muscle, Skeletal · Postprandial Period · Rats · Recombinant Proteins · Time Factors · Triglycerides · Animalia · Murinae
[PDF] [Abstract]

12 TR3 orphan receptor is expressed in vascular endothelial cells and mediates cell cycle arrest
article 2003    
Author: Arkenbout, E.K. · Bragt, M. van · Eldering, E. · Bree, C. van · Grimbergen, J.M. · Quax, P.H.A. · Pannekoek, H. · Vries, C.J.M. de
Keywords: Biology · Biomedical Research · Endothelial cells · TR3 orphan receptor · Vascular biology · Cell nucleus receptor · Cyclin A · Messenger RNA · Mitogen induced nuclear orphan receptor · Nerve growth factor receptor · Nuclear orphan receptor of t cells · Protein · Protein subunit · Receptor subtype · Thymidine · Unclassified drug · Adenovirus · Atherosclerosis · Blood vessel · Controlled study · Down regulation · Endothelium cell · Gene expression · Gene overexpression · Human cell · Medical assessment · Nonhuman · Nucleotide sequence · Protein expression · Smooth muscle fiber · Upregulation · Virus culture · Adenoviridae · Cell Cycle · Cell Division · Cells, Cultured · DNA, Complementary · Endothelium, Vascular · Gene Expression Regulation · Gene Transfer Techniques · Humans · Peptides · Protein Structure, Tertiary · Receptors, Steroid · Receptors, Thyroid Hormone · Sequence Deletion · Stem Cells · Trans-Activation (Genetics) · Umbilical Veins · Variation (Genetics) · Virus Replication
[Abstract]

13 Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: Efficient human cell infection and bypass of preexisting adenovirus immunity
article 2003    
Author: Vogels, R. · Zuijdgeest, D. · Rijnsoever, R. van · Hartkoorn, E. · Damen, I. · Béthune, M.-P. de · Kostense, S. · Penders, G. · Helmus, N. · Koudstaal, W. · Cecchini, M. · Wetterwald, A. · Sprangers, M. · Lemckert, A. · Ophorst, O. · Koel, B. · Meerendonk, M. van · Quax, P. · Panitti, L. · Grimbergen, J. · Bout, A. · Goudsmit, J. · Havenga, M.
Keywords: Biology · Biomedical Research · Adenovirus vector · Animal cell · Controlled study · Dendritic cell · Gene insertion · Gene sequence · Gene therapy · Gene transfer · Genetic complementation · Genetic transduction · Human · Human adenovirus · Human adenovirus 35 · Human adenovirus 5 · Human cell · Immune response · Mouse · Nonhuman · Plasmid · Prevalence · Smooth muscle fiber · Synoviocyte · Vaccination · Virus immunity · Virus replication · Adenovirus E1B Proteins · Adenoviruses, Human · Animals · Antibodies, Viral · Cell Line · Cells, Cultured · Dendritic Cells · Gene Transfer Techniques · Genetic Vectors · Humans · Mice · Mice, Inbred BALB C · Muscle, Smooth · Neutralization Tests · Plasmids · Synovial Membrane · Vaccination · Virus Assembly · Virus Replication
[Abstract]

14 ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency
article 2008    
Author: Gerritsen, G. · Hoogt, C.C. van der · Schaap, F.G. · Voshol, P.J. · Kypreos, K.E. · Maeda, N. · Groen, A.K. · Havekes, L.M. · Rensen, P.C.N. · Dijk, K.W. van
Keywords: Health · Physiological Sciences · Adenovirus-mediated gene transfer · APOE2-knockin mice · Apolipoprotein A-V · Apolipoprotein C-III · Apolipoprotein E2 · Lipoprotein lipase-mediated very low density lipoprotein-triglyceride hydrolysis · apolipoprotein A · apolipoprotein A5 · apolipoprotein B · apolipoprotein C · apolipoprotein C3 · apolipoprotein D · apolipoprotein E · apolipoprotein M · beta2 glycoprotein 1 · clusterin · heparin · Apoa5 protein, mouse · apolipoprotein · Adenovirus · animal experiment · animal model · cholesterol blood level · conference paper · controlled study · disease association · female · gene overexpression · hypertriglyceridemia · in vivo study · lipoprotein deficiency · mouse · nonhuman · stimulation · triacylglycerol blood level · animal · blood · gene transfer · genetics · mouse mutant · physiology · Adenoviridae · Animals · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins · Gene Transfer Techniques · Hypertriglyceridemia · Lipids · Lipoprotein Lipase · Male · Mice · Mice, Knockout
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date