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Showing 1 to 19 of 19 found. | Sort by date

1 Effects of fenofibrate on hyperlipidemia and postprandial triglyceride metabolism in human apolipoprotein C1 transgenic mice
article 1998    
Author: Jong, M.C. · Dahlmans, V.E.H. · Princen, H.M.G. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Apo C · LDL-receptor · Transgenic mice · Triglycerides · Animals · Antilipemic Agents · Apolipoproteins C · Humans · Hyperlipidemias · Mice · Mice, Transgenic · Procetofen · Triglycerides
[Abstract]

2 Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis
article 1998    
Author: Hofker, M.H. · Vlijmen, B.J.M. van · Havekes, L.M.
Keywords: Health · APOE · Apolipoprotein · Cholesterol · Gene targeting · Lipoprotein · Triglyceride · Animals · Apolipoproteins E · Arteriosclerosis · Disease Models, Animal · Humans · Hyperlipidemias · Mice · Mice, Transgenic
[Abstract]

3 Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
article 2003    
Author: Gerritsen, G. · Kypreos, K.E. · Zee, A. van der · Teusink, B. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E4 · Apolipoproteins E · Cholesterol · Humans · Hyperlipidemias · Lipids · Lipoproteins · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Protein Isoforms · Protein Structure, Tertiary · Triglycerides
[PDF] [Abstract]

4 Lack of predictability of classical animal models for hypolipidemic activity: A good time for mice?
article 1998    
Author: Krause, B.R. · Princen, H.M.G.
Keywords: Health · Classic models · HMG-CoA reductase · Hypolipidemic activity · 3 (2,4 difluorophenyl) 1 heptyl 1 (4 neopentylbenzyl)urea · Animals · Antilipemic Agents · Disease Models, Animal · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hyperlipidemias · Lipids · Lipoproteins · Mice · Niacin
[Abstract]

5 Gender-related association between the -93T →Gg/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia
article 1998    
Author: Hoffer, M.J.V. · Bredie, S.J.H. · Snieder, H. · Reymer, P.W.A. · Demacker, P.N.M. · Havekes, L.M. · Boomsma, D.I. · Stalenhoef, A.F.H. · Frants, R.R. · Kastelein, J.J.P.
Keywords: Health · Familial combined hyperlipidemia · Family study · Genetic predisposition · Lipoprotein lipase · Mutation analysis · Adult · Amino Acid Sequence · DNA Mutational Analysis · Female · Haplotypes · Heterozygote · Humans · Hyperlipidemias · Likelihood Functions · Linkage (Genetics) · Lipids · Lipoprotein Lipase · Male · Middle Aged · Pedigree · Promoter Regions (Genetics) · Sex Characteristics
[Abstract]

6 Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1
article 1998    
Author: Jong, M.C. · Gijbels, M.J.J. · Dahlmans, V.E.H. · Gorp, P.J.J. van · Koopman, S.-J. · Ponec, M. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Apolipoprotein C · Hypertriglyceridemia · Sebaceous glands · Sebum production · Triglycerides · Animals · Apolipoprotein C-I · Apolipoproteins C · Epidermis · Female · Humans · Hyperlipidemias · Lipids · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Skin Abnormalities
[Abstract]

7 Genetic analysis of sex and generation differences in plasma lipid, lipoprotein, and apolipoprotein levels in adolescent twins and their parents
article 1996    
Author: Boomsma, D.I. · Kempen, H.J.M. · Gevers Leuven, J.A. · Havekes, L. · Knijff, P. de · Frants, R.R.
Keywords: Health · ApoA1 · ApoA2 · ApoB · ApoE · HDL · LDL · Adolescent · Adult · Age Distribution · Aged · Apolipoproteins · Cholesterol · Diseases in Twins · Female · Humans · Hyperlipidemias · Lipoproteins · Male · Middle Aged · Models, Genetic · Netherlands · Phenotype · Sex Distribution · Variation (Genetics)
[Abstract]

8 Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice
article 1998    
Author: Vlijmen, B.J.M. van · Mensink, R.P. · Hof, H.B. van 't · Offermans, R.F.G. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Dietary fish oil · Hypertipidemia · n-3 fatty acids · Transgenic mice · VLDL metabolism · Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Cholesterol · Cholesterol, Dietary · Dietary Fats · Female · Fish Oils · Humans · Hyperlipidemias · Kinetics · Lipoproteins · Lipoproteins, HDL · Lipoproteins, IDL · Lipoproteins, LDL · Lipoproteins, VLDL · Mice · Mice, Transgenic · Triglycerides
[PDF] [Abstract]

9 Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia
article 1997    
Author: Maat, M.P.M. de · Knipscheer, H.C. · Kastelein, J.J.P. · Kluft, C.
Keywords: Biology · C reactive protein · Ciprofibrate · Acute phase response · Cardiovascular disease · Clinical trial · Controlled clinical trial · Controlled study · Drug effect · Drug mechanism · Fibrinogen blood level · Genetic polymorphism · Hypercholesterolemia · Major clinical study · Oral drug administration · Randomized controlled trial · Risk factor · Adult · Antilipemic Agents · Clofibric Acid · Female · Fibrinogen · Gemfibrozil · Humans · Hyperlipidemias · Male · Middle Aged
[Abstract]

10 Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism
article 1999    
Author: Sijbrands, E.J.G. · Hoffer, M.J.V. · Meinders, A.E. · Havekes, L.M. · Frants, R.R. · Smelt, A.H.M. · Knijff, P. de
Keywords: Apolipoprotein E · Hyperinsulinemia · Hyperlipoproteinemia type III · Xanthomas · Adult · Aged · Aged, 80 and over · Apolipoprotein A-I · Apolipoprotein C-III · Apolipoprotein E2 · Apolipoproteins A · Apolipoproteins C · Apolipoproteins E · Cholesterol, HDL · Cholesterol, LDL · Cholesterol, VLDL · Family Health · Female · Gene Expression · Haplotypes · Homozygote · Humans · Hyperinsulinism · Hyperlipidemias · Male · Middle Aged · Pedigree · Polymorphism, Single Nucleotide · Promoter Regions (Genetics) · Xanthomatosis
[Abstract]

11 Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus.
article 2003    
Author: Ree, M.A. van de · Maat, M.P. de · Kluft, C. · Meinders, A.E. · Princen, H.M. · Huisman, M.V.
Keywords: Atorvastatin · Blood clotting factor 8a · Hemostatic agent · Heptanoic acid derivative · Biosynthesis · Blood · Cardiovascular disease · Clinical trial · Controlled clinical trial · Controlled study · Dose response · Double blind procedure · Non insulin dependent diabetes mellitus · Pathology · Randomized controlled trial · Time · Aged · Cardiovascular Diseases · Diabetes Mellitus, Type 2 · Dose-Response Relationship, Drug · Double-Blind Method · Factor VIIIa · Female · Fibrinogen · Hemostatics · Heptanoic Acids · Humans · Hyperlipidemias · Male · Middle Aged · Placebos · Pyrroles · Risk Factors · Time Factors · Tissue Plasminogen Activator · von Willebrand Factor
[Abstract]

12 Quantitative assessment of aortic atherosclerosis in APOE*3 leiden transgenic mice and its relationship to serum cholesterol exposure
article 1996    
Author: Groot, P.H.E. · Vlijmen, B.J.M. van · Benson, G.M. · Hofker, M.H. · Schiffelers, R. · Vidgeon-Hart, M. · Havekes, L.M.
Keywords: Biology · animal model · apolipoprotein E · diet · familial dyslipoproteinemia · hyperlipidemia · apolipoprotein e · cholesterol · animal experiment · animal model · animal tissue · aorta atherosclerosis · aorta sinus · article · atherosclerosis · cholesterol blood level · cholesterol diet · controlled study · dyslipoproteinemia · feeding · female · hyperlipidemia · hypolipemia · lipid diet · male · mouse · nonhuman · priority journal · transgenic mouse · Animals · Aortic Diseases · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Cholesterol · Cholesterol, Dietary · Dietary Fats · Female · Hyperlipidemias · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Sinus of Valsalva
[Abstract]

13 Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice
article 2006    
Author: Weel, V. van · Vries, M. de · Voshol, P.J. · Verloop, R.E. · Eilers, P.H.C. · Hinsbergh, V.W.M. van · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Arteriogenesis · Cholesterol · Collateral circulation · Diabetes · NOD mice · Peripheral vascular disease · Glucose · Streptozocin · Triacylglycerol · Lipid · Angiogenesis · Angiography · Animal model · Artery occlusion · Cholesterol blood level · Controlled study · Diabetes mellitus · Diet · Fatty acid blood level · Femoral artery · Glucose blood level · Glucose metabolism · Hypercholesterolemia · Hyperglycemia · Insulin blood level · Insulin resistance · Laser Doppler flowmetry · Lipid metabolism · Male · Mouse · Nonhuman · Postoperative period · Blood · Collateral circulation · Comparative study · Experimental diabetes mellitus · Genetics · Growth, development and aging · Metabolism · Mouse strain · Pathophysiology · Physiology · Vascularization · Acute Disease · Animals · Apolipoprotein E3 · Apolipoproteins E · Arteries · Blood Glucose · Cholesterol · Collateral Circulation · Diabetes Mellitus, Experimental · Hindlimb · Hypercholesterolemia · Hyperglycemia · Hyperlipidemias · Insulin · Insulin Resistance · Ischemia · Lipids · Male · Mice · Mice, Inbred Strains · Neovascularization, Physiologic
[Abstract]

14 ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
article 2005    
Author: Gerritsen, G. · Rensen, P.C.N. · Kypreos, K.E. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · Adenovirus-mediated gene transfer · Lipoprotein lipase-mediated triglyceride hydrolysis · Mice · Very low density lipoprotein · Cholesterol · Fatty acid · Intermediate density lipoprotein · Lipoprotein · Triacylglycerol · Lipid · Lipoprotein lipase · Animal experiment · Animal tissue · Cholesterol blood level · Controlled study · Dose response · Emulsion · Female · Gene dosage · Gene overexpression · Hydrolysis · Hyperlipidemia · In vitro study · In vivo study · Injection · Lipoprotein deficiency · Mouse · Nonhuman · Protein blood level · White adipose tissue · Animal · Biosynthesis · Blood · Genetic transfection · Genetics · Metabolism · Mouse mutant · Animals · Apolipoprotein C-III · Apolipoprotein E4 · Apolipoproteins C · Apolipoproteins E · Humans · Hyperlipidemias · Lipids · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Mice · Mice, Knockout · Transfection · Triglycerides
[PDF] [Abstract]

15 Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL
article 2006    
Author: Westerterp, M. · Haan, W. de · Berbée, J.F.P. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Lipases transgenic mouse models · Very low density lipoprotein · apolipoprotein B · cholesterol · fatty acid · heparin · lipid · olive oil · triacylglycerol · very low density lipoprotein · animal experiment · animal tissue · cholesterol blood level · concentration response · controlled study · enzyme inhibition · gene dosage · gonad · hyperlipidemia · intestine absorption · knockout mouse · lipid absorption · lipid blood level · lipid metabolism · lipolysis · mouse · nonhuman · postprandial state · protein expression · triacylglycerol blood level · white adipose tissue · Animals · Apolipoprotein C-I · Apolipoproteins C · Apolipoproteins E · Cholesterol · Hyperlipidemias · Intestines · Lipase · Lipoprotein Lipase · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Postprandial Period
[PDF] [Abstract]

16 Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance
article 2004    
Author: Muurling, M. · Hoek, A.M. van den · Mensink, R.P. · Pijl, H. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Free fatty acid metabolism · Hepatic fat accumulation · Lipid metabolism · Peroxisome proliferator-activated receptor-γ · Rosiglitazone · Diacylglycerol · Glucose · Ketone body · Peroxisome proliferator activated receptor gamma · Rosiglitazone · Triacylglycerol · Adipose tissue · Animal experiment · Animal model · Animal tissue · APOC1 gene · Cholesterol blood level · Controlled study · Fatty acid metabolism · Gene · Gene overexpression · Gluconeogenesis · Glucose blood level · Glucose transport · Hyperglycemia · Hyperinsulinemia · Hyperlipidemia · Insulin blood level · Insulin resistance · Lipid metabolism · Lipid storage · Mouse · Nonhuman · Obesity · Transgenic mouse · Triacylglycerol blood level · Weight reduction · Animals · Apolipoprotein C-I · Apolipoproteins C · Blood Glucose · Body Weight · Fatty Acids · Fatty Liver · Gene Expression · Humans · Hyperglycemia · Hyperinsulinism · Hyperlipidemias · Insulin · Insulin Resistance · Mice · Mice, Transgenic
[PDF] [Abstract]

17 Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons from Animal Models
article 2004    
Author: Boer, M. den · Voshol, P.J. · Kuipers, F. · Havekes, L.M. · Romijn, J.A.
Keywords: Biology · Biomedical Research · Fatty acid metabolism · Glucose metabolism · Insulin resistance · Lipoprotein metabolism · Mouse models · Alcohol · Triacylglycerol · Animal experiment · Animal model · Disease association · Dyslipidemia · Endocrine system · Genetic transcription · Glucose metabolism · Lnsulin resistance · Lipid liver level · Metabolic syndrome X · Mouse · Non insulin dependent diabetes mellitus · Nonhuman · Partition coefficient · Pathophysiology · Rodent · Short survey · Adipose Tissue · Animals · Diabetes Mellitus, Type 2 · Dogs · Fatty Acids · Fatty Liver · Glucose · Homeostasis · Humans · Hyperlipidemias · Insulin Resistance · Liver · Metabolic Syndrome X · Mice · Models, Animal · Models, Biological · Obesity · Rats · Rats, Zucker · Transcription, Genetic · Triglycerides
[Abstract]

18 Hyperlipidaemia is associated with increased insulin-mediated glucose metabolism, reduced fatty acid metabolism and normal blood pressure in transgenic mice overexpressing human apolipoprotein C1
article 2001    
Author: Koopmans, S.J. · Jong, M.C. · Que, I. · Dahlmans, V.E.H. · Pijl, H. · Radder, J.K. · Frölich, M. · Havekes, L.M.
Keywords: Biology · APOC1 · Hypertension · Insulin resistance · Insulin resistance syndrome · Lipoprotein · NEFA · Fatty acid · Palmitic acid · Triacylglycerol · Tritium · Very low density lipoprotein · Adipose tissue · Animal model · Animal tissue · Blood pressure · Cholesterol blood level · Clearance · Controlled study · Fatty acid metabolism · Gene overexpression · Glucose blood level · Glucose clamp technique · Glucose metabolism · Glycogen synthesis · Glycolysis · Heart rate · Hyperinsulinemia · Hyperlipidemia · Hypertension · In vivo study · Infusion · Insulin resistance · Lipid transport · Lipogenesis · Mean arterial pressure · Mouse · Nonhuman · Skeletal muscle · Transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins C · Blood Glucose · Blood Pressure · Cholesterol · Fatty Acids, Nonesterified · Gene Expression · Glucose · Glucose Clamp Technique · Glycogen · Humans · Hyperlipidemias · Insulin · Lipid Metabolism · Liver · Mice · Mice, Transgenic · Muscle, Skeletal · Palmitic Acid · Triglycerides · Tritium
[Abstract]

19 Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
article 2005    
Author: Espirito Santo, S.M.S. · Rensen, P.C.N. · Goudriaan, J.R. · Bensadoun, A. · Bovenschen, N. · Voshol, P.J. · Havekes, L.M. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Apolipoprotein E · Hepatic lipase · Hyperlipidemia · Lipoprotein lipase · Low density lipoprotein receptor · Postprandial response · Transgenic mice · Very low density lipoprotein receptor · Very low density lipoproteins · Lipid · Low density lipoprotein receptor · Low density lipoprotein receptor related protein · Triacylglycerol lipase · Very low density lipoprotein receptor · Leucine responsive regulatory protein · Lipoprotein · Transcription factor · Animal experiment · Animal model · Animal tissue · Controlled study · Female · gene deletion · Hyperlipidemia · Lipid blood level · Lipid diet · Male · Mouse · Nonhuman · Protein defect · Species comparison · Triacylglycerol blood level · Triacylglycerol lipase blood level · Wild type · Chemistry · Genetics · Metabolism · Pathology · Physiology · Polymerase chain reaction · Time · Transgenic mouse · Alleles · Animals · Cholesterol · DNA-Binding Proteins · Genotype · Hyperlipidemias · Leucine-Responsive Regulatory Protein · Lipid Metabolism · Lipoproteins · Mice · Mice, Transgenic · Polymerase Chain Reaction · Receptors, LDL · Time Factors · Transcription Factors · Triglycerides
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date