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1 Reduction of use of animals in regulatory genotoxicity testing : Identification and implementation opportunities-Report from an ECVAM workshop
article 2009    
Author: Pfuhler, S. · Kirkland, D. · Kasper, P. · Hayashi, M. · Vanparys, P. · Carmichael, P. · Dertinger, S. · Eastmond, D. · Elhajouji, A. · Krul, C.A.M. · Rothfuss, A. · Schoening, G. · Smith, A. · Speit, G. · Thomas, C. · Benthem, J. van · Corvi, R.
Keywords: Biology · Physiological Sciences · Animal use · Genotoxicity in vivo · Reduction
[Abstract]

2 Relative absorption and dermal loading of chemical substances : Consequences for risk assessment (Extended Abstract)
article 2007    
Author: Buist, H.E. · Schaafsma, G. · Sandt, J.J.M. van de
Keywords: Biology · Dermal absorption · Dermal loading · Risk assessment · Skin irritation · In vitro · In vivo · Food and Nutrition · Healthy Living

3 Sub-chronic toxicity study in rats orally exposed to nanostructured silica
article 2014    
Author: Zande, M. van der · Vandebriel, R.J. · Groot, M.J. · Kramer, E. · Herrera Rivera, Z.E. · Rasmussen, K. · Ossenkoppele, J.S. · Tromp, P. · Gremmer, E.R. · Peters, R.J.B. · Hendriksen, P.J. · Marvin, H.J.P. · Hoogenboom, R.L.A.P. · Peijnenburg, A.A.C.M. · Bouwmeester, H.
Keywords: Biology · In vivo · Nano · Oral exposure · Silica · Synthetic amorphous silica · Toxicity · Urban Development · Built Environment · Earth / Environmental · AEC - Applied Environmental Chemistry · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Preventie tegen flauwvallen tijdens de behandeling : kan dat?
article 2014    
Author: Houtem, C.M.H.H. van · Vermaire, J.H.
Keywords: Health · Bloed-letsel-injectiefobie · Naaldfobie · Diagnostiek · Applied tension · Graduele exposure in vivo · Healthy for Life · Healthy Living · Behavioural Changes · LS - Life Style · ELSS - Earth, Life and Social Sciences
[Abstract]

5 A multivariable model for predicting the frictional behaviour and hydration of the human skin
article 2013    
Author: Veijgen, N.K. · Heide, E. van der · Masen, M.A.
Keywords: Materials · Dynamic friction · Epidermis · Hydration · In vivo · Measurement · Static friction · Statistical modelling · High Tech Systems & Materials · Industrial Innovation · Mechatronics, Mechanics & Materials · MPC - Materials Performance Centre · TS - Technical Sciences
[Abstract]

6 Oxygen-tension measurements - The first step towards prevention and early detection of anastomotic leakage
article 2007    
Author: Tanase, D. · French, P.J. · Komen, N. · Kleinrensink, G.J. · Jeekel, J. · Lange, J.F. · Draaijer, A.
Keywords: Analytical research · Carbon dioxide · Leakage (fluid) · Oxygen · Oxygenation · Surgery · Temperature sensors · Early detections · In-vivo · Measurement systems · Rat kidneys · Recovery periods · Reperfusion · Sensor chips · Sensor systems · Tension measurements · Tissue oxygenations · Sensors
[Abstract]

7 Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human
article 2013    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Biology · Alternative for animal testing · Embryonic stem cell test (EST) · In vitro-in vivo (IVIV) extrapolation · Phenol · Physiologically based kinetic (PBK) modelling · Risk assessment · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Development of a combined in Vitro Physiologically Based Kinetic (PBK) and Monte Carlo modelling approach to predict interindividual human variation in phenol-induced developmental toxicity
article 2017    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Nutrition · Alternatives for animal testing · In vitro-in vivo extrapolation (IVIVE) · Interindividual differences · Monte Carlo simulation · PBK or PBPK modelling · UGT · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Evaluating in vitro-in vivo extrapolation of toxicokinetics
article 2018    
Author: Wambaugh, J.F. · Hughes, M.F. · Ring, C.L. · MacMillan, D.K. · Ford, J. · Fennell, T.R. · Black, S.R. · Snyder, R.W. · Sipes, N.S. · Wetmore, B.A. · Westerhout, J. · Setzer, R.W. · Pearce, R.G. · Simmons, J.E. · Thomas, R.S.
Keywords: Biology · Environmental chemicals · IVIVE · Toxicokinetics · Animal experiment · Animal tissue · Clearance · Drug bioavailability · Health hazard · In vitro study · In vivo study · Nonhuman · Plasma · Prediction · Rat · Steady state · Toxicokinetics · Uncertainty · Volume of distribution
[Abstract]

10 Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds
article 2007    
Author: Freidig, A.P. · Dekkers, S. · Verwei, M. · Zvinavashe, E. · Bessems, J.G.M. · Sandt, J.J.M. van de
Keywords: Biology · Analytical research · Biomedical research · Acute rodent toxicity · In vitro-in vivo correlation · QSAR · chemical compound · acute toxicity · article · clinical research · hazard assessment · in vitro study · in vivo study · LD 50 · mouse · nonhuman · prediction · priority journal · quantitative structure activity relation · rat · reference database · validation study · Algorithms · Animals · Data Interpretation, Statistical · Endpoint Determination · European Union · Forecasting · Hazardous Substances · Humans · Legislation · Lethal Dose 50 · Quantitative Structure-Activity Relationship · Reproducibility of Results · Animalia · Rattus · Rodentia
[Abstract]

11 Bioavailability and biodistribution of differently charged polystyrene nanoparticles upon oral exposure in rats
article 2015    
Author: Walczak, A.P. · Hendriksen, P.J.M. · Woutersen, R.A. · Zande, M. van der · Undas, A.K. · Helsdingen, R. · Berg, H.H.J. van den · Rietjens, I.M.C.M. · Bouwmeester, H.
Keywords: Nanotechnology · Bioavailability · Biodistribution · In vivo · Oral exposure · Polystyrene nanoparticles · Surface properties · Biochemistry · Nanoparticles · Polystyrenes · Rats · Risk assessment · Tissue · Nanoparticle · Polystyrene · Animal experiment · Animal model · Animal tissue · Controlled study · Heart · In vitro study · In vivo study · Intestine wall · Kidney · Male · Nonhuman · Prediction · Small intestine · Stomach wall · Surface charge · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

12 Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals
article 2005    
Author: Stierum, R. · Heijne, W. · Kienhuis, A. · Ommen, B. van · Groten, J.
Keywords: Toxicology Nutrition · Physiological Sciences · In vitro · In vivo · Liver · Toxicogenomics · bromobenzene · butylcresol · chemical compound · curcumin · food additive · gallic acid propyl ester · proteome · tiabendazole · transcriptome · biochemistry · bioinformatics · comparative toxicology · conference paper · disease marker · DNA fingerprinting · gene expression profiling · genetic procedures · genetic toxicology · genomics · in vitro study · in vivo study · laboratory · liver toxicity · metabolomics · molecular biology · nonhuman · prediction · proteomics · rat · technology · toxicological parameters · transcriptomics · Animals · Food Additives · Genomics · Humans · Liver · Toxicology
[Abstract]

13 In vitro models for the prediction of in vivo performance of oral dosage forms
article 2014    
Author: Kostewicz, E.S. · Abrahamsson, B. · Brewster, M. · Brouwers, J. · Butler, J. · Carlert, S. · Dickinson, P.A. · Dressman, J. · Holm, R. · Klein, S. · Mann, J. · McAllister, M. · Minekus, M. · Muenster, U. · Müllertz, A. · Verwei, M. · Vertzoni, M. · Weitschies, W. · Augustijns, P.
Keywords: Biology · Biorelevant · In vitro evaluation · In vivo biopharmaceutical performance · Innovative Medicines Initiative (IMI) · Oral Biopharmaceutical Tools (OrBiTo) · Oral drug formulations · Albendazole · Amprenavir · Bile acid · Celecoxib · Cinnarizine · Cyclodextrin · Danazol · Diclofenac · Dipyridamole · Excipient · Gelucire · Ketoconazole · Loviride · Montelukast · Octanol · Propranolol · Saquinavir · Controlled drug release · Drug absorption · Drug bioavailability · Drug development · Drug dosage form · Drug formulation · Drug penetration · Drug solubility · Gastrointestinal motility · Human · Hydrodynamics · In vitro study · In vivo study · Lipolysis · Nonhuman · Precipitation · Prediction · Priority journal · Quality control · Review · Simulation · Tablet disintegration · Food and Nutrition · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · ELSS - Earth, Life and Social Sciences
[Abstract]

14 Comparative in vitro-in vivo percutaneous penetration of the fungicide ortho-phenylphenol
article 2002    
Author: Cnubben, N.H.P. · Elliott, G.R. · Hakkert, B.C. · Meuling, W.J.A. · Sandt, J.J.M. van de
Keywords: Health · Dermal penetration · In vitro-in vivo comparison · Ortho-phenylphenol · Risk assessment · 2 hydroxybiphenyl · 2-phenylphenol · Biphenyl derivative · Fungicide · Animal tissue · Biotransformation · Controlled study · Human · Human tissue · In vitro study · In vivo study · Male · Nonhuman · Skin absorption · Skin culture · Skin penetration · Thickness · Toxicokinetics · Urinary excretion · Adult · Animal · Comparative study · Dose response · Epidermis · Intradermal drug administration · Membrane · Metabolism · Outbred strain · Permeability · Swine · Wistar rat · Administration, Cutaneous · Adult · Animal · Animals, Outbred Strains · Biphenyl Compounds · Comparative Study · Dose-Response Relationship, Drug · Epidermis · Female · Fungicides, Industrial · Human · In Vitro · Male · Membranes · Permeability · Rats · Rats, Wistar · Skin Absorption · Support, Non-U.S. Gov't · Swine · Animals · Humans · Sus scrofa
[Abstract]

15 Relative absorption and dermal loading of chemical substances: Consequences for risk assessment
article 2009    
Author: Buist, H.E. · Schaafsma, G. · Sandt, J.J.M. van de
Keywords: Chemistry · Food and Chemical Risk Analysis · Dermal absorption · Dermal loading · In vitro · In vivo · Risk assessment · Skin irritation · 1 methyl 2 pyrrolidinone · 2 ethoxyethanol · aminolevulinic acid · aminolevulinic acid hexyl ester · aminolevulinic acid methyl ester · atrazine · azinphos methyl · benzo[a]pyrene · benzoic acid · catechol · chemical compound · disulfoton · flurbiprofen · hexachlorobenzene · hydrocortisone · ibuprofen · iprodione · malathion · mevinphos · naloxone · parathion · pentachlorophenol · pesticide · phosmet · pyrene · testosterone · triclosan · trimethylamine · volatile agent · zinc chloride · article · health hazard · human · in vitro study · in vivo study · molecular weight · nonhuman · priority journal · risk assessment · skin absorption · skin irritation
[Abstract]

16 Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics
article 2015    
Author: Bosgra, S. · Westerhout, J.
Keywords: Toxicology · In vitro test battery · In vitro-in vivo extrapolation · Protein binding · TK modeling · Toxicokinetics · 2 ethylhexanoic acid · Ammonium derivative · Cyclosporin A · Diethylstilbestrol · Endosulfan · Gluphosinate ammonium · Hexanoic acid derivative · Methoxyacetic acid · Methylhexanoic acid · Methylmercuric chloride · Phthalic acid 2 ethylhexyl monoester · Retinoic acid · Unclassified drug · Valproic acid · Animal experiment · Clinical observation · Controlled study · Developmental toxicity · In vitro study · In vivo study · Mouse · Mouse defense test battery · Nonhuman · Predictive value · Protein binding · Quantitative analysis · Rat · Reproductive toxicity · Risk assessment · Simulation · Toxicokinetics · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

17 Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2014    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, Y.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro-in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Food and Nutrition · Healthy Living · Life Triskelion BV · RAPID - Risk Assessment Products in Developmentv ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences TNO Bedrijven

18 Genotoxicity and mutagenicity
article 2005    
Author: Maurici, D. · Aardema, M. · Corvi, R. · Kleber, M. · Krul, C.A.M. · Laurent, C. · Loprieno, N. · Pasanen, M. · Pfuhler, S. · Phillips, B. · Sabbioni, E. · Sanner, T. · Vanparys, P.
Keywords: Toxicology · Physiological sciences · Animal testing replacement · Animal testing alternatives · Chromosome aberration · Comet assay · DNA damage · DNA synthesis · Gene mutation · Genotoxicity · In vitro study · In vivo study · Micronucleus test · Mitotic recombination · Mutagenicity · Sister chromatid exchange · Toxicity testing · Toxicogenetics · Toxicokinetics · Toxicological parameters · Carcinogen testing · Cell culture · Chemistry · Legal aspects · Structure activity relation · Animalia · Consumer product safety · Cosmetics · European Union · Structure-Activity Relationship

19 A mechanistic approach to predicting the friction behaviour of human skin
article 2012    
Author: Kuilenburg, J. van · Masen, M.A. · Heide, E. van der
Keywords: Materials · Contact Mechanics · Contact parameters · Fingerprint ridges · Friction behavior · Friction behaviour · In-vivo experiments · Laser technologies · Ultra-short pulsed · Deformation · Friction · Geometry · Skin · Tribology · Behavioral research · High Tech Systems & Materials · Industrial Innovation · Mechatronics, Mechanics & Materials · MPC - Materials Performance Centre · TS - Technical Sciences
[Abstract]

20 Toxicology in the 21st century - Working our way towards a visionary reality
article 2011    
Author: Berg, N. · Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Roggen, E.L.
Keywords: Health · -Omics · 21st Century vision · 3Rs · Computational · In vitro · Replacement · Testing strategy · Toxicity testing · Validation · article · biological model · education · Europe · ex vivo study · financial management · in vitro study · in vivo study · interpersonal communication · leadership · medical research · practice guideline · risk assessment · standardization · systems biology · toxicity testing · toxicology · validation process · Animalia · Healthy living · Biomedical Innovations · Themalijn
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 105 found. Next | Sort by date