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1 The interplay of glutathione-related processes in antioxidant defense
article 2001    
Author: Cnubben, N.H.P. · Rietjens, I.M.C.M. · Wortelboer, H. · Zanden, J.J. van · Bladeren, P.J. van
Keywords: Environment · Antioxidant · Glutathione · Glutathione S-transferases · Multidrug resistance associated protein · Oxidative stress
[Abstract]

2 Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione
article 1994    
Author: Dirven, H.A.A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Biology · Biotransformation · Cyclophosphamide · Glutathione · Glutathione Transferase · Human · Isoenzymes · Phosphoramide Mustards · Support, Non-U.S. Gov't
[Abstract]

3 Glutathione conjugation as a bioactivation reaction
article 2000    
Author: Bladeren, P.J. van
Keywords: Nutrition · Bioactivation · Glutathione conjugates · Glutathione S-transferases · Cysteine · Glutathione · Glutathione transferase · Lyase · Catalysis · Chemical binding · Chemical reaction · Chromosomal localization · Conjugation · Covalent bond · Detoxification · Enzyme activation · Enzyme activity · Enzyme induction · Enzyme inhibition · Enzyme mechanism · Gene location · Genetic polymorphism · Human · Nonhuman · Protein expression · Reaction analysis · Reduction · Animals · Biotransformation · Carbon-Sulfur Lyases · Enzyme Induction · Glutathione · Glutathione Transferase · Humans · Metabolic Detoxication, Drug · Oxidation-Reduction · Xenobiotics
[Abstract]

4 GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid
article 1998    
Author: Iersel, M.L.P.S. van · Lipzig, M.M.H. van · Rietjens, I.M.C.M. · Vervoort, J. · Bladeren, P.J. van
Keywords: EA, ethacrynic acid · Ethacrynic acid · Glutathione S-transferase · Stereoselectivity · Etacrynic acid · Glutathione · Glutathione transferase · Multidrug resistance protein · Chemical reaction · Conjugate · Controlled study · Diastereoisomer · Drug conjugation · Enzyme mechanism · Glutathione metabolism · Human cell · Melanoma cell · Nuclear magnetic resonance spectroscopy · Stereochemistry · Amino Acid Substitution · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Point Mutation · Stereoisomerism · Substrate Specificity · Tumor Cells, Cultured
[PDF] [Abstract]

5 Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system
article 1999    
Author: Iersel, M.L.P.S. van · Cnubben, N.H.P. · Smink, N. · Koeman, J.H. · Bladeren, P.J. van
Keywords: Nutrition · Cells · Glutathione S-transferases · Inhibition · Metabolism · Prostaglandin A2 · 1 chloro 2,4 dinitrobenzene · Glutathione · Glutathione transferase · Prostaglandin a2 · Glutathione transferase P1 · GSTP1 protein, human · Isoenzyme · Prostaglandin A · Prostaglandin A2 · Biotransformation · Cell function · Cell metabolism · Cell proliferation · Controlled study · Cytotoxicity · Enzyme activity · Enzyme modification · Human · Human cell · Melanoma cell · Priority journal · Cell culture · Drug antagonism · Melanoma · Metabolism · Biotransformation · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Prostaglandins A · Tumor Cells, Cultured
[Abstract]

6 Conjugation of isoprene monoepoxides with glutathione, catalyzed by α, μ, π and θ-class glutathione S-transferases of rat and man
article 1999    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Salmon, F.G.C. · Bladeren, P.J. van
Keywords: Nutrition · Glutathione S-transferase · Isoprene · Metabolism · Polymorphism · Cytochrome p450 · Epoxide · Epoxide hydrolase · Glutathione · Glutathione transferase · Isoprene · Conjugate · Conjugation · Controlled study · High performance liquid chromatography · Human · Liver · Liver metabolism · Mouse · Rat · Xenobiotic metabolism · Animals · Chromatography, High Pressure Liquid · Epoxy Compounds · Glutathione · Glutathione Transferase · Humans · Liver · Mice · Rats · Rats, Wistar · Species Specificity · Subcellular Fractions
[Abstract]

7 Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes
article 1996    
Author: Aar, E.M. van der · Buikema, D. · Commandeur, J.N.M. · Koppele, J.M. te · Ommen, B. van · Bladeren, P.J. van · Vermeulen, N.P.E.
Keywords: Nutrition · glutathione transferase · isoenzyme · nitrobenzene derivative · animal tissue · article · controlled study · enzyme kinetics · enzyme specificity · glutathione metabolism · nonhuman · rat · Animals · Chromatography, Affinity · Dinitrochlorobenzene · Glutathione Transferase · Isoenzymes · Kidney · Kinetics · Liver · Rats · Spectrophotometry, Ultraviolet · Substrate Specificity · Animalia · Felis catus
[Abstract]

8 Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans
article 1995    
Author: Nijhoff, W.A. · Grubben, M.J.A.L. · Nagengast, F.M. · Jansen, J.B.M.J. · Verhagen, H. · Poppel, G. van · Peters, W.H.M.
Keywords: Biology · Adult · Brassica · Cross-Over Studies · Duodenum · Energy Intake · Enzyme Induction · Female · Glucosinolates · Glutathione · Glutathione Transferase · Human · Intestines · Isoenzymes · Lymphocytes · Male · Metabolic Detoxication, Drug · Rectum · Thiocyanates
[Abstract]

9 Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin
article 2003    
Author: Zanden, J.J. van · Hamman, O.B. · Iersel, M.L.P.S. van · Boeren, S. · Cnubben, N.H.P. · Lo Bello, M. · Vervoort, J. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · Cysteine · Glutathione S-transferase · Inhibition · Quercetin · Quinone · ascorbic acid · cysteine · flavonoid · glutathione · glutathione transferase · isoenzyme · mutant protein · quercetin · article · chemical interaction · concentration response · covalent bond · dimerization · enzyme inhibition · human · incubation time · inhibition kinetics · time · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Glutathione Transferase · Humans · Mass Spectrometry · Molecular Structure · Monophenol Monooxygenase · Mutation · Quercetin
[Abstract]

10 Glutathione conjugation of the cytostatic drug ifosfamide and the role of human glutathione S-transferases
article 1995    
Author: Dirven, H.A.A.M. · Megens, L. · Oudshoorn, M.J. · Dingemanse, M.A. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione transferase · Ifosfamide · Cancer chemotherapy · Drug conjugation · Drug detoxification · Drug resistance · Enzyme activity · Human · Human tissue · Leukemia · Lymphoma · Solid tumor · Antineoplastic Agents, Alkylating · Biotransformation · Chromatography, High Pressure Liquid · Drug Resistance, Neoplasm · Glutathione · Glutathione Transferase · Human · Ifosfamide · Isoenzymes · Magnetic Resonance Spectroscopy · Metabolic Detoxication, Drug · Spectrometry, Mass, Fast Atom Bombardment · Support, Non-U.S. Gov't
[Abstract]

11 The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa
article 1995    
Author: Dirven, H.A.A.M. · Dictus, E.L.J.T. · Broeders, N.L.H.L. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione reductase · Tepa · Thiotepa · Conformational transition · Drug conformation · Drug conjugation · Drug protein binding · Drug resistance · Enzyme activity · Priority journal · Chromatography, High Pressure Liquid · Female · Glutathione · Glutathione Transferase · Human · Isoenzymes · Kinetics · Liver · Magnetic Resonance Spectroscopy · Placenta · Pregnancy · Support, Non-U.S. Gov't · Thiotepa
[Abstract]

12 Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells
article 2004    
Author: Zanden, J.J. van · Geraets, L. · Wortelboer, H.M. · Bladeren, P.J. van · Rietjens, I.M.C.M. · Cnubben, N.H.P.
Keywords: Biology Toxicology · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · 50% inhibition concentration · CDNB · DNP-SG · Glutathione · Glutathione conjugate · Glutathione S-transferase · GS-X · GSH · GST · IC50 · MRP · Multidrug resistance associated protein · P-gp · S-(2,4-dinitrophenyl)glutathione · 3',4' dihydroxyflavone · carbon · catechin · catechol derivative · eriodictyol · flavanoid · flavone derivative · galanin · glutathione transferase · hydroxyl group · kaempferol · luteolin · morin · multidrug resistance protein 1 · multidrug resistance protein 2 · myricetin · quercetin · taxifolin · unclassified drug · animal cell · article · breast cancer · cell strain MCF 7 · chemical bond · controlled study · drug activity · drug potency · enzyme activity · enzyme inhibition · genetic transfection · human · human cell · IC 50 · lipophilicity · nonhuman · priority journal · structure activity relation · toxicokinetics · Biological Transport · Breast Neoplasms · Carrier Proteins · Drug Resistance, Multiple · Drug Resistance, Neoplasm · Flavonoids · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Membrane Transport Modulators · Membrane Transport Proteins · Multidrug Resistance-Associated Proteins · Structure-Activity Relationship · Tumor Cells, Cultured
[Abstract]

13 A glutathione S-transferase with activity towards cis-1,2- dichloroepoxyethane is involved in isoprene utilization by Rhodococcus sp. strain AD45
article 1998    
Author: Hylckama Vlieg, J.E.T. van · Kingma, J. · Wijngaard, A.J. van den · Janssen, D.B.
Keywords: Nutrition · 1,2 dichloroepoxyethane · Ethylene · Glutathione transferase · Industrial chemical · Isoprene · Unclassified drug · Biodegradation · Dechlorination · Detoxification · Enzyme activity · Enzyme isolation · Kinetics · Nonhuman · Biodegradation, Environmental · Butadienes · Epoxy Compounds · Glutathione Transferase · Hemiterpenes · Oxidation-Reduction · Pentanes · Rhodococcus · Negibacteria · Rhodococcus sp.
[PDF] [Abstract]

14 Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane
article 1995    
Author: Ploemen, J.H.T.M. · Wormhoudt, L.W. · Ommen, B. van · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Biology · Class theta · Chromatography, High Pressure Liquid · Cytosol · Dinitrochlorobenzene · Epoxy Compounds · Erythrocytes · Ethylene Dibromide · Glutathione · Glutathione Transferase · Human · Isoenzymes · Kinetics · Nitrophenols · Polymorphism (Genetics) · Support, Non-U.S. Gov't · Animalia
[Abstract]

15 Identification of multiple target sites for a glutathione conjugate on glutathione-S-transferase by matrix-assisted laser desorption/ionization mass spectrometry
article 1996    
Author: Jespersen, S. · Ploemen, J.H.T.M. · Bladeren, P.J. · Niessen, W.M.A. · Tjaden, U.R. · Greef, J. van der
Keywords: Nutrition · GSTCBQ target residues · Mapping site-specific mutagenesis · Binding Sites · Chloranil · Enzyme Inhibitors · Glutathione · Glutathione Transferase · Molecular Weight · Mutagenesis, Site-Directed · Peptide Mapping · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
[Abstract]

16 Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in caco-2 cells
article 2007    
Author: Usta, M. · Wortelboer, H.M. · Vervoort, J. · Boersma, M.G. · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Toxicology and Applied Pharmacology · curcumin · glutathione transferase · adult · aged · article · atom · catalysis · cell strain CACO 2 · conjugate · drug degradation · drug excretion · drug structure · female · glutathione metabolism · human · human cell · human tissue · intestine · intestine epithelium cell · liquid chromatography · liver cytosol · male · mass spectrometry · monolayer culture · proton nuclear magnetic resonance · Adult · Aged · Caco-2 Cells · Curcumin · Cytosol · Female · Glutathione · Glutathione Transferase · Humans · Intestines · Liver · Magnetic Resonance Spectroscopy · Male · Metabolic Detoxication, Phase II · Middle Aged · Molecular Structure
[Abstract]

17 In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate
article 1996    
Author: Ploemen, J.-P.H.T.M. · Iersel, M.L.P.S. van · Wormhoudt, L.W. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: diethyldithiocarbamate · disulfiram · gl utathion e · glutathione S-transferases · in vitro · inhibition · 1 chloro 2,4 dinitrobenzene · 1,2 epoxy 3 (4 nitrophenoxy)propane · aldehyde dehydrogenase inhibitor · diethyldithiocarbamic acid · disulfiram · dithiothreitol · glutathione transferase · isoenzyme · thiol · unclassified drug · article · controlled study · drug metabolism · enzyme inactivation · enzyme inhibition · enzyme purification · enzyme substrate · human · nonhuman · priority journal · rat · reduction · Animals · Disulfiram · Dithiothreitol · Ditiocarb · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Rats · Spectrophotometry, Ultraviolet · Time Factors
[Abstract]

18 Establishment of the enzymatic protein acetylation independent of acetyl CoA : recombinant glutathione S-transferase 3-3 is acetylated by a novel membrane-bound transacetylane using 7,8-diacetoxy-4-methyl coumarin as the acetyl donor
article 2002    
Author: Kohli, E. · Gaspari, M. · Raj, H.G. · Parmar, V.S. · Greef, J. van der · Gupta, G. · Kumari, R. · Prasad, A.K. · Goel, S. · Pal, G. · Tyagi, K. · Jain, S.C. · Ahmad, N. · Watterson, A.C. · Olsen, C.E.
Keywords: Acetyl Coenzyme A · Acetylation · Acetylesterase · Coumarins · Glutathione Transferase · Recombinant Proteins · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
[PDF] [Abstract]

19 A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide : relevance of extrahepatic metabolism
article 2000    
Author: Hissink, A.M. · Wormhoudt, L.W. · Sherratt, P.J. · Hayes, J.D. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Ethylene dibromide · Extrapolation · Glutathione S-transferase · Interindividual variation · PBPK · Risk assessment · 1,2 dibromoethane · cytochrome P450 · glutathione · glutathione transferase · animal experiment · animal model · article · biotransformation · controlled study · male · nonhuman · pharmacokinetics · prediction · rat · risk assessment · toxicity testing · xenobiotic metabolism · Administration, Oral · Animals · Area Under Curve · Biotransformation · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethylene Dibromide · Glutathione Transferase · Humans · Injections, Intravenous · Liver · Male · Models, Biological · Rats · Rats, Wistar · Risk Assessment
[Abstract]

20 Selection of Arabidopsis mutants overexpressing genes driven by the promoter of an auxin-inducible glutathione S-transferase gene
article 1999    
Author: Kop, D.A.M. van der · Schuyer, M. · Pinas, J.E. · Zaal, B.J. van der · Hooykaas, P.J.J.
Keywords: Nutrition · Arabidopsis thaliana · Auxin-responsive gene expression · Developmental mutants · Glutathione S-transferase · GST · Gup mutant · Auxin · Beta glucuronidase · Gene expression · Glutathione transferase · Kanamycin · Reporter gene · Transgenic plant · Arabidopsis · Chromosome Mapping · Crosses, Genetic · DNA, Bacterial · Enzyme Induction · Ethyl Methanesulfonate · Gene Expression Regulation, Plant · Genes, Plant · Glutathione Transferase · Indoleacetic Acids · Mutagenesis · Mutagens · Mutation · Phenotype · Plants, Genetically Modified · Promoter Regions (Genetics) · Recombinant Fusion Proteins · Up-Regulation
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 77 found. Next | Sort by date